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Last Name

Gennadiy Petrovich Moiseyev

TitleProf,Asst of Research
InstitutionUniversity of Oklahoma Health Sciences Center
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    R43EY017229     (MOISEYEV, GENNADIY)May 1, 2006 - Apr 30, 2008
    Cocktail of Angiogenic Inhibitors for the Treatment of Diabetic Macular Edema
    Role: Principal Investigator

    R43EY016298     (MOISEYEV, GENNADIY)Aug 1, 2005 - Jan 31, 2008
    Treatment of Retinal Vascular Leakage Using Angiostatin
    Role: Principal Investigator

    R01EY012231     (MA, JIAN-XING)Jul 1, 1998 - Aug 31, 2022
    Studies of RPE65
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shin Y, Moiseyev G, Petrukhin K, Cioffi CL, Muthuraman P, Takahashi Y, Ma JX. A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration. Biochim Biophys Acta Mol Basis Dis. 2018 Jul; 1864(7):2420-2429. PMID: 29684583.
      View in: PubMed
    2. Du M, Phelps E, Balangue MJ, Dockins A, Moiseyev G, Shin Y, Kane S, Otalora L, Ma JX, Farjo R, Farjo KM. Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):4375–4383. PMID: 28813718.
      View in: PubMed
    3. Malechka VV, Moiseyev G, Takahashi Y, Shin Y, Ma JX. Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy. Am J Pathol. 2017 Oct; 187(10):2222-2231. PMID: 28734946.
      View in: PubMed
    4. Shin Y, Moiseyev G, Chakraborty D, Ma JX. A Dominant Mutation in Rpe65, D477G, Delays Dark Adaptation and Disturbs the Visual Cycle in the Mutant Knock-In Mice. Am J Pathol. 2017 Mar; 187(3):517-527. PMID: 28041994.
      View in: PubMed
    5. He X, Cheng R, Park K, Benyajati S, Moiseyev G, Sun C, Olson LE, Yang Y, Eby BK, Lau K, Ma JX. Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway. Kidney Int. 2017 03; 91(3):642-657. PMID: 27914705.
      View in: PubMed
    6. Harper AR, Wang X, Moiseyev G, Ma JX, Summers JA. Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia. Invest Ophthalmol Vis Sci. 2016 Sep 01; 57(11):4886-4897. PMID: 27654415.
      View in: PubMed
    7. Stiles M, Moiseyev GP, Budda ML, Linens A, Brush RS, Qi H, White GL, Wolf RF, Ma JX, Floyd R, Anderson RE, Mandal NA. PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage. PLoS One. 2015; 10(12):e0145305. PMID: 26694648; PMCID: PMC4687940.
    8. Du M, Otalora L, Martin AA, Moiseyev G, Vanlandingham P, Wang Q, Farjo R, Yeganeh A, Quiambao A, Farjo KM. Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism. Mol Cell Biol. 2015 Aug; 35(16):2771-89. PMID: 26055327; PMCID: PMC4508322.
    9. Harper AR, Wiechmann AF, Moiseyev G, Ma JX, Summers JA. Identification of active retinaldehyde dehydrogenase isoforms in the postnatal human eye. PLoS One. 2015; 10(3):e0122008. PMID: 25793304; PMCID: PMC4368790.
    10. Takahashi Y, Moiseyev G, Ma JX. Identification of key residues determining isomerohydrolase activity of human RPE65. J Biol Chem. 2014 Sep 26; 289(39):26743-51. PMID: 25112876; PMCID: PMC4175317.
    11. Dobri N, Qin Q, Kong J, Yamamoto K, Liu Z, Moiseyev G, Ma JX, Allikmets R, Sparrow JR, Petrukhin K. A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis. Invest Ophthalmol Vis Sci. 2013 Jan 07; 54(1):85-95. PMID: 23211825; PMCID: PMC3544424.
    12. Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma JX. Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 Dec; 32(24):5103-15. PMID: 23071093; PMCID: PMC3510526.
    13. Chucair-Elliott AJ, Elliott MH, Wang J, Moiseyev GP, Ma JX, Politi LE, Rotstein NP, Akira S, Uematsu S, Ash JD. Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium. J Biol Chem. 2012 Jul 13; 287(29):24092-102. PMID: 22645143; PMCID: PMC3397836.
    14. Takahashi Y, Moiseyev G, Nikolaeva O, Ma JX. Identification of the key residues determining the product specificity of isomerohydrolase. Biochemistry. 2012 May 22; 51(20):4217-25. PMID: 22512451; PMCID: PMC3358571.
    15. Hu Y, Chen Y, Moiseyev G, Takahashi Y, Mott R, Ma JX. Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice. Invest Ophthalmol Vis Sci. 2011 Jul 25; 52(8):5507-14. PMID: 21551411; PMCID: PMC3176065.
    16. Mandal MN, Moiseyev GP, Elliott MH, Kasus-Jacobi A, Li X, Chen H, Zheng L, Nikolaeva O, Floyd RA, Ma JX, Anderson RE. Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. J Biol Chem. 2011 Sep 16; 286(37):32491-501. PMID: 21785167; PMCID: PMC3173208.
    17. Farjo KM, Moiseyev G, Nikolaeva O, Sandell LL, Trainor PA, Ma JX. RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis. Dev Biol. 2011 Sep 15; 357(2):347-55. PMID: 21782811; PMCID: PMC3164597.
    18. Takahashi Y, Moiseyev G, Chen Y, Nikolaeva O, Ma JX. An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species. FEBS J. 2011 Aug; 278(16):2913-26. PMID: 21676174; PMCID: PMC3354629.
    19. Nikolaeva O, Moiseyev G, Rodgers KK, Ma JX. Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity. Biochem J. 2011 Jun 15; 436(3):591-7. PMID: 21446919.
      View in: PubMed
    20. Takahashi Y, Moiseyev G, Chen Y, Farjo K, Nikolaeva O, Ma JX. An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain. FEBS J. 2011 Apr; 278(6):973-87. PMID: 21235714; PMCID: PMC3073448.
    21. Moiseyev G, Nikolaeva O, Chen Y, Farjo K, Takahashi Y, Ma JX. Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease. Proc Natl Acad Sci U S A. 2010 Oct 12; 107(41):17551-6. PMID: 20876139; PMCID: PMC2955102.
    22. Nikolaeva O, Takahashi Y, Moiseyev G, Ma JX. Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65. Biochem Biophys Res Commun. 2010 Jan 22; 391(4):1757-61. PMID: 20043869; PMCID: PMC2812700.
    23. Farjo KM, Moiseyev G, Takahashi Y, Crouch RK, Ma JX. The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5089-97. PMID: 19458327.
      View in: PubMed
    24. Nikolaeva O, Takahashi Y, Moiseyev G, Ma JX. Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane. FEBS J. 2009 Jun; 276(11):3020-30. PMID: 19490105; PMCID: PMC2777724.
    25. Takahashi Y, Moiseyev G, Farjo K, Ma JX. Characterization of key residues and membrane association domains in retinol dehydrogenase 10. Biochem J. 2009 Apr 01; 419(1):113-22, 1 p following 122. PMID: 19102727; PMCID: PMC2728083.
    26. Chen Y, Hu Y, Moiseyev G, Zhou KK, Chen D, Ma JX. Photoreceptor degeneration and retinal inflammation induced by very low-density lipoprotein receptor deficiency. Microvasc Res. 2009 Jun; 78(1):119-27. PMID: 19281829; PMCID: PMC2728019.
    27. Takahashi Y, Moiseyev G, Ablonczy Z, Chen Y, Crouch RK, Ma JX. Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65. J Biol Chem. 2009 Jan 30; 284(5):3211-8. PMID: 19049981; PMCID: PMC2631947.
    28. Moiseyev G, Takahashi Y, Chen Y, Kim S, Ma JX. RPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species. J Biol Chem. 2008 Mar 28; 283(13):8110-7. PMID: 18216020; PMCID: PMC2276383.
    29. Kanan Y, Kasus-Jacobi A, Moiseyev G, Sawyer K, Ma JX, Al-Ubaidi MR. Retinoid processing in cone and Müller cell lines. Exp Eye Res. 2008 Feb; 86(2):344-54. PMID: 18163989; PMCID: PMC2947831.
    30. Sandell LL, Sanderson BW, Moiseyev G, Johnson T, Mushegian A, Young K, Rey JP, Ma JX, Staehling-Hampton K, Trainor PA. RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev. 2007 May 01; 21(9):1113-24. PMID: 17473173; PMCID: PMC1855236.
    31. Kanan Y, Moiseyev G, Agarwal N, Ma JX, Al-Ubaidi MR. Light induces programmed cell death by activating multiple independent proteases in a cone photoreceptor cell line. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):40-51. PMID: 17197514.
      View in: PubMed
    32. Takahashi Y, Moiseyev G, Chen Y, Ma JX. The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5191-6. PMID: 17122102.
      View in: PubMed
    33. Chen Y, Moiseyev G, Takahashi Y, Ma JX. Impacts of two point mutations of RPE65 from Leber's congenital amaurosis on the stability, subcellular localization and isomerohydrolase activity of RPE65. FEBS Lett. 2006 Jul 24; 580(17):4200-4. PMID: 16828753.
      View in: PubMed
    34. Takahashi Y, Chen Y, Moiseyev G, Ma JX. Two point mutations of RPE65 from patients with retinal dystrophies decrease the stability of RPE65 protein and abolish its isomerohydrolase activity. J Biol Chem. 2006 Aug 04; 281(31):21820-6. PMID: 16754667.
      View in: PubMed
    35. Chen Y, Moiseyev G, Takahashi Y, Ma JX. RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1177-84. PMID: 16505056.
      View in: PubMed
    36. Moiseyev G, Takahashi Y, Chen Y, Gentleman S, Redmond TM, Crouch RK, Ma JX. RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. J Biol Chem. 2006 Feb 03; 281(5):2835-40. PMID: 16319067.
      View in: PubMed
    37. Takahashi Y, Moiseyev G, Chen Y, Ma JX. Identification of conserved histidines and glutamic acid as key residues for isomerohydrolase activity of RPE65, an enzyme of the visual cycle in the retinal pigment epithelium. FEBS Lett. 2005 Oct 10; 579(24):5414-8. PMID: 16198348.
      View in: PubMed
    38. Moiseyev G, Chen Y, Takahashi Y, Wu BX, Ma JX. RPE65 is the isomerohydrolase in the retinoid visual cycle. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12413-8. PMID: 16116091; PMCID: PMC1194921.
    39. Peshenko IV, Moiseyev GP, Olshevskaya EV, Dizhoor AM. Factors that determine Ca2+ sensitivity of photoreceptor guanylyl cyclase. Kinetic analysis of the interaction between the Ca2+-bound and the Ca2+-free guanylyl cyclase activating proteins (GCAPs) and recombinant photoreceptor guanylyl cyclase 1 (RetGC-1). Biochemistry. 2004 Nov 02; 43(43):13796-804. PMID: 15504042.
      View in: PubMed
    40. Wu BX, Moiseyev G, Chen Y, Rohrer B, Crouch RK, Ma JX. Identification of RDH10, an All-trans Retinol Dehydrogenase, in Retinal Muller Cells. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):3857-62. PMID: 15505029.
      View in: PubMed
    41. Marneros AG, Keene DR, Hansen U, Fukai N, Moulton K, Goletz PL, Moiseyev G, Pawlyk BS, Halfter W, Dong S, Shibata M, Li T, Crouch RK, Bruckner P, Olsen BR. Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J. 2004 Jan 14; 23(1):89-99. PMID: 14685281; PMCID: PMC1271654.
    42. Chen Y, Moiseyev G, Wu BX, Ma JX, Crouch RK. Visual cycle retinoid processing proteins are present in HEK293S cells. Vision Res. 2003 Dec; 43(28):3037-44. PMID: 14611939.
      View in: PubMed
    43. Fan J, Rohrer B, Moiseyev G, Ma JX, Crouch RK. Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13662-7. PMID: 14578454; PMCID: PMC263870.
    44. Moiseyev G, Crouch RK, Goletz P, Oatis J, Redmond TM, Ma JX. Retinyl esters are the substrate for isomerohydrolase. Biochemistry. 2003 Feb 25; 42(7):2229-38. PMID: 12590612.
      View in: PubMed
    45. Znoiko SL, Crouch RK, Moiseyev G, Ma JX. Identification of the RPE65 protein in mammalian cone photoreceptors. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1604-9. PMID: 11980880.
      View in: PubMed
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