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Jian Xu

TitleProf,Asst
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Endocrinology
Address941 Stanton L Young Blvd
Oklahoma City OK 73104-5019
Phone405/271-8001
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    Collapse Biography 
    Collapse education and training
    University of Oklahoma Health Sciences Center, USAPostdoc08/2008Mechanisms of Diabetes
    University of Tennessee Medical Center, USAPostdoc04/2005Mechanisms of CVD
    University of Konstanz, Konstanz, GermanyPostdoc01/2004Biochemical Pharmacology
    University of Konstanz, Konstanz, GermanyPhD10/2002Biochemical Pharmacology
    Xinjiang Agricultural University, Urumqi, ChinaMA07/1988Physiology and biochemistry
    Shaanxi Normal University, Xi'an, ChinaBS07/1985Biology
    Collapse awards and honors
    2008 - 2008Postdoctoral Fellowship Award, American Heart Association
    2004 - 2005The Physicians’ Medical Education and Research Foundation Award, University of Tennessee Medical Center
    1998 - 1998Advance of Science and Technology Prize, Xinjiang Agricultural University
    1997 - 1997Visiting Scholar to University of Konstanz, National Natural Science Foundation of China
    1997 - 1997Advance of Science and Technology Prize, Xinjiang Agricultural University
    1995 - 1995Visiting Scholar to Commonwealth of Scientific and Industrial Research Organization (CSIRO), National Natural Science Foundation of China
    1991 - 1991Advance of Science and Technology Prize, Xinjiang Agricultural University

    Collapse Overview 
    Collapse overview
    Patients with diabetes are at significantly increased risk for both microvascular and cardiovascular adverse events. This is because diabetes promotes disease in nearly all blood vessel types and sizes. Vascular complications are responsible for most of the morbidity, hospitalizations, and mortality in patients with diabetes. Dysregulated endothelial function is one of the major factors contributing to the development of vascular complications in diabetes. By using cell culture and mouse models, our lab explores endothelial regulated pathways that lead to dysmetabolism, a characteristic of metabolic disorders, including diabetes, insulin resistance, and obesity. Our previous research investigated the roles of endothelial regulation on peripheral angiogenesis and dysregulated inflammation in diabetes. As a logical extension to these studies, our current research centers on mechanisms underlying the endothelial regulation of metabolic disorders. Our long-term goal is to translate our bench-side pre-clinical findings to the bedside clinical practice, by providing insights into the development of much-needed management and therapy for these disorders.

    For details, please visit my lab on http://www.ouhsc.edu/Endocrinology/Faculty/Xu.asp.


    Collapse Research 
    Collapse research activities and funding
    HR17-046     (XU, JIAN)Sep 1, 2017 - Aug 31, 2020
    OCAST
    Endothelial regulation of high-fat diet-induced obesity
    Role: PI

    R01HL130845     (CHEN, HONG)Jan 1, 2016 - Dec 31, 2019
    NIH
    Mechanisms regulating VEGF receptors in diabetic angiogenesis
    Role: Co-PI

    HR14-062     (XU, JIAN)Sep 1, 2014 - Aug 31, 2017
    OCAST
    Role of ULK1 in Diabetic Impairment of Angiogenesis
    Role: PI

    14BGIA20030027     (XU, JIAN)Jul 1, 2014 - Jun 30, 2016
    American Heart Association
    Role of endothelial autophagy in diabetes-induced angiogenesis impairment
    Role: PI

    1-12-JF-58     (XU, JIAN)Jan 1, 2012 - Dec 31, 2014
    American Diabetes Association
    The role of eNOS-derived nitric oxide in the regulation of 26S proteasome functionality in diabetes
    Role: PI

    HR11-200     (XU, JIAN)Jul 1, 2011 - Jun 30, 2014
    OCAST
    Diabetes, 26S proteasomes and caloric restriction
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Li M, Qian M, Xu J. Vascular Endothelial Regulation of Obesity-Associated Insulin Resistance. Front Cardiovasc Med. 2017; 4:51. PMID: 28848738.
      View in: PubMed
    2. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    3. Xing J, Liu H, Yang H, Chen R, Chen Y, Xu J. Upregulation of Unc-51-like kinase 1 by nitric oxide stabilizes SIRT1, independent of autophagy. PLoS One. 2014; 9(12):e116165. PMID: 25541949; PMCID: PMC4277463.
    4. Liu H, Yu S, Zhang H, Xu J. Identification of nitric oxide as an endogenous inhibitor of 26S proteasomes in vascular endothelial cells. PLoS One. 2014; 9(5):e98486. PMID: 24853093; PMCID: PMC4031199.
    5. Liu H, Wang Z, Yu S, Xu J. Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory response†. Cardiovasc Res. 2014 Jul 01; 103(1):131-9. PMID: 24788415; PMCID: PMC4133591.
    6. Li Y, Liu H, Xu QS, Du YG, Xu J. Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-?B and endothelial inflammatory response. Carbohydr Polym. 2014 Jan; 99:568-78. PMID: 24274545; PMCID: PMC3843148.
    7. Liu H, Yu S, Zhang H, Xu J. Angiogenesis impairment in diabetes: role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2. PLoS One. 2012; 7(10):e46720. PMID: 23056421; PMCID: PMC3463541.
    8. Liu H, Yu S, Xu W, Xu J. Enhancement of 26S proteasome functionality connects oxidative stress and vascular endothelial inflammatory response in diabetes mellitus. Arterioscler Thromb Vasc Biol. 2012 Sep; 32(9):2131-40. PMID: 22772755; PMCID: PMC3432586.
    9. Xu J, Wang S, Viollet B, Zou MH. Regulation of the proteasome by AMPK in endothelial cells: the role of O-GlcNAc transferase (OGT). PLoS One. 2012; 7(5):e36717. PMID: 22574218; PMCID: PMC3345026.
    10. Xu J, Wang S, Zhang M, Wang Q, Asfa S, Zou MH. Tyrosine nitration of PA700 links proteasome activation to endothelial dysfunction in mouse models with cardiovascular risk factors. PLoS One. 2012; 7(1):e29649. PMID: 22272240; PMCID: PMC3260160.
    11. Zhang M, Song P, Xu J, Zou MH. Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):125-32. PMID: 20947827; PMCID: PMC3005129.
    12. Wang S, Zhang M, Liang B, Xu J, Xie Z, Liu C, Viollet B, Yan D, Zou MH. AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res. 2010 Apr 02; 106(6):1117-28. PMID: 20167927; PMCID: PMC2920052.
    13. Xu J, Zou MH. Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation. 2009 Sep 29; 120(13):1266-86. PMID: 19786641; PMCID: PMC2910587.
    14. Xu J, Wang S, Wu Y, Song P, Zou MH. Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension. Hypertension. 2009 Sep; 54(3):625-32. PMID: 19597039; PMCID: PMC2910588.
    15. Wang S, Xu J, Song P, Viollet B, Zou MH. In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I. Diabetes. 2009 Aug; 58(8):1893-901. PMID: 19528375; PMCID: PMC2712774.
    16. Song P, Zhang M, Wang S, Xu J, Choi HC, Zou MH. Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling. J Biol Chem. 2009 Jun 19; 284(25):17120-8. PMID: 19403525; PMCID: PMC2719350.
    17. Wang S, Xu J, Song P, Wu Y, Zhang J, Chul Choi H, Zou MH. Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure. Hypertension. 2008 Sep; 52(3):484-90. PMID: 18645049; PMCID: PMC3523107.
    18. Dong Y, Wu Y, Wu M, Wang S, Zhang J, Xie Z, Xu J, Song P, Wilson K, Zhao Z, Lyons T, Zou MH. Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthase. J Cell Mol Med. 2009 Sep; 13(9A):2899-910. PMID: 18624772; PMCID: PMC2821526.
    19. Choi HC, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, Zou MH. Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo. J Biol Chem. 2008 Jul 18; 283(29):20186-97. PMID: 18474592; PMCID: PMC2459304.
    20. Song P, Xie Z, Wu Y, Xu J, Dong Y, Zou MH. Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. J Biol Chem. 2008 May 02; 283(18):12446-55. PMID: 18321849; PMCID: PMC2431011.
    21. Zhang M, Dong Y, Xu J, Xie Z, Wu Y, Song P, Guzman M, Wu J, Zou MH. Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide. Circ Res. 2008 Feb 15; 102(3):328-37. PMID: 18063812; PMCID: PMC2869198.
    22. Wenzel P, Daiber A, Oelze M, Brandt M, Closs E, Xu J, Thum T, Bauersachs J, Ertl G, Zou MH, Förstermann U, Münzel T. Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Atherosclerosis. 2008 May; 198(1):65-76. PMID: 18061195; PMCID: PMC2889614.
    23. Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, Zou MH. Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner. Circulation. 2007 Oct 02; 116(14):1585-95. PMID: 17875968.
      View in: PubMed
    24. Xu J, Wu Y, Song P, Zhang M, Wang S, Zou MH. Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus. Circulation. 2007 Aug 21; 116(8):944-53. PMID: 17679617.
      View in: PubMed
    25. Wu Y, Song P, Xu J, Zhang M, Zou MH. Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase. J Biol Chem. 2007 Mar 30; 282(13):9777-88. PMID: 17255104.
      View in: PubMed
    26. Nie H, Wu JL, Zhang M, Xu J, Zou MH. Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo. Diabetes. 2006 Nov; 55(11):3133-41. PMID: 17065353.
      View in: PubMed
    27. Xu J, Xie Z, Reece R, Pimental D, Zou MH. Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite. Arterioscler Thromb Vasc Biol. 2006 Dec; 26(12):2688-95. PMID: 17023679.
      View in: PubMed
    28. Xu J, Lucas R, Wendel A. The potential of GM-CSF to improve resistance against infections in organ transplantation. Trends Pharmacol Sci. 2004 May; 25(5):254-8. PMID: 15120491.
      View in: PubMed
    29. Xu J, von Aulock S, Lucas R, Wendel A. Potential of colony-stimulating factors to improve host defense in organ transplant recipients. Current Opinion in Organ Transplantation. 2004; 9(4):411-7.
    30. Xu J, Lucas R, Schuchmann M, Kühnle S, Meergans T, Barreiros AP, Lohse AW, Otto G, Wendel A. GM-CSF restores innate, but not adaptive, immune responses in glucocorticoid-immunosuppressed human blood in vitro. J Immunol. 2003 Jul 15; 171(2):938-47. PMID: 12847265.
      View in: PubMed
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