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Natarajan Dhanasekaran

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentStephenson Cancer Center
Address975 NE 10th St
Oklahoma City OK 73104-5419
Phone405/271-6590
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    Collapse Research 
    Collapse research activities and funding
    R01GM049897     (DHANASEKARAN, DANNY N.)Mar 1, 1996 - Jun 30, 2006
    NIH
    Functional analysis of G alpha 12/G alpha 13 G-proteins
    Role: Principal Investigator

    R21CA125752     (DHANASEKARAN, DANNY N.)Jun 26, 2007 - Mar 31, 2010
    NIH
    G-Protein Signaling in Pancreatic Cancer
    Role: Principal Investigator

    R01CA116984     (DHANASEKARAN, DANNY N.)Jun 27, 2007 - Apr 30, 2013
    NIH
    G Proteins and Their Receptors in Tumor Cell Metastasis
    Role: Principal Investigator

    R01CA123233     (DHANASEKARAN, DANNY N.)Dec 15, 2007 - Nov 30, 2014
    NIH
    Regulation of JNK-signaling molecules by the gep oncogenes
    Role: Principal Investigator

    P20GM103639     (DHANASEKARAN, DANNY N.)Sep 5, 2012 - May 31, 2017
    NIH
    Mentoring Translational Cancer Research in Oklahoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Xia D, Lai DV, Wu W, Webb ZD, Yang Q, Zhao L, Yu Z, Thorpe JE, Disch BC, Ihnat MA, Jayaraman M, Dhanasekaran DN, Stratton KL, Cookson MS, Fung KM, Lin HK. Transition from androgenic to neurosteroidal action of 5a-androstane-3a, 17ß-diol through the type A ?-aminobutyric acid receptor in prostate cancer progression. J Steroid Biochem Mol Biol. 2017 Nov 20. PMID: 29155210.
      View in: PubMed
    2. Ferraresi A, Titone R, Follo C, Castiglioni A, Chiorino G, Dhanasekaran DN, Isidoro C. The protein restriction mimetic Resveratrol is an autophagy inducer stronger than amino acid starvation in ovarian cancer cells. Mol Carcinog. 2017 Dec; 56(12):2681-2691. PMID: 28856729.
      View in: PubMed
    3. Kim B, Jung JW, Jung J, Han Y, Suh DH, Kim HS, Dhanasekaran DN, Song YS. PGC1a induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells. Oncotarget. 2017 Sep 01; 8(36):60299-60311. PMID: 28947972.
      View in: PubMed
    4. Chakraborty PK, Mustafi SB, Xiong X, Dwivedi SKD, Nesin V, Saha S, Zhang M, Dhanasekaran D, Jayaraman M, Mannel R, Moore K, McMeekin S, Yang D, Zuna R, Ding K, Tsiokas L, Bhattacharya R, Mukherjee P. MICU1 drives glycolysis and chemoresistance in ovarian cancer. Nat Commun. 2017 May 22; 8:14634. PMID: 28530221.
      View in: PubMed
    5. Jayaraman M, Radhakrishnan R, Mathews CA, Yan M, Husain S, Moxley KM, Song YS, Dhanasekaran DN. Identification of novel diagnostic and prognostic miRNA signatures in endometrial cancer. Genes Cancer. 2017 May; 8(5-6):566-576. PMID: 28740575.
      View in: PubMed
    6. Kim S, Gwak H, Kim HS, Kim B, Dhanasekaran DN, Song YS. Malignant ascites enhances migratory and invasive properties of ovarian cancer cells with membrane bound IL-6R in vitro. Oncotarget. 2016 Dec 13; 7(50):83148-83159. PMID: 27825119.
      View in: PubMed
    7. Ha JH, Yan M, Gomathinayagam R, Jayaraman M, Husain S, Liu J, Mukherjee P, Reddy EP, Song YS, Dhanasekaran DN. Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer. Oncotarget. 2016 Nov 08; 7(45):72845-72859. PMID: 27655714.
      View in: PubMed
    8. Kim B, Kim HS, Kim S, Haegeman G, Tsang BK, Dhanasekaran DN, Song YS. Adipose Stromal Cells from Visceral and Subcutaneous Fat Facilitate Migration of Ovarian Cancer Cells via IL-6/JAK2/STAT3 Pathway. Cancer Res Treat. 2017 Apr; 49(2):338-349. PMID: 27456942.
      View in: PubMed
    9. Ha JH, Ward JD, Radhakrishnan R, Jayaraman M, Song YS, Dhanasekaran DN. Lysophosphatidic acid stimulates epithelial to mesenchymal transition marker Slug/Snail2 in ovarian cancer cells via Gai2, Src, and HIF1a signaling nexus. Oncotarget. 2016 Jun 21; 7(25):37664-37679. PMID: 27166196.
      View in: PubMed
    10. Nguyen CB, Kotturi H, Waris G, Mohammed A, Chandrakesan P, May R, Sureban S, Weygant N, Qu D, Rao CV, Dhanasekaran DN, Bronze MS, Houchen CW, Ali N. (Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression. Cancer Res. 2016 Aug 15; 76(16):4887-96. PMID: 27287718; PMCID: PMC4987271 [Available on 08/15/17].
    11. Srivastava A, Babu A, Filant J, Moxley KM, Ruskin R, Dhanasekaran D, Sood AK, McMeekin S, Ramesh R. Exploitation of Exosomes as Nanocarriers for Gene-, Chemo-, and Immune-Therapy of Cancer. J Biomed Nanotechnol. 2016 Jun; 12(6):1159-73. PMID: 27319211.
      View in: PubMed
    12. Gwak H, Kim Y, An H, Dhanasekaran DN, Song YS. Metformin induces degradation of cyclin D1 via AMPK/GSK3ß axis in ovarian cancer. Mol Carcinog. 2017 Feb; 56(2):349-358. PMID: 27128966.
      View in: PubMed
    13. Gwak H, Kim S, Dhanasekaran DN, Song YS. Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells. Cancer Lett. 2016 Feb 28; 371(2):347-53. PMID: 26704305.
      View in: PubMed
    14. Seo JA, Kim B, Dhanasekaran DN, Tsang BK, Song YS. Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca2+ ATPase activity in ovarian cancer cells. Cancer Lett. 2016 Feb 01; 371(1):30-7. PMID: 26607901.
      View in: PubMed
    15. Chakraborty PK, Xiong X, Mustafi SB, Saha S, Dhanasekaran D, Mandal NA, McMeekin S, Bhattacharya R, Mukherjee P. Role of cystathionine beta synthase in lipid metabolism in ovarian cancer. Oncotarget. 2015 Nov 10; 6(35):37367-84. PMID: 26452259; PMCID: PMC4741935.
    16. Ali N, Chandrakesan P, Nguyen CB, Husain S, Gillaspy AF, Huycke M, Berry WL, May R, Qu D, Weygant N, Sureban SM, Bronze MS, Dhanasekaran DN, Houchen CW. Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases. Oncotarget. 2015 Aug 21; 6(24):20327-44. PMID: 25948779; PMCID: PMC4653008.
    17. Yan M, Ha JH, Dhanasekaran DN. Ga13 Stimulates the Tyrosine Phosphorylation of Ric-8A. J Mol Signal. 2015 Jul 27; 10:3. PMID: 27096001; PMCID: PMC4831272.
    18. Ha JH, Gomathinayagam R, Yan M, Jayaraman M, Ramesh R, Dhanasekaran DN. Determinant role for the gep oncogenes, Ga12/13, in ovarian cancer cell proliferation and xenograft tumor growth. Genes Cancer. 2015 Jul; 6(7-8):356-364. PMID: 26413218; PMCID: PMC4575922.
    19. Song YS, Kim HS, Aoki D, Dhanasekaran DN, Tsang BK. Ovarian cancer. Biomed Res Int. 2014; 2014:764323. PMID: 25587539; PMCID: PMC4283453.
    20. Ward JD, Ha JH, Jayaraman M, Dhanasekaran DN. LPA-mediated migration of ovarian cancer cells involves translocalization of Gai2 to invadopodia and association with Src and ß-pix. Cancer Lett. 2015 Jan 28; 356(2 Pt B):382-91. PMID: 25451317; PMCID: PMC4821470.
    21. Yang YM, Lee WH, Lee CG, An J, Kim ES, Kim SH, Lee SK, Lee CH, Dhanasekaran DN, Moon A, Hwang S, Lee SJ, Park JW, Kim KM, Kim SG. Ga12 gep oncogene deregulation of p53-responsive microRNAs promotes epithelial-mesenchymal transition of hepatocellular carcinoma. Oncogene. 2015 May 28; 34(22):2910-21. PMID: 25065598.
      View in: PubMed
    22. Gomathinayagam R, Muralidharan J, Ha JH, Varadarajalu L, Dhanasekaran DN. Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration. Genes Cancer. 2014 Mar; 5(3-4):84-99. PMID: 25053987; PMCID: PMC4091533.
    23. Gardner JA, Ha JH, Jayaraman M, Dhanasekaran DN. The gep proto-oncogene Ga13 mediates lysophosphatidic acid-mediated migration of pancreatic cancer cells. Pancreas. 2013 Jul; 42(5):819-28. PMID: 23508014; PMCID: PMC3686977.
    24. Singhal A, Jayaraman M, Dhanasekaran DN, Kohli V. Molecular and serum markers in hepatocellular carcinoma: predictive tools for prognosis and recurrence. Crit Rev Oncol Hematol. 2012 May; 82(2):116-40. PMID: 21680198.
      View in: PubMed
    25. Goldsmith ZG, Ha JH, Jayaraman M, Dhanasekaran DN. Lysophosphatidic Acid Stimulates the Proliferation of Ovarian Cancer Cells via the gep Proto-Oncogene Ga(12). Genes Cancer. 2011 May; 2(5):563-75. PMID: 21901169; PMCID: PMC3161422.
    26. Kumar RN, Shore SK, Dhanasekaran N. Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3. Oncogene. 2006 Feb 09; 25(6):899-906. PMID: 16247467.
      View in: PubMed
    27. Radhika V, Hee Ha J, Jayaraman M, Tsim ST, Dhanasekaran N. Mitogenic signaling by lysophosphatidic acid (LPA) involves Galpha12. Oncogene. 2005 Jun 30; 24(28):4597-603. PMID: 15856019.
      View in: PubMed
    28. Kumar RN, Radhakrishnan R, Ha JH, Dhanasekaran N. Proteome analysis of NIH3T3 cells transformed by activated Galpha12: regulation of leukemia-associated protein SET. J Proteome Res. 2004 Nov-Dec; 3(6):1177-83. PMID: 15595726.
      View in: PubMed
    29. Radhika V, Onesime D, Ha JH, Dhanasekaran N. Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1. J Biol Chem. 2004 Nov 19; 279(47):49406-13. PMID: 15339924.
      View in: PubMed
    30. Goldsmith ZG, Dhanasekaran N. The microrevolution: applications and impacts of microarray technology on molecular biology and medicine (review). Int J Mol Med. 2004 Apr; 13(4):483-95. PMID: 15010847.
      View in: PubMed
    31. Dermott JM, Ha JH, Lee CH, Dhanasekaran N. Differential regulation of Jun N-terminal kinase and p38MAP kinase by Galpha12. Oncogene. 2004 Jan 08; 23(1):226-32. PMID: 14712227.
      View in: PubMed
    32. Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP. JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14189-94. PMID: 12391307; PMCID: PMC137859.
    33. Ha JH, Dhanasekaran N, Koh HC, Lee CH. Single amino acid of g(alpha16) (Ala(228)) is responsible for the ability of chemoattractant C5a receptor to induce G(alpha16)-mediated inositol phosphate release. Biochem Biophys Res Commun. 2000 Nov 19; 278(2):426-31. PMID: 11097853.
      View in: PubMed
    34. Gebauer G, Peter AT, Onesime D, Dhanasekaran N. Apoptosis of ovarian granulosa cells: correlation with the reduced activity of ERK-signaling module. J Cell Biochem. 1999 Dec 15; 75(4):547-54. PMID: 10572238.
      View in: PubMed
    35. Dermott JM, Reddy MR, Onesime D, Reddy EP, Dhanasekaran N. Oncogenic mutant of Galpha12 stimulates cell proliferation through cycloxygenase-2 signaling pathway. Oncogene. 1999 Dec 02; 18(51):7185-9. PMID: 10602471.
      View in: PubMed
    36. Vara Prasad MV, Dhanasekaran N. GTPase deficient mutant of G(alpha13) regulates the expression of Egr-1 through the small GTPase Rho. Oncogene. 1999 Feb 25; 18(8):1639-42. PMID: 10102635.
      View in: PubMed
    37. Dhanasekaran N, Premkumar Reddy E. Signaling by dual specificity kinases. Oncogene. 1998 Sep 17; 17(11 Reviews):1447-55. PMID: 9779990.
      View in: PubMed
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