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John Robert Stanley

TitleProf,Clin Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCMT Obstetrics & Gynecology
Address4502 E 41st St
Tulsa OK 74135-0001
Phone918/660-8350
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    Collapse Research 
    Collapse research activities and funding
    T32AR007465     (MILLAR, SARAH E.)Jul 1, 1983 - Apr 30, 2019
    NIH/NIAMS
    DERMATOLOGY RESEARCH TRAINING GRANT
    Role: Co-Principal Investigator

    R01AR043776     (STANLEY, JOHN R)Jul 1, 1996 - Jun 30, 2002
    NIH/NIAMS
    FUNCTION OF PEMPHIGUS VULGARIS ANTIGEN
    Role: Principal Investigator

    R01AR045437     (STANLEY, JOHN R)Sep 1, 1998 - Aug 31, 2003
    NIH/NIAMS
    PATHOGENESIS OF PEMPHIGUS
    Role: Principal Investigator

    R01AR048223     (STANLEY, JOHN R)Apr 1, 2002 - Mar 31, 2008
    NIH/NIAMS
    Mechanisms of Blister Formation by Staphylococcal Toxins
    Role: Principal Investigator

    R01AR052672     (STANLEY, JOHN R)Jul 1, 2005 - Jun 30, 2016
    NIH/NIAMS
    Cloning and genetics of human pemphigus autoantibodies
    Role: Principal Investigator

    P30AR057217     (STANLEY, JOHN R)Jul 1, 2009 - Jun 30, 2014
    NIH/NIAMS
    Core Center
    Role: Principal Investigator

    R03DA032475     (STANLEY, JOHN R)Mar 1, 2011 - Feb 28, 2013
    NIH/NIDA
    High throughput screening to find inhibitors of pathogenic pemphigus antibodies
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Chen J, Zheng Q, Hammers CM, Ellebrecht CT, Mukherjee EM, Tang HY, Lin C, Yuan H, Pan M, Langenhan J, Komorowski L, Siegel DL, Payne AS, Stanley JR. Proteomic Analysis of Pemphigus Autoantibodies Indicates a Larger, More Diverse, and More Dynamic Repertoire than Determined by B Cell Genetics. Cell Rep. 2017 Jan 03; 18(1):237-247. PMID: 28052253.
      View in: PubMed
    2. Yoshida K, Ishii K, Shimizu A, Yokouchi M, Amagai M, Shiraishi K, Shirakata Y, Stanley JR, Ishiko A. Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. J Dermatol Sci. 2017 Mar; 85(3):197-207. PMID: 28024684.
      View in: PubMed
    3. Hammers CM, Stanley JR. Mechanisms of Disease: Pemphigus and Bullous Pemphigoid. Annu Rev Pathol. 2016 May 23; 11:175-97. PMID: 26907530.
      View in: PubMed
    4. Ludwig RJ, Borradori L, Diaz LA, Hashimoto T, Hertl M, Ibrahim SM, Jonkman MF, Kitajima Y, Murrell DF, Schmidt E, Shimizu H, Stanley JR, Woodley DT, Zillikens D. From epidemiology and genetics to diagnostics, outcome measures, and novel treatments in autoimmune bullous diseases. J Invest Dermatol. 2014 Sep; 134(9):2298-2300. PMID: 25120143.
      View in: PubMed
    5. Hammers CM, Chen J, Lin C, Kacir S, Siegel DL, Payne AS, Stanley JR. Persistence of anti-desmoglein 3 IgG(+) B-cell clones in pemphigus patients over years. J Invest Dermatol. 2015 Mar; 135(3):742-749. PMID: 25142730; PMCID: PMC4294994.
    6. Hammers CM, Stanley JR. Antibody phage display: technique and applications. J Invest Dermatol. 2014 Feb; 134(2):1-5. PMID: 24424458; PMCID: PMC3951127.
    7. Hammers CM, Stanley JR. Desmoglein-1, differentiation, and disease. J Clin Invest. 2013 Apr; 123(4):1419-22. PMID: 23524961; PMCID: PMC3613937.
    8. Kouno M, Lin C, Schechter NM, Siegel D, Yang X, Seykora JT, Stanley JR. Targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand to keratinocytes with a pemphigus mAb. J Invest Dermatol. 2013 Sep; 133(9):2212-20. PMID: 23439393; PMCID: PMC3681880.
    9. Toumi A, Saleh MA, Yamagami J, Abida O, Kallel M, Masmoudi A, Makni S, Turki H, Hachiya T, Kuroda K, Stanley JR, Masmoudi H, Amagai M. Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus. J Dermatol Sci. 2013 Apr; 70(1):19-25. PMID: 23489520; PMCID: PMC3622174.
    10. Lunardon L, Tsai KJ, Propert KJ, Fett N, Stanley JR, Werth VP, Tsai DE, Payne AS. Adjuvant rituximab therapy of pemphigus: a single-center experience with 31 patients. Arch Dermatol. 2012 Sep; 148(9):1031-6. PMID: 22710375; PMCID: PMC3658473.
    11. Basu A, Alaupovic P, Wu M, Jenkins AJ, Yu Y, Nankervis AJ, Hanssen KF, Scholz H, Henriksen T, Lorentzen B, Clausen T, Garg SK, Menard MK, Hammad SM, Scardo JA, Stanley JR, Dashti A, Aston CE, Lyons TJ. Plasma lipoproteins and preeclampsia in women with type 1 diabetes: a prospective study. J Clin Endocrinol Metab. 2012 May; 97(5):1752-62. PMID: 22438226; PMCID: PMC3339882.
    12. Stanley JR. Synergy of understanding dermatologic disease and epidermal biology. J Clin Invest. 2012 Feb; 122(2):436-9. PMID: 22293181; PMCID: PMC3266808.
    13. Amagai M, Stanley JR. Desmoglein as a target in skin disease and beyond. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):776-84. PMID: 22189787; PMCID: PMC3279627.
    14. Yamagami J, Payne AS, Kacir S, Ishii K, Siegel DL, Stanley JR. Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity. J Clin Invest. 2010 Nov; 120(11):4111-7. PMID: 20978359; PMCID: PMC2964997.
    15. Yamagami J, Kacir S, Ishii K, Payne AS, Siegel DL, Stanley JR. Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus. J Immunol. 2009 Nov 01; 183(9):5615-21. PMID: 19843946; PMCID: PMC2766247.
    16. Stanley JR, Ishii K, Siegel DL, Payne AS. Update on the cloning of monoclonal anti-desmoglein antibodies from human pemphigus patients: implications for targeted therapy. Vet Dermatol. 2009 Oct; 20(5-6):327-30. PMID: 20178468; PMCID: PMC2829729.
    17. Yokouchi M, Saleh MA, Kuroda K, Hachiya T, Stanley JR, Amagai M, Ishii K. Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence. J Invest Dermatol. 2009 Sep; 129(9):2156-66. PMID: 19340014; PMCID: PMC2813511.
    18. Stanley JR, Amagai M. Autoimmune bullous diseases: historical perspectives. J Invest Dermatol. 2008 Oct 06; 128(E3):E16-8. PMID: 21233823.
      View in: PubMed
    19. Stanley JR, Amagai M. Autoimmune Bullous Diseases: Historical Perspectives. J Invest Dermatol. 2008 Oct; 128 Suppl 3:E16-8. PMID: 26875735.
      View in: PubMed
    20. Ishii K, Lin C, Siegel DL, Stanley JR. Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies. J Invest Dermatol. 2008 Apr; 128(4):939-48. PMID: 18007588; PMCID: PMC2597791.
    21. Payne AS, Siegel DL, Stanley JR. Targeting pemphigus autoantibodies through their heavy-chain variable region genes. J Invest Dermatol. 2007 Jul; 127(7):1681-91. PMID: 17392832.
      View in: PubMed
    22. Kowalczyk AP, Rubenstein DS, Garrod DR, Green KJ, Stanley JR. Milestones in Investigative Dermatology: The Desmosome. J Invest Dermatol. 2007 Jan; 127 Suppl 3:E1. PMID: 26879533.
      View in: PubMed
    23. Stanley JR, Amagai M. Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N Engl J Med. 2006 Oct 26; 355(17):1800-10. PMID: 17065642.
      View in: PubMed
    24. Anzai H, Stanley JR, Amagai M. Production of low titers of anti-desmoglein 1 IgG autoantibodies in some patients with staphylococcal scalded skin syndrome. J Invest Dermatol. 2006 Sep; 126(9):2139-41. PMID: 16691200.
      View in: PubMed
    25. Stanley JR. Albert M. Kligman: 90 years old on March 17, 2006. J Invest Dermatol. 2006 Apr; 126(4):697-8. PMID: 16541089.
      View in: PubMed
    26. Schechter NM, Choi EJ, Wang ZM, Hanakawa Y, Stanley JR, Kang Y, Clayman GL, Jayakumar A. Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI). Biol Chem. 2005 Nov; 386(11):1173-84. PMID: 16307483.
      View in: PubMed
    27. Payne AS, Ishii K, Kacir S, Lin C, Li H, Hanakawa Y, Tsunoda K, Amagai M, Stanley JR, Siegel DL. Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. J Clin Invest. 2005 Apr; 115(4):888-99. PMID: 15841178; PMCID: PMC1070425.
    28. Hanakawa Y, Stanley JR. Mechanisms of blister formation by staphylococcal toxins. J Biochem. 2004 Dec; 136(6):747-50. PMID: 15671483.
      View in: PubMed
    29. Hanakawa Y, Li H, Lin C, Stanley JR, Cotsarelis G. Desmogleins 1 and 3 in the companion layer anchor mouse anagen hair to the follicle. J Invest Dermatol. 2004 Nov; 123(5):817-22. PMID: 15482466.
      View in: PubMed
    30. Payne AS, Hanakawa Y, Amagai M, Stanley JR. Desmosomes and disease: pemphigus and bullous impetigo. Curr Opin Cell Biol. 2004 Oct; 16(5):536-43. PMID: 15363804.
      View in: PubMed
    31. Hanakawa Y, Schechter NM, Lin C, Nishifuji K, Amagai M, Stanley JR. Enzymatic and molecular characteristics of the efficiency and specificity of exfoliative toxin cleavage of desmoglein 1. J Biol Chem. 2004 Feb 13; 279(7):5268-77. PMID: 14630910.
      View in: PubMed
    32. Hanakawa Y, Selwood T, Woo D, Lin C, Schechter NM, Stanley JR. Calcium-dependent conformation of desmoglein 1 is required for its cleavage by exfoliative toxin. J Invest Dermatol. 2003 Aug; 121(2):383-9. PMID: 12880431.
      View in: PubMed
    33. Wu H, Stanley JR, Cotsarelis G. Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. J Invest Dermatol. 2003 Jun; 120(6):1052-7. PMID: 12787134.
      View in: PubMed
    34. Hanakawa Y, Schechter NM, Lin C, Garza L, Li H, Yamaguchi T, Fudaba Y, Nishifuji K, Sugai M, Amagai M, Stanley JR. Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. J Clin Invest. 2002 Jul; 110(1):53-60. PMID: 12093888; PMCID: PMC151035.
    35. Hanakawa Y, Matsuyoshi N, Stanley JR. Expression of desmoglein 1 compensates for genetic loss of desmoglein 3 in keratinocyte adhesion. J Invest Dermatol. 2002 Jul; 119(1):27-31. PMID: 12164920.
      View in: PubMed
    36. Amagai M, Yamaguchi T, Hanakawa Y, Nishifuji K, Sugai M, Stanley JR. Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1. J Invest Dermatol. 2002 May; 118(5):845-50. PMID: 11982763.
      View in: PubMed
    37. Li S, Stanley JR, Draper ML, Mirabile CP, Coleman FH, Mulvihill JJ. Rapid prenatal diagnosis of trisomies 13, 18, 21 and sex chromosome anomalies by fluorescence in situ hybridization: a year's experience. J Okla State Med Assoc. 2002 Apr; 95(4):244-6. PMID: 11957840.
      View in: PubMed
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