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Karla K Rodgers

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
Address940 Stanton L Young Blvd
Oklahoma City OK 73104-5020
Phone405/271-2227
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    Collapse Research 
    Collapse research activities and funding
    F32GM016039     (RODGERS, KARLA K)Oct 14, 1994
    NIH/NIGMS
    CYSTEINE-RICH REGION OF RAG-1
    Role: Principal Investigator

    R01AI054467     (RODGERS, KARLA K)Sep 15, 2003 - Dec 31, 2009
    NIH/NIAID
    Protein-DNA Interactions in V(D)J Recombination
    Role: Principal Investigator

    R21AI094141     (RODGERS, KARLA K)Aug 25, 2012 - Jul 31, 2014
    NIH/NIAID
    Regulation of the VDJ recombinase during genotoxic stress
    Role: Principal Investigator

    R03AI126001     (RODGERS, KARLA K)Jun 13, 2016 - May 31, 2018
    NIH/NIAID
    Single cell visualization of the V(D)J recombinase complex
    Role: Principal Investigator

    R21AI128137     (RODGERS, KARLA K)Jun 1, 2017 - May 31, 2019
    NIH/NIAID
    Nuclear export-dependent functions of RAG2 in the DNA damage response system
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rodgers KK. Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures. Trends Biochem Sci. 2017 Jan; 42(1):72-84. PMID: 27825771.
      View in: PubMed
    2. Ding XQ, Thapa A, Ma H, Xu J, Elliott MH, Rodgers KK, Smith ML, Wang JS, Pittler SJ, Kefalov VJ. The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility. J Biol Chem. 2016 Apr 15; 291(16):8721-34. PMID: 26893377; PMCID: PMC4861441 [Available on 04/15/17].
    3. Byrum JN, Zhao S, Rahman NS, Gwyn LM, Rodgers W, Rodgers KK. An interdomain boundary in RAG1 facilitates cooperative binding to RAG2 in formation of the V(D)J recombinase complex. Protein Sci. 2015 May; 24(5):861-73. PMID: 25676158; PMCID: PMC4420534.
    4. Rodgers W, Byrum JN, Sapkota H, Rahman NS, Cail RC, Zhao S, Schatz DG, Rodgers KK. Spatio-temporal regulation of RAG2 following genotoxic stress. DNA Repair (Amst). 2015 Mar; 27:19-27. PMID: 25625798; PMCID: PMC4336829.
    5. Awasthi S, Anbanandam A, Rodgers KK. Structure of a TLR4-interacting SPA4 peptide. RSC Adv. 2015; 5(35):27431-27438. PMID: 25870755.
      View in: PubMed
    6. Sheikh MO, Schafer CM, Powell JT, Rodgers KK, Mooers BH, West CM. Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein. Biochemistry. 2014 Mar 18; 53(10):1657-69. PMID: 24506136; PMCID: PMC3985704.
    7. Chakraborty D, Rodgers KK, Conley SM, Naash MI. Structural characterization of the second intra-discal loop of the photoreceptor tetraspanin RDS. FEBS J. 2013 Jan; 280(1):127-38. PMID: 23121719; PMCID: PMC3652632.
    8. Chollangi S, Mather T, Rodgers KK, Ash JD. A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. J Biol Chem. 2012 Sep 21; 287(39):32848-59. PMID: 22829597; PMCID: PMC3463309.
    9. Gupta VK, Rajala A, Rodgers KK, Rajala RV. Mechanism involved in the modulation of photoreceptor-specific cyclic nucleotidegated channel by the tyrosine kinase adapter protein Grb14. Protein Cell. 2011 Nov; 2(11):906-17. PMID: 22180090; PMCID: PMC3405905.
    10. Nikolaeva O, Moiseyev G, Rodgers KK, Ma JX. Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity. Biochem J. 2011 Jun 15; 436(3):591-7. PMID: 21446919.
      View in: PubMed
    11. Arbuckle JL, Rahman NS, Zhao S, Rodgers W, Rodgers KK. Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding. BMC Biochem. 2011 May 20; 12:23. PMID: 21599978; PMCID: PMC3124419.
    12. Matveev AV, Fitzgerald JB, Xu J, Malykhina AP, Rodgers KK, Ding XQ. The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change. Biochemistry. 2010 Mar 02; 49(8):1628-39. PMID: 20088482; PMCID: PMC2829136.
    13. Gwyn LM, Peak MM, De P, Rahman NS, Rodgers KK. A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity. J Mol Biol. 2009 Jul 31; 390(5):863-78. PMID: 19500590; PMCID: PMC2782368.
    14. Zhao S, Gwyn LM, De P, Rodgers KK. A non-sequence-specific DNA binding mode of RAG1 is inhibited by RAG2. J Mol Biol. 2009 Apr 03; 387(3):744-58. PMID: 19232525; PMCID: PMC2659343.
    15. De P, Zhao S, Gwyn LM, Godderz LJ, Peak MM, Rodgers KK. Thermal dependency of RAG1 self-association properties. BMC Biochem. 2008 Jan 30; 9:5. PMID: 18234093; PMCID: PMC2270275.
    16. Rahman NS, Godderz LJ, Stray SJ, Capra JD, Rodgers KK. DNA cleavage of a cryptic recombination signal sequence by RAG1 and RAG2. Implications for partial V(H) gene replacement. J Biol Chem. 2006 May 05; 281(18):12370-80. PMID: 16531612.
      View in: PubMed
    17. Zhu G, Zhai P, He X, Wakeham N, Rodgers K, Li G, Tang J, Zhang XC. Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5. EMBO J. 2004 Oct 13; 23(20):3909-17. PMID: 15457209; PMCID: PMC524345.
    18. Terzyan S, Wakeham N, Zhai P, Rodgers K, Zhang XC. Characterization of Lys-698-to-Met substitution in human plasminogen catalytic domain. Proteins. 2004 Aug 01; 56(2):277-84. PMID: 15211511.
      View in: PubMed
    19. De P, Rodgers KK. Putting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1. Immunol Rev. 2004 Aug; 200:70-82. PMID: 15242397.
      View in: PubMed
    20. De P, Peak MM, Rodgers KK. DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated. Mol Cell Biol. 2004 Aug; 24(15):6850-60. PMID: 15254250; PMCID: PMC444861.
    21. He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J. Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. Biochemistry. 2003 Oct 28; 42(42):12174-80. PMID: 14567678.
      View in: PubMed
    22. Godderz LJ, Rahman NS, Risinger GM, Arbuckle JL, Rodgers KK. Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase. Nucleic Acids Res. 2003 Apr 01; 31(7):2014-23. PMID: 12655019; PMCID: PMC152797.
    23. Peak MM, Arbuckle JL, Rodgers KK. The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer. J Biol Chem. 2003 May 16; 278(20):18235-40. PMID: 12644467.
      View in: PubMed
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