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Courtney Wayne Houchen

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Gastroenterology
Address800 Stanton L Young Blvd
Oklahoma City OK 73104-0001
Phone405/271-5428
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    Collapse Research 
    Collapse research activities and funding
    K08DK002822     (HOUCHEN, COURTNEY WAYNE)Sep 15, 2000 - Jun 30, 2006
    NIH/NIDDK
    PROSTAGLANDIN E2 RECEPTORS IN GASTROINTESTINAL INJURY
    Role: Principal Investigator

    R03DK065887     (HOUCHEN, COURTNEY WAYNE)Feb 1, 2004 - Nov 30, 2008
    NIH/NIDDK
    PROSTAGLANDINS AND GASTROINTESTINAL DNA DAMAGE
    Role: Principal Investigator

    U01DK085508     (HOUCHEN, COURTNEY WAYNE)Sep 30, 2009 - Aug 31, 2015
    NIH/NIDDK
    Isolation and Characterization of Intestinal Stem Cells Using Novel Markers (RP)
    Role: Principal Investigator

    R21CA137482     (HOUCHEN, COURTNEY WAYNE)Apr 1, 2010 - Mar 31, 2012
    NIH/NCI
    Pancreatic Stem Cells and Cancer
    Role: Principal Investigator

    I01BX001952     (HOUCHEN, COURTNEY WAYNE)Oct 1, 2013 - Sep 30, 2017
    VA
    The Gastrointestinal Stem Cell Response to Injury
    Role: Principal Investigator

    R21CA186175     (HOUCHEN, COURTNEY WAYNE)Dec 1, 2014 - Nov 30, 2016
    NIH/NCI
    Targeting DCLK1 kinase activity in pancreatic cancer
    Role: Principal Investigator

    R01CA182869     (HOUCHEN, COURTNEY WAYNE)Apr 1, 2015 - Mar 31, 2020
    NIH/NCI
    The role of DCLK1 in the initiation of pancreatic ductal adenocarcinoma
    Role: Principal Investigator

    R01CA214017     (HOUCHEN, COURTNEY WAYNE)Jun 15, 2017 - May 31, 2022
    NIH/NCI
    The role of Dclk1 in the initiation of colorectal cancer
    Role: Principal Investigator

    R25MD011564     (STONER, JULIE A)Sep 24, 2017 - May 31, 2022
    NIH/NIMHD
    Addressing Health Disparities among Oklahoma Minority and Rural Communities through Clinical Research Education and Career Development
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell. 2017 Jul 06; 21(1):78-90.e6. PMID: 28686870.
      View in: PubMed
    2. Chandrakesan P, May R, Weygant N, Qu D, Berry WL, Sureban SM, Ali N, Rao C, Huycke M, Bronze MS, Houchen CW. Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury. Sci Rep. 2016 Nov 23; 6:37667. PMID: 27876863.
      View in: PubMed
    3. Nguyen CB, Houchen CW, Ali N. APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases. Exp Biol Med (Maywood). 2017 Feb; 242(3):242-249. PMID: 27694285.
      View in: PubMed
    4. Weygant N, Ge Y, Qu D, Kaddis JS, Berry WL, May R, Chandrakesan P, Bannerman-Menson E, Vega KJ, Tomasek JJ, Bronze MS, An G, Houchen CW. Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem-like Cells Marked by DCLK1 Kinase. Cancer Res. 2016 Jul 15; 76(14):4090-9. PMID: 27287716.
      View in: PubMed
    5. Nguyen CB, Kotturi H, Waris G, Mohammed A, Chandrakesan P, May R, Sureban S, Weygant N, Qu D, Rao CV, Dhanasekaran DN, Bronze MS, Houchen CW, Ali N. (Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression. Cancer Res. 2016 Aug 15; 76(16):4887-96. PMID: 27287718; PMCID: PMC4987271 [Available on 08/15/17].
    6. Westphalen CB, Takemoto Y, Tanaka T, Macchini M, Jiang Z, Renz BW, Chen X, Ormanns S, Nagar K, Tailor Y, May R, Cho Y, Asfaha S, Worthley DL, Hayakawa Y, Urbanska AM, Quante M, Reichert M, Broyde J, Subramaniam PS, Remotti H, Su GH, Rustgi AK, Friedman RA, Honig B, Califano A, Houchen CW, Olive KP, Wang TC. Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis. Cell Stem Cell. 2016 Apr 07; 18(4):441-55. PMID: 27058937; PMCID: PMC4826481 [Available on 04/07/17].
    7. Bergstrom K, Liu X, Zhao Y, Gao N, Wu Q, Song K, Cui Y, Li Y, McDaniel JM, McGee S, Chen W, Huycke MM, Houchen CW, Zenewicz LA, West CM, Chen H, Braun J, Fu J, Xia L. Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice. Gastroenterology. 2016 Jul; 151(1):152-164.e11. PMID: 27059389.
      View in: PubMed
    8. Liu L, Xu HX, Wang WQ, Wu CT, Xiang JF, Liu C, Long J, Xu J, Fu de L, Ni QX, Houchen CW, Postier RG, Li M, Yu XJ. Serum CA125 is a novel predictive marker for pancreatic cancer metastasis and correlates with the metastasis-associated burden. Oncotarget. 2016 Feb 02; 7(5):5943-56. PMID: 26745601; PMCID: PMC4868732.
    9. Sureban SM, Madhoun MF, May R, Qu D, Ali N, Fazili J, Weygant N, Chandrakesan P, Ding K, Lightfoot SA, Houchen CW. Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism. Oncotarget. 2015 Nov 10; 6(35):37200-15. PMID: 26468984; PMCID: PMC4741924.
    10. Chandrakesan P, May R, Qu D, Weygant N, Taylor VE, Li JD, Ali N, Sureban SM, Qante M, Wang TC, Bronze MS, Houchen CW. Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal. Oncotarget. 2015 Oct 13; 6(31):30876-86. PMID: 26362399; PMCID: PMC4741574.
    11. Zhang Q, Sun X, Yang J, Ding H, LeBrun D, Ding K, Houchen CW, Postier RG, Ambrose CG, Li Z, Bi X, Li M. ZIP4 silencing improves bone loss in pancreatic cancer. Oncotarget. 2015 Sep 22; 6(28):26041-51. PMID: 26305676; PMCID: PMC4694884.
    12. Ali N, Chandrakesan P, Nguyen CB, Husain S, Gillaspy AF, Huycke M, Berry WL, May R, Qu D, Weygant N, Sureban SM, Bronze MS, Dhanasekaran DN, Houchen CW. Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases. Oncotarget. 2015 Aug 21; 6(24):20327-44. PMID: 25948779; PMCID: PMC4653008.
    13. Qu D, Weygant N, May R, Chandrakesan P, Madhoun M, Ali N, Sureban SM, An G, Schlosser MJ, Houchen CW. Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis. PLoS One. 2015; 10(8):e0134212. PMID: 26285154; PMCID: PMC4540568.
    14. Kantara C, Moya SM, Houchen CW, Umar S, Ullrich RL, Singh P, Carney DH. Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity. Lab Invest. 2015 Nov; 95(11):1222-33. PMID: 26280221; PMCID: PMC4626368.
    15. Sureban SM, May R, Qu D, Chandrakesan P, Weygant N, Ali N, Lightfoot SA, Ding K, Umar S, Schlosser MJ, Houchen CW. Dietary Pectin Increases Intestinal Crypt Stem Cell Survival following Radiation Injury. PLoS One. 2015; 10(8):e0135561. PMID: 26270561; PMCID: PMC4536042.
    16. Sureban SM, Qu D, Houchen CW. Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1. Curr Pharmacol Rep. 2015 Aug 01; 1(4):217-222. PMID: 26366338.
      View in: PubMed
    17. Mohammed A, Janakiram NB, Madka V, Brewer M, Ritchie RL, Lightfoot S, Kumar G, Sadeghi M, Patlolla JM, Yamada HY, Cruz-Monserrate Z, May R, Houchen CW, Steele VE, Rao CV. Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression. Oncotarget. 2015 Jun 20; 6(17):15524-39. PMID: 25906749; PMCID: PMC4558168.
    18. Qu D, Johnson J, Chandrakesan P, Weygant N, May R, Aiello N, Rhim A, Zhao L, Zheng W, Lightfoot S, Pant S, Irvan J, Postier R, Hocker J, Hanas JS, Ali N, Sureban SM, An G, Schlosser MJ, Stanger B, Houchen CW. Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells. PLoS One. 2015; 10(2):e0118933. PMID: 25723399; PMCID: PMC4344195.
    19. Weygant N, Qu D, May R, Tierney RM, Berry WL, Zhao L, Agarwal S, Chandrakesan P, Chinthalapally HR, Murphy NT, Li JD, Sureban SM, Schlosser MJ, Tomasek JJ, Houchen CW. DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma. Oncotarget. 2015 Feb 10; 6(4):2193-205. PMID: 25605241; PMCID: PMC4385845.
    20. Dimas K, Tsimplouli C, Houchen C, Pantazis P, Sakellaridis N, Tsangaris GT, Anastasiadou E, Ramanujam RP. An Ethanol Extract of Hawaiian Turmeric: Extensive In Vitro Anticancer Activity Against Human Colon Cancer Cells. Altern Ther Health Med. 2015; 21 Suppl 2:46-54. PMID: 26308760.
      View in: PubMed
    21. Chandrakesan P, Weygant N, May R, Qu D, Chinthalapally HR, Sureban SM, Ali N, Lightfoot SA, Umar S, Houchen CW. DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition. Oncotarget. 2014 Oct 15; 5(19):9269-80. PMID: 25211188; PMCID: PMC4253433.
    22. Whorton J, Sureban SM, May R, Qu D, Lightfoot SA, Madhoun M, Johnson M, Tierney WM, Maple JT, Vega KJ, Houchen CW. DCLK1 is detectable in plasma of patients with Barrett's esophagus and esophageal adenocarcinoma. Dig Dis Sci. 2015 Feb; 60(2):509-13. PMID: 25283374.
      View in: PubMed
    23. Baruah A, Buttar N, Chandra R, Chen X, Clemons NJ, Compare D, El-Rifai W, Gu J, Houchen CW, Koh SY, Li W, Nardone G, Phillips WA, Sharma A, Singh I, Upton MP, Vega KJ, Wu X. Translational research on Barrett's esophagus. Ann N Y Acad Sci. 2014 Sep; 1325:170-86. PMID: 25266024.
      View in: PubMed
    24. Le V, Syed S, Vega KJ, Sharma T, Madhoun MF, Srinivasan N, Houchen CW. Patient prompting of their physician resulted in increased colon cancer screening referrals. World J Gastrointest Oncol. 2014 Jul 15; 6(7):257-62. PMID: 25024817; PMCID: PMC4092342.
    25. Sureban SM, May R, Weygant N, Qu D, Chandrakesan P, Bannerman-Menson E, Ali N, Pantazis P, Westphalen CB, Wang TC, Houchen CW. XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism. Cancer Lett. 2014 Aug 28; 351(1):151-61. PMID: 24880079.
      View in: PubMed
    26. Weygant N, Qu D, Berry WL, May R, Chandrakesan P, Owen DB, Sureban SM, Ali N, Janknecht R, Houchen CW. Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer. 2014 May 06; 13:103. PMID: 24885928; PMCID: PMC4030036.
    27. Westphalen CB, Asfaha S, Hayakawa Y, Takemoto Y, Lukin DJ, Nuber AH, Brandtner A, Setlik W, Remotti H, Muley A, Chen X, May R, Houchen CW, Fox JG, Gershon MD, Quante M, Wang TC. Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest. 2014 Mar; 124(3):1283-95. PMID: 24487592; PMCID: PMC3934168.
    28. May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, Li L, Sureban SM, Houchen CW. Brief report: Dclk1 deletion in tuft cells results in impaired epithelial repair after radiation injury. Stem Cells. 2014 Mar; 32(3):822-7. PMID: 24123696; PMCID: PMC4603545.
    29. Ong BA, Vega KJ, Houchen CW. Intestinal stem cells and the colorectal cancer microenvironment. World J Gastroenterol. 2014 Feb 28; 20(8):1898-909. PMID: 24587669; PMCID: PMC3934460.
    30. Qu D, May R, Sureban SM, Weygant N, Chandrakesan P, Ali N, Li L, Barrett T, Houchen CW. Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury. Am J Physiol Gastrointest Liver Physiol. 2014 Mar 01; 306(5):G404-11. PMID: 24368703; PMCID: PMC3949020.
    31. Ali N, Allam H, Bader T, May R, Basalingappa KM, Berry WL, Chandrakesan P, Qu D, Weygant N, Bronze MS, Umar S, Janknecht R, Sureban SM, Huycke M, Houchen CW. Fluvastatin interferes with hepatitis C virus replication via microtubule bundling and a doublecortin-like kinase-mediated mechanism. PLoS One. 2013; 8(11):e80304. PMID: 24260365; PMCID: PMC3833963.
    32. Bishnupuri KS, Sainathan SK, Bishnupuri K, Leahy DR, Luo Q, Anant S, Houchen CW, Dieckgraefe BK. Reg4-induced mitogenesis involves Akt-GSK3ß-ß-Catenin-TCF-4 signaling in human colorectal cancer. Mol Carcinog. 2014 Feb; 53 Suppl 1:E169-80. PMID: 24151146; PMCID: PMC4565142.
    33. Sureban SM, May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, Pantazis P, Rao CV, Postier RG, Houchen CW. DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer. PLoS One. 2013; 8(9):e73940. PMID: 24040120; PMCID: PMC3767662.
    34. Magness ST, Puthoff BJ, Crissey MA, Dunn J, Henning SJ, Houchen C, Kaddis JS, Kuo CJ, Li L, Lynch J, Martin MG, May R, Niland JC, Olack B, Qian D, Stelzner M, Swain JR, Wang F, Wang J, Wang X, Yan K, Yu J, Wong MH. A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G542-51. PMID: 23928185; PMCID: PMC3798732.
    35. Qu D, Sureban SM, Houchen CW. Epigenetic variants and biomarkers for colon cancer. Am J Pathol. 2012 Jun; 180(6):2205-7. PMID: 22542494.
      View in: PubMed
    36. Vega KJ, May R, Sureban SM, Lightfoot SA, Qu D, Reed A, Weygant N, Ramanujam R, Souza R, Madhoun M, Whorton J, Anant S, Meltzer SJ, Houchen CW. Identification of the putative intestinal stem cell marker doublecortin and CaM kinase-like-1 in Barrett's esophagus and esophageal adenocarcinoma. J Gastroenterol Hepatol. 2012 Apr; 27(4):773-80. PMID: 21916995; PMCID: PMC3289765.
    37. Stelzner M, Helmrath M, Dunn JC, Henning SJ, Houchen CW, Kuo C, Lynch J, Li L, Magness ST, Martin MG, Wong MH, Yu J. A nomenclature for intestinal in vitro cultures. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15; 302(12):G1359-63. PMID: 22461030; PMCID: PMC3378093.
    38. Pantazis P, Dimas K, Wyche JH, Anant S, Houchen CW, Panyam J, Ramanujam RP. Preparation of siRNA-encapsulated PLGA nanoparticles for sustained release of siRNA and evaluation of encapsulation efficiency. Methods Mol Biol. 2012; 906:311-9. PMID: 22791444.
      View in: PubMed
    39. Sainathan SK, Bishnupuri KS, Aden K, Luo Q, Houchen CW, Anant S, Dieckgraefe BK. Toll-like receptor-7 ligand Imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis. Inflamm Bowel Dis. 2012 May; 18(5):955-67. PMID: 21953855; PMCID: PMC3878618.
    40. Ali N, Allam H, May R, Sureban SM, Bronze MS, Bader T, Umar S, Anant S, Houchen CW. Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts. J Virol. 2011 Dec; 85(23):12292-303. PMID: 21937640; PMCID: PMC3209402.
    41. Sureban SM, May R, Mondalek FG, Qu D, Ponnurangam S, Pantazis P, Anant S, Ramanujam RP, Houchen CW. Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism. J Nanobiotechnology. 2011 Sep 19; 9:40. PMID: 21929751; PMCID: PMC3200989.
    42. Subramaniam D, Ramalingam S, Linehan DC, Dieckgraefe BK, Postier RG, Houchen CW, Jensen RA, Anant S. RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells. PLoS One. 2011 Feb 11; 6(2):e16958. PMID: 21347286; PMCID: PMC3037932.
    43. Sureban SM, May R, Lightfoot SA, Hoskins AB, Lerner M, Brackett DJ, Postier RG, Ramanujam R, Mohammed A, Rao CV, Wyche JH, Anant S, Houchen CW. DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. Cancer Res. 2011 Mar 15; 71(6):2328-38. PMID: 21285251; PMCID: PMC3072762.
    44. Ponnurangam S, Mondalek FG, Govind J, Subramaniam D, Houchen CW, Anant S, Pantazis P, Ramanujam RP. Urine and serum analysis of consumed curcuminoids using an IkappaB-luciferase surrogate marker assay. In Vivo. 2010 Nov-Dec; 24(6):861-4. PMID: 21164045; PMCID: PMC3050505.
    45. Mondalek FG, Ponnurangam S, Govind J, Houchen C, Anant S, Pantazis P, Ramanujam RP. Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP. J Nanobiotechnology. 2010 Jul 15; 8:17. PMID: 20633276; PMCID: PMC2911398.
    46. May R, Sureban SM, Lightfoot SA, Hoskins AB, Brackett DJ, Postier RG, Ramanujam R, Rao CV, Wyche JH, Anant S, Houchen CW. Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas. Am J Physiol Gastrointest Liver Physiol. 2010 Aug; 299(2):G303-10. PMID: 20522640; PMCID: PMC2928534.
    47. Subramaniam D, Ramalingam S, Houchen CW, Anant S. Cancer stem cells: a novel paradigm for cancer prevention and treatment. Mini Rev Med Chem. 2010 May; 10(5):359-71. PMID: 20370703; PMCID: PMC2874098.
    48. Anant S, Houchen CW, Pawar V, Ramalingam S. Role of RNA-Binding Proteins in Colorectal Carcinogenesis. Curr Colorectal Cancer Rep. 2010 Mar 02; 6(2):68-73. PMID: 20401169.
      View in: PubMed
    49. Pantazis P, Varman A, Simpson-Durand C, Thorpe J, Ramalingam S, Subramaniam D, Houchen C, Ihnat M, Anant S, Ramanujam RP. Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo. Altern Ther Health Med. 2010 Mar-Apr; 16(2):12-4. PMID: 20232614.
      View in: PubMed
    50. Bishnupuri KS, Luo Q, Sainathan SK, Kikuchi K, Sureban SM, Sabarinathan M, Gross JH, Aden K, May R, Houchen CW, Anant S, Dieckgraefe BK. Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis. Gastroenterology. 2010 Feb; 138(2):616-26, 626.e1-2. PMID: 19900450; PMCID: PMC2819553.
    51. May R, Sureban SM, Hoang N, Riehl TE, Lightfoot SA, Ramanujam R, Wyche JH, Anant S, Houchen CW. Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively. Stem Cells. 2009 Oct; 27(10):2571-9. PMID: 19676123; PMCID: PMC3049723.
    52. Han Z, Dimas K, Tian X, Wang Y, Hemmi H, Yamada K, Kato N, Pantazis P, Ramanujam RJ, Anant S, Wyche JH, Houchen CW. 14-3-3sigma-dependent resistance to cisplatin. Anticancer Res. 2009 Jun; 29(6):2009-14. PMID: 19528459.
      View in: PubMed
    53. Sureban SM, May R, Ramalingam S, Subramaniam D, Natarajan G, Anant S, Houchen CW. Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism. Gastroenterology. 2009 Aug; 137(2):649-59, 659.e1-2. PMID: 19445940; PMCID: PMC2775069.
    54. Anant S, Houchen CW. HuR and TTP: two RNA binding proteins that deliver message from the 3' end. Gastroenterology. 2009 May; 136(5):1495-8. PMID: 19327732; PMCID: PMC2803091.
    55. George RJ, Sturmoski MA, May R, Sureban SM, Dieckgraefe BK, Anant S, Houchen CW. Loss of p21Waf1/Cip1/Sdi1 enhances intestinal stem cell survival following radiation injury. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G245-54. PMID: 19056768; PMCID: PMC2643902.
    56. Wang X, Allen TD, May RJ, Lightfoot S, Houchen CW, Huycke MM. Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect. Cancer Res. 2008 Dec 01; 68(23):9909-17. PMID: 19047172; PMCID: PMC2596646.
    57. Subramaniam D, Giridharan P, Murmu N, Shankaranarayanan NP, May R, Houchen CW, Ramanujam RP, Balakrishnan A, Vishwakarma RA, Anant S. Activation of apoptosis by 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde, a novel compound from Aegle marmelos. Cancer Res. 2008 Oct 15; 68(20):8573-81. PMID: 18922933; PMCID: PMC2692325.
    58. Allen TD, Moore DR, Wang X, Casu V, May R, Lerner MR, Houchen C, Brackett DJ, Huycke MM. Dichotomous metabolism of Enterococcus faecalis induced by haematin starvation modulates colonic gene expression. J Med Microbiol. 2008 Oct; 57(Pt 10):1193-204. PMID: 18809545; PMCID: PMC2692828.
    59. Subramaniam D, May R, Sureban SM, Lee KB, George R, Kuppusamy P, Ramanujam RP, Hideg K, Dieckgraefe BK, Houchen CW, Anant S. Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity. Cancer Res. 2008 Mar 15; 68(6):1962-9. PMID: 18339878.
      View in: PubMed
    60. Natarajan G, Ramalingam S, Ramachandran I, May R, Queimado L, Houchen CW, Anant S. CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe. Am J Physiol Gastrointest Liver Physiol. 2008 May; 294(5):G1235-44. PMID: 18325984.
      View in: PubMed
    61. Sureban SM, May R, George RJ, Dieckgraefe BK, McLeod HL, Ramalingam S, Bishnupuri KS, Natarajan G, Anant S, Houchen CW. Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo. Gastroenterology. 2008 May; 134(5):1448-58. PMID: 18471519.
      View in: PubMed
    62. Subramaniam D, Natarajan G, Ramalingam S, Ramachandran I, May R, Queimado L, Houchen CW, Anant S. Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1025-32. PMID: 18292181.
      View in: PubMed
    63. Ramalingam S, Natarajan G, Schafer C, Subramaniam D, May R, Ramachandran I, Queimado L, Houchen CW, Anant S. Novel intestinal splice variants of RNA-binding protein CUGBP2: isoform-specific effects on mitotic catastrophe. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G971-81. PMID: 18258790; PMCID: PMC4464843.
    64. Subramaniam D, Ramalingam S, May R, Dieckgraefe BK, Berg DE, Pothoulakis C, Houchen CW, Wang TC, Anant S. Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. Gastroenterology. 2008 Apr; 134(4):1070-82. PMID: 18395088.
      View in: PubMed
    65. Sainathan SK, Hanna EM, Gong Q, Bishnupuri KS, Luo Q, Colonna M, White FV, Croze E, Houchen C, Anant S, Dieckgraefe BK. Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis. Inflamm Bowel Dis. 2008 Jan; 14(1):88-99. PMID: 17932977; PMCID: PMC4565141.
    66. May R, Riehl TE, Hunt C, Sureban SM, Anant S, Houchen CW. Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells. 2008 Mar; 26(3):630-7. PMID: 18055444.
      View in: PubMed
    67. George RJ, Sturmoski MA, Anant S, Houchen CW. EP4 mediates PGE2 dependent cell survival through the PI3 kinase/AKT pathway. Prostaglandins Other Lipid Mediat. 2007 Feb; 83(1-2):112-20. PMID: 17259077; PMCID: PMC1886004.
    68. Bishnupuri KS, Luo Q, Korzenik JR, Henderson JO, Houchen CW, Anant S, Dieckgraefe BK. Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes. Cancer Biol Ther. 2006 Dec; 5(12):1714-20. PMID: 17106246.
      View in: PubMed
    69. Sureban SM, Murmu N, Rodriguez P, May R, Maheshwari R, Dieckgraefe BK, Houchen CW, Anant S. Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation. Gastroenterology. 2007 Mar; 132(3):1055-65. PMID: 17383427.
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    70. Riehl TE, George RJ, Sturmoski MA, May R, Dieckgraefe B, Anant S, Houchen CW. Azoxymethane protects intestinal stem cells and reduces crypt epithelial mitosis through a COX-1-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2006 Dec; 291(6):G1062-70. PMID: 17038629.
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    71. Bishnupuri KS, Luo Q, Murmu N, Houchen CW, Anant S, Dieckgraefe BK. Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. Gastroenterology. 2006 Jan; 130(1):137-49. PMID: 16401477.
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    72. Sainathan SK, Tu L, Bishnupuri KS, Han M, Li A, Newberry RD, McDonald KG, Crimmins DL, Houchen C, Anant S, Dieckgraefe BK. PEGylated murine Granulocyte-macrophage colony-stimulating factor: production, purification, and characterization. Protein Expr Purif. 2005 Dec; 44(2):94-103. PMID: 16213750.
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    73. Anant S, Murmu N, Houchen CW, Mukhopadhyay D, Riehl TE, Young SG, Morrison AR, Stenson WF, Davidson NO. Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression. Gastroenterology. 2004 Oct; 127(4):1139-49. PMID: 15480992.
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    74. Murmu N, Jung J, Mukhopadhyay D, Houchen CW, Riehl TE, Stenson WF, Morrison AR, Arumugam T, Dieckgraefe BK, Anant S. Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage. Proc Natl Acad Sci U S A. 2004 Sep 21; 101(38):13873-8. PMID: 15358864; PMCID: PMC518846.
    75. Mukhopadhyay D, Jung J, Murmu N, Houchen CW, Dieckgraefe BK, Anant S. CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury. Ann N Y Acad Sci. 2003 Dec; 1010:504-9. PMID: 15033780.
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    76. Houchen CW. FGF-20: FGFs--they keep growing and growing and growing! Inflamm Bowel Dis. 2003 Mar; 9(2):133. PMID: 12769450.
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    77. Mukhopadhyay D, Houchen CW, Kennedy S, Dieckgraefe BK, Anant S. Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2. Mol Cell. 2003 Jan; 11(1):113-26. PMID: 12535526.
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    78. Houchen CW, Sturmoski MA, Anant S, Breyer RM, Stenson WF. Prosurvival and antiapoptotic effects of PGE2 in radiation injury are mediated by EP2 receptor in intestine. Am J Physiol Gastrointest Liver Physiol. 2003 Mar; 284(3):G490-8. PMID: 12431904.
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    79. Dieckgraefe BK, Crimmins DL, Landt V, Houchen C, Anant S, Porche-Sorbet R, Ladenson JH. Expression of the regenerating gene family in inflammatory bowel disease mucosa: Reg Ialpha upregulation, processing, and antiapoptotic activity. J Investig Med. 2002 Nov; 50(6):421-34. PMID: 12425429.
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