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Christina Bourne

TitleAssistant Professor
InstitutionUniversity of Oklahoma, Norman
DepartmentChemistry/Biochemistry
Address620 Parrington Oval
Norman OK
Phone(405) 325-4812
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Muthuramalingam M, White JC, Bourne CR. Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways. Toxins (Basel). 2016 Jul 09; 8(7). PMID: 27409636; PMCID: PMC4963847.
    2. Muddala NP, Nammalwar B, Selvaraju S, Bourne CR, Henry M, Bunce RA, Berlin KD, Barrow EW, Barrow WW. Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex. Molecules. 2015 Apr 21; 20(4):7222-44. PMID: 25905602; PMCID: PMC4445145.
    3. Nammalwar B, Bourne CR, Wakeham N, Bourne PC, Barrow EW, Muddala NP, Bunce RA, Berlin KD, Barrow WW. Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis. Bioorg Med Chem. 2015 Jan 01; 23(1):203-11. PMID: 25435253; PMCID: PMC4278362.
    4. Nammalwar B, Muddala NP, Bourne CR, Henry M, Bourne PC, Bunce RA, Barrow EW, Berlin KD, Barrow WW. Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis. Molecules. 2014 Mar 17; 19(3):3231-46. PMID: 24642909; PMCID: PMC4016962.
    5. Bourne CR, Wakeham N, Webb N, Nammalwar B, Bunce RA, Berlin KD, Barrow WW. The structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveal restrictions to cofactor docking. Biochemistry. 2014 Feb 25; 53(7):1228-38. PMID: 24495113; PMCID: PMC3985486.
    6. Bourne CR. Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery. Antibiotics (Basel). 2014 Jan 21; 3(1):1-28. PMID: 27025730; PMCID: PMC4790348.
    7. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics. Org Prep Proced Int. 2013; 45(1):66-71. PMID: 23788820.
      View in: PubMed
    8. Bourne CR, Wakeham N, Nammalwar B, Tseitin V, Bourne PC, Barrow EW, Mylvaganam S, Ramnarayan K, Bunce RA, Berlin KD, Barrow WW. Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase. Biochim Biophys Acta. 2013 Jan; 1834(1):46-52. PMID: 22999981; PMCID: PMC3530638.
    9. Nammalwar B, Bourne CR, Bunce RA, Wakeham N, Bourne PC, Ramnarayan K, Mylvaganam S, Berlin KD, Barrow EW, Barrow WW. Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines. ChemMedChem. 2012 Nov; 7(11):1974-82. PMID: 22930550; PMCID: PMC3570588.
    10. Barrow EW, Clinkenbeard PA, Duncan-Decocq RA, Perteet RF, Hill KD, Bourne PC, Valderas MW, Bourne CR, Clarkson NL, Clinkenbeard KD, Barrow WW. High-throughput screening of a diversity collection using biodefense category A and B priority pathogens. J Biomol Screen. 2012 Aug; 17(7):946-56. PMID: 22653912; PMCID: PMC3700734.
    11. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis. Eur J Med Chem. 2012 Aug; 54:387-96. PMID: 22703705; PMCID: PMC3408765.
    12. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Approaches to Iodinated Derivatives of Vanillin and Isovanillin. Org Prep Proced Int. 2012; 44(2):146-152. PMID: 23805008.
      View in: PubMed
    13. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Microwave-assisted Heck Synthesis of Substituted 2,4-Diaminopyrimidine-based Antibiotics. Org Prep Proced Int. 2012; 44(3):281-287. PMID: 23805009.
      View in: PubMed
    14. Bourne CR, Bunce RA, Bourne PC, Berlin KD, Barrow EW, Barrow WW. Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity. Antimicrob Agents Chemother. 2009 Jul; 53(7):3065-73. PMID: 19364848; PMCID: PMC2704665.
    15. Stray SJ, Bourne CR, Punna S, Lewis WG, Finn MG, Zlotnick A. A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8138-43. PMID: 15928089; PMCID: PMC1149411.
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