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James J Tomasek

TitleVice President for Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentResearch Administration Office
Address1000 Stanton L Young Blvd
Oklahoma City OK 73117-1295
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    Collapse Research 
    Collapse research activities and funding
    R01GM060651     (TOMASEK, JAMES J)Feb 1, 2000 - Jul 31, 2018
    NIH/NIGMS
    Fibroblast Differentiation in Wound Healing
    Role: Principal Investigator

    R01AI047314     (TOMASEK, JAMES J)Apr 1, 2000 - Mar 31, 2006
    NIH/NIAID
    ADHESIVE AND PROTEOLYTIC FUNCTION OF MDC-L
    Role: Principal Investigator

    R03EY014435     (TOMASEK, JAMES J)Jan 16, 2003 - Dec 31, 2006
    NIH/NEI
    Gene Therapy for Retinal Detachment
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Weygant N, Ge Y, Qu D, Kaddis JS, Berry WL, May R, Chandrakesan P, Bannerman-Menson E, Vega KJ, Tomasek JJ, Bronze MS, An G, Houchen CW. Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem-like Cells Marked by DCLK1 Kinase. Cancer Res. 2016 Jul 15; 76(14):4090-9. PMID: 27287716.
      View in: PubMed
    2. Weygant N, Qu D, May R, Tierney RM, Berry WL, Zhao L, Agarwal S, Chandrakesan P, Chinthalapally HR, Murphy NT, Li JD, Sureban SM, Schlosser MJ, Tomasek JJ, Houchen CW. DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma. Oncotarget. 2015 Feb 10; 6(4):2193-205. PMID: 25605241; PMCID: PMC4385845.
    3. McBride JD, Jenkins AJ, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin CT, Aston CE, Lyons TJ, Tomasek JJ, Ma JX. Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol. 2014 Jun; 134(6):1725-34. PMID: 24463424; PMCID: PMC4065799.
    4. Van De Water L, Varney S, Tomasek JJ. Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention. Adv Wound Care (New Rochelle). 2013 May; 2(4):122-141. PMID: 24527336.
      View in: PubMed
    5. Tomasek JJ, Haaksma CJ, Schwartz RJ, Howard EW. Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen. 2013 Jan-Feb; 21(1):166-76. PMID: 23253249; PMCID: PMC3540133.
    6. Howard EW, Crider BJ, Updike DL, Bullen EC, Parks EE, Haaksma CJ, Sherry DM, Tomasek JJ. MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype. Exp Cell Res. 2012 Aug 01; 318(13):1542-53. PMID: 22449415; PMCID: PMC4164435.
    7. Crider BJ, Risinger GM, Haaksma CJ, Howard EW, Tomasek JJ. Myocardin-related transcription factors A and B are key regulators of TGF-ß1-induced fibroblast to myofibroblast differentiation. J Invest Dermatol. 2011 Dec; 131(12):2378-85. PMID: 21776010; PMCID: PMC3199034.
    8. Haaksma CJ, Schwartz RJ, Tomasek JJ. Myoepithelial cell contraction and milk ejection are impaired in mammary glands of mice lacking smooth muscle alpha-actin. Biol Reprod. 2011 Jul; 85(1):13-21. PMID: 21368298; PMCID: PMC3123380.
    9. Komatsu I, Bond J, Selim A, Tomasek JJ, Levin LS, Levinson H. Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II. J Hand Surg Am. 2010 Oct; 35(10):1580-8. PMID: 20888494; PMCID: PMC2953964.
    10. Mirastschijski U, Schnabel R, Claes J, Schneider W, Agren MS, Haaksma C, Tomasek JJ. Matrix metalloproteinase inhibition delays wound healing and blocks the latent transforming growth factor-beta1-promoted myofibroblast formation and function. Wound Repair Regen. 2010 Mar-Apr; 18(2):223-34. PMID: 20409148; PMCID: PMC2859473.
    11. Risinger GM, Updike DL, Bullen EC, Tomasek JJ, Howard EW. TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB. Am J Physiol Cell Physiol. 2010 Jan; 298(1):C191-201. PMID: 19846754; PMCID: PMC2806150.
    12. Tomasek JJ, Haaksma CJ, Schwartz RJ, Vuong DT, Zhang SX, Ash JD, Ma JX, Al-Ubaidi MR. Deletion of smooth muscle alpha-actin alters blood-retina barrier permeability and retinal function. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2693-700. PMID: 16723488.
      View in: PubMed
    13. Tomasek JJ, Vaughan MB, Kropp BP, Gabbiani G, Martin MD, Haaksma CJ, Hinz B. Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity. Wound Repair Regen. 2006 May-Jun; 14(3):313-20. PMID: 16808810.
      View in: PubMed
    14. Gallucci RM, Lee EG, Tomasek JJ. IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice. J Invest Dermatol. 2006 Mar; 126(3):561-8. PMID: 16397521.
      View in: PubMed
    15. Tomasek JJ, McRae J, Owens GK, Haaksma CJ. Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element. Am J Pathol. 2005 May; 166(5):1343-51. PMID: 15855636; PMCID: PMC1606390.
    16. Mirastschijski U, Haaksma CJ, Tomasek JJ, Agren MS. Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds. Exp Cell Res. 2004 Oct 01; 299(2):465-75. PMID: 15350544.
      View in: PubMed
    17. Zimmerman RA, Tomasek JJ, McRae J, Haaksma CJ, Schwartz RJ, Lin HK, Cowan RL, Jones AN, Kropp BP. Decreased expression of smooth muscle alpha-actin results in decreased contractile function of the mouse bladder. J Urol. 2004 Oct; 172(4 Pt 2):1667-72. PMID: 15371786.
      View in: PubMed
    18. Lin HK, Cowan R, Moore P, Zhang Y, Yang Q, Peterson JA, Tomasek JJ, Kropp BP, Cheng E. Characterization of neuropathic bladder smooth muscle cells in culture. J Urol. 2004 Mar; 171(3):1348-52. PMID: 14767346.
      View in: PubMed
    19. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002 May; 3(5):349-63. PMID: 11988769.
      View in: PubMed
    20. Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell. 2001 Sep; 12(9):2730-41. PMID: 11553712; PMCID: PMC59708.
    21. Spyres LM, Qa'Dan M, Meader A, Tomasek JJ, Howard EW, Ballard JD. Cytosolic delivery and characterization of the TcdB glucosylating domain by using a heterologous protein fusion. Infect Immun. 2001 Jan; 69(1):599-601. PMID: 11119561; PMCID: PMC97927.
    22. Vaughan MB, Howard EW, Tomasek JJ. Transforming growth factor-beta1 promotes the morphological and functional differentiation of the myofibroblast. Exp Cell Res. 2000 May 25; 257(1):180-9. PMID: 10854066.
      View in: PubMed
    23. Parizi M, Howard EW, Tomasek JJ. Regulation of LPA-promoted myofibroblast contraction: role of Rho, myosin light chain kinase, and myosin light chain phosphatase. Exp Cell Res. 2000 Feb 01; 254(2):210-20. PMID: 10640419.
      View in: PubMed
    24. Rayan GM, Haaksma CJ, Tomasek JJ, McCarthy KJ. Basement membrane chondroitin sulfate proteoglycan and vascularization of the developing mammalian limb bud. J Hand Surg Am. 2000 Jan; 25(1):150-8. PMID: 10642486.
      View in: PubMed
    25. Kropp BP, Zhang Y, Tomasek JJ, Cowan R, Furness PD, Vaughan MB, Parizi M, Cheng EY. Characterization of cultured bladder smooth muscle cells: assessment of in vitro contractility. J Urol. 1999 Nov; 162(5):1779-84. PMID: 10524934.
      View in: PubMed
    26. Rayan GM, Abercrombie MP, Linsenmayer TF, Fitch JM, Tomasek JJ. Distribution of type IV collagen during avian limb bud development. J Hand Surg Am. 1999 May; 24(3):619-27. PMID: 10357545.
      View in: PubMed
    27. Tomasek JJ, Vaughan MB, Haaksma CJ. Cellular structure and biology of Dupuytren's disease. Hand Clin. 1999 Feb; 15(1):21-34. PMID: 10050239.
      View in: PubMed
    28. Vu TK, Liu RW, Haaksma CJ, Tomasek JJ, Howard EW. Identification and cloning of the membrane-associated serine protease, hepsin, from mouse preimplantation embryos. J Biol Chem. 1997 Dec 12; 272(50):31315-20. PMID: 9395459.
      View in: PubMed
    29. Porpaczy Z, Tomasek JJ, Freeman DA. Internalized plasma membrane cholesterol passes through an endosome compartment that is distinct from the acid vesicle-lysosome compartment. Exp Cell Res. 1997 Aug 01; 234(2):217-24. PMID: 9260888.
      View in: PubMed
    30. Tomasek JJ, Halliday NL, Updike DL, Ahern-Moore JS, Vu TK, Liu RW, Howard EW. Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeleton. J Biol Chem. 1997 Mar 14; 272(11):7482-7. PMID: 9054450.
      View in: PubMed
    31. Rayan GM, Parizi M, Tomasek JJ. Pharmacologic regulation of Dupuytren's fibroblast contraction in vitro. J Hand Surg Am. 1996 Nov; 21(6):1065-70. PMID: 8969433.
      View in: PubMed
    32. Howard EW, Benton R, Ahern-Moore J, Tomasek JJ. Cellular contraction of collagen lattices is inhibited by nonenzymatic glycation. Exp Cell Res. 1996 Oct 10; 228(1):132-7. PMID: 8892980.
      View in: PubMed
    33. Pilcher BK, Levine NS, Tomasek JJ. Thrombin promotion of isometric contraction in fibroblasts: its extracellular mechanism of action. Plast Reconstr Surg. 1995 Oct; 96(5):1188-95. PMID: 7568497.
      View in: PubMed
    34. Halliday NL, Tomasek JJ. Mechanical properties of the extracellular matrix influence fibronectin fibril assembly in vitro. Exp Cell Res. 1995 Mar; 217(1):109-17. PMID: 7867709.
      View in: PubMed
    35. Rayan GM, Tomasek JJ. Generation of contractile force by cultured Dupuytren's disease and normal palmar fibroblasts. Tissue Cell. 1994 Oct; 26(5):747-56. PMID: 9437248.
      View in: PubMed
    36. Halliday NL, Rayan GM, Zardi L, Tomasek JJ. Distribution of ED-A and ED-B containing fibronectin isoforms in Dupuytren's disease. J Hand Surg Am. 1994 May; 19(3):428-34. PMID: 8056970.
      View in: PubMed
    37. Pilcher BK, Kim DW, Carney DH, Tomasek JJ. Thrombin stimulates fibroblast-mediated collagen lattice contraction by its proteolytically activated receptor. Exp Cell Res. 1994 Apr; 211(2):368-73. PMID: 8143785.
      View in: PubMed
    38. Tomasek JJ, Meyers SW, Basinger JB, Green DT, Shew RL. Diabetic and age-related enhancement of collagen-linked fluorescence in cortical bones of rats. Life Sci. 1994; 55(11):855-61. PMID: 8072386.
      View in: PubMed
    39. Tomasek JJ, Akiyama SK. Fibroblast-mediated collagen gel contraction does not require fibronectin-alpha 5 beta 1 integrin interaction. Anat Rec. 1992 Oct; 234(2):153-60. PMID: 1416102.
      View in: PubMed
    40. Tomasek JJ, Haaksma CJ, Eddy RJ, Vaughan MB. Fibroblast contraction occurs on release of tension in attached collagen lattices: dependency on an organized actin cytoskeleton and serum. Anat Rec. 1992 Mar; 232(3):359-68. PMID: 1543260.
      View in: PubMed
    41. Tomasek JJ, Haaksma CJ. Fibronectin filaments and actin microfilaments are organized into a fibronexus in Dupuytren's diseased tissue. Anat Rec. 1991 Jun; 230(2):175-82. PMID: 1867394.
      View in: PubMed
    42. Godfrey HP, Canfield LS, Kindler HL, Angadi CV, Tomasek JJ, Goodman JW. Production of a fibronectin-associated lymphokine by cloned mouse T cells. J Immunol. 1988 Sep 01; 141(5):1508-15. PMID: 3261752.
      View in: PubMed
    43. Abercrombie MP, Tomasek JJ. Effects of enzyme isolation on the basal lamina of developing avian limb bud epithelia. In Vitro Cell Dev Biol. 1988 Aug; 24(8):803-10. PMID: 3045073.
      View in: PubMed
    44. Eddy RJ, Petro JA, Tomasek JJ. Evidence for the nonmuscle nature of the "myofibroblast" of granulation tissue and hypertropic scar. An immunofluorescence study. Am J Pathol. 1988 Feb; 130(2):252-60. PMID: 3277440; PMCID: PMC1880515.
    45. Tomasek JJ, Schultz RJ, Haaksma CJ. Extracellular matrix-cytoskeletal connections at the surface of the specialized contractile fibroblast (myofibroblast) in Dupuytren disease. J Bone Joint Surg Am. 1987 Dec; 69(9):1400-7. PMID: 3440798.
      View in: PubMed
    46. Tomasek JJ, Schultz RJ, Episalla CW, Newman SA. The cytoskeleton and extracellular matrix of the Dupuytren's disease "myofibroblast": an immunofluorescence study of a nonmuscle cell type. J Hand Surg Am. 1986 May; 11(3):365-71. PMID: 3519746.
      View in: PubMed
    47. Tomasek JJ, Brier JA. Extracellular matrix maintains apical ectodermal ridge in culture. Prog Clin Biol Res. 1986; 217B:433-6. PMID: 3749200.
      View in: PubMed
    48. Newman SA, Frenz DA, Tomasek JJ, Paulsen DF. Matrix-driven translocation: possible role in precartilage mesenchymal condensation. Prog Clin Biol Res. 1986; 217B:199-202. PMID: 2428060.
      View in: PubMed
    49. Newman SA, Frenz DA, Tomasek JJ, Rabuzzi DD. Matrix-driven translocation of cells and nonliving particles. Science. 1985 May 17; 228(4701):885-9. PMID: 4001925.
      View in: PubMed
    50. Tomasek JJ, Hay ED. Analysis of the role of microfilaments and microtubules in acquisition of bipolarity and elongation of fibroblasts in hydrated collagen gels. J Cell Biol. 1984 Aug; 99(2):536-49. PMID: 6146628; PMCID: PMC2113263.
    51. Tomasek JJ, Hay ED, Fujiwara K. Collagen modulates cell shape and cytoskeleton of embryonic corneal and fibroma fibroblasts: distribution of actin, alpha-actinin, and myosin. Dev Biol. 1982 Jul; 92(1):107-22. PMID: 7106372.
      View in: PubMed
    52. Tomasek JJ, Mazurkiewicz JE, Newman SA. Nonuniform distribution of fibronectin during avian limb development. Dev Biol. 1982 Mar; 90(1):118-26. PMID: 7037503.
      View in: PubMed
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