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Jian-Xing Ma

TitleProf,George L Cross Rsrch &Chr
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPhysiology
Address941 Stanton L Young Blvd
Oklahoma City OK 73104-5019
Phone405/271-4372
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    Collapse Biography 
    Collapse education and training
    Jiangxi Medical College, CHINAMD1984Medicine
    Chinese Academy of Medical Sciences, Beijing, CHINAMS1987Pharmacology
    Medical University of South Carolina, Charleston, SCPhD1993Biochemistry

    Collapse Research 
    Collapse research activities and funding
    P30GM122744     (MA, JIAN-XING)Jul 1, 2017 - Jun 30, 2022
    NIH/NIGMS
    Mentoring Diabetes Research in Oklahoma
    Role: Principal Investigator

    R01EY019309     (MA, JIAN-XING)Mar 1, 2009 - Mar 31, 2022
    NIH/NEI
    A new pathogenic mechanism for diabetic retinopathy
    Role: Principal Investigator

    R01EY018659     (MA, JIAN-XING)Dec 1, 2007 - May 31, 2020
    NIH/NEI
    The role of the Wnt signaling pathway in choroidal neovascularization
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Shin Y, Moiseyev G, Petrukhin K, Cioffi CL, Muthuraman P, Takahashi Y, Ma JX. A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration. Biochim Biophys Acta. 2018 Jul; 1864(7):2420-2429. PMID: 29684583.
      View in: PubMed
    2. Qiu F, Shin Y, Chen D, Cheng R, Chen Q, Zhou K, Larrick JW, Mendelson AR, Ma JX. Anti-angiogenic effect of a humanized antibody blocking the Wnt/ß-catenin signaling pathway. Microvasc Res. 2018 Apr 07; 119:29-37. PMID: 29630973.
      View in: PubMed
    3. Dou XZ, Nath D, Shin Y, Ma JX, Duerfeldt AS. Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPARa selective agonists: New leads for oculovascular conditions. Bioorg Med Chem Lett. 2018 Apr 05. PMID: 29628329.
      View in: PubMed
    4. Sharif R, Priyadarsini S, Rowsey TG, Ma JX, Karamichos D. Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea. J Vis Exp. 2018 01 24; (131). PMID: 29443018.
      View in: PubMed
    5. Liu Q, Zhang F, Zhang X, Cheng R, Ma JX, Yi J, Li J. Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation. Mol Cell Biochem. 2017 Dec 21. PMID: 29264825.
      View in: PubMed
    6. Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z, Gong Y, Kinter M, Humphries KM, Szweda LI, Smith LEH, Ma JX. PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. PMID: 29183319.
      View in: PubMed
    7. Qiu F, Matlock G, Chen Q, Zhou K, Du Y, Wang X, Ma JX. Therapeutic Effects of PPARa Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017 10 01; 58(12):5065-5075. PMID: 28980001.
      View in: PubMed
    8. Deng G, Moran EP, Cheng R, Matlock G, Zhou K, Moran D, Chen D, Yu Q, Ma JX. Therapeutic Effects of a Novel Agonist of Peroxisome Proliferator-Activated Receptor Alpha for the Treatment of Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2017 10 01; 58(12):5030-5042. PMID: 28979999.
      View in: PubMed
    9. Priyadarsini S, Rowsey TG, Ma JX, Karamichos D. Unravelling the stromal-nerve interactions in the human diabetic cornea. Exp Eye Res. 2017 11; 164:22-30. PMID: 28827027.
      View in: PubMed
    10. Du M, Phelps E, Balangue MJ, Dockins A, Moiseyev G, Shin Y, Kane S, Otalora L, Ma JX, Farjo R, Farjo KM. Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):4375–4383. PMID: 28813718.
      View in: PubMed
    11. Malechka VV, Moiseyev G, Takahashi Y, Shin Y, Ma JX. Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy. Am J Pathol. 2017 Oct; 187(10):2222-2231. PMID: 28734946.
      View in: PubMed
    12. Chen Q, Ma JX. Canonical Wnt signaling in diabetic retinopathy. Vision Res. 2017 10; 139:47-58. PMID: 28545982.
      View in: PubMed
    13. Zheng X, Cui H, Yin Y, Zhang Y, Zong R, Bao X, Ma JX, Liu Z, Zhou Y. SERPINA3K Ameliorates the Corneal Oxidative Injury Induced by 4-Hydroxynonenal. Invest Ophthalmol Vis Sci. 2017 06 01; 58(7):2874-2883. PMID: 28586911.
      View in: PubMed
    14. Qiu F, Liu Z, Zhou Y, He J, Gong S, Bai X, Zeng Y, Liu Z, Ma JX. Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration. Sci Rep. 2017 04 28; 7(1):1263. PMID: 28455497.
      View in: PubMed
    15. Vanlandingham PA, Nuno DJ, Quiambao AB, Phelps E, Wassel RA, Ma JX, Farjo KM, Farjo RA. Inhibition of Stat3 by a Small Molecule Inhibitor Slows Vision Loss in a Rat Model of Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2017 04 01; 58(4):2095-2105. PMID: 28395025.
      View in: PubMed
    16. Fu H, Vadalia N, Xue ER, Johnson C, Wang L, Yang WY, Sanchez C, Nelson J, Chen Q, Choi ET, Ma JX, Yu J, Wang H, Yang X. Thrombus leukocytes exhibit more endothelial cell-specific angiogenic markers than peripheral blood leukocytes do in acute coronary syndrome patients, suggesting a possibility of trans-differentiation: a comprehensive database mining study. J Hematol Oncol. 2017 03 23; 10(1):74. PMID: 28335793.
      View in: PubMed
    17. McBride JD, Liu X, Berry WL, Janknecht R, Cheng R, Zhou K, Badiavas EV, Ma JX. Transgenic expression of a canonical Wnt inhibitor, kallistatin, is associated with decreased circulating CD19+ B lymphocytes in the peripheral blood. Int J Hematol. 2017 Jun; 105(6):748-757. PMID: 28299632.
      View in: PubMed
    18. Chen Q, Qiu F, Zhou K, Matlock HG, Takahashi Y, Rajala RVS, Yang Y, Moran E, Ma JX. Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARa. Diabetes. 2017 06; 66(6):1671-1682. PMID: 28270521.
      View in: PubMed
    19. Shin Y, Moiseyev G, Chakraborty D, Ma JX. A Dominant Mutation in Rpe65, D477G, Delays Dark Adaptation and Disturbs the Visual Cycle in the Mutant Knock-In Mice. Am J Pathol. 2017 Mar; 187(3):517-527. PMID: 28041994.
      View in: PubMed
    20. Priyadarsini S, Sarker-Nag A, Rowsey TG, Ma JX, Karamichos D. Establishment of a 3D In Vitro Model to Accelerate the Development of Human Therapies against Corneal Diabetes. PLoS One. 2016; 11(12):e0168845. PMID: 28005998.
      View in: PubMed
    21. He X, Cheng R, Park K, Benyajati S, Moiseyev G, Sun C, Olson LE, Yang Y, Eby BK, Lau K, Ma JX. Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway. Kidney Int. 2017 03; 91(3):642-657. PMID: 27914705.
      View in: PubMed
    22. Tan H, Yi H, Zhao W, Ma JX, Zhang Y, Zhou X. Intraglomerular crosstalk elaborately regulates podocyte injury and repair in diabetic patients: insights from a 3D multiscale modeling study. Oncotarget. 2016 Nov 08; 7(45):73130-73146. PMID: 27683034.
      View in: PubMed
    23. Zhou J, Ge L, Jia C, Zheng X, Cui H, Zong R, Bao X, Yin Y, Ma JX, Li W, Liu Z, Zhou Y. ROS-mediated Different Homeostasis of Murine Corneal Epithelial Progenitor Cell Line under Oxidative Stress. Sci Rep. 2016 11 02; 6:36481. PMID: 27805062.
      View in: PubMed
    24. Priyadarsini S, McKay TB, Sarker-Nag A, Allegood J, Chalfant C, Ma JX, Karamichos D. Complete metabolome and lipidome analysis reveals novel biomarkers in the human diabetic corneal stroma. Exp Eye Res. 2016 Dec; 153:90-100. PMID: 27742548.
      View in: PubMed
    25. Chen Q, Takahashi Y, Oka K, Ma JX. Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling. Mol Cell Biol. 2016 Oct 15; 36(20):2645-54. PMID: 27528615.
      View in: PubMed
    26. Harper AR, Wang X, Moiseyev G, Ma JX, Summers JA. Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia. Invest Ophthalmol Vis Sci. 2016 Sep 01; 57(11):4886-4897. PMID: 27654415.
      View in: PubMed
    27. Cheng R, Ding L, He X, Takahashi Y, Ma JX. Interaction of PPARa With the Canonic Wnt Pathway in the Regulation of Renal Fibrosis. Diabetes. 2016 Dec; 65(12):3730-3743. PMID: 27543085.
      View in: PubMed
    28. Moran EP, Wang Z, Chen J, Sapieha P, Smith LE, Ma JX. Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications. Am J Physiol Heart Circ Physiol. 2016 Sep 01; 311(3):H738-49. PMID: 27473938.
      View in: PubMed
    29. Yu JY, Du M, Elliott MH, Wu M, Fu D, Yang S, Basu A, Gu X, Ma JX, Aston CE, Lyons TJ. Extravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes. Diabetologia. 2016 09; 59(9):2026-35. PMID: 27306616; PMCID: PMC4969344.
    30. Altiok EI, Browne S, Khuc E, Moran EP, Qiu F, Zhou K, Santiago-Ortiz JL, Ma JX, Chan MF, Healy KE. sFlt Multivalent Conjugates Inhibit Angiogenesis and Improve Half-Life In Vivo. PLoS One. 2016; 11(6):e0155990. PMID: 27257918; PMCID: PMC4892585.
    31. LeBlanc ME, Wang W, Chen X, Ji Y, Shakya A, Shen C, Zhang C, Gonzalez V, Brewer M, Ma JX, Wen R, Zhang F, Li W. The regulatory role of hepatoma-derived growth factor as an angiogenic factor in the eye. Mol Vis. 2016; 22:374-86. PMID: 27122967; PMCID: PMC4842004.
    32. Zong R, Zhou T, Lin Z, Bao X, Xiu Y, Chen Y, Chen L, Ma JX, Liu Z, Zhou Y. Down-Regulation of MicroRNA-184 Is Associated With Corneal Neovascularization. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1398-407. PMID: 27018842.
      View in: PubMed
    33. Stiles M, Moiseyev GP, Budda ML, Linens A, Brush RS, Qi H, White GL, Wolf RF, Ma JX, Floyd R, Anderson RE, Mandal NA. PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage. PLoS One. 2015; 10(12):e0145305. PMID: 26694648; PMCID: PMC4687940.
    34. Tuo J, Wang Y, Cheng R, Li Y, Chen M, Qiu F, Qian H, Shen D, Penalva R, Xu H, Ma JX, Chan CC. Wnt signaling in age-related macular degeneration: human macular tissue and mouse model. J Transl Med. 2015 Oct 17; 13:330. PMID: 26476672; PMCID: PMC4609061.
    35. He X, Cheng R, Benyajati S, Ma JX. PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases. Clin Sci (Lond). 2015 Jun; 128(11):805-23. PMID: 25881671; PMCID: PMC4557399.
    36. Chen L, Zong R, Zhou J, Ge L, Zhou T, Ma JX, Liu Z, Zhou Y. The oxidant role of 4-hydroxynonenal in corneal epithelium. Sci Rep. 2015 May 29; 5:10630. PMID: 26023743; PMCID: PMC4448499.
    37. Harper AR, Wiechmann AF, Moiseyev G, Ma JX, Summers JA. Identification of active retinaldehyde dehydrogenase isoforms in the postnatal human eye. PLoS One. 2015; 10(3):e0122008. PMID: 25793304; PMCID: PMC4368790.
    38. Takahashi Y, Chen Q, Rajala RVS, Ma JX. MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization. FEBS Lett. 2015 Apr 28; 589(10):1143-1149. PMID: 25796186; PMCID: PMC4406844.
    39. Chang B, Tessneer KL, McManus J, Liu X, Hahn S, Pasula S, Wu H, Song H, Chen Y, Cai X, Dong Y, Brophy ML, Rahman R, Ma JX, Xia L, Chen H. Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun. 2015 Mar 16; 6:6380. PMID: 25871009; PMCID: PMC4397653.
    40. Cheng R, Ma JX. Angiogenesis in diabetes and obesity. Rev Endocr Metab Disord. 2015 Mar; 16(1):67-75. PMID: 25663658; PMCID: PMC4351724.
    41. Wang Z, Cheng R, Lee K, Tyagi P, Ding L, Kompella UB, Chen J, Xu X, Ma JX. Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):855-64. PMID: 25657312; PMCID: PMC4376607.
    42. Moran EP, Ma JX. Therapeutic Effects of PPAR a on Neuronal Death and Microvascular Impairment. PPAR Res. 2015; 2015:595426. PMID: 25705219; PMCID: PMC4326216.
    43. Hu S, Liu H, Ha Y, Luo X, Motamedi M, Gupta MP, Ma JX, Tilton RG, Zhang W. Posttranslational modification of Sirt6 activity by peroxynitrite. Free Radic Biol Med. 2015 Feb; 79:176-85. PMID: 25476852; PMCID: PMC4339438.
    44. Qi W, Yang C, Dai Z, Che D, Feng J, Mao Y, Cheng R, Wang Z, He X, Zhou T, Gu X, Yan L, Yang X, Ma JX, Gao G. High levels of pigment epithelium-derived factor in diabetes impair wound healing through suppression of Wnt signaling. Diabetes. 2015 Apr; 64(4):1407-19. PMID: 25368097.
      View in: PubMed
    45. Zhu C, Pan F, Ge L, Zhou J, Chen L, Zhou T, Zong R, Xiao X, Dong N, Yang M, Ma JX, Liu Z, Zhou Y. SERPINA3K plays antioxidant roles in cultured pterygial epithelial cells through regulating ROS system. PLoS One. 2014; 9(10):e108859. PMID: 25296038; PMCID: PMC4189792.
    46. Zhou KK, Benyajati S, Le Y, Cheng R, Zhang W, Ma JX. Interruption of Wnt signaling in Müller cells ameliorates ischemia-induced retinal neovascularization. PLoS One. 2014; 9(10):e108454. PMID: 25271989; PMCID: PMC4182699.
    47. Lee K, Shin Y, Cheng R, Park K, Hu Y, McBride J, He X, Takahashi Y, Ma JX. Receptor heterodimerization as a novel mechanism for the regulation of Wnt/ß-catenin signaling. J Cell Sci. 2014 Nov 15; 127(Pt 22):4857-69. PMID: 25271056; PMCID: PMC4231303.
    48. Wei Q, Zhang F, Richardson MM, Roy NH, Rodgers W, Liu Y, Zhao W, Fu C, Ding Y, Huang C, Chen Y, Sun Y, Ding L, Hu Y, Ma JX, Boulton ME, Pasula S, Wren JD, Tanaka S, Huang X, Thali M, Hämmerling GJ, Zhang XA. CD82 restrains pathological angiogenesis by altering lipid raft clustering and CD44 trafficking in endothelial cells. Circulation. 2014 Oct 21; 130(17):1493-504. PMID: 25149363; PMCID: PMC4411083.
    49. Rajala A, Wang Y, Zhu Y, Ranjo-Bishop M, Ma JX, Mao C, Rajala RV. Nanoparticle-assisted targeted delivery of eye-specific genes to eyes significantly improves the vision of blind mice in vivo. Nano Lett. 2014 Sep 10; 14(9):5257-63. PMID: 25115433; PMCID: PMC4160266.
    50. Takahashi Y, Moiseyev G, Ma JX. Identification of key residues determining isomerohydrolase activity of human RPE65. J Biol Chem. 2014 Sep 26; 289(39):26743-51. PMID: 25112876; PMCID: PMC4175317.
    51. Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins AJ, Keech AC, Humphries KM, Gu X, Elliott MH, Xia X, Ma JX. Peroxisome proliferator-activated receptor a protects capillary pericytes in the retina. Am J Pathol. 2014 Oct; 184(10):2709-20. PMID: 25108226; PMCID: PMC4188867.
    52. Zhou T, Chen L, Huang CH, Lin Z, Zong R, Zhu C, Pan F, Ma JX, Liu ZG, Zhou Y. Serine Proteinase Inhibitor SERPINA3K Suppresses Corneal Neovascularization via Inhibiting Wnt Signaling and VEGF. Invest Ophthalmol Vis Sci. 2014 Jul 15. PMID: 25028361.
      View in: PubMed
    53. Wang Z, Moran E, Ding L, Cheng R, Xu X, Ma JX. PPARa regulates mobilization and homing of endothelial progenitor cells through the HIF-1a/SDF-1 pathway. Invest Ophthalmol Vis Sci. 2014 May 20; 55(6):3820-32. PMID: 24845641; PMCID: PMC4064689.
    54. Moran E, Ding L, Wang Z, Cheng R, Chen Q, Moore R, Takahashi Y, Ma JX. Protective and antioxidant effects of PPARa in the ischemic retina. Invest Ophthalmol Vis Sci. 2014 May 13; 55(7):4568-76. PMID: 24825105; PMCID: PMC4109406.
    55. Wang Z, Zhao H, Ma JX, Xu X. Inhibition of pathological corneal neovascularization by a small peptide derived from human apolipoprotein (a) Kringle V. Cornea. 2014 Apr; 33(4):405-13. PMID: 24452210.
      View in: PubMed
    56. McBride JD, Jenkins AJ, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin CT, Aston CE, Lyons TJ, Tomasek JJ, Ma JX. Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol. 2014 Jun; 134(6):1725-1734. PMID: 24463424; PMCID: PMC4065799.
    57. Jenkins AJ, Fu D, Azar M, Stoner JA, Kaufman DG, Zhang S, Klein RL, Lopes-Virella MF, Ma JX, Lyons TJ. Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients. J Diabetes Complications. 2014 May-Jun; 28(3):353-9. PMID: 24560422; PMCID: PMC4009500.
    58. Hu Y, Chen Y, Ding L, He X, Takahashi Y, Gao Y, Shen W, Cheng R, Chen Q, Qi X, Boulton ME, Ma JX. Pathogenic role of diabetes-induced PPAR-a down-regulation in microvascular dysfunction. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15401-6. PMID: 24003152; PMCID: PMC3780907.
    59. Murray AR, Chen Q, Takahashi Y, Zhou KK, Park K, Ma JX. MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model. Invest Ophthalmol Vis Sci. 2013 Mar 05; 54(3):1689-97. PMID: 23404117; PMCID: PMC3626515.
    60. Ichimura K, Kawashima Y, Nakamura T, Powell R, Hidoh Y, Terai S, Sakaida I, Kodera Y, Tsuji T, Ma JX, Sakai T, Matsumoto H, Obara T. Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy. Biochem Biophys Res Commun. 2013 Feb 22; 431(4):712-7. PMID: 23353086; PMCID: PMC3587682.
    61. Hu Y, Chen Y, Lin M, Lee K, Mott RA, Ma JX. Pathogenic role of the Wnt signaling pathway activation in laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci. 2013 Jan 07; 54(1):141-54. PMID: 23211829; PMCID: PMC3544418.
    62. Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma JX. Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 Dec; 32(24):5103-15. PMID: 23071093; PMCID: PMC3510526.
    63. Chen Y, Hu Y, Lin M, Jenkins AJ, Keech AC, Mott R, Lyons TJ, Ma JX. Therapeutic effects of PPARa agonists on diabetic retinopathy in type 1 diabetes models. Diabetes. 2013 Jan; 62(1):261-72. PMID: 23043158; PMCID: PMC3526044.
    64. Lin M, Hu Y, Chen Y, Zhou KK, Jin J, Zhu M, Le YZ, Ge J, Ma JX. Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization. Invest Ophthalmol Vis Sci. 2012 Sep 14; 53(10):6197-206. PMID: 22915031; PMCID: PMC4113187.
    65. Lee K, Hu Y, Ding L, Chen Y, Takahashi Y, Mott R, Ma JX. Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathy. Diabetes. 2012 Nov; 61(11):2948-57. PMID: 22891217; PMCID: PMC3478529.
    66. Chucair-Elliott AJ, Elliott MH, Wang J, Moiseyev GP, Ma JX, Politi LE, Rotstein NP, Akira S, Uematsu S, Ash JD. Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium. J Biol Chem. 2012 Jul 13; 287(29):24092-102. PMID: 22645143; PMCID: PMC3397836.
    67. Takahashi Y, Moiseyev G, Nikolaeva O, Ma JX. Identification of the key residues determining the product specificity of isomerohydrolase. Biochemistry. 2012 May 22; 51(20):4217-25. PMID: 22512451; PMCID: PMC3358571.
    68. Hu Y, Chen Y, Moiseyev G, Takahashi Y, Mott R, Ma JX. Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice. Invest Ophthalmol Vis Sci. 2011 Jul 25; 52(8):5507-14. PMID: 21551411; PMCID: PMC3176065.
    69. Mandal MN, Moiseyev GP, Elliott MH, Kasus-Jacobi A, Li X, Chen H, Zheng L, Nikolaeva O, Floyd RA, Ma JX, Anderson RE. Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. J Biol Chem. 2011 Sep 16; 286(37):32491-501. PMID: 21785167; PMCID: PMC3173208.
    70. Farjo KM, Moiseyev G, Nikolaeva O, Sandell LL, Trainor PA, Ma JX. RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis. Dev Biol. 2011 Sep 15; 357(2):347-55. PMID: 21782811; PMCID: PMC3164597.
    71. Takahashi Y, Moiseyev G, Chen Y, Nikolaeva O, Ma JX. An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species. FEBS J. 2011 Aug; 278(16):2913-26. PMID: 21676174; PMCID: PMC3354629.
    72. Longeras R, Farjo K, Ihnat M, Ma JX. A PEDF-derived peptide inhibits retinal neovascularization and blocks mobilization of bone marrow-derived endothelial progenitor cells. Exp Diabetes Res. 2012; 2012:518426. PMID: 21754923; PMCID: PMC3132462.
    73. Nikolaeva O, Moiseyev G, Rodgers KK, Ma JX. Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity. Biochem J. 2011 Jun 15; 436(3):591-7. PMID: 21446919.
      View in: PubMed
    74. Park K, Lee K, Zhang B, Zhou T, He X, Gao G, Murray AR, Ma JX. Identification of a novel inhibitor of the canonical Wnt pathway. Mol Cell Biol. 2011 Jul; 31(14):3038-51. PMID: 21576363; PMCID: PMC3133395.
    75. Takahashi Y, Moiseyev G, Chen Y, Farjo K, Nikolaeva O, Ma JX. An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain. FEBS J. 2011 Apr; 278(6):973-87. PMID: 21235714; PMCID: PMC3073448.
    76. Park K, Jin J, Hu Y, Zhou K, Ma JX. Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization. Am J Pathol. 2011 Feb; 178(2):688-98. PMID: 21281801; PMCID: PMC3070578.
    77. Ma JB, Jiang L, Asokanthan SF. Influence of surface effects on the pull-in instability of NEMS electrostatic switches. Nanotechnology. 2010 Dec 17; 21(50):505708. PMID: 21098949.
      View in: PubMed
    78. Zhang B, Ma JX. Wnt pathway antagonists and angiogenesis. Protein Cell. 2010 Oct; 1(10):898-906. PMID: 21204016; PMCID: PMC4875116.
    79. Farjo KM, Ma JX. The potential of nanomedicine therapies to treat neovascular disease in the retina. J Angiogenes Res. 2010 Oct 08; 2:21. PMID: 20932321; PMCID: PMC2958857.
    80. Moiseyev G, Nikolaeva O, Chen Y, Farjo K, Takahashi Y, Ma JX. Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease. Proc Natl Acad Sci U S A. 2010 Oct 12; 107(41):17551-6. PMID: 20876139; PMCID: PMC2955102.
    81. Jenkins AJ, McBride JD, Januszewski AS, Karschimkus CS, Zhang B, O'Neal DN, Nelson CL, Chung JS, Harper CA, Lyons TJ, Ma JX. Increased serum kallistatin levels in type 1 diabetes patients with vascular complications. J Angiogenes Res. 2010 Sep 22; 2:19. PMID: 20860825; PMCID: PMC2954956.
    82. Murray AR, Ma JX. PEDF as a treatment for cervical cancer. Cancer Biol Ther. 2010 Jun 15; 9(12):975-7. PMID: 20424516.
      View in: PubMed
    83. Zhang B, Abreu JG, Zhou K, Chen Y, Hu Y, Zhou T, He X, Ma JX. Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):6900-5. PMID: 20351274; PMCID: PMC2872418.
    84. Zhang B, Zhou KK, Ma JX. Inhibition of connective tissue growth factor overexpression in diabetic retinopathy by SERPINA3K via blocking the WNT/beta-catenin pathway. Diabetes. 2010 Jul; 59(7):1809-16. PMID: 20299474; PMCID: PMC2889783.
    85. Nikolaeva O, Takahashi Y, Moiseyev G, Ma JX. Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65. Biochem Biophys Res Commun. 2010 Jan 22; 391(4):1757-61. PMID: 20043869; PMCID: PMC2812700.
    86. Bai Y, Ma JX, Guo J, Wang J, Zhu M, Chen Y, Le YZ. Müller cell-derived VEGF is a significant contributor to retinal neovascularization. J Pathol. 2009 Dec; 219(4):446-54. PMID: 19768732.
      View in: PubMed
    87. Chen Y, Hu Y, Zhou T, Zhou KK, Mott R, Wu M, Boulton M, Lyons TJ, Gao G, Ma JX. Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models. Am J Pathol. 2009 Dec; 175(6):2676-85. PMID: 19893025; PMCID: PMC2789621.
    88. Wang M, Wang JJ, Li J, Park K, Qian X, Ma JX, Zhang SX. Pigment epithelium-derived factor suppresses adipogenesis via inhibition of the MAPK/ERK pathway in 3T3-L1 preadipocytes. Am J Physiol Endocrinol Metab. 2009 Dec; 297(6):E1378-87. PMID: 19808909; PMCID: PMC2793046.
    89. Park K, Chen Y, Hu Y, Mayo AS, Kompella UB, Longeras R, Ma JX. Nanoparticle-mediated expression of an angiogenic inhibitor ameliorates ischemia-induced retinal neovascularization and diabetes-induced retinal vascular leakage. Diabetes. 2009 Aug; 58(8):1902-13. PMID: 19491211; PMCID: PMC2712783.
    90. Farjo KM, Moiseyev G, Takahashi Y, Crouch RK, Ma JX. The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5089-97. PMID: 19458327.
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    91. Nikolaeva O, Takahashi Y, Moiseyev G, Ma JX. Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane. FEBS J. 2009 Jun; 276(11):3020-30. PMID: 19490105; PMCID: PMC2777724.
    92. Takahashi Y, Moiseyev G, Farjo K, Ma JX. Characterization of key residues and membrane association domains in retinol dehydrogenase 10. Biochem J. 2009 Apr 01; 419(1):113-22, 1 p following 122. PMID: 19102727; PMCID: PMC2728083.
    93. Zhang B, Hu Y, Ma JX. Anti-inflammatory and antioxidant effects of SERPINA3K in the retina. Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3943-52. PMID: 19324842.
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    94. Chen Y, Hu Y, Moiseyev G, Zhou KK, Chen D, Ma JX. Photoreceptor degeneration and retinal inflammation induced by very low-density lipoprotein receptor deficiency. Microvasc Res. 2009 Jun; 78(1):119-27. PMID: 19281829; PMCID: PMC2728019.
    95. Zhang B, Ma JX. SERPINA3K prevents oxidative stress induced necrotic cell death by inhibiting calcium overload. PLoS One. 2008; 3(12):e4077. PMID: 19115003; PMCID: PMC2605247.
    96. Takahashi Y, Moiseyev G, Ablonczy Z, Chen Y, Crouch RK, Ma JX. Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65. J Biol Chem. 2009 Jan 30; 284(5):3211-8. PMID: 19049981; PMCID: PMC2631947.
    97. Jenkins A, Zhang SX, Gosmanova A, Aston C, Dashti A, Baker MZ, Lyons T, Ma JX. Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients. Diabetes Res Clin Pract. 2008 Oct; 82(1):e5-7. PMID: 18715664; PMCID: PMC2597065.
    98. Zhang SX, Wang JJ, Dashti A, Wilson K, Zou MH, Szweda L, Ma JX, Lyons TJ. Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein. J Mol Endocrinol. 2008 Sep; 41(3):135-43. PMID: 18586837; PMCID: PMC2714421.
    99. Wu M, Chen Y, Wilson K, Chirindel A, Ihnat MA, Yu Y, Boulton ME, Szweda LI, Ma JX, Lyons TJ. Intraretinal leakage and oxidation of LDL in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2008 Jun; 49(6):2679-85. PMID: 18362112.
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    100. Chen Y, Znoiko S, DeGrip WJ, Crouch RK, Ma JX. Salamander blue-sensitive cones lost during metamorphosis. Photochem Photobiol. 2008 Jul-Aug; 84(4):855-62. PMID: 18331398; PMCID: PMC2662474.
    101. Wang JJ, Zhang SX, Mott R, Chen Y, Knapp RR, Cao W, Ma JX. Anti-inflammatory effects of pigment epithelium-derived factor in diabetic nephropathy. Am J Physiol Renal Physiol. 2008 May; 294(5):F1166-73. PMID: 18322021.
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    102. Ma JX, Zhang SX, Wang JJ. Down-regulation of angiogenic inhibitors: a potential pathogenic mechanism for diabetic complications. Curr Diabetes Rev. 2005 May; 1(2):183-96. PMID: 18220594.
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