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Guangpu Li

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
Phone405/271-2227
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    Collapse Biography 
    Collapse education and training
    Washington University School of MedicinePhD1991Molecular Biology
    Washington University School of MedicinePostdoc1994Cell Biology

    Collapse Research 
    Collapse research activities and funding
    5R01GM074692-09     (LI, GUANGPU)Sep 25, 2006 - Jan 31, 2016
    NIH
    Structural and Functional Specificity of Rab GTPases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Xie Q, Chen A, Zhang Y, Zhang C, Hu Y, Luo Z, Wang B, Yun Y, Zhou J, Li G, Wang Z. ESCRT-III accessory proteins regulate fungal development and plant infection in Fusarium graminearum. Curr Genet. 2019 Aug; 65(4):1041-1055. PMID: 30927052.
      View in: PubMed
    2. Li Y, Zheng X, Zhu M, Chen M, Zhang S, He F, Chen X, Lv J, Pei M, Zhang Y, Zhang Y, Wang W, Zhang J, Wang M, Wang Z, Li G, Lu G. MoIVD-Mediated Leucine Catabolism Is Required for Vegetative Growth, Conidiation and Full Virulence of the Rice Blast Fungus Magnaporthe oryzae. Front Microbiol. 2019; 10:444. PMID: 30923517.
      View in: PubMed
    3. Xie Q, Chen A, Zhang Y, Yuan M, Xie W, Zhang C, Zheng W, Wang Z, Li G, Zhou J. Component Interaction of ESCRT Complexes Is Essential for Endocytosis-Dependent Growth, Reproduction, DON Production and Full Virulence in Fusarium graminearum. Front Microbiol. 2019; 10:180. PMID: 30809208.
      View in: PubMed
    4. Zheng H, Li L, Miao P, Wu C, Chen X, Yuan M, Fang T, Norvienyeku J, Li G, Zheng W, Wang Z, Zhou J. FgSec2A, a guanine nucleotide exchange factor of FgRab8, is important for polarized growth, pathogenicity and deoxynivalenol production in Fusarium graminearum. Environ Microbiol. 2018 09; 20(9):3378-3392. PMID: 30105886.
      View in: PubMed
    5. Yan Q, Lin M, Huang W, Teymournejad O, Johnson JM, Hays FA, Liang Z, Li G, Rikihisa Y. Ehrlichia type IV secretion system effector Etf-2 binds to active RAB5 and delays endosome maturation. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):E8977-E8986. PMID: 30181274.
      View in: PubMed
    6. Zheng H, Miao P, Lin X, Li L, Wu C, Chen X, Abubakar YS, Norvienyeku J, Li G, Zhou J, Wang Z, Zheng W. Small GTPase Rab7-mediated FgAtg9 trafficking is essential for autophagy-dependent development and pathogenicity in Fusarium graminearum. PLoS Genet. 2018 07; 14(7):e1007546. PMID: 30044782.
      View in: PubMed
    7. Banworth MJ, Li G. Consequences of Rab GTPase dysfunction in genetic or acquired human diseases. Small GTPases. 2018 03 04; 9(1-2):158-181. PMID: 29239692.
      View in: PubMed
    8. Zheng H, Guo Z, Xi Y, Yuan M, Lin Y, Wu C, Abubakar YS, Dou X, Li G, Wang Z, Zheng W, Zhou J. Sorting nexin (MoVps17) is required for fungal development and plant infection by regulating endosome dynamics in the rice blast fungus. Environ Microbiol. 2017 10; 19(10):4301-4317. PMID: 28836715.
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    9. Zhang X, Wang G, Yang C, Huang J, Chen X, Zhou J, Li G, Norvienyeku J, Wang Z. A HOPS Protein, MoVps41, Is Crucially Important for Vacuolar Morphogenesis, Vegetative Growth, Reproduction and Virulence in Magnaporthe oryzae. Front Plant Sci. 2017; 8:1091. PMID: 28713398.
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    10. Yang CD, Dang X, Zheng HW, Chen XF, Lin XL, Zhang DM, Abubakar YS, Chen X, Lu G, Wang Z, Li G, Zhou J. Two Rab5 Homologs Are Essential for the Development and Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae. Front Plant Sci. 2017; 8:620. PMID: 28529514.
      View in: PubMed
    11. Zhang D, Marlin MC, Liang Z, Ahmad M, Ashpole NM, Sonntag WE, Zhao ZJ, Li G. The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. J Biol Chem. 2016 Nov 11; 291(46):23895-23905. PMID: 27655914.
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    12. Chen A, Xie Q, Lin Y, Xu H, Shang W, Zhang J, Zhang D, Zheng W, Li G, Wang Z. Septins are involved in nuclear division, morphogenesis and pathogenicity in Fusarium graminearum. Fungal Genet Biol. 2016 09; 94:79-87. PMID: 27387218.
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    13. Li Y, Zhu J, Hu J, Meng X, Zhang Q, Zhu K, Chen X, Chen X, Li G, Wang Z, Lu G. Functional characterization of electron-transferring flavoprotein and its dehydrogenase required for fungal development and plant infection by the rice blast fungus. Sci Rep. 2016 04 26; 6:24911. PMID: 27113712.
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    14. Zheng H, Zheng W, Wu C, Yang J, Xi Y, Xie Q, Zhao X, Deng X, Lu G, Li G, Ebbole D, Zhou J, Wang Z. Rab GTPases are essential for membrane trafficking-dependent growth and pathogenicity in Fusarium graminearum. Environ Microbiol. 2015 Nov; 17(11):4580-99. PMID: 26177389.
      View in: PubMed
    15. Maskey D, Marlin MC, Kim S, Kim S, Ong EC, Li G, Tsiokas L. Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. EMBO J. 2015 Oct 01; 34(19):2424-40. PMID: 26206584.
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    16. Qi Y, Marlin MC, Liang Z, Zhang D, Zhou J, Wang Z, Lu G, Li G. Expression and localization of exocytic and recycling Rabs from Magnaporthe oryzae in mammalian cells. Methods Cell Biol. 2015; 130:35-45. PMID: 26360026.
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    17. Marlin MC, Li G. Differential effects of overexpression of Rab5 and Rab22 on autophagy in PC12 cells with or without NGF. Methods Mol Biol. 2015; 1298:295-304. PMID: 25800852.
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    18. Li G, Marlin MC. Rab family of GTPases. Methods Mol Biol. 2015; 1298:1-15. PMID: 25800828.
      View in: PubMed
    19. Qi Y, Liang Z, Wang Z, Lu G, Li G. Determination of Rab5 activity in the cell by effector pull-down assay. Methods Mol Biol. 2015; 1298:259-70. PMID: 25800849.
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    20. Marlin MC, Li G. Biogenesis and function of the NGF/TrkA signaling endosome. Int Rev Cell Mol Biol. 2015; 314:239-57. PMID: 25619719.
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    21. Okon IS, Coughlan KA, Zhang C, Moriasi C, Ding Y, Song P, Zhang W, Li G, Zou MH. Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis. J Clin Invest. 2014 Oct; 124(10):4590-602. PMID: 25180605.
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    22. Qi Y, Marlin MC, Liang Z, Berry WL, Janknecht R, Zhou J, Wang Z, Lu G, Li G. Distinct biochemical and functional properties of two Rab5 homologs from the rice blast fungus Magnaporthe oryzae. J Biol Chem. 2014 Oct 10; 289(41):28299-309. PMID: 25164815.
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    23. Wu KY, He M, Hou QQ, Sheng AL, Yuan L, Liu F, Liu WW, Li G, Jiang XY, Luo ZG. Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections. Sci Signal. 2014 Aug 26; 7(340):ra81. PMID: 25161316.
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    24. Ye W, Chen X, Zhong Z, Chen M, Shi L, Zheng H, Lin Y, Zhang D, Lu G, Li G, Chen J, Wang Z. Putative RhoGAP proteins orchestrate vegetative growth, conidiogenesis and pathogenicity of the rice blast fungus Magnaporthe oryzae. Fungal Genet Biol. 2014 Jun; 67:37-50. PMID: 24731806.
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    25. Yang L, Wu K, Gao P, Liu X, Li G, Wu Z. GsLRPK, a novel cold-activated leucine-rich repeat receptor-like protein kinase from Glycine soja, is a positive regulator to cold stress tolerance. Plant Sci. 2014 Feb; 215-216:19-28. PMID: 24388511.
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    26. Songbai Z, Zhenguo D, Liang Y, Zhengjie Y, Kangcheng W, Guangpu L, Zujian W, Lianhui X. Identification and characterization of the interaction between viroplasm-associated proteins from two different plant-infecting reoviruses and eEF-1A of rice. Arch Virol. 2013 Oct; 158(10):2031-9. PMID: 23605590.
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    27. Coughlan K, Huang X, He X, Chung CH, Li G, Tang J. Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP). Biochim Biophys Acta. 2013 Jun; 1833(6):1562-71. PMID: 23517619.
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    28. Wang L, Liang Z, Li G. Rab22 controls NGF signaling and neurite outgrowth in PC12 cells. Mol Biol Cell. 2011 Oct; 22(20):3853-60. PMID: 21849477.
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    29. Li G. Rab GTPases, membrane trafficking and diseases. Curr Drug Targets. 2011 Jul 01; 12(8):1188-93. PMID: 21561417.
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    30. Zhu H, Qian H, Li G. Delayed onset of positive feedback activation of Rab5 by Rabex-5 and Rabaptin-5 in endocytosis. PLoS One. 2010 Feb 16; 5(2):e9226. PMID: 20169068.
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    31. Zhu H, Liang Z, Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Mol Biol Cell. 2009 Nov; 20(22):4720-9. PMID: 19759177.
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    32. Chen J, Zheng W, Zheng S, Zhang D, Sang W, Chen X, Li G, Lu G, Wang Z. Rac1 is required for pathogenicity and Chm1-dependent conidiogenesis in rice fungal pathogen Magnaporthe grisea. PLoS Pathog. 2008 Nov; 4(11):e1000202. PMID: 19008945.
      View in: PubMed
    33. Zhu H, Zhu G, Liu J, Liang Z, Zhang XC, Li G. Rabaptin-5-independent membrane targeting and Rab5 activation by Rabex-5 in the cell. Mol Biol Cell. 2007 Oct; 18(10):4119-28. PMID: 17699593.
      View in: PubMed
    34. Zhu G, Chen J, Liu J, Brunzelle JS, Huang B, Wakeham N, Terzyan S, Li X, Rao Z, Li G, Zhang XC. Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. EMBO J. 2007 Jul 25; 26(14):3484-93. PMID: 17581628.
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    35. Liu J, Lamb D, Chou MM, Liu YJ, Li G. Nerve growth factor-mediated neurite outgrowth via regulation of Rab5. Mol Biol Cell. 2007 Apr; 18(4):1375-84. PMID: 17267689.
      View in: PubMed
    36. Zhu G, Zhai P, He X, Wakeham N, Rodgers K, Li G, Tang J, Zhang XC. Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5. EMBO J. 2004 Oct 13; 23(20):3909-17. PMID: 15457209.
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    37. Zhu G, Zhai P, Liu J, Terzyan S, Li G, Zhang XC. Structural basis of Rab5-Rabaptin5 interaction in endocytosis. Nat Struct Mol Biol. 2004 Oct; 11(10):975-83. PMID: 15378032.
      View in: PubMed
    38. Li G, Zhang XC. GTP hydrolysis mechanism of Ras-like GTPases. J Mol Biol. 2004 Jul 23; 340(5):921-32. PMID: 15236956.
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    39. Liang Z, Veeraprame H, Bayan N, Li G. The C-terminus of prenylin is important in forming a dimer conformation necessary for endoplasmic-reticulum-to-Golgi transport. Biochem J. 2004 May 15; 380(Pt 1):43-9. PMID: 14979871.
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    40. Terzyan S, Zhu G, Li G, Zhang XC. Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution. Acta Crystallogr D Biol Crystallogr. 2004 Jan; 60(Pt 1):54-60. PMID: 14684892.
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    41. Zhai P, He X, Liu J, Wakeham N, Zhu G, Li G, Tang J, Zhang XC. The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle. Biochemistry. 2003 Dec 02; 42(47):13901-8. PMID: 14636058.
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    42. Li G. Biology can be helpful to open-minded physicists. Nature. 2003 Jan 09; 421(6919):111. PMID: 12520277.
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    43. Li G, Qian H. Sensitivity and specificity amplification in signal transduction. Cell Biochem Biophys. 2003; 39(1):45-59. PMID: 12835528.
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    44. Zhu G, Liu J, Terzyan S, Zhai P, Li G, Zhang XC. High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop. J Biol Chem. 2003 Jan 24; 278(4):2452-60. PMID: 12433916.
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    45. Li G, Qian H. Kinetic timing: a novel mechanism that improves the accuracy of GTPase timers in endosome fusion and other biological processes. Traffic. 2002 Apr; 3(4):249-55. PMID: 11929606.
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    46. Lin J, Liang Z, Zhang Z, Li G. Membrane topography and topogenesis of prenylated Rab acceptor (PRA1). J Biol Chem. 2001 Nov 09; 276(45):41733-41. PMID: 11535589.
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    47. Li G, Liang Z. Phosphate-binding loop and Rab GTPase function: mutations at Ser29 and Ala30 of Rab5 lead to loss-of-function as well as gain-of-function phenotype. Biochem J. 2001 May 01; 355(Pt 3):681-9. PMID: 11311130.
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    48. Liang Z, Li G. Mouse prenylated Rab acceptor is a novel Golgi membrane protein. Biochem Biophys Res Commun. 2000 Aug 28; 275(2):509-16. PMID: 10964695.
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    49. Liang Z, Mather T, Li G. GTPase mechanism and function: new insights from systematic mutational analysis of the phosphate-binding loop residue Ala30 of Rab5. Biochem J. 2000 Mar 01; 346 Pt 2:501-8. PMID: 10677372.
      View in: PubMed
    50. Liu K, Li G. Catalytic domain of the p120 Ras GAP binds to RAb5 and stimulates its GTPase activity. J Biol Chem. 1998 Apr 24; 273(17):10087-90. PMID: 9553053.
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    51. Li G, D'Souza-Schorey C, Barbieri MA, Cooper JA, Stahl PD. Uncoupling of membrane ruffling and pinocytosis during Ras signal transduction. J Biol Chem. 1997 Apr 18; 272(16):10337-40. PMID: 9099668.
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    52. Li G. Rab5 GTPase and endocytosis. Biocell. 1996 Dec; 20(3):325-30. PMID: 9031601.
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    53. Barbieri MA, Li G, Mayorga LS, Stahl PD. Characterization of Rab5:Q79L-stimulated endosome fusion. Arch Biochem Biophys. 1996 Feb 01; 326(1):64-72. PMID: 8579373.
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    54. Li G, D'Souza-Schorey C, Barbieri MA, Roberts RL, Klippel A, Williams LT, Stahl PD. Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10207-11. PMID: 7479754.
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    55. D'Souza-Schorey C, Li G, Colombo MI, Stahl PD. A regulatory role for ARF6 in receptor-mediated endocytosis. Science. 1995 Feb 24; 267(5201):1175-8. PMID: 7855600.
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    56. Li G, Barbieri MA, Stahl PD. Myristoylation cannot functionally replace the isoprenylation of Rab5. Arch Biochem Biophys. 1995 Jan 10; 316(1):529-34. PMID: 7840662.
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    57. Barbieri MA, Li G, Colombo MI, Stahl PD. Rab5, an early acting endosomal GTPase, supports in vitro endosome fusion without GTP hydrolysis. J Biol Chem. 1994 Jul 22; 269(29):18720-2. PMID: 7913465.
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    58. Li G, Barbieri MA, Colombo MI, Stahl PD. Structural features of the GTP-binding defective Rab5 mutants required for their inhibitory activity on endocytosis. J Biol Chem. 1994 May 20; 269(20):14631-5. PMID: 8182071.
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    59. Li G, Stahl PD. Structure-function relationship of the small GTPase rab5. J Biol Chem. 1993 Nov 15; 268(32):24475-80. PMID: 8226999.
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    60. Li G, Rice CM. The signal for translational readthrough of a UGA codon in Sindbis virus RNA involves a single cytidine residue immediately downstream of the termination codon. J Virol. 1993 Aug; 67(8):5062-7. PMID: 8331741.
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    61. Li G, Stahl PD. Post-translational processing and membrane association of the two early endosome-associated rab GTP-binding proteins (rab4 and rab5). Arch Biochem Biophys. 1993 Aug 01; 304(2):471-8. PMID: 8346922.
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    62. Li GP, PrĂ¡gai BM, Rice CM. Rescue of Sindbis virus-specific RNA replication and transcription by using a vaccinia virus recombinant. J Virol. 1991 Dec; 65(12):6714-23. PMID: 1834861.
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    63. Li GP, La Starza MW, Hardy WR, Strauss JH, Rice CM. Phosphorylation of Sindbis virus nsP3 in vivo and in vitro. Virology. 1990 Nov; 179(1):416-27. PMID: 2145690.
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    64. Li GP, Rice CM. Mutagenesis of the in-frame opal termination codon preceding nsP4 of Sindbis virus: studies of translational readthrough and its effect on virus replication. J Virol. 1989 Mar; 63(3):1326-37. PMID: 2521676.
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