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Guangpu Li

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
Address975 NE 10th St
Oklahoma City OK 73104-5419
Phone405/271-2227
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    Collapse Biography 
    Collapse education and training
    Washington University School of MedicinePhD1991Molecular Biology
    Washington University School of MedicinePostdoc1994Cell Biology

    Collapse Research 
    Collapse research activities and funding
    5R01GM074692-09     (LI, GUANGPU)Sep 25, 2006 - Jan 31, 2016
    NIH
    Structural and Functional Specificity of Rab GTPases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Banworth MJ, Li G. Consequences of Rab GTPase dysfunction in genetic or acquired human diseases. Small GTPases. 2018 Mar 04; 9(1-2):158-181. PMID: 29239692.
      View in: PubMed
    2. Zheng H, Guo Z, Xi Y, Yuan M, Lin Y, Wu C, Abubakar YS, Dou X, Li G, Wang Z, Zheng W, Zhou J. Sorting nexin (MoVps17) is required for fungal development and plant infection by regulating endosome dynamics in the rice blast fungus. Environ Microbiol. 2017 Oct; 19(10):4301-4317. PMID: 28836715.
      View in: PubMed
    3. Zhang X, Wang G, Yang C, Huang J, Chen X, Zhou J, Li G, Norvienyeku J, Wang Z. A HOPS Protein, MoVps41, Is Crucially Important for Vacuolar Morphogenesis, Vegetative Growth, Reproduction and Virulence in Magnaporthe oryzae. Front Plant Sci. 2017; 8:1091. PMID: 28713398.
      View in: PubMed
    4. Yang CD, Dang X, Zheng HW, Chen XF, Lin XL, Zhang DM, Abubakar YS, Chen X, Lu G, Wang Z, Li G, Zhou J. Two Rab5 Homologs Are Essential for the Development and Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae. Front Plant Sci. 2017; 8:620. PMID: 28529514.
      View in: PubMed
    5. Zhang D, Marlin MC, Liang Z, Ahmad M, Ashpole NM, Sonntag WE, Zhao ZJ, Li G. The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. J Biol Chem. 2016 Nov 11; 291(46):23895-23905. PMID: 27655914.
      View in: PubMed
    6. Chen A, Xie Q, Lin Y, Xu H, Shang W, Zhang J, Zhang D, Zheng W, Li G, Wang Z. Septins are involved in nuclear division, morphogenesis and pathogenicity in Fusarium graminearum. Fungal Genet Biol. 2016 09; 94:79-87. PMID: 27387218.
      View in: PubMed
    7. Li Y, Zhu J, Hu J, Meng X, Zhang Q, Zhu K, Chen X, Chen X, Li G, Wang Z, Lu G. Functional characterization of electron-transferring flavoprotein and its dehydrogenase required for fungal development and plant infection by the rice blast fungus. Sci Rep. 2016 04 26; 6:24911. PMID: 27113712; PMCID: PMC4845064.
    8. Zheng H, Zheng W, Wu C, Yang J, Xi Y, Xie Q, Zhao X, Deng X, Lu G, Li G, Ebbole D, Zhou J, Wang Z. Rab GTPases are essential for membrane trafficking-dependent growth and pathogenicity in Fusarium graminearum. Environ Microbiol. 2015 Nov; 17(11):4580-99. PMID: 26177389.
      View in: PubMed
    9. Maskey D, Marlin MC, Kim S, Kim S, Ong EC, Li G, Tsiokas L. Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. EMBO J. 2015 Oct 01; 34(19):2424-40. PMID: 26206584; PMCID: PMC4601663 [Available on 10/01/16].
    10. Qi Y, Marlin MC, Liang Z, Zhang D, Zhou J, Wang Z, Lu G, Li G. Expression and localization of exocytic and recycling Rabs from Magnaporthe oryzae in mammalian cells. Methods Cell Biol. 2015; 130:35-45. PMID: 26360026.
      View in: PubMed
    11. Marlin MC, Li G. Differential effects of overexpression of Rab5 and Rab22 on autophagy in PC12 cells with or without NGF. Methods Mol Biol. 2015; 1298:295-304. PMID: 25800852.
      View in: PubMed
    12. Li G, Marlin MC. Rab family of GTPases. Methods Mol Biol. 2015; 1298:1-15. PMID: 25800828.
      View in: PubMed
    13. Qi Y, Liang Z, Wang Z, Lu G, Li G. Determination of Rab5 activity in the cell by effector pull-down assay. Methods Mol Biol. 2015; 1298:259-70. PMID: 25800849.
      View in: PubMed
    14. Marlin MC, Li G. Biogenesis and function of the NGF/TrkA signaling endosome. Int Rev Cell Mol Biol. 2015; 314:239-57. PMID: 25619719; PMCID: PMC4307610.
    15. Okon IS, Coughlan KA, Zhang C, Moriasi C, Ding Y, Song P, Zhang W, Li G, Zou MH. Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis. J Clin Invest. 2014 Oct; 124(10):4590-602. PMID: 25180605; PMCID: PMC4191012.
    16. Qi Y, Marlin MC, Liang Z, Berry WL, Janknecht R, Zhou J, Wang Z, Lu G, Li G. Distinct biochemical and functional properties of two Rab5 homologs from the rice blast fungus Magnaporthe oryzae. J Biol Chem. 2014 Oct 10; 289(41):28299-309. PMID: 25164815; PMCID: PMC4192484.
    17. Wu KY, He M, Hou QQ, Sheng AL, Yuan L, Liu F, Liu WW, Li G, Jiang XY, Luo ZG. Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections. Sci Signal. 2014 Aug 26; 7(340):ra81. PMID: 25161316; PMCID: PMC4659511.
    18. Ye W, Chen X, Zhong Z, Chen M, Shi L, Zheng H, Lin Y, Zhang D, Lu G, Li G, Chen J, Wang Z. Putative RhoGAP proteins orchestrate vegetative growth, conidiogenesis and pathogenicity of the rice blast fungus Magnaporthe oryzae. Fungal Genet Biol. 2014 Jun; 67:37-50. PMID: 24731806.
      View in: PubMed
    19. Yang L, Wu K, Gao P, Liu X, Li G, Wu Z. GsLRPK, a novel cold-activated leucine-rich repeat receptor-like protein kinase from Glycine soja, is a positive regulator to cold stress tolerance. Plant Sci. 2014 Feb; 215-216:19-28. PMID: 24388511.
      View in: PubMed
    20. Songbai Z, Zhenguo D, Liang Y, Zhengjie Y, Kangcheng W, Guangpu L, Zujian W, Lianhui X. Identification and characterization of the interaction between viroplasm-associated proteins from two different plant-infecting reoviruses and eEF-1A of rice. Arch Virol. 2013 Oct; 158(10):2031-9. PMID: 23605590.
      View in: PubMed
    21. Coughlan K, Huang X, He X, Chung CH, Li G, Tang J. Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP). Biochim Biophys Acta. 2013 Jun; 1833(6):1562-71. PMID: 23517619; PMCID: PMC3753662.
    22. Wang L, Liang Z, Li G. Rab22 controls NGF signaling and neurite outgrowth in PC12 cells. Mol Biol Cell. 2011 Oct; 22(20):3853-60. PMID: 21849477; PMCID: PMC3192864.
    23. Li G. Rab GTPases, membrane trafficking and diseases. Curr Drug Targets. 2011 Jul 01; 12(8):1188-93. PMID: 21561417.
      View in: PubMed
    24. Zhu H, Qian H, Li G. Delayed onset of positive feedback activation of Rab5 by Rabex-5 and Rabaptin-5 in endocytosis. PLoS One. 2010 Feb 16; 5(2):e9226. PMID: 20169068; PMCID: PMC2821916.
    25. Zhu H, Liang Z, Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Mol Biol Cell. 2009 Nov; 20(22):4720-9. PMID: 19759177; PMCID: PMC2777102.
    26. Chen J, Zheng W, Zheng S, Zhang D, Sang W, Chen X, Li G, Lu G, Wang Z. Rac1 is required for pathogenicity and Chm1-dependent conidiogenesis in rice fungal pathogen Magnaporthe grisea. PLoS Pathog. 2008 Nov; 4(11):e1000202. PMID: 19008945; PMCID: PMC2575402.
    27. Zhu H, Zhu G, Liu J, Liang Z, Zhang XC, Li G. Rabaptin-5-independent membrane targeting and Rab5 activation by Rabex-5 in the cell. Mol Biol Cell. 2007 Oct; 18(10):4119-28. PMID: 17699593; PMCID: PMC1995700.
    28. Zhu G, Chen J, Liu J, Brunzelle JS, Huang B, Wakeham N, Terzyan S, Li X, Rao Z, Li G, Zhang XC. Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. EMBO J. 2007 Jul 25; 26(14):3484-93. PMID: 17581628; PMCID: PMC1933402.
    29. Liu J, Lamb D, Chou MM, Liu YJ, Li G. Nerve growth factor-mediated neurite outgrowth via regulation of Rab5. Mol Biol Cell. 2007 Apr; 18(4):1375-84. PMID: 17267689; PMCID: PMC1838971.
    30. Zhu G, Zhai P, He X, Wakeham N, Rodgers K, Li G, Tang J, Zhang XC. Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5. EMBO J. 2004 Oct 13; 23(20):3909-17. PMID: 15457209; PMCID: PMC524345.
    31. Zhu G, Zhai P, Liu J, Terzyan S, Li G, Zhang XC. Structural basis of Rab5-Rabaptin5 interaction in endocytosis. Nat Struct Mol Biol. 2004 Oct; 11(10):975-83. PMID: 15378032.
      View in: PubMed
    32. Li G, Zhang XC. GTP hydrolysis mechanism of Ras-like GTPases. J Mol Biol. 2004 Jul 23; 340(5):921-32. PMID: 15236956.
      View in: PubMed
    33. Liang Z, Veeraprame H, Bayan N, Li G. The C-terminus of prenylin is important in forming a dimer conformation necessary for endoplasmic-reticulum-to-Golgi transport. Biochem J. 2004 May 15; 380(Pt 1):43-9. PMID: 14979871; PMCID: PMC1224162.
    34. Terzyan S, Zhu G, Li G, Zhang XC. Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution. Acta Crystallogr D Biol Crystallogr. 2004 Jan; 60(Pt 1):54-60. PMID: 14684892.
      View in: PubMed
    35. Zhai P, He X, Liu J, Wakeham N, Zhu G, Li G, Tang J, Zhang XC. The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle. Biochemistry. 2003 Dec 02; 42(47):13901-8. PMID: 14636058.
      View in: PubMed
    36. Li G. Biology can be helpful to open-minded physicists. Nature. 2003 Jan 09; 421(6919):111. PMID: 12520277.
      View in: PubMed
    37. Li G, Qian H. Sensitivity and specificity amplification in signal transduction. Cell Biochem Biophys. 2003; 39(1):45-59. PMID: 12835528.
      View in: PubMed
    38. Zhu G, Liu J, Terzyan S, Zhai P, Li G, Zhang XC. High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop. J Biol Chem. 2003 Jan 24; 278(4):2452-60. PMID: 12433916.
      View in: PubMed
    39. Li G, Qian H. Kinetic timing: a novel mechanism that improves the accuracy of GTPase timers in endosome fusion and other biological processes. Traffic. 2002 Apr; 3(4):249-55. PMID: 11929606.
      View in: PubMed
    40. Lin J, Liang Z, Zhang Z, Li G. Membrane topography and topogenesis of prenylated Rab acceptor (PRA1). J Biol Chem. 2001 Nov 09; 276(45):41733-41. PMID: 11535589; PMCID: PMC1350924.
    41. Li G, Liang Z. Phosphate-binding loop and Rab GTPase function: mutations at Ser29 and Ala30 of Rab5 lead to loss-of-function as well as gain-of-function phenotype. Biochem J. 2001 May 01; 355(Pt 3):681-9. PMID: 11311130.
      View in: PubMed
    42. Liang Z, Li G. Mouse prenylated Rab acceptor is a novel Golgi membrane protein. Biochem Biophys Res Commun. 2000 Aug 28; 275(2):509-16. PMID: 10964695.
      View in: PubMed
    43. Liang Z, Mather T, Li G. GTPase mechanism and function: new insights from systematic mutational analysis of the phosphate-binding loop residue Ala30 of Rab5. Biochem J. 2000 Mar 01; 346 Pt 2:501-8. PMID: 10677372.
      View in: PubMed
    44. Liu K, Li G. Catalytic domain of the p120 Ras GAP binds to RAb5 and stimulates its GTPase activity. J Biol Chem. 1998 Apr 24; 273(17):10087-90. PMID: 9553053.
      View in: PubMed
    45. Li G, D'Souza-Schorey C, Barbieri MA, Cooper JA, Stahl PD. Uncoupling of membrane ruffling and pinocytosis during Ras signal transduction. J Biol Chem. 1997 Apr 18; 272(16):10337-40. PMID: 9099668.
      View in: PubMed
    46. Li G. Rab5 GTPase and endocytosis. Biocell. 1996 Dec; 20(3):325-30. PMID: 9031601.
      View in: PubMed
    47. Barbieri MA, Li G, Mayorga LS, Stahl PD. Characterization of Rab5:Q79L-stimulated endosome fusion. Arch Biochem Biophys. 1996 Feb 01; 326(1):64-72. PMID: 8579373.
      View in: PubMed
    48. Li G, D'Souza-Schorey C, Barbieri MA, Roberts RL, Klippel A, Williams LT, Stahl PD. Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10207-11. PMID: 7479754.
      View in: PubMed
    49. D'Souza-Schorey C, Li G, Colombo MI, Stahl PD. A regulatory role for ARF6 in receptor-mediated endocytosis. Science. 1995 Feb 24; 267(5201):1175-8. PMID: 7855600.
      View in: PubMed
    50. Li G, Barbieri MA, Stahl PD. Myristoylation cannot functionally replace the isoprenylation of Rab5. Arch Biochem Biophys. 1995 Jan 10; 316(1):529-34. PMID: 7840662.
      View in: PubMed
    51. Barbieri MA, Li G, Colombo MI, Stahl PD. Rab5, an early acting endosomal GTPase, supports in vitro endosome fusion without GTP hydrolysis. J Biol Chem. 1994 Jul 22; 269(29):18720-2. PMID: 7913465.
      View in: PubMed
    52. Li G, Barbieri MA, Colombo MI, Stahl PD. Structural features of the GTP-binding defective Rab5 mutants required for their inhibitory activity on endocytosis. J Biol Chem. 1994 May 20; 269(20):14631-5. PMID: 8182071.
      View in: PubMed
    53. Li G, Stahl PD. Structure-function relationship of the small GTPase rab5. J Biol Chem. 1993 Nov 15; 268(32):24475-80. PMID: 8226999.
      View in: PubMed
    54. Li G, Rice CM. The signal for translational readthrough of a UGA codon in Sindbis virus RNA involves a single cytidine residue immediately downstream of the termination codon. J Virol. 1993 Aug; 67(8):5062-7. PMID: 8331741.
      View in: PubMed
    55. Li G, Stahl PD. Post-translational processing and membrane association of the two early endosome-associated rab GTP-binding proteins (rab4 and rab5). Arch Biochem Biophys. 1993 Aug 01; 304(2):471-8. PMID: 8346922.
      View in: PubMed
    56. Li GP, PrĂ¡gai BM, Rice CM. Rescue of Sindbis virus-specific RNA replication and transcription by using a vaccinia virus recombinant. J Virol. 1991 Dec; 65(12):6714-23. PMID: 1834861.
      View in: PubMed
    57. Li GP, La Starza MW, Hardy WR, Strauss JH, Rice CM. Phosphorylation of Sindbis virus nsP3 in vivo and in vitro. Virology. 1990 Nov; 179(1):416-27. PMID: 2145690.
      View in: PubMed
    58. Li GP, Rice CM. Mutagenesis of the in-frame opal termination codon preceding nsP4 of Sindbis virus: studies of translational readthrough and its effect on virus replication. J Virol. 1989 Mar; 63(3):1326-37. PMID: 2521676.
      View in: PubMed
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