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Zhizhuang J Zhao

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPathology
Address940 Stanton L Young Blvd
Oklahoma City OK 73104-5020
Phone405/271-9344
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    Collapse Research 
    Collapse research activities and funding
    R01HL057393     (ZHAO, ZHIZHUANG J)Aug 1, 1997 - Jun 30, 2002
    NIH/NHLBI
    TYROSINE PHOSPHATASES IN SIGNAL TRANSDUCTION
    Role: Principal Investigator

    R01CA075218     (ZHAO, ZHIZHUANG J)Dec 7, 1998 - Nov 30, 2003
    NIH/NCI
    PROTEIN TYROSINE PHOSPHATASES IN POLYCYTHEMIA VERA
    Role: Principal Investigator

    R01HL076309     (ZHAO, ZHIZHUANG JOE)Apr 1, 2004 - Mar 31, 2010
    NIH/NHLBI
    Tyrosine Phosphatase in Signal Transduction
    Role: Principal Investigator

    R01HL079441     (ZHAO, ZHIZHUANG JOE)Apr 1, 2006 - Mar 31, 2012
    NIH/NHLBI
    Tyrosine Phosphatase PTP-MEG2 and Hematopoiesis
    Role: Principal Investigator

    R01HL094591     (ZHAO, ZHIZHUANG JOE)Sep 15, 2009 - Aug 31, 2011
    NIH/NHLBI
    Tyrosine Kinase JAK2 and Myeloproliferative Disorders
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chen Y, Pan Y, Guo Y, Zhao W, Ho WT, Wang J, Xu M, Yang FC, Zhao ZJ. Tyrosine kinase inhibitors targeting FLT3 in the treatment of acute myeloid leukemia. Stem Cell Investig. 2017; 4:48. PMID: 28607922.
      View in: PubMed
    2. Hannafon BN, Trigoso YD, Calloway CL, Zhao YD, Lum DH, Welm AL, Zhao ZJ, Blick KE, Dooley WC, Ding WQ. Plasma exosome microRNAs are indicative of breast cancer. Breast Cancer Res. 2016 Sep 08; 18(1):90. PMID: 27608715; PMCID: PMC5016889.
    3. Guo Y, Fu X, Huo B, Wang Y, Sun J, Meng L, Hao T, Zhao ZJ, Hu X. GATA2 regulates GATA1 expression through LSD1-mediated histone modification. Am J Transl Res. 2016; 8(5):2265-74. PMID: 27347333; PMCID: PMC4891438.
    4. Agarwal A, Morrone K, Bartenstein M, Zhao ZJ, Verma A, Goel S. Bone marrow fibrosis in primary myelofibrosis: pathogenic mechanisms and the role of TGF-ß. Stem Cell Investig. 2016; 3:5. PMID: 27358897; PMCID: PMC4923632.
    5. Zhao W, Ho WT, Zhao ZJ. Quantitative analyses of myelofibrosis by determining hydroxyproline. Stem Cell Investig. 2015; 2:2. PMID: 27358870; PMCID: PMC4923646.
    6. Li J, Liu X, Chu H, Fu X, Li T, Hu L, Xing S, Li G, Gu J, Zhao ZJ. Specific dephosphorylation of Janus Kinase 2 by protein tyrosine phosphatases. Proteomics. 2015 Jan; 15(1):68-76. PMID: 25354842.
      View in: PubMed
    7. Cherry M, Khawandanah M, Zhao ZJ, Srour S, Ozer H, Selby G, Ghabache B, Al-Kali A. Erlotinib is not effective in patients with JAK2V617F-positive polycythemia vera. Ann Hematol. 2015 Apr; 94(4):717-9. PMID: 25380996.
      View in: PubMed
    8. Zhao BF, Zhao ZJ. Molecular cloning and characterization of a tyrosine phosphatase from Monosiga brevicollis. Biochem Biophys Res Commun. 2014 Oct 31; 453(4):761-6. PMID: 25445586.
      View in: PubMed
    9. Zhao W, Zou K, Farasyn T, Ho WT, Zhao ZJ. Generation and characterization of a JAK2V617F-containing erythroleukemia cell line. PLoS One. 2014; 9(7):e99017. PMID: 25036984; PMCID: PMC4103785.
    10. Wang BY, Xu XS, Cui YX, Wang H, Liu G, Zhao ZJ, Ma JF, Fu XQ. Caenorhabditis elegans eyes absent ortholog EYA-1 is required for stress resistance. Biochemistry (Mosc). 2014 Jul; 79(7):653-62. PMID: 25108328.
      View in: PubMed
    11. Jin X, Zhao W, Kirabo A, Park SO, Ho WT, Sayeski PP, Zhao ZJ. Elevated levels of mast cells are involved in pruritus associated with polycythemia vera in JAK2V617F transgenic mice. J Immunol. 2014 Jul 15; 193(2):477-84. PMID: 24920845.
      View in: PubMed
    12. Shi K, Zhao W, Chen Y, Ho WT, Yang P, Zhao ZJ. Cardiac hypertrophy associated with myeloproliferative neoplasms in JAK2V617F transgenic mice. J Hematol Oncol. 2014 Mar 19; 7:25. PMID: 24646493; PMCID: PMC3995113.
    13. Zhao ZJ, Liu D. A new Stem Cell Investigation. Stem Cell Investig. 2014; 1:1. PMID: 27358849; PMCID: PMC4923505.
    14. Jin X, Zhao W, Shi K, Ho WT, Zhao ZJ. Generation of a new congenic mouse strain with enhanced chymase expression in mast cells. PLoS One. 2013; 8(12):e84340. PMID: 24391943; PMCID: PMC3877308.
    15. Guo Y, Chen Y, Xu X, Fu X, Zhao ZJ. SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells. J Hematol Oncol. 2012 Dec 06; 5:72. PMID: 23216927; PMCID: PMC3524753.
    16. Yu X, Ma J, Lin F, Zhao W, Fu X, Zhao ZJ. Myotubularin family phosphatase ceMTM3 is required for muscle maintenance by preventing excessive autophagy in Caenorhabditis elegans. BMC Cell Biol. 2012 Oct 31; 13:28. PMID: 23114011; PMCID: PMC3506462.
    17. Hassed SJ, Wiley GB, Wang S, Lee JY, Li S, Xu W, Zhao ZJ, Mulvihill JJ, Robertson J, Warner J, Gaffney PM. RBPJ mutations identified in two families affected by Adams-Oliver syndrome. Am J Hum Genet. 2012 Aug 10; 91(2):391-5. PMID: 22883147; PMCID: PMC3415535.
    18. Chen Y, Guo Y, Han J, Ho WT, Li S, Fu X, Zhao ZJ. Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity. J Hematol Oncol. 2012 Jul 16; 5:39. PMID: 22800464; PMCID: PMC3419602.
    19. Zhao W, Du Y, Ho WT, Fu X, Zhao ZJ. JAK2V617F and p53 mutations coexist in erythroleukemia and megakaryoblastic leukemic cell lines. Exp Hematol Oncol. 2012 Jun 21; 1(1):15. PMID: 23210734; PMCID: PMC3514099.
    20. Zhao AH, Gao R, Zhao ZJ. Development of a highly sensitive method for detection of JAK2V617F. J Hematol Oncol. 2011 Oct 10; 4:40. PMID: 21985400; PMCID: PMC3207960.
    21. Yu X, Zhao W, Ma J, Fu X, Zhao ZJ. Beneficial and harmful effects of alcohol exposure on Caenorhabditis elegans worms. Biochem Biophys Res Commun. 2011 Sep 09; 412(4):757-62. PMID: 21871869.
      View in: PubMed
    22. Ma J, Li Z, Xing S, Ho WT, Fu X, Zhao ZJ. Tea contains potent inhibitors of tyrosine phosphatase PTP1B. Biochem Biophys Res Commun. 2011 Apr 01; 407(1):98-102. PMID: 21371422; PMCID: PMC3070786.
    23. Zhao W, Gao R, Lee J, Xing S, Ho WT, Fu X, Li S, Zhao ZJ. Relevance of JAK2V617F positivity to hematological diseases--survey of samples from a clinical genetics laboratory. J Hematol Oncol. 2011 Jan 14; 4:4. PMID: 21235771; PMCID: PMC3032761.
    24. Wang S, Dong H, Han J, Ho WT, Fu X, Zhao ZJ. Identification of a variant form of tyrosine phosphatase LYP. BMC Mol Biol. 2010 Nov 02; 11:78. PMID: 21044313; PMCID: PMC2987843.
    25. Tophkhane C, Yang S, Zhao ZJ, Yang X. Cell density-dependent regulation of p73 in breast cancer cells. Int J Oncol. 2009 Dec; 35(6):1429-34. PMID: 19885566.
      View in: PubMed
    26. Ma J, Zeng F, Ho WT, Teng L, Li Q, Fu X, Zhao ZJ. Characterization and functional studies of a FYVE domain-containing phosphatase in C. elegans. J Cell Biochem. 2008 Aug 01; 104(5):1843-52. PMID: 18393358; PMCID: PMC2562989.
    27. Xing S, Wanting TH, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ. Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood. 2008 May 15; 111(10):5109-17. PMID: 18334677; PMCID: PMC2384138.
    28. Li Z, Xing S, Wang S, Ho WT, Zhao ZJ. Characterization of a highly effective protein substrate for analysis of JAK2(V617F) Activity. Exp Hematol. 2007 Nov; 35(11):1624-32. PMID: 17764811; PMCID: PMC2128699.
    29. Sutton BC, Allen RA, Zhao ZJ, Dunn ST. Detection of the JAK2V617F mutation by asymmetric PCR and melt curve analysis. Cancer Biomark. 2007; 3(6):315-24. PMID: 18048969.
      View in: PubMed
    30. Li Z, Xu M, Xing S, Ho WT, Ishii T, Li Q, Fu X, Zhao ZJ. Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth. J Biol Chem. 2007 Feb 09; 282(6):3428-32. PMID: 17178722; PMCID: PMC2096634.
    31. Xu X, Zhang Q, Luo J, Xing S, Li Q, Krantz SB, Fu X, Zhao ZJ. JAK2(V617F): Prevalence in a large Chinese hospital population. Blood. 2007 Jan 01; 109(1):339-42. PMID: 16946305; PMCID: PMC1785080.
    32. Zhao R, Xing S, Li Z, Fu X, Li Q, Krantz SB, Zhao ZJ. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem. 2005 Jun 17; 280(24):22788-92. PMID: 15863514; PMCID: PMC1201515.
    33. Zhao R, Fu X, Teng L, Li Q, Zhao ZJ. Blocking the function of tyrosine phosphatase SHP-2 by targeting its Src homology 2 domains. J Biol Chem. 2003 Oct 31; 278(44):42893-8. PMID: 12913007.
      View in: PubMed
    34. Zhao R, Fu X, Li Q, Krantz SB, Zhao ZJ. Specific interaction of protein tyrosine phosphatase-MEG2 with phosphatidylserine. J Biol Chem. 2003 Jun 20; 278(25):22609-14. PMID: 12702726.
      View in: PubMed
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