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Deepa S Sathyaseelan

TitleProf,Asst of Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDepartment of Geriatrics
Address975 NE 10th St
Oklahoma City OK 73104-5419
Phone405/271-2633
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    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
         Jul 1, 2017 - Mar 1, 2018
    Pilot Project-Oklahoma Nathan Shock Center of Aging
    Development of an Assay to Measure Necroptosis by the Levels of Circulating mtDNA
    Role Description: The goal of this Pilot Project is to develop a sensitive and quantitative assay to assess the necroptosis status of an animal (or human) by measuring the levels of mitochondrial DNA in blood.

    5 P20 GM103636-03     (Deepa Sathyaseelan)Jun 1, 2015 - Feb 28, 2016
    NIH COBRE (Pilot Project-Expanding Excellence in Developmental Biology)
    Role of Mitochondrial Protease ClpP in Adipose Tissue Development
    Role Description: The major goal of this project is to understand how mitochondrial matrix protease ClpP regulates adipose tissue development. We will test the hypothesis that deficiency of mitochondrial protease ClpP can alter fat deposition in adipocytes through changes in mitochondrial fat metabolism.
    Role: Sub-Project PI

    5 P20 GM103636-02     (Deepa Sathyaseelan)Jul 1, 2014 - Feb 28, 2015
    NIH COBRE(Pilot Project-Expanding Excellence in Developmental Biology)
    Mitochondrial matrix protease ClpP in development
    Role: Sub-Project PI

    A13415     (Deepa Sathyaseelan)Jul 1, 2013 - Jun 30, 2015
    American Federation for Aging Research
    Mitochondrial matrix protease ClpP in aging and cell survival.
    Role Description: The major goal of this project is to understand how mitochondrial matrix protease ClpP regulates aging.
    Role: PI

    13BGIA14670024     (Deepa Sathyaseelan)Jan 1, 2013 - Dec 31, 2014
    American Heart Association
    Molecular mechanisms of mitochondrial stress modulated insulin sensitivity.
    Role Description: The overall goal of this project is to test the hypothesis that up-regulation of the mitochondrial unfolded protein response (UPRmt) can modulate insulin sensitivity through changes in mitochondrial number, altered mitochondrial function and enhanced fat metabolism.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Snider TA, Richardson A, Stoner JA, Deepa SS. The Geropathology Grading Platform demonstrates that mice null for Cu/Zn-superoxide dismutase show accelerated biological aging. Geroscience. 2018 Feb 24. PMID: 29478190.
      View in: PubMed
    2. Matyi S, Jackson J, Garrett K, Deepa SS, Unnikrishnan A. The effect of different levels of dietary restriction on glucose homeostasis and metabolic memory. Geroscience. 2018 Feb 17. PMID: 29455275.
      View in: PubMed
    3. Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS. Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. EMBO Rep. 2018 Mar; 19(3). PMID: 29420235.
      View in: PubMed
    4. Bhaskaran S, Unnikrishnan A, Ranjit R, Qaisar R, Pharaoh G, Matyi S, Kinter M, Deepa SS. A fish oil diet induces mitochondrial uncoupling and mitochondrial unfolded protein response in epididymal white adipose tissue of mice. Free Radic Biol Med. 2017 Jul; 108:704-714. PMID: 28455142.
      View in: PubMed
    5. Hill S, Deepa SS, Sataranatarajan K, Premkumar P, Pulliam D, Liu Y, Soto VY, Fischer KE, Van Remmen H. Sco2 deficient mice develop increased adiposity and insulin resistance. Mol Cell Endocrinol. 2017 Nov 05; 455:103-114. PMID: 28428045.
      View in: PubMed
    6. Deepa SS, Bhaskaran S, Espinoza S, Brooks SV, McArdle A, Jackson MJ, Van Remmen H, Richardson A. A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse. Geroscience. 2017 Apr; 39(2):187-198. PMID: 28409332.
      View in: PubMed
    7. Zhang Y, Unnikrishnan A, Deepa SS, Liu Y, Li Y, Ikeno Y, Sosnowska D, Van Remmen H, Richardson A. A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence. Redox Biol. 2017 04; 11:30-37. PMID: 27846439.
      View in: PubMed
    8. Deepa SS, Bhaskaran S, Ranjit R, Qaisar R, Nair BC, Liu Y, Walsh ME, Fok WC, Van Remmen H. Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation. Free Radic Biol Med. 2016 Feb; 91:281-92. PMID: 26721594.
      View in: PubMed
    9. Pulliam DA, Deepa SS, Liu Y, Hill S, Lin AL, Bhattacharya A, Shi Y, Sloane L, Viscomi C, Zeviani M, Van Remmen H. Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses. Biochem J. 2014 Sep 01; 462(2):359-71. PMID: 24911525; PMCID: PMC4145821.
    10. Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V. Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice. J Cereb Blood Flow Metab. 2013 Oct; 33(10):1605-11. PMID: 23838831; PMCID: PMC3790931.
    11. Deepa SS, Walsh ME, Hamilton RT, Pulliam D, Shi Y, Hill S, Li Y, Van Remmen H. Rapamycin Modulates Markers of Mitochondrial Biogenesis and Fatty Acid Oxidation in the Adipose Tissue of db/db Mice. J Biochem Pharmacol Res. 2013 Jun; 1(2):114-123. PMID: 24010023.
      View in: PubMed
    12. Bhaskaran S, Dileep KV, Deepa SS, Sadasivan C, Klausner M, Krishnegowda NK, Tekmal RR, VandeBerg JL, Nair HB. Gossypin as a novel selective dual inhibitor of V-RAF murine sarcoma viral oncogene homolog B1 and cyclin-dependent kinase 4 for melanoma. Mol Cancer Ther. 2013 Apr; 12(4):361-72. PMID: 23543365.
      View in: PubMed
    13. Deepa SS, Pulliam D, Hill S, Shi Y, Walsh ME, Salmon A, Sloane L, Zhang N, Zeviani M, Viscomi C, Musi N, Van Remmen H. Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity. FASEB J. 2013 Apr; 27(4):1371-80. PMID: 23241310.
      View in: PubMed
    14. Mizumoto S, Murakoshi S, Kalayanamitra K, Deepa SS, Fukui S, Kongtawelert P, Yamada S, Sugahara K. Highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: insights into the sugar sequences with bioactivities. Glycobiology. 2013 Feb; 23(2):155-68. PMID: 23019154.
      View in: PubMed
    15. Deepa SS, Zhou L, Ryu J, Wang C, Mao X, Li C, Zhang N, Musi N, DeFronzo RA, Liu F, Dong LQ. APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway. Mol Endocrinol. 2011 Oct; 25(10):1773-85. PMID: 21835890; PMCID: PMC3182423.
    16. Carulli D, Pizzorusso T, Kwok JC, Putignano E, Poli A, Forostyak S, Andrews MR, Deepa SS, Glant TT, Fawcett JW. Animals lacking link protein have attenuated perineuronal nets and persistent plasticity. Brain. 2010 Aug; 133(Pt 8):2331-47. PMID: 20566484.
      View in: PubMed
    17. Zhou L, Deepa SS, Etzler JC, Ryu J, Mao X, Fang Q, Liu DD, Torres JM, Jia W, Lechleiter JD, Liu F, Dong LQ. Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways. J Biol Chem. 2009 Aug 14; 284(33):22426-35. PMID: 19520843; PMCID: PMC2755964.
    18. Deepa SS, Dong LQ. APPL1: role in adiponectin signaling and beyond. Am J Physiol Endocrinol Metab. 2009 Jan; 296(1):E22-36. PMID: 18854421; PMCID: PMC2636986.
    19. Pothacharoen P, Kalayanamitra K, Deepa SS, Fukui S, Hattori T, Fukushima N, Hardingham T, Kongtawelert P, Sugahara K. Two related but distinct chondroitin sulfate mimetope octasaccharide sequences recognized by monoclonal antibody WF6. J Biol Chem. 2007 Nov 30; 282(48):35232-46. PMID: 17884822.
      View in: PubMed
    20. Deepa SS, Yamada S, Fukui S, Sugahara K. Structural determination of novel sulfated octasaccharides isolated from chondroitin sulfate of shark cartilage and their application for characterizing monoclonal antibody epitopes. Glycobiology. 2007 Jun; 17(6):631-45. PMID: 17317718.
      View in: PubMed
    21. Deepa SS, Kalayanamitra K, Ito Y, Kongtawelert P, Fukui S, Yamada S, Mikami T, Sugahara K. Novel sulfated octa- and decasaccharides from squid cartilage chondroitin sulfate E: sequencing and application for determination of the epitope structure of the monoclonal antibody MO-225. Biochemistry. 2007 Mar 06; 46(9):2453-65. PMID: 17284053.
      View in: PubMed
    22. Deepa SS, Carulli D, Galtrey C, Rhodes K, Fukuda J, Mikami T, Sugahara K, Fawcett JW. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. J Biol Chem. 2006 Jun 30; 281(26):17789-800. PMID: 16644727.
      View in: PubMed
    23. Deepa SS, Yamada S, Zako M, Goldberger O, Sugahara K. Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of midkine, pleiotrophin, and basic fibroblast growth factor. J Biol Chem. 2004 Sep 03; 279(36):37368-76. PMID: 15226297.
      View in: PubMed
    24. Deepa SS, Arumughan C. Purification and characterization of soluble peroxidase from oil palm (Elaeis guineensis Jacq) leaf. Phytochemistry. 2002 Nov; 61(5):503-11. PMID: 12409016.
      View in: PubMed
    25. Deepa SS, Umehara Y, Higashiyama S, Itoh N, Sugahara K. Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors. Implications as a physiological binding partner in the brain and other tissues. J Biol Chem. 2002 Nov 15; 277(46):43707-16. PMID: 12221095.
      View in: PubMed
    26. Yamada S, Okada Y, Ueno M, Iwata S, Deepa SS, Nishimura S, Fujita M, Van Die I, Hirabayashi Y, Sugahara K. Determination of the glycosaminoglycan-protein linkage region oligosaccharide structures of proteoglycans from Drosophila melanogaster and Caenorhabditis elegans. J Biol Chem. 2002 Aug 30; 277(35):31877-86. PMID: 12058048.
      View in: PubMed
    27. Sivan YS, Alwin Jayakumar Y, Arumughan C, Sundaresan A, Jayalekshmy A, Suja KP, Soban Kumar DR, Deepa SS, Damodaran M, Soman CR, Raman Kutty V, Sankara Sarma P. Impact of vitamin A supplementation through different dosages of red palm oil and retinol palmitate on preschool children. J Trop Pediatr. 2002 Feb; 48(1):24-8. PMID: 11871368.
      View in: PubMed
    28. Sivan YS, Jayakumar YA, Arumughan C, Sundaresan A, Balachandran C, Job J, Deepa SS, Shihina SL, Damodaran M, Soman CR, Raman Kutty V, Sankara Sarma P. Impact of beta-carotene supplementation through red palm. J Trop Pediatr. 2001 Apr; 47(2):67-72. PMID: 11336137.
      View in: PubMed
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