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Danny Natajaran Dhanasekaran

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentStephenson Cancer Center
Address975 NE 10th St
Oklahoma City OK 73104-5419
Phone405/271-6590
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    Collapse Biography 
    Collapse education and training
    Indian Institute of Science, Bangalore, IndiaPhD1984Biochemistry

    Collapse Research 
    Collapse research activities and funding
    P20GM103639     (DHANASEKARAN, DANNY N.)Sep 5, 2012 - May 31, 2017
    NIH/NIGMS
    Mentoring Translational Cancer Research in Oklahoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Han Y, Cho U, Kim S, Park IS, Cho JH, Dhanasekaran DN, Song YS. Tumour microenvironment on mitochondrial dynamics and chemoresistance in cancer. Free Radic Res. 2018 Apr 19; 1-17. PMID: 29607684.
      View in: PubMed
    2. Chakraborty PK, Murphy B, Mustafi SB, Dey A, Xiong X, Rao G, Naz S, Zhang M, Yang D, Dhanasekaran DN, Bhattacharya R, Mukherjee P. Cystathionine ß-synthase regulates mitochondrial morphogenesis in ovarian cancer. FASEB J. 2018 Mar 01; fj201701095R. PMID: 29494264.
      View in: PubMed
    3. Ha JH, Radhakrishnan R, Jayaraman M, Yan M, Ward JD, Fung KM, Moxley K, Sood AK, Isidoro C, Mukherjee P, Song YS, Dhanasekaran DN. LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response. Cancer Res. 2018 Apr 15; 78(8):1923-1934. PMID: 29386184.
      View in: PubMed
    4. Xia D, Lai DV, Wu W, Webb ZD, Yang Q, Zhao L, Yu Z, Thorpe JE, Disch BC, Ihnat MA, Jayaraman M, Dhanasekaran DN, Stratton KL, Cookson MS, Fung KM, Lin HK. Transition from androgenic to neurosteroidal action of 5a-androstane-3a, 17ß-diol through the type A ?-aminobutyric acid receptor in prostate cancer progression. J Steroid Biochem Mol Biol. 2018 Apr; 178:89-98. PMID: 29155210.
      View in: PubMed
    5. Ferraresi A, Titone R, Follo C, Castiglioni A, Chiorino G, Dhanasekaran DN, Isidoro C. The protein restriction mimetic Resveratrol is an autophagy inducer stronger than amino acid starvation in ovarian cancer cells. Mol Carcinog. 2017 Dec; 56(12):2681-2691. PMID: 28856729.
      View in: PubMed
    6. Dhanasekaran DN, Reddy EP. JNK-signaling: A multiplexing hub in programmed cell death. Genes Cancer. 2017 Sep; 8(9-10):682-694. PMID: 29234486.
      View in: PubMed
    7. Kim B, Jung JW, Jung J, Han Y, Suh DH, Kim HS, Dhanasekaran DN, Song YS. PGC1a induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells. Oncotarget. 2017 Sep 01; 8(36):60299-60311. PMID: 28947972.
      View in: PubMed
    8. Chakraborty PK, Mustafi SB, Xiong X, Dwivedi SKD, Nesin V, Saha S, Zhang M, Dhanasekaran D, Jayaraman M, Mannel R, Moore K, McMeekin S, Yang D, Zuna R, Ding K, Tsiokas L, Bhattacharya R, Mukherjee P. MICU1 drives glycolysis and chemoresistance in ovarian cancer. Nat Commun. 2017 May 22; 8:14634. PMID: 28530221.
      View in: PubMed
    9. Jayaraman M, Radhakrishnan R, Mathews CA, Yan M, Husain S, Moxley KM, Song YS, Dhanasekaran DN. Identification of novel diagnostic and prognostic miRNA signatures in endometrial cancer. Genes Cancer. 2017 May; 8(5-6):566-576. PMID: 28740575.
      View in: PubMed
    10. Kim S, Gwak H, Kim HS, Kim B, Dhanasekaran DN, Song YS. Malignant ascites enhances migratory and invasive properties of ovarian cancer cells with membrane bound IL-6R in vitro. Oncotarget. 2016 Dec 13; 7(50):83148-83159. PMID: 27825119.
      View in: PubMed
    11. Ha JH, Yan M, Gomathinayagam R, Jayaraman M, Husain S, Liu J, Mukherjee P, Reddy EP, Song YS, Dhanasekaran DN. Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer. Oncotarget. 2016 Nov 08; 7(45):72845-72859. PMID: 27655714.
      View in: PubMed
    12. Kim B, Kim HS, Kim S, Haegeman G, Tsang BK, Dhanasekaran DN, Song YS. Adipose Stromal Cells from Visceral and Subcutaneous Fat Facilitate Migration of Ovarian Cancer Cells via IL-6/JAK2/STAT3 Pathway. Cancer Res Treat. 2017 Apr; 49(2):338-349. PMID: 27456942.
      View in: PubMed
    13. Ha JH, Ward JD, Radhakrishnan R, Jayaraman M, Song YS, Dhanasekaran DN. Lysophosphatidic acid stimulates epithelial to mesenchymal transition marker Slug/Snail2 in ovarian cancer cells via Gai2, Src, and HIF1a signaling nexus. Oncotarget. 2016 Jun 21; 7(25):37664-37679. PMID: 27166196.
      View in: PubMed
    14. Nguyen CB, Kotturi H, Waris G, Mohammed A, Chandrakesan P, May R, Sureban S, Weygant N, Qu D, Rao CV, Dhanasekaran DN, Bronze MS, Houchen CW, Ali N. (Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression. Cancer Res. 2016 08 15; 76(16):4887-96. PMID: 27287718; PMCID: PMC4987271 [Available on 08/15/17].
    15. Srivastava A, Babu A, Filant J, Moxley KM, Ruskin R, Dhanasekaran D, Sood AK, McMeekin S, Ramesh R. Exploitation of Exosomes as Nanocarriers for Gene-, Chemo-, and Immune-Therapy of Cancer. J Biomed Nanotechnol. 2016 Jun; 12(6):1159-73. PMID: 27319211.
      View in: PubMed
    16. Gwak H, Kim Y, An H, Dhanasekaran DN, Song YS. Metformin induces degradation of cyclin D1 via AMPK/GSK3ß axis in ovarian cancer. Mol Carcinog. 2017 02; 56(2):349-358. PMID: 27128966.
      View in: PubMed
    17. Gwak H, Kim S, Dhanasekaran DN, Song YS. Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells. Cancer Lett. 2016 Feb 28; 371(2):347-53. PMID: 26704305.
      View in: PubMed
    18. Seo JA, Kim B, Dhanasekaran DN, Tsang BK, Song YS. Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca2+ ATPase activity in ovarian cancer cells. Cancer Lett. 2016 Feb 01; 371(1):30-7. PMID: 26607901.
      View in: PubMed
    19. Chakraborty PK, Xiong X, Mustafi SB, Saha S, Dhanasekaran D, Mandal NA, McMeekin S, Bhattacharya R, Mukherjee P. Role of cystathionine beta synthase in lipid metabolism in ovarian cancer. Oncotarget. 2015 Nov 10; 6(35):37367-84. PMID: 26452259; PMCID: PMC4741935.
    20. Ali N, Chandrakesan P, Nguyen CB, Husain S, Gillaspy AF, Huycke M, Berry WL, May R, Qu D, Weygant N, Sureban SM, Bronze MS, Dhanasekaran DN, Houchen CW. Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases. Oncotarget. 2015 Aug 21; 6(24):20327-44. PMID: 25948779; PMCID: PMC4653008.
    21. Yan M, Ha JH, Dhanasekaran DN. Ga13 Stimulates the Tyrosine Phosphorylation of Ric-8A. J Mol Signal. 2015 Jul 27; 10:3. PMID: 27096001; PMCID: PMC4831272.
    22. Ha JH, Gomathinayagam R, Yan M, Jayaraman M, Ramesh R, Dhanasekaran DN. Determinant role for the gep oncogenes, Ga12/13, in ovarian cancer cell proliferation and xenograft tumor growth. Genes Cancer. 2015 Jul; 6(7-8):356-364. PMID: 26413218; PMCID: PMC4575922.
    23. Song YS, Kim HS, Aoki D, Dhanasekaran DN, Tsang BK. Ovarian cancer. Biomed Res Int. 2014; 2014:764323. PMID: 25587539; PMCID: PMC4283453.
    24. Ward JD, Ha JH, Jayaraman M, Dhanasekaran DN. LPA-mediated migration of ovarian cancer cells involves translocalization of Gai2 to invadopodia and association with Src and ß-pix. Cancer Lett. 2015 Jan 28; 356(2 Pt B):382-91. PMID: 25451317; PMCID: PMC4821470.
    25. Yang YM, Lee WH, Lee CG, An J, Kim ES, Kim SH, Lee SK, Lee CH, Dhanasekaran DN, Moon A, Hwang S, Lee SJ, Park JW, Kim KM, Kim SG. Ga12 gep oncogene deregulation of p53-responsive microRNAs promotes epithelial-mesenchymal transition of hepatocellular carcinoma. Oncogene. 2015 May 28; 34(22):2910-21. PMID: 25065598.
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    26. Gomathinayagam R, Muralidharan J, Ha JH, Varadarajalu L, Dhanasekaran DN. Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration. Genes Cancer. 2014 Mar; 5(3-4):84-99. PMID: 25053987; PMCID: PMC4091533.
    27. Dhanasekaran D. G protein signaling in tumor cell growth and metastasis. Mol Cytogenet. 2014; 7(Suppl 1 Proceedings of the International Conference on Human):I56. PMID: 24940381; PMCID: PMC4043405.
    28. Ha JH, Ward JD, Varadarajalu L, Kim SG, Dhanasekaran DN. The gep proto-oncogene Ga12 mediates LPA-stimulated activation of CREB in ovarian cancer cells. Cell Signal. 2014 Jan; 26(1):122-32. PMID: 24055910; PMCID: PMC3992271.
    29. Dhanasekaran DN. Monographs editor. Genes Cancer. 2013 Sep; 4(9-10):331. PMID: 24349629; PMCID: PMC3863343.
    30. Dhanasekaran DN. JNK Signaling Network and Cancer. Genes Cancer. 2013 Sep; 4(9-10):332-3. PMID: 24349630; PMCID: PMC3863342.
    31. Gardner JA, Ha JH, Jayaraman M, Dhanasekaran DN. The gep proto-oncogene Ga13 mediates lysophosphatidic acid-mediated migration of pancreatic cancer cells. Pancreas. 2013 Jul; 42(5):819-28. PMID: 23508014; PMCID: PMC3686977.
    32. Ward JD, Dhanasekaran DN. LPA Stimulates the Phosphorylation of p130Cas via Gai2 in Ovarian Cancer Cells. Genes Cancer. 2012 Sep; 3(9-10):578-91. PMID: 23486563; PMCID: PMC3591094.
    33. Singhal A, Jayaraman M, Dhanasekaran DN, Kohli V. Molecular and serum markers in hepatocellular carcinoma: predictive tools for prognosis and recurrence. Crit Rev Oncol Hematol. 2012 May; 82(2):116-40. PMID: 21680198.
      View in: PubMed
    34. Goldsmith ZG, Ha JH, Jayaraman M, Dhanasekaran DN. Lysophosphatidic Acid Stimulates the Proliferation of Ovarian Cancer Cells via the gep Proto-Oncogene Ga(12). Genes Cancer. 2011 May; 2(5):563-75. PMID: 21901169; PMCID: PMC3161422.
    35. Kashef K, Radhakrishnan R, Lee CM, Reddy EP, Dhanasekaran DN. Neoplastic transformation induced by the gep oncogenes involves the scaffold protein JNK-interacting leucine zipper protein. Neoplasia. 2011 Apr; 13(4):358-64. PMID: 21472140; PMCID: PMC3071084.
    36. Jalagadugula G, Mao G, Kaur G, Dhanasekaran DN, Rao AK. Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1. Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4):921-7. PMID: 21252065; PMCID: PMC3066073.
    37. Radhakrishnan R, Ha JH, Dhanasekaran DN. Mitogenic Signaling by the gep Oncogene Involves the Upregulation of S-Phase Kinase-Associated Protein 2. Genes Cancer. 2010 Oct; 1(10):1033-43. PMID: 21533006; PMCID: PMC3083023.
    38. Jalagadugula G, Mao G, Kaur G, Goldfinger LE, Dhanasekaran DN, Rao AK. Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency. Blood. 2010 Dec 23; 116(26):6037-45. PMID: 20876458; PMCID: PMC3031389.
    39. Yang YM, Lee S, Nam CW, Ha JH, Jayaraman M, Dhanasekaran DN, Lee CH, Kwak MK, Kim SG. G(alpha)12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation. Carcinogenesis. 2010 Jul; 31(7):1230-7. PMID: 20478922.
      View in: PubMed
    40. Reddy HK, Graña X, Dhanasekaran DN, Litvin J, Reddy EP. Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C Mutation. Genes Cancer. 2010 Jan; 1(1):69-80. PMID: 20634902; PMCID: PMC2904236.
    41. Xu H, Dhanasekaran DN, Lee CM, Reddy EP. Regulation of neurite outgrowth by interactions between the scaffolding protein, JNK-associated leucine zipper protein, and neuronal growth-associated protein superior cervical ganglia clone 10. J Biol Chem. 2010 Feb 05; 285(6):3548-53. PMID: 19959466; PMCID: PMC2823494.
    42. Dhanasekaran DN, Radhika V, Proikas-Cezanne T, Jayaraman M, Ha J. Heterologous expression of olfactory receptors for targeted chemosensing. Ann N Y Acad Sci. 2009 Jul; 1170:157-60. PMID: 19686128.
      View in: PubMed
    43. Suzuki H, Kimura K, Shirai H, Eguchi K, Higuchi S, Hinoki A, Ishimaru K, Brailoiu E, Dhanasekaran DN, Stemmle LN, Fields TA, Frank GD, Autieri MV, Eguchi S. Endothelial nitric oxide synthase inhibits G12/13 and rho-kinase activated by the angiotensin II type-1 receptor: implication in vascular migration. Arterioscler Thromb Vasc Biol. 2009 Feb; 29(2):217-24. PMID: 19095998; PMCID: PMC2704976.
    44. Jalagadugula G, Dhanasekaran DN, Rao AK. Phorbol 12-myristate 13-acetate (PMA) responsive sequence in Galphaq promoter during megakaryocytic differentiation. Regulation by EGR-1 and MAP kinase pathway. Thromb Haemost. 2008 Nov; 100(5):821-8. PMID: 18989526; PMCID: PMC2688737.
    45. Dhanasekaran DN, Reddy EP. JNK signaling in apoptosis. Oncogene. 2008 Oct 20; 27(48):6245-51. PMID: 18931691; PMCID: PMC3063296.
    46. Dhanasekaran DN, Kashef K, Lee CM, Xu H, Reddy EP. Scaffold proteins of MAP-kinase modules. Oncogene. 2007 May 14; 26(22):3185-202. PMID: 17496915.
      View in: PubMed
    47. Goldsmith ZG, Dhanasekaran DN. G protein regulation of MAPK networks. Oncogene. 2007 May 14; 26(22):3122-42. PMID: 17496911.
      View in: PubMed
    48. Dhanasekaran DN, Johnson GL. MAPKs: function, regulation, role in cancer and therapeutic targeting. Oncogene. 2007 May 14; 26(22):3097-9. PMID: 17496908.
      View in: PubMed
    49. Radhika V, Proikas-Cezanne T, Jayaraman M, Onesime D, Ha JH, Dhanasekaran DN. Chemical sensing of DNT by engineered olfactory yeast strain. Nat Chem Biol. 2007 Jun; 3(6):325-30. PMID: 17486045.
      View in: PubMed
    50. Sun L, Mao G, Kunapuli SP, Dhanasekaran DN, Rao AK. Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization. Platelets. 2007 May; 18(3):217-23. PMID: 17497434.
      View in: PubMed
    51. Dhanasekaran DN. An open access journal of molecular signaling: a critical need at a critical time. J Mol Signal. 2006 Nov 10; 1:1. PMID: 17224077; PMCID: PMC1761142.
    52. Jalagadugula G, Dhanasekaran DN, Kim S, Kunapuli SP, Rao AK. Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells. J Thromb Haemost. 2006 Dec; 4(12):2678-86. PMID: 16995904.
      View in: PubMed
    53. Dhanasekaran DN. Transducing the signals: a G protein takes a new identity. Sci STKE. 2006 Aug 08; 2006(347):pe31. PMID: 16896192.
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    54. Kashef K, Xu H, Reddy EP, Dhanasekaran DN. Endodermal differentiation of murine embryonic carcinoma cells by retinoic acid requires JLP, a JNK-scaffolding protein. J Cell Biochem. 2006 Jul 01; 98(4):715-22. PMID: 16619266.
      View in: PubMed
    55. Kumar RN, Shore SK, Dhanasekaran N. Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3. Oncogene. 2006 Feb 09; 25(6):899-906. PMID: 16247467.
      View in: PubMed
    56. Reece EA, Wu YK, Zhao Z, Dhanasekaran D. Dietary vitamin and lipid therapy rescues aberrant signaling and apoptosis and prevents hyperglycemia-induced diabetic embryopathy in rats. Am J Obstet Gynecol. 2006 Feb; 194(2):580-5. PMID: 16458664.
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    57. Kumar RN, Ha JH, Radhakrishnan R, Dhanasekaran DN. Transactivation of platelet-derived growth factor receptor alpha by the GTPase-deficient activated mutant of Galpha12. Mol Cell Biol. 2006 Jan; 26(1):50-62. PMID: 16354679; PMCID: PMC1317640.
    58. Kashef K, Lee CM, Ha JH, Reddy EP, Dhanasekaran DN. JNK-interacting leucine zipper protein is a novel scaffolding protein in the Galpha13 signaling pathway. Biochemistry. 2005 Nov 01; 44(43):14090-6. PMID: 16245925.
      View in: PubMed
    59. Jayaraman M, Radhika V, Bamne MN, Ramos R, Briggs R, Dhanasekaran DN. Engineered Saccharomyces cerevisiae strain BioS-OS1/2, for the detection of oxidative stress. Biotechnol Prog. 2005 Sep-Oct; 21(5):1373-9. PMID: 16209540.
      View in: PubMed
    60. Radhika V, Hee Ha J, Jayaraman M, Tsim ST, Dhanasekaran N. Mitogenic signaling by lysophosphatidic acid (LPA) involves Galpha12. Oncogene. 2005 Jun 30; 24(28):4597-603. PMID: 15856019.
      View in: PubMed
    61. Radhika V, Milkevitch M, Audigé V, Proikas-Cezanne T, Dhanasekaran N. Engineered Saccharomyces cerevisiae strain BioS-1, for the detection of water-borne toxic metal contaminants. Biotechnol Bioeng. 2005 Apr 05; 90(1):29-35. PMID: 15712302.
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    62. Reece EA, Ma XD, Zhao Z, Wu YK, Dhanasekaran D. Aberrant patterns of cellular communication in diabetes-induced embryopathy in rats: II, apoptotic pathways. Am J Obstet Gynecol. 2005 Mar; 192(3):967-72. PMID: 15746699.
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    63. Vedhachalam C, Liu L, Nickel M, Dhanasekaran P, Anantharamaiah GM, Lund-Katz S, Rothblat GH, Phillips MC. Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids. J Biol Chem. 2004 Nov 26; 279(48):49931-9. PMID: 15383537.
      View in: PubMed
    64. Goldsmith ZG, Dhanasekaran N. The microrevolution: applications and impacts of microarray technology on molecular biology and medicine (review). Int J Mol Med. 2004 Apr; 13(4):483-95. PMID: 15010847.
      View in: PubMed
    65. Peter AT, Dhanasekaran N. Apoptosis of granulosa cells: a review on the role of MAPK-signalling modules. Reprod Domest Anim. 2003 Jun; 38(3):209-13. PMID: 12753555.
      View in: PubMed
    66. Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP. JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14189-94. PMID: 12391307; PMCID: PMC137859.
    67. Gabbeta J, Vaidyula VR, Dhanasekaran DN, Rao AK. Human platelet Galphaq deficiency is associated with decreased Galphaq gene expression in platelets but not neutrophils. Thromb Haemost. 2002 Jan; 87(1):129-33. PMID: 11848441.
      View in: PubMed
    68. Dermott JM, Dhanasekaran N. Determining cellular role of G alpha 12. Methods Enzymol. 2002; 344:298-309. PMID: 11771390.
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    69. Radhika V, Dhanasekaran N. Transforming G proteins. Oncogene. 2001 Mar 26; 20(13):1607-14. PMID: 11313908.
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    70. Dermott JM, Wadsworth SJ, van Rossum GD, Dhanasekaran N. Activated mutant of Galpha(12) enhances the hyperosmotic stress response of NIH3T3 cells. J Cell Biochem. 2001; 81(1):1-8. PMID: 11180393.
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    71. Ha JH, Dhanasekaran N, Koh HC, Lee CH. Single amino acid of g(alpha16) (Ala(228)) is responsible for the ability of chemoattractant C5a receptor to induce G(alpha16)-mediated inositol phosphate release. Biochem Biophys Res Commun. 2000 Nov 19; 278(2):426-31. PMID: 11097853.
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    72. Gebauer G, Mirakhur B, Nguyen Q, Shore SK, Simpkins H, Dhanasekaran N. Cisplatin-resistance involves the defective processing of MEKK1 in human ovarian adenocarcinoma 2008/C13 cells. Int J Oncol. 2000 Feb; 16(2):321-5. PMID: 10639576.
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    73. Gebauer G, Peter AT, Onesime D, Dhanasekaran N. Apoptosis of ovarian granulosa cells: correlation with the reduced activity of ERK-signaling module. J Cell Biochem. 1999 Dec 15; 75(4):547-54. PMID: 10572238.
      View in: PubMed
    74. Dermott JM, Reddy MR, Onesime D, Reddy EP, Dhanasekaran N. Oncogenic mutant of Galpha12 stimulates cell proliferation through cycloxygenase-2 signaling pathway. Oncogene. 1999 Dec 02; 18(51):7185-9. PMID: 10602471.
      View in: PubMed
    75. Vara Prasad MV, Dhanasekaran N. GTPase deficient mutant of G(alpha13) regulates the expression of Egr-1 through the small GTPase Rho. Oncogene. 1999 Feb 25; 18(8):1639-42. PMID: 10102635.
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    76. Dhanasekaran N. Cell signaling: an overview. Oncogene. 1998 Sep 17; 17(11 Reviews):1329-30. PMID: 9779980.
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    77. Dhanasekaran N, Tsim ST, Dermott JM, Onesime D. Regulation of cell proliferation by G proteins. Oncogene. 1998 Sep 17; 17(11 Reviews):1383-94. PMID: 9779986.
      View in: PubMed
    78. Gabbeta J, Dhanasekaran N, Rao AK. G alpha q cDNA sequence from human platelets. Thromb Res. 1998 Jul 01; 91(1):29-32. PMID: 9700850.
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    79. Dhanasekaran N, Prasad MV. G protein subunits and cell proliferation. Biol Signals Recept. 1998 Mar-Apr; 7(2):109-17. PMID: 9629462.
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    80. Walsh AB, Dhanasekaran M, Bar-Sagi D, Kumar CC. SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway. Oncogene. 1997 Nov 20; 15(21):2553-60. PMID: 9399643.
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    81. Wadsworth SJ, Gebauer G, van Rossum GD, Dhanasekaran N. Ras-dependent signaling by the GTPase-deficient mutant of Galpha12. J Biol Chem. 1997 Nov 14; 272(46):28829-32. PMID: 9360946.
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    82. Kelsen SG, Anakwe O, Aksoy MO, Reddy PJ, Dhanasekaran N. IL-1 beta alters beta-adrenergic receptor adenylyl cyclase system function in human airway epithelial cells. Am J Physiol. 1997 Sep; 273(3 Pt 1):L694-700. PMID: 9316506.
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    83. Gabbeta J, Yang X, Kowalska MA, Sun L, Dhanasekaran N, Rao AK. Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8750-5. PMID: 9238049; PMCID: PMC23110.
    84. Wang P, Dhanasekaran N, Luthin GR. ERK activation and cellular proliferation in response to muscarinic acetylcholine receptor agonists. Ann N Y Acad Sci. 1997 May 30; 812:182-3. PMID: 9186737.
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    85. Luthin GR, Wang P, Zhou H, Dhanasekaran D, Ruggieri MR. Role of m1 receptor-G protein coupling in cell proliferation in the prostate. Life Sci. 1997; 60(13-14):963-8. PMID: 9121362; PMCID: PMC3277865.
    86. Dhanasekaran N, Dermott JM. Signaling by the G12 class of G proteins. Cell Signal. 1996 Jun; 8(4):235-45. PMID: 8842523.
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    87. Buhl AM, Johnson NL, Dhanasekaran N, Johnson GL. G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J Biol Chem. 1995 Oct 20; 270(42):24631-4. PMID: 7559569.
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    88. Prasad MV, Dermott JM, Heasley LE, Johnson GL, Dhanasekaran N. Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of G alpha 12 and G alpha 13. J Biol Chem. 1995 Aug 04; 270(31):18655-9. PMID: 7629196.
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    89. Dhanasekaran N, Heasley LE, Johnson GL. G protein-coupled receptor systems involved in cell growth and oncogenesis. Endocr Rev. 1995 Jun; 16(3):259-70. PMID: 7671848.
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    90. Dhanasekaran N, Osawa S, Johnson GL. The NH2-terminal alpha subunit attenuator domain confers regulation of G protein activation by beta gamma complexes. J Cell Biochem. 1991 Dec; 47(4):352-8. PMID: 1795017.
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    91. Johnson GL, Dhanasekaran N, Gupta SK, Lowndes JM, Vaillancourt RR, Ruoho AE. Genetic and structural analysis of G protein alpha subunit regulatory domains. J Cell Biochem. 1991 Oct; 47(2):136-46. PMID: 1661737.
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    92. Osawa S, Heasley LE, Dhanasekaran N, Gupta SK, Woon CW, Berlot C, Johnson GL. Mutation of the Gs protein alpha subunit NH2 terminus relieves an attenuator function, resulting in constitutive adenylyl cyclase stimulation. Mol Cell Biol. 1990 Jun; 10(6):2931-40. PMID: 1692962; PMCID: PMC360656.
    93. Vaillancourt RR, Dhanasekaran N, Johnson GL, Ruoho AE. 2-Azido-[32P]NAD+, a photoactivatable probe for G-protein structure: evidence for holotransducin oligomers in which the ADP-ribosylated carboxyl terminus of alpha interacts with both alpha and gamma subunits. Proc Natl Acad Sci U S A. 1990 May; 87(10):3645-9. PMID: 2111013; PMCID: PMC53959.
    94. Heasley LE, Dhanasekaran N, Gupta SK, Osawa S, Johnson GL. Chimeras of the Gs alpha subunit that had the NH2- or COOH-terminal sequence substituted for the corresponding region of the Gi alpha subunit constitutively activate adenylyl cyclase. Soc Gen Physiol Ser. 1990; 45:117-24. PMID: 2165634.
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    95. Dhanasekaran N, Moudgal NR. Biochemical and histological validation of a model to study follicular atresia in rats. Endocrinol Exp. 1989 Sep; 23(3):155-66. PMID: 2806185.
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    96. Johnson GL, Dhanasekaran N. The G-protein family and their interaction with receptors. Endocr Rev. 1989 Aug; 10(3):317-31. PMID: 2550214.
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    97. Dhanasekaran N, Moudgal NR. Studies on follicular atresia: role of gonadotropins and gonadal steroids in regulating cathepsin-D activity of preovulatory follicles in the rat. Mol Cell Endocrinol. 1989 May; 63(1-2):133-42. PMID: 2502456.
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    98. Dhanasekaran N, Wessling-Resnick M, Kelleher DJ, Johnson GL, Ruoho AE. Mapping of the carboxyl terminus within the tertiary structure of transducin's alpha subunit using the heterobifunctional cross-linking reagent, 125I-N-(3-iodo-4-azidophenylpropionamido-S-(2-thiopyridyl) cysteine. J Biol Chem. 1988 Dec 05; 263(34):17942-50. PMID: 3192520.
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    99. Dhanasekaran N, Moudgal NR. Gonadotropin regulation of rat ovarian lysosomes: existence of a hormone specific dual control mechanism. Biosci Rep. 1988 Jun; 8(3):279-85. PMID: 3145041.
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    100. Dhanasekaran N, Moudgal NR. Studies on follicular atresia: role of tropic hormone and steroids in regulating cathepsin-D activity of preantral follicles of the immature rat. Mol Cell Endocrinol. 1986 Jan; 44(1):77-84. PMID: 3081387.
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    101. Dhanasekaran N, Sheela Rani CS, Moudgal NR. Studies on follicular atresia: lysosomal enzyme activity and gonadotropin receptors of granulosa cells following administration or withdrawal of gonadotropins in the rat. Mol Cell Endocrinol. 1983 Nov; 33(1):97-112. PMID: 6315511.
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