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Darrin Randal Akins

TitleProfessor
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMicrobiology & Immunology
Address940 Stanton L Young Blvd
Oklahoma City OK 73104-5020
Phone405/271-2133
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    Collapse Research 
    Collapse research activities and funding
    P20RR016478     (AKINS, DARRIN R)Sep 6, 2001 - Mar 31, 2014
    NIH/NCRR
    Oklahoma IDeA Network of Biomedical Research Excellence
    Role: Principal Investigator

    P20GM103447     (AKINS, DARRIN R)Sep 6, 2001 - Apr 30, 2019
    NIH/NIGMS
    Oklahoma IDeA Network of Biomedical Research Excellence
    Role: Principal Investigator

    R01AI059373     (AKINS, DARRIN R)Apr 1, 2004 - Feb 28, 2017
    NIH/NIAID
    Outer membrane proteins of Borrelia burgdorferi
    Role: Principal Investigator

    R21AI064629     (AKINS, DARRIN R)Apr 1, 2006 - Mar 31, 2009
    NIH/NIAID
    Complement evasion by Borrelia burgdorferi
    Role: Principal Investigator

    R21AI085310     (AKINS, DARRIN R)May 24, 2010 - Apr 30, 2013
    NIH/NIAID
    Surface Lipoproteins and Serum Resistance in Borrelia burgdorferi
    Role: Principal Investigator

    R56AI059373     (AKINS, DARRIN R)Sep 27, 2011 - Mar 14, 2012
    NIH/NIAID
    Outer membrane proteins of Borrelia burgdorferi
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Iqbal H, Kenedy MR, Lybecker M, Akins DR. The TamB ortholog of Borrelia burgdorferi interacts with the ß-barrel assembly machine (BAM) complex protein BamA. Mol Microbiol. 2016 Dec; 102(5):757-774. PMID: 27588694.
      View in: PubMed
    2. Kenedy MR, Scott EJ, Shrestha B, Anand A, Iqbal H, Radolf JD, Dyer DW, Akins DR. Consensus computational network analysis for identifying candidate outer membrane proteins from Borrelia spirochetes. BMC Microbiol. 2016 Jul 11; 16(1):141. PMID: 27400788; PMCID: PMC4939628.
    3. Dunn JP, Kenedy MR, Iqbal H, Akins DR. Characterization of the ß-barrel assembly machine accessory lipoproteins from Borrelia burgdorferi. BMC Microbiol. 2015 Mar 24; 15:70. PMID: 25887384; PMCID: PMC4377024.
    4. Dao HD, Kota P, James JA, Stoner JA, Akins DR. Assessment of Translational and Interdisciplinary Clinical Research at an Oklahoma Health Sciences Center. J Okla State Med Assoc. 2015 Mar; 108(3):93-101. PMID: 26242016; PMCID: PMC4686264.
    5. Day MW, Jackson LA, Akins DR, Dyer DW, Chavez-Bueno S. Whole-Genome Sequences of the Archetypal K1 Escherichia coli Neonatal Isolate RS218 and Contemporary Neonatal Bacteremia Clinical Isolates SCB11, SCB12, and SCB15. Genome Announc. 2015 Feb 26; 3(1). PMID: 25720688; PMCID: PMC4342429.
    6. Chavez-Bueno S, Day MW, Toby IT, Akins DR, Dyer DW. Genome Sequence of SCB34, a Sequence Type 131 Multidrug-Resistant Escherichia coli Isolate Causing Neonatal Early-Onset Sepsis. Genome Announc. 2014 Jun 12; 2(3). PMID: 24926049; PMCID: PMC4056292.
    7. Kenedy MR, Luthra A, Anand A, Dunn JP, Radolf JD, Akins DR. Structural modeling and physicochemical characterization provide evidence that P66 forms a ß-barrel in the Borrelia burgdorferi outer membrane. J Bacteriol. 2014 Feb; 196(4):859-72. PMID: 24317399; PMCID: PMC3911182.
    8. Kenedy MR, Lenhart TR, Akins DR. The role of Borrelia burgdorferi outer surface proteins. FEMS Immunol Med Microbiol. 2012 Oct; 66(1):1-19. PMID: 22540535; PMCID: PMC3424381.
    9. Lenhart TR, Kenedy MR, Yang X, Pal U, Akins DR. BB0324 and BB0028 are constituents of the Borrelia burgdorferi ß-barrel assembly machine (BAM) complex. BMC Microbiol. 2012 Apr 20; 12:60. PMID: 22519960; PMCID: PMC3356241.
    10. Caimano MJ, Kenedy MR, Kairu T, Desrosiers DC, Harman M, Dunham-Ems S, Akins DR, Pal U, Radolf JD. The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infect Immun. 2011 Aug; 79(8):3117-30. PMID: 21606185; PMCID: PMC3147546.
    11. Kenedy MR, Akins DR. The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the lyme disease spirochete. Infect Immun. 2011 Apr; 79(4):1451-7. PMID: 21282413; PMCID: PMC3067540.
    12. Yang X, Lenhart TR, Kariu T, Anguita J, Akins DR, Pal U. Characterization of unique regions of Borrelia burgdorferi surface-located membrane protein 1. Infect Immun. 2010 Nov; 78(11):4477-87. PMID: 20696833; PMCID: PMC2976337.
    13. Lenhart TR, Akins DR. Borrelia burgdorferi locus BB0795 encodes a BamA orthologue required for growth and efficient localization of outer membrane proteins. Mol Microbiol. 2010 Feb; 75(3):692-709. PMID: 20025662.
      View in: PubMed
    14. Kenedy MR, Vuppala SR, Siegel C, Kraiczy P, Akins DR. CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi. Infect Immun. 2009 Jul; 77(7):2773-82. PMID: 19451251; PMCID: PMC2708555.
    15. Coleman AS, Yang X, Kumar M, Zhang X, Promnares K, Shroder D, Kenedy MR, Anderson JF, Akins DR, Pal U. Borrelia burgdorferi complement regulator-acquiring surface protein 2 does not contribute to complement resistance or host infectivity. PLoS One. 2008 Aug 20; 3(8):3010e. PMID: 18714378; PMCID: PMC2526170.
    16. Brooks CS, Vuppala SR, Jett AM, Akins DR. Identification of Borrelia burgdorferi outer surface proteins. Infect Immun. 2006 Jan; 74(1):296-304. PMID: 16368984; PMCID: PMC1346608.
    17. Alitalo A, Meri T, Comstedt P, Jeffery L, Tornberg J, Strandin T, Lankinen H, Bergström S, Cinco M, Vuppala SR, Akins DR, Meri S. Expression of complement factor H binding immunoevasion proteins in Borrelia garinii isolated from patients with neuroborreliosis. Eur J Immunol. 2005 Oct; 35(10):3043-53. PMID: 16208765.
      View in: PubMed
    18. Brooks CS, Vuppala SR, Jett AM, Alitalo A, Meri S, Akins DR. Complement regulator-acquiring surface protein 1 imparts resistance to human serum in Borrelia burgdorferi. J Immunol. 2005 Sep 01; 175(5):3299-308. PMID: 16116222.
      View in: PubMed
    19. Mashburn LM, Jett AM, Akins DR, Whiteley M. Staphylococcus aureus serves as an iron source for Pseudomonas aeruginosa during in vivo coculture. J Bacteriol. 2005 Jan; 187(2):554-66. PMID: 15629927; PMCID: PMC543556.
    20. Alitalo A, Meri T, Chen T, Lankinen H, Cheng ZZ, Jokiranta TS, Seppälä IJ, Lahdenne P, Hefty PS, Akins DR, Meri S. Lysine-dependent multipoint binding of the Borrelia burgdorferi virulence factor outer surface protein E to the C terminus of factor H. J Immunol. 2004 May 15; 172(10):6195-201. PMID: 15128807.
      View in: PubMed
    21. Anderton JM, Tokarz R, Thill CD, Kuhlow CJ, Brooks CS, Akins DR, Katona LI, Benach JL. Whole-genome DNA array analysis of the response of Borrelia burgdorferi to a bactericidal monoclonal antibody. Infect Immun. 2004 Apr; 72(4):2035-44. PMID: 15039324; PMCID: PMC375205.
    22. Gilmore KS, Srinivas P, Akins DR, Hatter KL, Gilmore MS. Growth, development, and gene expression in a persistent Streptococcus gordonii biofilm. Infect Immun. 2003 Aug; 71(8):4759-66. PMID: 12874358; PMCID: PMC166047.
    23. Brooks CS, Hefty PS, Jolliff SE, Akins DR. Global analysis of Borrelia burgdorferi genes regulated by mammalian host-specific signals. Infect Immun. 2003 Jun; 71(6):3371-83. PMID: 12761121; PMCID: PMC155701.
    24. Ojaimi C, Brooks C, Casjens S, Rosa P, Elias A, Barbour A, Jasinskas A, Benach J, Katona L, Radolf J, Caimano M, Skare J, Swingle K, Akins D, Schwartz I. Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays. Infect Immun. 2003 Apr; 71(4):1689-705. PMID: 12654782; PMCID: PMC152086.
    25. Hefty PS, Brooks CS, Jett AM, White GL, Wikel SK, Kennedy RC, Akins DR. OspE-related, OspF-related, and Elp lipoproteins are immunogenic in baboons experimentally infected with Borrelia burgdorferi and in human lyme disease patients. J Clin Microbiol. 2002 Nov; 40(11):4256-65. PMID: 12409407; PMCID: PMC139709.
    26. Alitalo A, Meri T, Lankinen H, Seppälä I, Lahdenne P, Hefty PS, Akins D, Meri S. Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs. J Immunol. 2002 Oct 01; 169(7):3847-53. PMID: 12244181.
      View in: PubMed
    27. Hefty PS, Jolliff SE, Caimano MJ, Wikel SK, Akins DR. Changes in temporal and spatial patterns of outer surface lipoprotein expression generate population heterogeneity and antigenic diversity in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun. 2002 Jul; 70(7):3468-78. PMID: 12065486; PMCID: PMC128081.
    28. Elias AF, Stewart PE, Grimm D, Caimano MJ, Eggers CH, Tilly K, Bono JL, Akins DR, Radolf JD, Schwan TG, Rosa P. Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background. Infect Immun. 2002 Apr; 70(4):2139-50. PMID: 11895980; PMCID: PMC127854.
    29. Ojaimi C, Brooks C, Akins D, Casjens S, Rosa P, Elias A, Barbour A, Jasinskas A, Benach J, Katonah L, Radolf J, Caimano M, Skare J, Swingle K, Sims S, Schwartz I. Borrelia burgdorferi gene expression profiling with membrane-based arrays. Methods Enzymol. 2002; 358:165-77. PMID: 12474386.
      View in: PubMed
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