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Last Name

Jialing Lin

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
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    Collapse Biography 
    Collapse education and training
    Peking University, Beijing, CHINAMSc1986Biology
    University of Tennessee, Memphis, TNPhD1994Biochemistry
    Texas A&M University , College Station, TXPostdoc1998Medical Biochemistry and Genetics

    Collapse Research 
    Collapse research activities and funding
    5P20GM103640-07     (WEST, ANN H)Aug 1, 2012 - May 31, 2022
    Oklahoma COBRE in Structural Biology
    Role: Co-Investigator

    2P20GM103640-06     (WEST, ANN H)Aug 1, 2012 - May 31, 2022
    Oklahoma COBRE in Structural Biology
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lin J, Johnson AE, Zhang Z. Photocrosslinking Approach to Investigate Protein Interactions in the BCL-2 Family. Methods Mol Biol. 2019; 1877:131-149. PMID: 30536003.
      View in: PubMed
    2. Niu X, Brahmbhatt H, Mergenthaler P, Zhang Z, Sang J, Daude M, Ehlert FGR, Diederich WE, Wong E, Zhu W, Pogmore J, Nandy JP, Satyanarayana M, Jimmidi RK, Arya P, Leber B, Lin J, Culmsee C, Yi J, Andrews DW. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017 Apr 20; 24(4):493-506.e5. PMID: 28392146.
      View in: PubMed
    3. Liao C, Zhang Z, Kale J, Andrews DW, Lin J, Li J. Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation. Sci Rep. 2016 07 06; 6:29502. PMID: 27381287.
      View in: PubMed
    4. Zhang Z, Subramaniam S, Kale J, Liao C, Huang B, Brahmbhatt H, Condon SG, Lapolla SM, Hays FA, Ding J, He F, Zhang XC, Li J, Senes A, Andrews DW, Lin J. BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes. EMBO J. 2016 Jan 18; 35(2):208-36. PMID: 26702098; PMCID: PMC4718459 [Available on 01/18/17].
    5. Ding J, Mooers BH, Zhang Z, Kale J, Falcone D, McNichol J, Huang B, Zhang XC, Xing C, Andrews DW, Lin J. After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. J Biol Chem. 2014 Apr 25; 289(17):11873-96. PMID: 24616095.
      View in: PubMed
    6. Medina AP, Lin J, Weigel PH. Hyaluronan synthase mediates dye translocation across liposomal membranes. BMC Biochem. 2012 Jan 25; 13:2. PMID: 22276637; PMCID: PMC3331846.
    7. Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q. Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. J Biol Chem. 2012 Jan 06; 287(2):1054-65. PMID: 22065578; PMCID: PMC3256916.
    8. Ko JK, Choi KH, Peng J, He F, Zhang Z, Weisleder N, Lin J, Ma J. Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanisms. J Biol Chem. 2011 Mar 18; 286(11):9038-48. PMID: 21189256; PMCID: PMC3059050.
    9. Ding J, Zhang Z, Roberts GJ, Falcone M, Miao Y, Shao Y, Zhang XC, Andrews DW, Lin J. Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif. J Biol Chem. 2010 Sep 10; 285(37):28749-63. PMID: 20584903; PMCID: PMC2937903.
    10. Zhang Z, Zhu W, Lapolla SM, Miao Y, Shao Y, Falcone M, Boreham D, McFarlane N, Ding J, Johnson AE, Zhang XC, Andrews DW, Lin J. Bax forms an oligomer via separate, yet interdependent, surfaces. J Biol Chem. 2010 Jun 04; 285(23):17614-27. PMID: 20382739; PMCID: PMC2878526.
    11. Peng J, Ding J, Tan C, Baggenstoss B, Zhang Z, Lapolla SM, Lin J. Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid. Apoptosis. 2009 Oct; 14(10):1145-53. PMID: 19701793; PMCID: PMC2858642.
    12. Peng J, Lapolla SM, Zhang Z, Lin J. The cytosolic domain of Bcl-2 forms small pores in model mitochondrial outer membrane after acidic pH-induced membrane association. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Feb; 26(1):130-7. PMID: 19334571; PMCID: PMC2844873.
    13. Kolluri SK, Zhu X, Zhou X, Lin B, Chen Y, Sun K, Tian X, Town J, Cao X, Lin F, Zhai D, Kitada S, Luciano F, O'Donnell E, Cao Y, He F, Lin J, Reed JC, Satterthwait AC, Zhang XK. A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell. 2008 Oct 07; 14(4):285-98. PMID: 18835031; PMCID: PMC2667967.
    14. Tian D, Das SG, Doshi JM, Peng J, Lin J, Xing C. sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell. Cancer Lett. 2008 Feb 08; 259(2):198-208. PMID: 18037229; PMCID: PMC2693013.
    15. Peng J, Tan C, Roberts GJ, Nikolaeva O, Zhang Z, Lapolla SM, Primorac S, Andrews DW, Lin J. tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation. J Biol Chem. 2006 Nov 24; 281(47):35802-11. PMID: 17005564; PMCID: PMC2825177.
    16. Dlugosz PJ, Billen LP, Annis MG, Zhu W, Zhang Z, Lin J, Leber B, Andrews DW. Bcl-2 changes conformation to inhibit Bax oligomerization. EMBO J. 2006 Jun 07; 25(11):2287-96. PMID: 16642033; PMCID: PMC1478188.
    17. Tan C, Dlugosz PJ, Peng J, Zhang Z, Lapolla SM, Plafker SM, Andrews DW, Lin J. Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2. J Biol Chem. 2006 May 26; 281(21):14764-75. PMID: 16571718; PMCID: PMC2826894.
    18. Zhang Z, Lapolla SM, Annis MG, Truscott M, Roberts GJ, Miao Y, Shao Y, Tan C, Peng J, Johnson AE, Zhang XC, Andrews DW, Lin J. Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax. J Biol Chem. 2004 Oct 15; 279(42):43920-8. PMID: 15302859; PMCID: PMC1350923.
    19. McCormick PJ, Miao Y, Shao Y, Lin J, Johnson AE. Cotranslational protein integration into the ER membrane is mediated by the binding of nascent chains to translocon proteins. Mol Cell. 2003 Aug; 12(2):329-41. PMID: 14536073.
      View in: PubMed
    20. Flanagan JJ, Chen JC, Miao Y, Shao Y, Lin J, Bock PE, Johnson AE. Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens. J Biol Chem. 2003 May 16; 278(20):18628-37. PMID: 12621052.
      View in: PubMed
    21. Lin J, Liang Z, Zhang Z, Li G. Membrane topography and topogenesis of prenylated Rab acceptor (PRA1). J Biol Chem. 2001 Nov 09; 276(45):41733-41. PMID: 11535589; PMCID: PMC1350924.
    22. Xia Z, Zhou Q, Lin J, Liu Y. Stable SNARE complex prior to evoked synaptic vesicle fusion revealed by fluorescence resonance energy transfer. J Biol Chem. 2001 Jan 19; 276(3):1766-71. PMID: 11035043.
      View in: PubMed
    23. Liao S, Lin J, Do H, Johnson AE. Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration. Cell. 1997 Jul 11; 90(1):31-41. PMID: 9230300.
      View in: PubMed
    24. Do H, Falcone D, Lin J, Andrews DW, Johnson AE. The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process. Cell. 1996 May 03; 85(3):369-78. PMID: 8616892.
      View in: PubMed
    25. Lin J, Addison R. The membrane topology of the carboxyl-terminal third of the Neurospora plasma membrane H(+)-ATPase. J Biol Chem. 1995 Mar 24; 270(12):6942-8. PMID: 7896844.
      View in: PubMed
    26. Lin J, Addison R. A novel integration signal that is composed of two transmembrane segments is required to integrate the Neurospora plasma membrane H(+)-ATPase into microsomes. J Biol Chem. 1995 Mar 24; 270(12):6935-41. PMID: 7896843.
      View in: PubMed
    27. Lin J, Addison R. Topology of the Neurospora plasma membrane H(+)-ATPase. Localization of a transmembrane segment. J Biol Chem. 1994 Feb 04; 269(5):3887-90. PMID: 8106434.
      View in: PubMed
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