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Hsueh-Kung Lin

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDept of Urology
Address800 Research Parkway
Oklahoma City OK 73104-3611
Phone405/271-6900
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    Collapse Biography 
    Collapse education and training
    Cornell University, Ithaca, NYMS1987Animal Genetics
    Cornell University, Ithaca, NYPhD1992Immunology
    University of Pennsylvania, Philadelphia, PAPostdoc1993Biochemistry & Biophysics
    University of Pennsylvania, Philadelphia, PAPostdoc1995Pharmacology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Xia D, Lai DV, Wu W, Webb ZD, Yang Q, Zhao L, Yu Z, Thorpe JE, Disch BC, Ihnat MA, Jayaraman M, Dhanasekaran DN, Stratton KL, Cookson MS, Fung KM, Lin HK. Transition from androgenic to neurosteroidal action of 5a-androstane-3a, 17ß-diol through the type A ?-aminobutyric acid receptor in prostate cancer progression. J Steroid Biochem Mol Biol. 2018 Apr; 178:89-98. PMID: 29155210.
      View in: PubMed
    2. Yang Q, Xia D, Towner RA, Smith N, Saunders D, Fung KM, Aston CE, Greenwood-Van Meerveld B, Hurst RE, Madihally SV, Kropp BP, Lin HK. Reduced urothelial regeneration in rat bladders augmented with permeable porcine small intestinal submucosa assessed by magnetic resonance imaging. J Biomed Mater Res B Appl Biomater. 2017 Sep 13. PMID: 28901710.
      View in: PubMed
    3. Xia D, Lou W, Fung KM, Wolley CL, Suhail MM, Lin HK. Cancer Chemopreventive Effects of Boswellia sacra Gum Resin Hydrodistillates on Invasive Urothelial Cell Carcinoma: Report of a Case. Integr Cancer Ther. 2017 Dec; 16(4):605-611. PMID: 27531547.
      View in: PubMed
    4. Lin HK, Madihally SV, Palmer B, Frimberger D, Fung KM, Kropp BP. Biomatrices for bladder reconstruction. Adv Drug Deliv Rev. 2015 Mar; 82-83:47-63. PMID: 25477305.
      View in: PubMed
    5. Dozmorov MG, Yang Q, Wu W, Wren J, Suhail MM, Woolley CL, Young DG, Fung KM, Lin HK. Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study. Chin Med. 2014; 9:18. PMID: 25006348; PMCID: PMC4086286.
    6. Wu W, Yang Q, Fung KM, Humphreys MR, Brame LS, Cao A, Fang YT, Shih PT, Kropp BP, Lin HK. Linking ?-aminobutyric acid A receptor to epidermal growth factor receptor pathways activation in human prostate cancer. Mol Cell Endocrinol. 2014 Mar 05; 383(1-2):69-79. PMID: 24296312.
      View in: PubMed
    7. Chang TS, Lin HK, Rogers KA, Brame LS, Yeh MM, Yang Q, Fung KM. Expression of aldo-keto reductase family 1 member C3 (AKR1C3) in neuroendocrine tumors & adenocarcinomas of pancreas, gastrointestinal tract, and lung. Int J Clin Exp Pathol. 2013; 6(11):2419-29. PMID: 24228104; PMCID: PMC3816811.
    8. Lin HK, Godiwalla SY, Palmer B, Frimberger D, Yang Q, Madihally SV, Fung KM, Kropp BP. Understanding roles of porcine small intestinal submucosa in urinary bladder regeneration: identification of variable regenerative characteristics of small intestinal submucosa. Tissue Eng Part B Rev. 2014 Feb; 20(1):73-83. PMID: 23777420; PMCID: PMC3922139.
    9. Ni X, Suhail MM, Yang Q, Cao A, Fung KM, Postier RG, Woolley C, Young G, Zhang J, Lin HK. Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model. BMC Complement Altern Med. 2012 Dec 13; 12:253. PMID: 23237355; PMCID: PMC3538159.
    10. Woolley CL, Suhail MM, Smith BL, Boren KE, Taylor LC, Schreuder MF, Chai JK, Casabianca H, Haq S, Lin HK, Al-Shahri AA, Al-Hatmi S, Young DG. Chemical differentiation of Boswellia sacra and Boswellia carterii essential oils by gas chromatography and chiral gas chromatography-mass spectrometry. J Chromatogr A. 2012 Oct 26; 1261:158-63. PMID: 22835693.
      View in: PubMed
    11. Miller VL, Lin HK, Murugan P, Fan M, Penning TM, Brame LS, Yang Q, Fung KM. Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma. Int J Clin Exp Pathol. 2012; 5(4):278-89. PMID: 22670171; PMCID: PMC3365826.
    12. Suhail MM, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, Fang YT, Woolley C, Young G, Lin HK. Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells. BMC Complement Altern Med. 2011 Dec 15; 11:129. PMID: 22171782; PMCID: PMC3258268.
    13. Dozmorov MG, Azzarello JT, Wren JD, Fung KM, Yang Q, Davis JS, Hurst RE, Culkin DJ, Penning TM, Lin HK. Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progression. BMC Cancer. 2010 Dec 06; 10:672. PMID: 21134280; PMCID: PMC3013086.
    14. Wu S, Patel KB, Booth LJ, Metcalf JP, Lin HK, Wu W. Protective essential oil attenuates influenza virus infection: an in vitro study in MDCK cells. BMC Complement Altern Med. 2010 Nov 15; 10:69. PMID: 21078173; PMCID: PMC2994788.
    15. Roth CC, Mondalek FG, Kibar Y, Ashley RA, Bell CH, Califano JA, Madihally SV, Frimberger D, Lin HK, Kropp BP. Bladder regeneration in a canine model using hyaluronic acid-poly(lactic-co-glycolic-acid) nanoparticle modified porcine small intestinal submucosa. BJU Int. 2011 Jul; 108(1):148-55. PMID: 20942834.
      View in: PubMed
    16. Mondalek FG, Ashley RA, Roth CC, Kibar Y, Shakir N, Ihnat MA, Fung KM, Grady BP, Kropp BP, Lin HK. Enhanced angiogenesis of modified porcine small intestinal submucosa with hyaluronic acid-poly(lactide-co-glycolide) nanoparticles: from fabrication to preclinical validation. J Biomed Mater Res A. 2010 Sep 01; 94(3):712-9. PMID: 20213816.
      View in: PubMed
    17. Zakharov V, Lin HK, Azzarello J, McMeekin S, Moore KN, Penning TM, Fung KM. Suppressed expression of type 2 3alpha/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) in endometrial hyperplasia and carcinoma. Int J Clin Exp Pathol. 2010 Jul 05; 3(6):608-17. PMID: 20661409; PMCID: PMC2907123.
    18. Park AL, Lin HK, Yang Q, Sing CW, Fan M, Mapstone TB, Gross NL, Gumerlock MK, Martin MD, Rabb CH, Fung KM. Differential expression of type 2 3a/type 5 17ß-hydroxysteroid dehydrogenase (AKR1C3) in tumors of the central nervous system. Int J Clin Exp Pathol. 2010 Mar 25; 3(8):743-54. PMID: 21151387; PMCID: PMC2993224.
    19. Azzarello J, Kropp BP, Fung KM, Lin HK. Age-dependent vascular endothelial growth factor expression and angiogenic capability of bladder smooth muscle cells: implications for cell-seeded technology in bladder tissue engineering. J Tissue Eng Regen Med. 2009 Dec; 3(8):579-89. PMID: 19685443.
      View in: PubMed
    20. Ashley RA, Yu Z, Fung KM, Frimberger D, Kropp BP, Penning TM, Lin HK. Developmental evaluation of aldo-keto reductase 1C3 expression in the cryptorchid testis. Urology. 2010 Jul; 76(1):67-72. PMID: 19942269.
      View in: PubMed
    21. Azzarello JT, Lin HK, Gherezghiher A, Zakharov V, Yu Z, Kropp BP, Culkin DJ, Penning TM, Fung KM. Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms' tumor. Int J Clin Exp Pathol. 2009 Nov 15; 3(2):147-55. PMID: 20126582; PMCID: PMC2809994.
    22. Ashley RA, Palmer BW, Schultz AD, Woodson BW, Roth CC, Routh JC, Fung KM, Frimberger D, Lin HK, Kropp BP. Leukocyte inflammatory response in a rat urinary bladder regeneration model using porcine small intestinal submucosa scaffold. Tissue Eng Part A. 2009 Nov; 15(11):3241-6. PMID: 19374486.
      View in: PubMed
    23. Ashley RA, Roth CC, Palmer BW, Kibar Y, Routh JC, Fung KM, Frimberger D, Lin HK, Kropp BP. Regional variations in small intestinal submucosa evoke differences in inflammation with subsequent impact on tissue regeneration in the rat bladder augmentation model. BJU Int. 2010 May; 105(10):1462-8. PMID: 19863527.
      View in: PubMed
    24. Dozmorov MG, Hurst RE, Culkin DJ, Kropp BP, Frank MB, Osban J, Penning TM, Lin HK. Unique patterns of molecular profiling between human prostate cancer LNCaP and PC-3 cells. Prostate. 2009 Jul 01; 69(10):1077-90. PMID: 19343732; PMCID: PMC2755240.
    25. Frank MB, Yang Q, Osban J, Azzarello JT, Saban MR, Saban R, Ashley RA, Welter JC, Fung KM, Lin HK. Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity. BMC Complement Altern Med. 2009 Mar 18; 9:6. PMID: 19296830; PMCID: PMC2664784.
    26. Lawrence BJ, Maase EL, Lin HK, Madihally SV. Multilayer composite scaffolds with mechanical properties similar to small intestinal submucosa. J Biomed Mater Res A. 2009 Mar 01; 88(3):634-43. PMID: 18314898.
      View in: PubMed
    27. Roth CC, Bell CH, Woodson B, Schultz AD, Palmer BW, Frimberger D, Fung KM, Lin HK, Kropp BP. Temporal differentiation and maturation of regenerated rat urothelium. BJU Int. 2009 Mar; 103(6):836-41. PMID: 19021621.
      View in: PubMed
    28. Yang Q, Titus MA, Fung KM, Lin HK. 5alpha-androstane-3alpha,17beta-diol supports human prostate cancer cell survival and proliferation through androgen receptor-independent signaling pathways: implication of androgen-independent prostate cancer progression. J Cell Biochem. 2008 Aug 01; 104(5):1612-24. PMID: 18320593.
      View in: PubMed
    29. Azzarello J, Fung KM, Lin HK. Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system. J Histochem Cytochem. 2008 Sep; 56(9):853-61. PMID: 18574251; PMCID: PMC2516960.
    30. Wang S, Yang Q, Fung KM, Lin HK. AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. Mol Cell Endocrinol. 2008 Jul 16; 289(1-2):60-6. PMID: 18508192.
      View in: PubMed
    31. Mondalek FG, Lawrence BJ, Kropp BP, Grady BP, Fung KM, Madihally SV, Lin HK. The incorporation of poly(lactic-co-glycolic) acid nanoparticles into porcine small intestinal submucosa biomaterials. Biomaterials. 2008 Mar; 29(9):1159-66. PMID: 18076986; PMCID: PMC2947939.
    32. Dozmorov MG, Yang Q, Matwalli A, Hurst RE, Culkin DJ, Kropp BP, Lin HK. 5alpha-androstane-3alpha,17beta-diol selectively activates the canonical PI3K/AKT pathway: a bioinformatics-based evidence for androgen-activated cytoplasmic signaling. Genomic Med. 2007; 1(3-4):139-46. PMID: 18923939; PMCID: PMC2269037.
    33. Dozmorov MG, Kropp BP, Hurst RE, Cheng EY, Lin HK. Differentially expressed gene networks in cultured smooth muscle cells from normal and neuropathic bladder. J Smooth Muscle Res. 2007 Apr; 43(2):55-72. PMID: 17598958.
      View in: PubMed
    34. Azzarello J, Ihnat MA, Kropp BP, Warnke LA, Lin HK. Assessment of angiogenic properties of biomaterials using the chicken embryo chorioallantoic membrane assay. Biomed Mater. 2007 Jun; 2(2):55-61. PMID: 18458436.
      View in: PubMed
    35. Zhang Y, Frimberger D, Cheng EY, Lin HK, Kropp BP. Challenges in a larger bladder replacement with cell-seeded and unseeded small intestinal submucosa grafts in a subtotal cystectomy model. BJU Int. 2006 Nov; 98(5):1100-5. PMID: 17034611.
      View in: PubMed
    36. Fung KM, Samara EN, Wong C, Metwalli A, Krlin R, Bane B, Liu CZ, Yang JT, Pitha JV, Culkin DJ, Kropp BP, Penning TM, Lin HK. Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma. Endocr Relat Cancer. 2006 Mar; 13(1):169-80. PMID: 16601286.
      View in: PubMed
    37. Saban R, Lin HK. How far are we from a urothelial gene chip? J Urol. 2006 Jan; 175(1):14-5. PMID: 16406861.
      View in: PubMed
    38. Zhang Y, Lin HK, Frimberger D, Epstein RB, Kropp BP. Growth of bone marrow stromal cells on small intestinal submucosa: an alternative cell source for tissue engineered bladder. BJU Int. 2005 Nov; 96(7):1120-5. PMID: 16225540.
      View in: PubMed
    39. Li X, Wong C, Mysel R, Slobodov G, Metwalli A, Kruska J, Manatt CS, Culkin DJ, Kropp BP, Lin HK. Screening and identification of differentially expressed transcripts in circulating cells of prostate cancer patients using suppression subtractive hybridization. Mol Cancer. 2005 Aug 08; 4(1):30. PMID: 16086835; PMCID: PMC1199617.
    40. Yang Q, Fung KM, Day WV, Kropp BP, Lin HK. Androgen receptor signaling is required for androgen-sensitive human prostate cancer cell proliferation and survival. Cancer Cell Int. 2005 Apr 06; 5(1):8. PMID: 15813967.
      View in: PubMed
    41. Lin HK, Steckelbroeck S, Fung KM, Jones AN, Penning TM. Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate. Steroids. 2004 Dec; 69(13-14):795-801. PMID: 15582534.
      View in: PubMed
    42. Kropp BP, Cheng EY, Lin HK, Zhang Y. Reliable and reproducible bladder regeneration using unseeded distal small intestinal submucosa. J Urol. 2004 Oct; 172(4 Pt 2):1710-3. PMID: 15371796.
      View in: PubMed
    43. Nunlist EH, Dozmorov I, Tang Y, Cowan R, Centola M, Lin HK. Partitioning of 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol activated pathways for stimulating human prostate cancer LNCaP cell proliferation. J Steroid Biochem Mol Biol. 2004 Jul; 91(3):157-70. PMID: 15276623.
      View in: PubMed
    44. Lin HK, Cowan R, Moore P, Zhang Y, Yang Q, Peterson JA, Tomasek JJ, Kropp BP, Cheng E. Characterization of neuropathic bladder smooth muscle cells in culture. J Urol. 2004 Mar; 171(3):1348-52. PMID: 14767346.
      View in: PubMed
    45. Andreoni CR, Lin HK, Olweny E, Landman J, Lee D, Bostwick D, Clayman RV. Comprehensive evaluation of ureteral healing after electrosurgical endopyelotomy in a porcine model: original report and review of the literature. J Urol. 2004 Feb; 171(2 Pt 1):859-69. PMID: 14713843.
      View in: PubMed
    46. Zhang Y, Kropp BP, Lin HK, Cowan R, Cheng EY. Bladder regeneration with cell-seeded small intestinal submucosa. Tissue Eng. 2004 Jan-Feb; 10(1-2):181-7. PMID: 15009944.
      View in: PubMed
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