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Douglas A Drevets

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Infectious Diseases
Address800 Stanton L Young Blvd
Oklahoma City OK 73104-0001
Phone405/278-3284
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    Collapse Research 
    Collapse research activities and funding
    R21NS082639     (DREVETS, DOUGLAS ALLEN)May 1, 2014 - Apr 30, 2016
    NIH/NINDS
    Inflammatory mediators and mechanisms during central nervous system infection
    Role: Principal Investigator

    R56AI057796     (DREVETS, DOUGLAS ALLEN)Apr 1, 2005 - Mar 31, 2007
    NIH/NIAID
    Monocyte Biology and Biodefense
    Role: Principal Investigator

    R21AI046651     (DREVETS, DOUGLAS ALLEN)Apr 1, 1999 - Mar 31, 2001
    NIH/NIAID
    TROJAN HORSE MECHANISM OF ENDOTHELIAL INVASION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Savitz JB, Teague TK, Misaki M, Macaluso M, Wurfel BE, Meyer M, Drevets D, Yates W, Gleason O, Drevets WC, Preskorn SH. Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial. Transl Psychiatry. 2018 Jan 24; 8(1):27. PMID: 29362444.
      View in: PubMed
    2. Prabhakaran V, Drevets DA, Ramajayam G, Manoj JJ, Anderson MP, Hanas JS, Rajshekhar V, Oommen A, Carabin H. Comparison of monocyte gene expression among patients with neurocysticercosis-associated epilepsy, Idiopathic Epilepsy and idiopathic headaches in India. PLoS Negl Trop Dis. 2017 Jun; 11(6):e0005664. PMID: 28622332.
      View in: PubMed
    3. Drevets DA. The importance of being in or out. FEMS Microbiol Lett. 2017 May 01; 364(10). PMID: 28379419.
      View in: PubMed
    4. Mera J, Vellozzi C, Hariri S, Carabin H, Drevets DA, Miller A, Reilley B, Essex W, Gahn D, Lyons L, Leston J, Ward JW. Identification and Clinical Management of Persons with Chronic Hepatitis C Virus Infection - Cherokee Nation, 2012-2015. MMWR Morb Mortal Wkly Rep. 2016 May 13; 65(18):461-6. PMID: 27172175.
      View in: PubMed
    5. Drevets DA, Canono BP, Campbell PA. Measurement of bacterial ingestion and killing by macrophages. Curr Protoc Immunol. 2015 Apr 01; 109:14.6.1-17. PMID: 25845563.
      View in: PubMed
    6. Riddell J, Kauffman CA, Smith JA, Assi M, Blue S, Buitrago MI, Deresinski S, Wright PW, Drevets DA, Norris SA, Vikram HR, Carson PJ, Vergidis P, Carpenter J, Seidenfeld SM, Wheat LJ. Histoplasma capsulatum endocarditis: multicenter case series with review of current diagnostic techniques and treatment. Medicine (Baltimore). 2014 Jul; 93(5):186-93. PMID: 25181311; PMCID: PMC4602453.
    7. Lockhart SM, Drevets DA. Reversible bone lesions induced by tenofovir disoproxil fumarate. AIDS. 2014 Jan 28; 28(3):450-1. PMID: 24670530.
      View in: PubMed
    8. Conrady CD, Zheng M, van Rooijen N, Drevets DA, Royer D, Alleman A, Carr DJ. Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis. J Immunol. 2013 Mar 15; 190(6):2807-17. PMID: 23382563; PMCID: PMC3594081.
    9. Hocker JR, Drevets DA, Dillon MJ, Hanas JS. Discriminating experimental Listeria monocytogenes infections in mice using serum profiling. Appl Microbiol Biotechnol. 2012 Nov; 96(4):1049-58. PMID: 23053068.
      View in: PubMed
    10. Savitz J, Preskorn S, Teague TK, Drevets D, Yates W, Drevets W. Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2x2 clinical trial. BMJ Open. 2012; 2(1):e000643. PMID: 22357572; PMCID: PMC3289990.
    11. Benefield RJ, Drevets DA, Huycke MM, Gentry CA. A multicenter evaluation of the safety of drotrecogin alfa (activated) in patients with baseline bleeding precautions. Curr Drug Saf. 2012 Feb; 7(1):3-7. PMID: 22663949.
      View in: PubMed
    12. Rakic-Martinez M, Drevets DA, Dutta V, Katic V, Kathariou S. Listeria monocytogenes strains selected on ciprofloxacin or the disinfectant benzalkonium chloride exhibit reduced susceptibility to ciprofloxacin, gentamicin, benzalkonium chloride, and other toxic compounds. Appl Environ Microbiol. 2011 Dec; 77(24):8714-21. PMID: 22003016; PMCID: PMC3233111.
    13. Fleckenstein JM, Bartels SR, Drevets PD, Bronze MS, Drevets DA. Infectious agents of food- and water-borne illnesses. Am J Med Sci. 2010 Sep; 340(3):238-46. PMID: 20823701.
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    14. Drevets DA, Schawang JE, Mandava VK, Dillon MJ, Leenen PJ. Severe Listeria monocytogenes infection induces development of monocytes with distinct phenotypic and functional features. J Immunol. 2010 Aug 15; 185(4):2432-41. PMID: 20631315.
      View in: PubMed
    15. van der Zee M, Dik WA, Kap YS, Dillon MJ, Benner R, Leenen PJ, Khan NA, Drevets DA. Synthetic human chorionic gonadotropin-related oligopeptides impair early innate immune responses to Listeria monocytogenes in Mice. J Infect Dis. 2010 Apr 01; 201(7):1072-80. PMID: 20170375.
      View in: PubMed
    16. Maeda K, Mehta H, Drevets DA, Coggeshall KM. IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production. Blood. 2010 Jun 10; 115(23):4699-706. PMID: 20351305; PMCID: PMC3790945.
    17. Drevets DA, Dillon MJ, Schawang JE, Stoner JA, Leenen PJ. IFN-gamma triggers CCR2-independent monocyte entry into the brain during systemic infection by virulent Listeria monocytogenes. Brain Behav Immun. 2010 Aug; 24(6):919-29. PMID: 20211719.
      View in: PubMed
    18. Conrady CD, Drevets DA, Carr DJ. Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing? J Neuroimmunol. 2010 Mar 30; 220(1-2):1-9. PMID: 19819030; PMCID: PMC2835842.
    19. Michel RG, Kinasewitz GT, Drevets DA, Levin JH, Warden DW. Prosthetic valve endocarditis caused by Candida lusitaniae, an uncommon pathogen: a case report. J Med Case Rep. 2009 May 14; 3:7611. PMID: 19830215; PMCID: PMC2726537.
    20. Gentry CA, Gross KB, Sud B, Drevets DA. Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding precautions. Crit Care Med. 2009 Jan; 37(1):19-25. PMID: 19050637.
      View in: PubMed
    21. Drevets DA, Schawang JE, Dillon MJ, Lerner MR, Bronze MS, Brackett DJ. Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain. J Immunol. 2008 Jul 01; 181(1):529-36. PMID: 18566419.
      View in: PubMed
    22. Drevets DA, Bronze MS. Listeria monocytogenes: epidemiology, human disease, and mechanisms of brain invasion. FEMS Immunol Med Microbiol. 2008 Jul; 53(2):151-65. PMID: 18462388.
      View in: PubMed
    23. Lockhart SM, Rathbun RC, Stephens JR, Baker DL, Drevets DA, Greenfield RA, Salvaggio MR, Vincent S. Cutaneous reactions with tenofovir disoproxil fumarate: a report of nine cases. AIDS. 2007 Jun 19; 21(10):1370-3. PMID: 17545718.
      View in: PubMed
    24. Jackson LA, Drevets DA, Dong ZM, Greenfield RA, Murphy JW. Levels of L-selectin (CD62L) on human leukocytes in disseminated cryptococcosis with and without associated HIV-1 infection. J Infect Dis. 2005 Apr 15; 191(8):1361-7. PMID: 15776384.
      View in: PubMed
    25. Sunderkötter C, Nikolic T, Dillon MJ, Van Rooijen N, Stehling M, Drevets DA, Leenen PJ. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol. 2004 Apr 01; 172(7):4410-7. PMID: 15034056.
      View in: PubMed
    26. Drevets DA, Dillon MJ, Schawang JS, Van Rooijen N, Ehrchen J, Sunderkötter C, Leenen PJ. The Ly-6Chigh monocyte subpopulation transports Listeria monocytogenes into the brain during systemic infection of mice. J Immunol. 2004 Apr 01; 172(7):4418-24. PMID: 15034057.
      View in: PubMed
    27. Drevets DA, Leenen PJ, Greenfield RA. Invasion of the central nervous system by intracellular bacteria. Clin Microbiol Rev. 2004 Apr; 17(2):323-47. PMID: 15084504; PMCID: PMC387409.
    28. Drevets DA. Plague. J Okla State Med Assoc. 2002 Dec; 95(12):752-4. PMID: 12596433.
      View in: PubMed
    29. Greenfield RA, Drevets DA, Gilmore MS. Anthrax. J Okla State Med Assoc. 2002 Sep; 95(9):587-91. PMID: 12362648.
      View in: PubMed
    30. Greenfield RA, Drevets DA, Machado LJ, Voskuhl GW, Cornea P, Bronze MS. Bacterial pathogens as biological weapons and agents of bioterrorism. Am J Med Sci. 2002 Jun; 323(6):299-315. PMID: 12074485.
      View in: PubMed
    31. Campbell PA, Canono BP, Drevets DA. Measurement of bacterial ingestion and killing by macrophages. Curr Protoc Immunol. 2001 May; Chapter 14:Unit 14.6. PMID: 18432724.
      View in: PubMed
    32. Drevets DA, Jelinek TA, Freitag NE. Listeria monocytogenes-infected phagocytes can initiate central nervous system infection in mice. Infect Immun. 2001 Mar; 69(3):1344-50. PMID: 11179297; PMCID: PMC98026.
    33. Drevets DA, Leenen PJ. Leukocyte-facilitated entry of intracellular pathogens into the central nervous system. Microbes Infect. 2000 Nov; 2(13):1609-18. PMID: 11113380.
      View in: PubMed
    34. Drevets DA. Dissemination of Listeria monocytogenes by infected phagocytes. Infect Immun. 1999 Jul; 67(7):3512-7. PMID: 10377133; PMCID: PMC116538.
    35. Wilson SL, Drevets DA. Listeria monocytogenes infection and activation of human brain microvascular endothelial cells. J Infect Dis. 1998 Dec; 178(6):1658-66. PMID: 9815218.
      View in: PubMed
    36. Shaffer DN, Drevets DA, Farr RW. Listeria monocytogenes rhomboencephalitis with cranial-nerve palsies: a case report. W V Med J. 1998 Mar-Apr; 94(2):80-3. PMID: 9581507.
      View in: PubMed
    37. Drevets DA. Listeria monocytogenes virulence factors that stimulate endothelial cells. Infect Immun. 1998 Jan; 66(1):232-8. PMID: 9423863; PMCID: PMC107882.
    38. Drevets DA. Listeria monocytogenes infection of cultured endothelial cells stimulates neutrophil adhesion and adhesion molecule expression. J Immunol. 1997 Jun 01; 158(11):5305-13. PMID: 9164950.
      View in: PubMed
    39. Sawyer RT, Drevets DA, Campbell PA, Potter TA. Internalin A can mediate phagocytosis of Listeria monocytogenes by mouse macrophage cell lines. J Leukoc Biol. 1996 Nov; 60(5):603-10. PMID: 8929551.
      View in: PubMed
    40. Drevets DA, Leenen PJ, Campbell PA. Complement receptor type 3 mediates phagocytosis and killing of Listeria monocytogenes by a TNF-alpha- and IFN-gamma-stimulated macrophage precursor hybrid. Cell Immunol. 1996 Apr 10; 169(1):1-6. PMID: 8612281.
      View in: PubMed
    41. Drevets DA, Sawyer RT, Potter TA, Campbell PA. Listeria monocytogenes infects human endothelial cells by two distinct mechanisms. Infect Immun. 1995 Nov; 63(11):4268-76. PMID: 7591057; PMCID: PMC173606.
    42. Leenen PJ, Canono BP, Drevets DA, Voerman JS, Campbell PA. TNF-alpha and IFN-gamma stimulate a macrophage precursor cell line to kill Listeria monocytogenes in a nitric oxide-independent manner. J Immunol. 1994 Dec 01; 153(11):5141-7. PMID: 7525724.
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    43. Fu YX, Roark CE, Kelly K, Drevets D, Campbell P, O'Brien R, Born W. Immune protection and control of inflammatory tissue necrosis by gamma delta T cells. J Immunol. 1994 Oct 01; 153(7):3101-15. PMID: 8089489.
      View in: PubMed
    44. Drevets DA, Canono BP, Leenen PJ, Campbell PA. Gentamicin kills intracellular Listeria monocytogenes. Infect Immun. 1994 Jun; 62(6):2222-8. PMID: 8188344; PMCID: PMC186501.
    45. Drevets DA, Leenen PJ, Campbell PA. Complement receptor type 3 (CD11b/CD18) involvement is essential for killing of Listeria monocytogenes by mouse macrophages. J Immunol. 1993 Nov 15; 151(10):5431-9. PMID: 8228236.
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    46. Drevets DA, Canono BP, Campbell PA. Listericidal and nonlistericidal mouse macrophages differ in complement receptor type 3-mediated phagocytosis of L. monocytogenes and in preventing escape of the bacteria into the cytoplasm. J Leukoc Biol. 1992 Jul; 52(1):70-9. PMID: 1640177.
      View in: PubMed
    47. Drevets DA, Campbell PA. Macrophage phagocytosis: use of fluorescence microscopy to distinguish between extracellular and intracellular bacteria. J Immunol Methods. 1991 Aug 28; 142(1):31-8. PMID: 1919019.
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    48. Drevets DA, Campbell PA. Roles of complement and complement receptor type 3 in phagocytosis of Listeria monocytogenes by inflammatory mouse peritoneal macrophages. Infect Immun. 1991 Aug; 59(8):2645-52. PMID: 1906842; PMCID: PMC258068.
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