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David C Kem

TitleRegents Professor
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Endocrinology
Address1000 N Lincoln Blvd
Oklahoma City OK 73104-3252
Phone405/271-5896
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    F06TW001419     (KEM, DAVID C)Aug 4, 1989
    NIH/FIC
    INOSITOL - CALCIUM MEDIATED ANP RELEASE
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fedorowski A, Li H, Yu X, Koelsch KA, Harris VM, Liles C, Murphy TA, Quadri SM, Scofield RH, Sutton R, Melander O, Kem DC. Antiadrenergic autoimmunity in postural tachycardia syndrome. Europace. 2016 Oct 04. PMID: 27702852.
      View in: PubMed
    2. Myers JM, Cooper LT, Kem DC, Stavrakis S, Kosanke SD, Shevach EM, Fairweather D, Stoner JA, Cox CJ, Cunningham MW. Cardiac myosin-Th17 responses promote heart failure in human myocarditis. JCI Insight. 2016 Jun 16; 1(9). PMID: 27366791.
      View in: PubMed
    3. Li H, Murphy T, Zhang L, Huang B, Veitla V, Scherlag BJ, Kem DC, Yu X. ß1-Adrenergic and M2 Muscarinic Autoantibodies and Thyroid Hormone Facilitate Induction of Atrial Fibrillation in Male Rabbits. Endocrinology. 2016 Jan; 157(1):16-22. PMID: 26517045.
      View in: PubMed
    4. Li H, Zhang L, Huang B, Veitla V, Scherlag BJ, Cunningham MW, Aston CE, Kem DC, Yu X. A peptidomimetic inhibitor suppresses the inducibility of ß1-adrenergic autoantibody-mediated cardiac arrhythmias in the rabbit. J Interv Card Electrophysiol. 2015 Dec; 44(3):205-12. PMID: 26446828.
      View in: PubMed
    5. Liles C, Li H, Veitla V, Liles JT, Murphy TA, Cunningham MW, Yu X, Kem DC. AT2R autoantibodies block angiotensin II and AT1R autoantibody-induced vasoconstriction. Hypertension. 2015 Oct; 66(4):830-5. PMID: 26259590; PMCID: PMC4567423 [Available on 10/01/16].
    6. Li H, Kem DC, Zhang L, Huang B, Liles C, Benbrook A, Gali H, Veitla V, Scherlag BJ, Cunningham MW, Yu X. Novel retro-inverso peptide inhibitor reverses angiotensin receptor autoantibody-induced hypertension in the rabbit. Hypertension. 2015 Apr; 65(4):793-9. PMID: 25691619; PMCID: PMC4359052.
    7. Galloway A, Li H, Vanderlinde-Wood M, Khan M, Benbrook A, Liles C, Zillner C, Rao V, Cunningham MW, Yu X, Kem DC. Activating autoantibodies to the ß1/2-adrenergic and M2 muscarinic receptors associate with atrial tachyarrhythmias in patients with hyperthyroidism. Endocrine. 2015 Jun; 49(2):457-63. PMID: 25500789.
      View in: PubMed
    8. Li H, Yu X, Cicala MV, Mantero F, Benbrook A, Veitla V, Cunningham MW, Kem DC. Prevalence of angiotensin II type 1 receptor (AT1R)-activating autoantibodies in primary aldosteronism. J Am Soc Hypertens. 2015 Jan; 9(1):15-20. PMID: 25537460; PMCID: PMC4314451.
    9. Li H, Scherlag BJ, Kem DC, Benbrook A, Zhang L, Huang B, Cunningham MW, Lazzara R, Yu X. Atrial tachyarrhythmias induced by the combined effects of ß1/2-adrenergic autoantibodies and thyroid hormone in the rabbit. J Cardiovasc Transl Res. 2014 Aug; 7(6):581-9. PMID: 24903978.
      View in: PubMed
    10. Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Benbrook A, Pitha JV, Lazzara R, Yu X. The Propensity for Inducing Atrial Fibrillation: A Comparative Study on Old versus Young Rabbits. J Aging Res. 2014; 2014:684918. PMID: 24719763; PMCID: PMC3955625.
    11. Li H, Yu X, Liles C, Khan M, Vanderlinde-Wood M, Galloway A, Zillner C, Benbrook A, Reim S, Collier D, Hill MA, Raj SR, Okamoto LE, Cunningham MW, Aston CE, Kem DC. Autoimmune basis for postural tachycardia syndrome. J Am Heart Assoc. 2014 Feb 26; 3(1):e000755. PMID: 24572257; PMCID: PMC3959717.
    12. Kem DC, Li H, Velarde-Miranda C, Liles C, Vanderlinde-Wood M, Galloway A, Khan M, Zillner C, Benbrook A, Rao V, Gomez-Sanchez CE, Cunningham MW, Yu X. Autoimmune mechanisms activating the angiotensin AT1 receptor in 'primary' aldosteronism. J Clin Endocrinol Metab. 2014 May; 99(5):1790-7. PMID: 24552217; PMCID: PMC4010696.
    13. Li H, Scherlag BJ, Kem DC, Benbrook A, Shen X, Cunningham MW, Lazzara R, Aston CE, Yu X. Inducible cardiac arrhythmias caused by enhanced ß1-adrenergic autoantibody expression in the rabbit. Am J Physiol Heart Circ Physiol. 2014 Feb; 306(3):H422-8. PMID: 24271491; PMCID: PMC3920144.
    14. Li H, Zuccolo J, Kem DC, Zillner C, Lee J, Smith K, James JA, Cunningham MW, Yu X. Implications of a vasodilatory human monoclonal autoantibody in postural hypotension. J Biol Chem. 2013 Oct 18; 288(42):30734-41. PMID: 24043632; PMCID: PMC3798543.
    15. Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Pitha JV, Cunningham MW, Lazzara R, Yu X. Atrial tachycardia provoked in the presence of activating autoantibodies to ß2-adrenergic receptor in the rabbit. Heart Rhythm. 2013 Mar; 10(3):436-41. PMID: 23178688; PMCID: PMC3723380.
    16. Li H, Kem DC, Reim S, Khan M, Vanderlinde-Wood M, Zillner C, Collier D, Liles C, Hill MA, Cunningham MW, Aston CE, Yu X. Agonistic autoantibodies as vasodilators in orthostatic hypotension: a new mechanism. Hypertension. 2012 Feb; 59(2):402-8. PMID: 22215709; PMCID: PMC3275920.
    17. Yu X, Stavrakis S, Hill MA, Huang S, Reim S, Li H, Khan M, Hamlett S, Cunningham MW, Kem DC. Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension. J Am Soc Hypertens. 2012 Jan-Feb; 6(1):40-7. PMID: 22130180; PMCID: PMC3259269.
    18. Xie Z, Lau K, Eby B, Lozano P, He C, Pennington B, Li H, Rathi S, Dong Y, Tian R, Kem D, Zou MH. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes. 2011 Jun; 60(6):1770-8. PMID: 21562078; PMCID: PMC3114402.
    19. Stavrakis S, Kem DC, Patterson E, Lozano P, Huang S, Szabo B, Cunningham MW, Lazzara R, Yu X. Opposing cardiac effects of autoantibody activation of ß-adrenergic and M2 muscarinic receptors in cardiac-related diseases. Int J Cardiol. 2011 May 05; 148(3):331-6. PMID: 20053466; PMCID: PMC3108570.
    20. Stavrakis S, Yu X, Patterson E, Huang S, Hamlett SR, Chalmers L, Pappy R, Cunningham MW, Morshed SA, Davies TF, Lazzara R, Kem DC. Activating autoantibodies to the beta-1 adrenergic and m2 muscarinic receptors facilitate atrial fibrillation in patients with Graves' hyperthyroidism. J Am Coll Cardiol. 2009 Sep 29; 54(14):1309-16. PMID: 19778674; PMCID: PMC2801559.
    21. Yu X, Kem DC. Proteasome inhibition during myocardial infarction. Cardiovasc Res. 2010 Jan 15; 85(2):312-20. PMID: 19744947.
      View in: PubMed
    22. Heflin LA, Street CB, Papavassiliou DV, Kem DC, Wu DH, O'Rear EA. Transient stenotic-like occlusions as a possible mechanism for renovascular hypertension due to aneurysm. J Am Soc Hypertens. 2009 May-Jun; 3(3):192-200. PMID: 20409959.
      View in: PubMed
    23. Yu X, Patterson E, Stavrakis S, Huang S, De Aos I, Hamlett S, Cunningham MW, Lazarra R, Kem DC. Development of cardiomyopathy and atrial tachyarrhythmias associated with activating autoantibodies to beta-adrenergic and muscarinic receptors. J Am Soc Hypertens. 2009 Mar-Apr; 3(2):133-40. PMID: 20409953; PMCID: PMC3116651.
    24. Yu X, Patterson E, Kem DC. Targeting proteasomes for cardioprotection. Curr Opin Pharmacol. 2009 Apr; 9(2):167-72. PMID: 19097937.
      View in: PubMed
    25. Mascaro-Blanco A, Alvarez K, Yu X, Lindenfeld J, Olansky L, Lyons T, Duvall D, Heuser JS, Gosmanova A, Rubenstein CJ, Cooper LT, Kem DC, Cunningham MW. Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies. Autoimmunity. 2008 Sep; 41(6):442-53. PMID: 18781470; PMCID: PMC3108569.
    26. Huang S, Patterson E, Yu X, Garrett MW, De Aos I, Kem DC. Proteasome inhibition 1 h following ischemia protects GRK2 and prevents malignant ventricular tachyarrhythmias and SCD in a model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1298-303. PMID: 18192226.
      View in: PubMed
    27. Kem DC, Yu X, Patterson E, Huang S, Stavrakis S, Szabo B, Olansky L, McCauley J, Cunningham MW. Autoimmune hypertensive syndrome. Hypertension. 2007 Nov; 50(5):829-34. PMID: 17923587; PMCID: PMC3127442.
    28. Kem DC, Metcalf JP, Cornea A, Dunnam M, Engelbrecht A, Yu X. Is pseudo-Cushing's syndrome in a critically ill patient "pseudo"? Hypothesis and supportive case report. Endocr Pract. 2007 Mar-Apr; 13(2):153-8. PMID: 17490929.
      View in: PubMed
    29. Yu X, Tesiram YA, Towner RA, Abbott A, Patterson E, Huang S, Garrett MW, Chandrasekaran S, Matsuzaki S, Szweda LI, Gordon BE, Kem DC. Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI). Cardiovasc Diabetol. 2007 Feb 19; 6:6. PMID: 17309798; PMCID: PMC1805425.
    30. Patterson E, Yu X, Huang S, Garrett M, Kem DC. Suppression of autonomic-mediated triggered firing in pulmonary vein preparations, 24 hours postcoronary artery ligation in dogs. J Cardiovasc Electrophysiol. 2006 Jul; 17(7):763-70. PMID: 16836675.
      View in: PubMed
    31. Yu X, Huang S, Patterson E, Garrett MW, Kaufman KM, Metcalf JP, Zhu M, Dunn ST, Kem DC. Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2005 Nov; 289(5):H1960-7. PMID: 15994860.
      View in: PubMed
    32. Kem DC, Lyons DF, Wenzl J, Halverstadt D, Yu X. Renin-dependent hypertension caused by nonfocal stenotic aberrant renal arteries: proof of a new syndrome. Hypertension. 2005 Aug; 46(2):380-5. PMID: 15967872.
      View in: PubMed
    33. Yu X, Patterson E, Huang S, Garrett MW, Kem DC. Tumor necrosis factor alpha, rapid ventricular tachyarrhythmias, and infarct size in canine models of myocardial infarction. J Cardiovasc Pharmacol. 2005 Feb; 45(2):153-9. PMID: 15654264.
      View in: PubMed
    34. Castro OL, Yu X, Kem DC. Diagnostic value of the post-captopril test in primary aldosteronism. Hypertension. 2002 Apr; 39(4):935-8. PMID: 11967253.
      View in: PubMed
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