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Institution

Natarajan Dhanasekaran

TitleProfessor
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentStephenson Cancer Center
Address975 NE 10th St
Oklahoma City OK 73104-5419
Phone405/271-6590
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    Collapse Research 
    Collapse research activities and funding
    R01GM049897     (DHANASEKARAN, DANNY N.)Mar 1, 1996 - Jun 30, 2006
    NIH
    Functional analysis of G alpha 12/G alpha 13 G-proteins
    Role: Principal Investigator

    R21CA125752     (DHANASEKARAN, DANNY N.)Jun 26, 2007 - Mar 31, 2010
    NIH
    G-Protein Signaling in Pancreatic Cancer
    Role: Principal Investigator

    R01CA116984     (DHANASEKARAN, DANNY N.)Jun 27, 2007 - Apr 30, 2013
    NIH
    G Proteins and Their Receptors in Tumor Cell Metastasis
    Role: Principal Investigator

    R01CA123233     (DHANASEKARAN, DANNY N.)Dec 15, 2007 - Nov 30, 2014
    NIH
    Regulation of JNK-signaling molecules by the gep oncogenes
    Role: Principal Investigator

    P20GM103639     (DHANASEKARAN, DANNY N.)Sep 5, 2012 - May 31, 2017
    NIH
    Mentoring Translational Cancer Research in Oklahoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kim S, Gwak H, Kim HS, Kim B, Dhanasekaran DN, Song YS. Malignant ascites enhances migratory and invasive properties of ovarian cancer cells with membrane bound IL-6R in vitro. Oncotarget. 2016 Dec 13; 7(50):83148-83159. PMID: 27825119.
      View in: PubMed
    2. Ha JH, Yan M, Gomathinayagam R, Jayaraman M, Husain S, Liu J, Mukherjee P, Reddy EP, Song YS, Dhanasekaran DN. Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer. Oncotarget. 2016 Nov 08; 7(45):72845-72859. PMID: 27655714.
      View in: PubMed
    3. Kim B, Kim HS, Kim S, Haegeman G, Tsang BK, Dhanasekaran DN, Song YS. Adipose Stromal Cells from Visceral and Subcutaneous Fat Facilitate Migration of Ovarian Cancer Cells via IL-6/JAK2/STAT3 Pathway. Cancer Res Treat. 2017 Apr; 49(2):338-349. PMID: 27456942.
      View in: PubMed
    4. Ha JH, Ward JD, Radhakrishnan R, Jayaraman M, Song YS, Dhanasekaran DN. Lysophosphatidic acid stimulates epithelial to mesenchymal transition marker Slug/Snail2 in ovarian cancer cells via Gai2, Src, and HIF1a signaling nexus. Oncotarget. 2016 Jun 21; 7(25):37664-37679. PMID: 27166196.
      View in: PubMed
    5. Nguyen CB, Kotturi H, Waris G, Mohammed A, Chandrakesan P, May R, Sureban S, Weygant N, Qu D, Rao CV, Dhanasekaran DN, Bronze MS, Houchen CW, Ali N. (Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression. Cancer Res. 2016 Aug 15; 76(16):4887-96. PMID: 27287718; PMCID: PMC4987271 [Available on 08/15/17].
    6. Gwak H, Kim Y, An H, Dhanasekaran DN, Song YS. Metformin induces degradation of cyclin D1 via AMPK/GSK3ß axis in ovarian cancer. Mol Carcinog. 2017 Feb; 56(2):349-358. PMID: 27128966.
      View in: PubMed
    7. Gwak H, Kim S, Dhanasekaran DN, Song YS. Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells. Cancer Lett. 2016 Feb 28; 371(2):347-53. PMID: 26704305.
      View in: PubMed
    8. Radhika V, Hee Ha J, Jayaraman M, Tsim ST, Dhanasekaran N. Mitogenic signaling by lysophosphatidic acid (LPA) involves Galpha12. Oncogene. 2005 Jun 30; 24(28):4597-603. PMID: 15856019.
      View in: PubMed
    9. Kumar RN, Radhakrishnan R, Ha JH, Dhanasekaran N. Proteome analysis of NIH3T3 cells transformed by activated Galpha12: regulation of leukemia-associated protein SET. J Proteome Res. 2004 Nov-Dec; 3(6):1177-83. PMID: 15595726.
      View in: PubMed
    10. Radhika V, Onesime D, Ha JH, Dhanasekaran N. Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1. J Biol Chem. 2004 Nov 19; 279(47):49406-13. PMID: 15339924.
      View in: PubMed
    11. Dermott JM, Ha JH, Lee CH, Dhanasekaran N. Differential regulation of Jun N-terminal kinase and p38MAP kinase by Galpha12. Oncogene. 2004 Jan 08; 23(1):226-32. PMID: 14712227.
      View in: PubMed
    12. Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP. JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14189-94. PMID: 12391307; PMCID: PMC137859.
    13. Ha JH, Dhanasekaran N, Koh HC, Lee CH. Single amino acid of g(alpha16) (Ala(228)) is responsible for the ability of chemoattractant C5a receptor to induce G(alpha16)-mediated inositol phosphate release. Biochem Biophys Res Commun. 2000 Nov 19; 278(2):426-31. PMID: 11097853.
      View in: PubMed
    14. Dermott JM, Reddy MR, Onesime D, Reddy EP, Dhanasekaran N. Oncogenic mutant of Galpha12 stimulates cell proliferation through cycloxygenase-2 signaling pathway. Oncogene. 1999 Dec 02; 18(51):7185-9. PMID: 10602471.
      View in: PubMed
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