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Venkateshwar Rao Chinthalapally

TitleGeorge L Cross Research Professor
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Hematology/Oncology
Address975 NE 10th St
Oklahoma City OK 73104-5419
Phone405/271-3224
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    Collapse Research 
    Collapse research activities and funding
    N01CN065108     (RAO, CHINTHALAPALLY V.)Sep 30, 1996 - Sep 29, 1999
    NIH
    EFFICACY STUDIES OF CHEMOPREVENTIVE AGENTS IN ANIMAL MOD
    Role: Principal Investigator

    N01CN075123     (RAO, CHINTHALAPALLY V.)Jul 31, 1997 - Jul 30, 2000
    NIH
    EFFICACY STUDIES OF CHEMOPREVENTIVE AGENTS IN ANIMALS
    Role: Principal Investigator

    R01CA080003     (RAO, CHINTHALAPALLY V.)Jul 1, 1999 - Jan 31, 2006
    NIH
    MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    Role: Principal Investigator

    R01CA094962     (RAO, CHINTHALAPALLY V.)Apr 1, 2002 - Mar 31, 2015
    NIH
    HMG-CoA Reductase and Polyamine Inhibitors for Prevention of Colorectal Cancer
    Role: Principal Investigator

    R01CA109247     (RAO, CHINTHALAPALLY V.)Sep 23, 2004 - Jun 30, 2010
    NIH
    PREVENTION OF COLORECTAL CANCER BY iNOS AND COX-2 SELECTIVE INHIBITORS
    Role: Principal Investigator

    N01CA000000     (WILLIAMS, MICKEY)Sep 1, 2013 - Sep 25, 2021
    NIH
    Molecular characterization and clinical assay development program
    Role: Co-Investigator

    261201200020I-0-26100006-1     (RAO, CHINTHALAPALLY)Aug 26, 2014 - Aug 25, 2016
    NIH
    HHSN2612012000201/HHSN26100006 Title: Preclinical In Vitro And In Vivo Screening Assays For Cancer Preventative Reagent Development, Project: Targeting CCK2R for Pancreatic Cancer Prevention
    Role: Principal Investigator

    261201200020I-0-26100007-1     (RAO, CHINTHALAPALLY)Sep 12, 2014 - Sep 11, 2016
    NIH
    HHSN261201200020I/HHSN26100007Preclinical In Vitro and In Vivo Development Assays for Cancer Preventative Reagent. Project Title: Chemoprevention by Aerosolized Bexarotene in Mouse Models of All T
    Role: Principal Investigator

    261201200013I-0-26100008-1     (RAO, CHINTHALAPALLY)Sep 15, 2014 - Sep 14, 2015
    NIH
    Molecular Heterogeneity of Inflammation and Growth Factor Pathways in Sporadic and Syndromic Colon Cancers: Implications for Prevention and Therapeutic TrialsPOP: 09/15/2014-09/14/2015
    Role: Principal Investigator

    261201200013I-0-26100010-1     (RAO, CHINTHALAPALLY)Sep 16, 2014 - Sep 15, 2016
    NIH
    HHSN2612012000131/HHSN26100010Base Contract Title: Preclinical Efficacy and Intermediate Endpoint Biomarkers. Task Order Title: Preclinical Studies to Evaluate the Combination of Metformin and As
    Role: Principal Investigator

    261201200013I-0-26100009-1     (RAO, CHINTHALAPALLY)Sep 18, 2014 - Sep 17, 2016
    NIH
    Multi-Antigen Vaccine for Lung Cancer PreventionPOP: 09/18/2014-09/17/2016
    Role: Principal Investigator

    I01BX003198     (RAO, CHINTHALAPALLY V.)Apr 1, 2016 - Mar 31, 2020
    NIH
    Targeting mPGES-1/5-LOX for Prevention of CRC in High-Risk Veterans
    Role: Principal Investigator

    R01CA213987     (RAO, CHINTHALAPALLY V.)Dec 15, 2016 - Nov 30, 2021
    NIH
    Safer Approaches to CRC Chemoprevention
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rao CV, Janakiram NB, Mohammed A. Molecular Pathways: Mucins and Drug Delivery in Cancer. Clin Cancer Res. 2017 Mar 15; 23(6):1373-1378. PMID: 28039261.
      View in: PubMed
    2. Rao CV, Asch AS, Yamada HY. Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer. Carcinogenesis. 2017 Jan; 38(1):2-11. PMID: 27838634.
      View in: PubMed
    3. Rao CV, Janakiram NB, Madka V, Kumar G, Scott EJ, Pathuri G, Bryant T, Kutche H, Zhang Y, Biddick L, Gali H, Zhao YD, Lightfoot S, Mohammed A. Small-Molecule Inhibition of GCNT3 Disrupts Mucin Biosynthesis and Malignant Cellular Behaviors in Pancreatic Cancer. Cancer Res. 2016 04 01; 76(7):1965-74. PMID: 26880801.
      View in: PubMed
    4. Yamada HY, Zhang Y, Reddy A, Mohammed A, Lightfoot S, Dai W, Rao CV. Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice. Carcinogenesis. 2015 Apr; 36(4):429-40. PMID: 25740822; PMCID: PMC4392605.
    5. Janakiram NB, Mohammed A, Bryant T, Lightfoot S, Collin PD, Steele VE, Rao CV. Improved innate immune responses by Frondanol A5, a sea cucumber extract, prevent intestinal tumorigenesis. Cancer Prev Res (Phila). 2015 Apr; 8(4):327-37. PMID: 25657017; PMCID: PMC4839268.
    6. Mohammed A, Janakiram NB, Madka V, Ritchie RL, Brewer M, Biddick L, Patlolla JM, Sadeghi M, Lightfoot S, Steele VE, Rao CV. Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling. Cancer Prev Res (Phila). 2014 Dec; 7(12):1198-209. PMID: 25248858; PMCID: PMC4310684.
    7. Janakiram NB, Mohammed A, Zhang Y, Brewer M, Bryant T, Lightfoot S, Steele VE, Rao CV. Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats. Cancer Prev Res (Phila). 2013 Dec; 6(12):1251-61. PMID: 24080207; PMCID: PMC4655595.
    8. Patlolla JM, Qian L, Biddick L, Zhang Y, Desai D, Amin S, Lightfoot S, Rao CV. ß-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells. Cancer Prev Res (Phila). 2013 Oct; 6(10):1140-9. PMID: 23963803.
      View in: PubMed
    9. Rao CV. Benzyl isothiocyanate: double trouble for breast cancer cells. Cancer Prev Res (Phila). 2013 Aug; 6(8):760-3. PMID: 23842793.
      View in: PubMed
    10. Rao CV, Patlolla JM, Cooma I, Kawamori T, Steele VE. Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ?-3 fatty acid rich perilla oil. Nutr Cancer. 2013; 65 Suppl 1:54-60. PMID: 23682783.
      View in: PubMed
    11. Rao CV, Kurkjian CD, Yamada HY. Mitosis-targeting natural products for cancer prevention and therapy. Curr Drug Targets. 2012 Dec; 13(14):1820-30. PMID: 23140292.
      View in: PubMed
    12. Rao CV, Mohammed A, Janakiram NB, Li Q, Ritchie RL, Lightfoot S, Vibhudutta A, Steele VE. Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48(Cre/+)-LSL-Kras(G12D/+) mice. Neoplasia. 2012 Sep; 14(9):778-87. PMID: 23019409; PMCID: PMC3459273.
    13. Rao CV, Yamada HY, Yao Y, Dai W. Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice. Carcinogenesis. 2009 Sep; 30(9):1469-74. PMID: 19372138; PMCID: PMC2736299.
    14. Rao CV, Swamy MV, Patlolla JM, Kopelovich L. Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ mice. Cancer Res. 2008 Sep 15; 68(18):7670-5. PMID: 18794156; PMCID: PMC2597360.
    15. Rao CV. Regulation of COX and LOX by curcumin. Adv Exp Med Biol. 2007; 595:213-26. PMID: 17569213.
      View in: PubMed
    16. Rao CV, Reddy BS, Steele VE, Wang CX, Liu X, Ouyang N, Patlolla JM, Simi B, Kopelovich L, Rigas B. Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets. Mol Cancer Ther. 2006 Jun; 5(6):1530-8. PMID: 16818512.
      View in: PubMed
    17. Rao CV, Yang YM, Swamy MV, Liu T, Fang Y, Mahmood R, Jhanwar-Uniyal M, Dai W. Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4365-70. PMID: 15767571; PMCID: PMC555497.
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