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Fernando Luis Esteban Florez

TitleProf,Asst
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentRestorative Sciences
Address1201 N Stonewall Ave
Oklahoma City OK 73117-1214
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    Collapse Biography 
    Collapse education and training
    The University of Marília, Marília College of Dentistry, Marília City, BrazilD.D.S.12/2002Dentistry
    The São Paulo State University, Araraquara College of Dentistry, Araraquara City, BrazilM.S.02/2009Restorative Dentistry
    The São Paulo State University, Araraquara College of Dentistry, Araraquara City, BrazilPh.D.02/2012Restorative Dentistry
    The University of Oklahoma Health Sciences Center College of Dentistry, Oklahoma City, U.S.A06/2015Dental Biomaterials
    Collapse awards and honors
    2015 - 2016Translating Practice into Research Program (TPIR), Oklahoma Shared Clinical & Translational Resources
    2017OU Growth Fund Award, The University of Oklahoma Office of Technology Development and The Presbyterian Health Foundation
    2017 - 2018Faculty Leadership Program, The University of Oklahoma Health Sciences Center
    2018Omicron Kappa Upsilon Honor Society, Oklahoma Omicron Pi Chapter

    Collapse Overview 
    Collapse overview
    I have significant experience in the areas of biophotonics, development of medical devices for surface sterilization using UV-C LEDs, antimicrobial photodynamic therapy, metaloxide nanoparticles, nanostructured dental adhesive resins with antibacterial and bioactive properties, advanced microscopy techniques (SEM, TEM, Dual-FIB SEM, EDS), high-throughput bioluminescence assays. My Ph.D. dissertation focused on the antibacterial properties of novel photosensitizers such as Curcumin and Hypericin against Streptococcus mutans (planktonic and biofilms). The long-term goal of my research is the development of antibacterial and bioactive biomaterials to improve the service lives of restorative materials and dental implants. I have worked as the principal investigator for six grants at local [OU Stipend Award ($ 20,000) and OU Growth Fund ($ 75,000)], state [OSCTR Pilot Grant ($ 75,000), OCAST HRP ($ 135,000)], national (Oak Ridge National Laboratory User Proposal) and international [ FAPESP, PIPE Program, phases I and II, (R$ 537,000)] levels. Since becoming an assistant professor at the Division of Dental Biomaterials at the College of Dentistry (July, 2015), I have filled a non-provisional international patent of a novel dental adhesive resin with antibacterial properties, published 14 peer-reviewed manuscripts, presented my research at national (AADR) and international conferences (IADR) and gave 6 invited international presentations (as featured or keynote speaker) to showcase the results from those projects.


    Collapse Research 
    Collapse research activities and funding
    CNMS2018-034     (Fernando Luis Esteban Florez)Jul 1, 2018 - Jun 30, 2019
    The Oak Ridge National Laboratory
    Development, fabrication of doped and co-doped titanium dioxide nanoparticles with bond-promoting functionalities. Advanced characterization using neutron scattering, hellion-ion microscopy and Dual-FIB-SEM
    Role: Principal Investigator

    OU Growth Fund Award     (Fernando Luis Esteban Florez)Jul 1, 2017 - Jun 30, 2018
    The Office of Technology Development and The Presbyterian Health Foundation
    Nitrogen-doped Titanium Dioxide Nanoparticles as Antibacterial, Bond-promoting and Bioactive Agents for Dental Adhesive Resins
    Role Description: Improvement of (i) current polymer compositions, (ii) nanoparticles’ interfacial chemistries and (iii) the antibacterial, bioactive and bond-promoting properties of N_TiO2. The successful completion of the research objectives will result in a polymer matrix designed specifically to optimize the generation and diffusion of reactive oxygen species (ROS), thereby increasing the chances for newly generated free radicals to be part of numerous oxidative reactions taking place at the surface of the material

    HR16-131     (Fernando Luis Esteban Florez)Jul 1, 2016 - Jun 30, 2019
    Oklahoma Center for the Advancement of Science & Technology
    Real-time quantification of cells' viability and "smart" adhesive resins with antibacterial, bond-promoting and bioactive properties.
    Role Description: The present research proposal specifically responds to the 2016 Oklahoma Health Research Program funding opportunity and is a logical next step in Dr. Florez’s long-term career goal to pursue new strategies to prevent the occurrence of secondary caries. This includes the development of a novel antibacterial adhesive resin with bioactive and bond-promoting properties, and the optimization of a high throughput, non-destructive and real-time bioluminescence assay to assess the metabolic activity of intact oral biofilms.
    Role: Principal Investigator

    OSCTR Pilot Grant     (Fernando Luis Esteban Florez)Jul 1, 2016 - Jun 30, 2017
    Oklahoma Shared Clinical and Translational Resources
    Antibacterial Adhesive Resins with On-Demand Properties Mediated by Visible Light
    Role Description: Development of dental adhesive resins with antibacterial properties enhanced by visible light irradiation
    Role: Principal Investigator

    CNMS2015-331     (Sharukh S. Khajotia)Jul 2, 2015 - Jun 30, 2017
    The Oak Ridge National Laboratory
    Antibacterial and Protein Binding Nanoparticles for Dental Adhesive Resins
    Role Description: Development of titanium dioxide nanoparticles that are either doped or co-doped with different elements (such as metals and non-metals)

    CNMS2013-331     (Sharukh S. Khajotia)Jul 1, 2013 - Jun 30, 2015
    The Oak Ridge National Laboratory
    Nitrogen-Doped Titanium Dioxide Nanoparticles as Antibacterial Agents for Dental Adhesive Systems
    Role Description: Development, fabrication and characterization of nitrogen-doped titanium dioxide nanoparticles
    Role: Co-Investigator

    Postdoctoral Stipend Award     (Fernando Luis Esteban Florez)Jul 1, 2012 - Jun 30, 2013
    The University of Oklahoma Health Sciences Center Office of The Vice President for Research
    Development of Preventive Strategies Against Secondary Caries in Bonded Restorations
    Role Description: (i) Characterization of the heterogeneous photocatalytic behavior of nitrogen-doped titanium dioxide nanoparticles in a commercial dental adhesive resin, (ii) improve the service lives of composite resin bonded restorations (iii) decrease the costs associated with oral health
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zielak, J.C., Gullin Neto, D., Cazella Zielak, M. A., Savaris, L.B., ESTEBAN FLOREZ*, F.L., Deliberador, T.M. . In vivo regeneration functionalities of organo-biomaterials containing water-soluble nacre extract. Heliyon. 2018; e00776(4):1-18.
    2. ESTEBAN FLOREZ, F.L.*, Hiers, R.D., Larson, P., Johnson, M., O’Rear, E., Rondinone, A.J., Khajotia S.S. Antibacterial dental adhesive resins containing nitrogen-doped titanium dioxide nanoparticles. Antibacterial dental adhesive resins containing nitrogen-doped titanium dioxide nanoparticles. Materials Science & Engineering C. 2018; (93):931-943.
    3. Lin, L., Currier, F., Kadioglu, O., ESTEBAN FLOREZ, F.L., Thompson, D.M., Khajotia, S.S. . Flexural Properties of Rectangular Nickel-Titanium Orthodontic Wires When Used as Ribbon Archwires. Angle Orthodontist. 2018.
    4. Gerber Corredor, N.S., Coelho, S.B., Deliberador, T.M., Junior, D.R., Baratto-Filho, F., ESTEBAN FLOREZ, F.L. Six-Year Follow-Up of Immature Tooth Revascularization With Enamel Matrix Proteins. Compendium of Continuing Education in Dentistry. 2018; 39(7).
    5. ESTEBAN FLOREZ, F.L.*, de Oliveira, M.R.M., de Oliveira Júnior, O.B., Hiers, R.D., Khajotia, S.S., Pretel, H. . Bioluminescence Analysis of Antibacterial Photodynamic Therapy Using Methylene Blue Mediated by Low-Intensity Level Laser Against Cariogenic Biofilms. Photomedicine and Laser Surgery. 2018; 36(5):258-265.
    6. Deliberador TM, Begnini GJ, Tomazinho F, Rezende CEE, Florez FLE, Leonardi DP. Immediate Implant Placement and Provisionalization Using the Patient's Extracted Crown: 12-Month Follow-Up. Compend Contin Educ Dent. 2018 Mar; 39(3):e18-e21. PMID: 29493254.
      View in: PubMed
    7. ESTEBAN FLOREZ, F.L., Khajotia, S.S., Rondinone, A.J. Compositions with Doped Titanium Dioxide Nanoparticles. 2018.
    8. Esteban Florez FL, Mendonça de Oliveira MR, de Oliveira Júnior OB, Hiers RD, Khajotia SS, Pretel H. Bioluminescence Analysis of Antibacterial Photodynamic Therapy Using Methylene Blue Mediated by Low-Intensity Level Laser Against Cariogenic Biofilms. Photomed Laser Surg. 2018 May; 36(5):258-265. PMID: 29315011.
      View in: PubMed
    9. Natale, L.C., Alania, Y., Rodrigues, M.C., Simões, A., de Souza, D.N., de LIMA, E., Arana-Chavez, V.E., Hewer, T.L.R. Hiers, R.D., ESTEBAN FLOREZ, F.L., Brito, G.E.S., Khajotia, S.S., Braga, R.R. Synthesis and characterization of silver phosphate/calcium phosphate mixed particles capable of silver nanoparticle formation by photoreduction. Material Sciences and Engineering C. 2017; 76:464-471.
    10. Esteban Florez FL, Hiers RD, Smart K, Kreth J, Qi F, Merritt J, Khajotia SS. Real-time assessment of Streptococcus mutans biofilm metabolism on resin composite. Dent Mater. 2016 10; 32(10):1263-1269. PMID: 27515531.
      View in: PubMed
    11. Panhóca VH, Esteban Florez FL, Corrêa TQ, Paolillo FR, de Souza CW, Bagnato VS. Oral Decontamination of Orthodontic Patients Using Photodynamic Therapy Mediated by Blue-Light Irradiation and Curcumin Associated with Sodium Dodecyl Sulfate. Photomed Laser Surg. 2016 Sep; 34(9):411-7. PMID: 27454528.
      View in: PubMed
    12. Oliveira, M., Férnandez, E., Bortollato, J., Oliveira Júnior, O.B., Bandeca, M., Khajotia, S.S., ESTEBAN FLOREZ, F.L. . Optical Dental Whitening Efficacy of Blue Covarine Toothpaste in Teeth Stained by Different Colors. Journal of Esthetic and Restorative Dentistry. 2016; 28:S68-S77.
    13. Panhoca, V.H., ESTEBAN FLOREZ, F.L., Faria Junior, N., Tanomaru, J.M.G., Rastelli, A.N.S., Kurachi, C., Bagnato, V.S. Evaluation of Antimicrobial Photodynamic Therapy Against Streptococcus mutans Biofilm in situ. The Journal of Contemporary Dental Practice. 2016; 3(17):184-91.
    14. Lizarelli, R.F.Z., Grandi, N.D.P., ESTEBAN FLOREZ, F.L., Grecco, C., Almeida-Lopes, L. Proceedings of SPIE. Clinical Study on Orofacial Photonic Hydration Using Phototherapy and Biomaterials. 2015; 9531:95411T1-9.
    15. Lizarelli, R.F.Z., Pizzo, R.C.A., ESTEBAN FLOREZ, F.L., Grecco, C., Speciali, J.G., Bagnato, V.S. Comparative Clinical Study Using Laser and LED-Therapy for Orofacial Pain Relief: Dentin Hypersensitivity and Cervicogenic Headache. Proceedings of SPIE. 2015; 9531:95311Q1-13.
    16. ESTEBAN FLOREZ, F.L.*, Del Arco, M.C.G., Salvador, S.L.S., Bagnato, V.S., Oliveira Júnior, O.B. . Viability Study of Antimicrobial Photodynamic Therapy using Curcumin, Hypericin and Photogem Photosensitizers in Planktonic Cells of Streptococcus mutans. Scientific Journal of Dentistry. 2015; 2(1):22-7.
    17. Arana-Correa, B.E., Sepúlveda-Navarro, W.F., ESTEBAN FLOREZ, F.L., Urban, V.M., Jorge, J.H., Campanha, N.H. Color Stability of Acrylic Resin Denture Teeth After Immersion in Different Beverages. European Journal of Prosthetic and Restorative Dentistry. 2014; 22(2).
    18. ESTEBAN FLOREZ, F.L., Panhoca, V.H., Andrade, M.F., Campos, E.A., Bagnato, V.S., Oliveira Júnior, O.B. In-office dental bleaching efficacy assessment in function of the light exposure regime by digital colorimetric reflectance spectroscopy. Journal of Dentistry and Oral Hygiene. 2011; 3(8):99-105.
    19. Oliveira Junior, O.B., Cioffi, M.S., ESTEBAN FLOREZ, F.L., Cesnik, R.M., Bagnato, V.S., Santos, D.R.C., Fornazari, F.P. Proceedings Volume 7162. Comparative Assessment of the Organization of the Colors of the Vita Classical Color Pallet by Digital Images and Visual Analysis for Dental Bleaching. 2009; 7162:7162G1-8.
    20. ESTEBAN FLOREZ, F.L.*, Figueiredo, A.C.R., Moriyama, L.T., Oliveira Júnior, O.B., BAGNATO, V.S. Proceedings Volume 7162, Lasers in Dentistry XV. In Vitro Study of the Influence of Pigments of Three Colored Gels Over the Light Distribution of Visible Light by Digital Images. 2009; 716209-1:716209-8.
    21. ESTEBAN FLOREZ, F.L.*, Vollet-Filho, J.D., Oliveira Júnior, O.B., Bagnato, V.S. Proceedings Volume 7162. Time-course Diffusion of Hydrogen Peroxide using Modern Technologies. 2009; 7162:7162K1-7.
    22. Zanirato Lizarelli, R.F., Moriyama, L.T., ESTEBAN FLOREZ, F.L., Jacomassi, D.P., Pelino, J.E.P., Bagnato, V.S. Proceedings Volume 6425. Aged Composite Resins Ablation Under Different Parameters of Er: YAG laser: Ablation Rate and Morphological Aspects. 2007; 6425:64250C1-10.
    23. Lins, E.C.C.C, ESTEBAN FLOREZ, F.L., Portero, P.P., Zanirato Lizarelli, R.F., Oliveira Júnior, O.B., Bagnato. Proceedings Volume 6425. Background Interference on the Color of Dental Composite Materials with Different Thickness by Digital Contrast. 2007; 6425:642511-1-642511-6.
    24. ESTEBAN FLOREZ, F.L.*, Lins, E.C.C.C., Paiva Portero, P., Zanirato Lizarelli, R.F., Oliveira Júnior, O.B., Bagnato, V.S. Proceedings Volume 6425. Investigation of Photo-bleaching Through Transmittance Method in Pigmented Solution: Understanding Possible Mechanisms and Advantages for Photo Dental Whitening. 2007; 6425:64250Y-1-64250Y-8.
    25. Lins, E.C.C.C., ESTEBAN FLOREZ, F.L., Figueiredo, A.C.R., Bagnato. Proceedings Volume 6425,. Digital Image Assessment of Metallic Post Morphological Detection Through Transillumination of Composite Materials. 2007; 642:642506-1-642506-8.
    26. ESTEBAN FLOREZ, F.L.*, Lins, E.C.C.C., Zanirato Lizarelli, R.F., Bagnato, V.S. Proceedings Volume 6137. Quantification of the Efficiency for Photo-bleached Pigments Using Cellulose Matrix as Substrate and Digitalized Gray Scale. 2006; 6137:61370C-1-61370C-7.
    27. Paiva Portero, P., ESTEBAN FLOREZ, F.L., Bagnato, V.S., Oliveira Júnior, O.B., MONTEIRO LOFFREDO, L.C. Proceedings Volume 6425. Colorimetric Evaluation of Composite Materials with Different Thickness by Reflectance Spectroscopy. 6425:64250Z-1-64250Z-6.
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