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Tracy Kent Teague

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentIntegrative Immunology Center
Address4502 E 41st St
Tulsa OK 74135-0001
Phone918/660-3921
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    Collapse Biography 
    Collapse education and training
    University of Texas Graduate School of Biomedical Sciences and MD Anderson Cancer Center, Houston, TXPhD1995Immunology
    Howard Hughes Medical Institute and National Jewish Medical and Research Center, Denver, COPosdoctoral1999Immunology

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    5P20RR015577-05     (CAPRA, J DONALD)Sep 30, 2000 - Jun 30, 2005
    NIH
    MENTORING IMMUNOLOGY IN OKLAHOMA--A BIOMEDICAL PROGRAM
    Role: Subproject Principal Investigator

    P20RR16478-02     (WAXMAN, FRANK J)Sep 1, 2002 - Aug 31, 2003
    NIH/NCRR
    Oklahoma BRIN subproject: Microarray analysis of gene expression profiles of developing thymocytes.
    Role: Subproject Prinicpal Investigator

    HR03-124     (TEAGUE, T KENT)Jul 1, 2003 - Jun 30, 2006
    Oklahoma Center for the Advancement of Science and Technology (OCAST)
    Differential IL-7 Signaling in T Cell Development
    Role: Principal Investigator

    HR07-095     (TEAGUE, T KENT)Aug 1, 2007 - Jul 31, 2010
    Oklahoma Center for the Advancement of Science and Technology (OCAST)
    MCL-1 Effects on T Cell Development and Homeostasis
    Role: Principal Investigator

    5P20RR016478-08 Sub-Project ID: 7223     (O'FARRELL, CAROLINE L)May 1, 2008 - Apr 30, 2009
    NIH/NCRR
    A COMPARISON OF SIGNALLING MOLECULES AND PATHWAYS IN THYMOCYTE DEVELOPMENT
    Role: Faculty sponsor

    2P20RR016478-09 Sub-Project ID: 6206     (O'FARRELL, CAROLINE LOUISE)May 1, 2009 - Mar 31, 2010
    NIH/NCRR
    A COMPARISON OF SIGNALLING MOLECULES AND PATHWAYS IN THYMOCYTE DEVELOPMENT
    Role: Faculty Sponsor

    HR09-166     (VAN DE WIELE, C JUSTIN)Aug 1, 2009 - Jun 30, 2012
    Oklahoma Center for the Advancement of Science and Technology (OCAST)
    In vitro development of T cells on engineered stroma
    Role: Co-Investigator

    10T-1401     (PRESKORN, SHELDON)Jul 1, 2011 - Jun 30, 2015
    Stanley Medical Research Institute
    Minocycline in the treatment of Bipolar Depression
    Role: Co-Investigator

    C1073607     (TEAGUE, T KENT)Aug 1, 2011 - Jul 1, 2015
    Oklahoma Tobacco Research Center
    Smoking, inflammation and neuromorphometric abnormalities in mood disorders
    Role: Principal Investigator

    R01MH098099     (BODURKA, JERZY ALEKSANDER)Sep 1, 2012 - Jul 31, 2016
    NIH
    Inflammatory Transcripts, Genes and Positive Valence System Function in Anhedonia
    Role: Co-Investigator

    1P20GM109097-01A1     (HAYS-GRUDO, JENNIFER)Jul 1, 2016 - Mar 31, 2021
    NIH
    Children's Health Equity Solutions Center (CHESC)
    Role: Biomarker Core Director

    HR16-003     (MILLER, KENNETH)Aug 1, 2016 - Jul 31, 2019
    Oklahoma Center for the Advancement of Science and Technology (OCAST)
    The role of glutamatergic sensory neurons in the initiation of and response to colitis.
    Role: Co-investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Meier TB, Drevets WC, Teague TK, Wurfel BE, Mueller SC, Bodurka J, Dantzer R, Savitz J. Kynurenic acid is reduced in females and oral contraceptive users: Implications for depression. Brain Behav Immun. 2017 Sep 01. PMID: 28867283.
      View in: PubMed
    2. Suzuki H, Savitz J, Kent Teague T, Gandhapudi SK, Tan C, Misaki M, McKinney BA, Irwin MR, Drevets WC, Bodurka J. Altered populations of natural killer cells, cytotoxic T lymphocytes, and regulatory T cells in major depressive disorder: Association with sleep disturbance. Brain Behav Immun. 2017 Nov; 66:193-200. PMID: 28645775.
      View in: PubMed
    3. Cho HJ, Savitz J, Dantzer R, Teague TK, Drevets WC, Irwin MR. Sleep disturbance and kynurenine metabolism in depression. J Psychosom Res. 2017 Aug; 99:1-7. PMID: 28712413.
      View in: PubMed
    4. Wurfel BE, Drevets WC, Bliss SA, McMillin JR, Suzuki H, Ford BN, Morris HM, Teague TK, Dantzer R, Savitz JB. Serum kynurenic acid is reduced in affective psychosis. Transl Psychiatry. 2017 May 02; 7(5):e1115. PMID: 28463241.
      View in: PubMed
    5. Meier TB, Lancaster MA, Mayer AR, Teague TK, Savitz J. Abnormalities in Functional Connectivity in Collegiate Football Athletes with and without a Concussion History: Implications and Role of Neuroactive Kynurenine Pathway Metabolites. J Neurotrauma. 2017 Feb 15; 34(4):824-837. PMID: 27618518.
      View in: PubMed
    6. Young KD, Drevets WC, Dantzer R, Teague TK, Bodurka J, Savitz J. Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression. Brain Behav Immun. 2016 Aug; 56:335-42. PMID: 27091600; PMCID: PMC4917447 [Available on 08/01/17].
    7. Meier TB, Savitz J, Singh R, Teague TK, Bellgowan PS. Smaller Dentate Gyrus and CA2 and CA3 Volumes Are Associated with Kynurenine Metabolites in Collegiate Football Athletes. J Neurotrauma. 2016 Jul 15; 33(14):1349-57. PMID: 26493952; PMCID: PMC4931724 [Available on 07/15/17].
    8. Meier TB, Bergamino M, Bellgowan PS, Teague TK, Ling JM, Jeromin A, Mayer AR. Longitudinal assessment of white matter abnormalities following sports-related concussion. Hum Brain Mapp. 2016 Feb; 37(2):833-45. PMID: 26663463.
      View in: PubMed
    9. Meier TB, Drevets WC, Wurfel BE, Ford BN, Morris HM, Victor TA, Bodurka J, Teague TK, Dantzer R, Savitz J. Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder. Brain Behav Immun. 2016 Mar; 53:39-48. PMID: 26546831; PMCID: PMC4783304 [Available on 03/01/17].
    10. Singh R, Savitz J, Teague TK, Polanski DW, Mayer AR, Bellgowan PS, Meier TB. Mood symptoms correlate with kynurenine pathway metabolites following sports-related concussion. J Neurol Neurosurg Psychiatry. 2016 Jun; 87(6):670-5. PMID: 26269650.
      View in: PubMed
    11. Savitz J, Dantzer R, Meier TB, Wurfel BE, Victor TA, McIntosh SA, Ford BN, Morris HM, Bodurka J, Teague TK, Drevets WC. Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder. Psychoneuroendocrinology. 2015 Dec; 62:54-8. PMID: 26232650; PMCID: PMC4637239 [Available on 12/01/16].
    12. Gandhapudi SK, Tan C, Marino JH, Taylor AA, Pack CC, Gaikwad J, Van De Wiele CJ, Wren JD, Teague TK. IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol. 2015 Apr 15; 194(8):3820-8. PMID: 25780034; PMCID: PMC4536257.
    13. Savitz J, Drevets WC, Wurfel BE, Ford BN, Bellgowan PS, Victor TA, Bodurka J, Teague TK, Dantzer R. Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder. Brain Behav Immun. 2015 May; 46:55-9. PMID: 25686798; PMCID: PMC4414807.
    14. Duffy FD, Miller-Cribbs JE, Clancy GP, Van De Wiele CJ, Teague TK, Crow S, Kollaja EA, Fox MD. Changing the culture of a medical school by orienting students and faculty toward community medicine. Acad Med. 2014 Dec; 89(12):1630-5. PMID: 25162616.
      View in: PubMed
    15. Savitz J, Dantzer R, Wurfel BE, Victor TA, Ford BN, Bodurka J, Bellgowan PS, Teague TK, Drevets WC. Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. Psychoneuroendocrinology. 2015 Feb; 52:200-11. PMID: 25486577; PMCID: PMC4297593.
    16. Savitz J, Drevets WC, Smith CM, Victor TA, Wurfel BE, Bellgowan PS, Bodurka J, Teague TK, Dantzer R. Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder. Neuropsychopharmacology. 2015 Jan; 40(2):463-71. PMID: 25074636; PMCID: PMC4443961.
    17. Singh R, Meier TB, Kuplicki R, Savitz J, Mukai I, Cavanagh L, Allen T, Teague TK, Nerio C, Polanski D, Bellgowan PS. Relationship of collegiate football experience and concussion with hippocampal volume and cognitive outcomes. JAMA. 2014 May 14; 311(18):1883-8. PMID: 24825643.
      View in: PubMed
    18. Savitz J, Frank MB, Victor T, Bebak M, Marino JH, Bellgowan PS, McKinney BA, Bodurka J, Kent Teague T, Drevets WC. Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain Behav Immun. 2013 Jul; 31:161-71. PMID: 23064081; PMCID: PMC3577998.
    19. Savitz J, Preskorn S, Teague TK, Drevets D, Yates W, Drevets W. Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2x2 clinical trial. BMJ Open. 2012; 2(1):e000643. PMID: 22357572; PMCID: PMC3289990.
    20. Tan C, Taylor AA, Coburn MZ, Marino JH, Van De Wiele CJ, Teague TK. Ten-color flow cytometry reveals distinct patterns of expression of CD124 and CD126 by developing thymocytes. BMC Immunol. 2011 Jun 20; 12:36. PMID: 21689450; PMCID: PMC3130696.
    21. Li X, Naylor MF, Le H, Nordquist RE, Teague TK, Howard CA, Murray C, Chen WR. Clinical effects of in situ photoimmunotherapy on late-stage melanoma patients: a preliminary study. Cancer Biol Ther. 2010 Dec 01; 10(11):1081-7. PMID: 20890121; PMCID: PMC3047103.
    22. Teague TK, Tan C, Marino JH, Davis BK, Taylor AA, Huey RW, Van De Wiele CJ. CD28 expression redefines thymocyte development during the pre-T to DP transition. Int Immunol. 2010 May; 22(5):387-97. PMID: 20203098.
      View in: PubMed
    23. Marino JH, Tan C, Taylor AA, Bentley C, Van De Wiele CJ, Ranne R, Paliotta M, Broughan TA, Teague TK. Differential IL-7 responses in developing human thymocytes. Hum Immunol. 2010 Apr; 71(4):329-33. PMID: 20074604; PMCID: PMC2896073.
    24. Marino JH, Tan C, Davis B, Han ES, Hickey M, Naukam R, Taylor A, Miller KS, Van De Wiele CJ, Teague TK. Disruption of thymopoiesis in ST6Gal I-deficient mice. Glycobiology. 2008 Sep; 18(9):719-26. PMID: 18535087; PMCID: PMC2733770.
    25. Van de Wiele CJ, Marino JH, Tan C, Kneale HA, Weber J, Morelli JN, Davis BK, Taylor AA, Teague TK. Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Cell Immunol. 2007 Nov-Dec; 250(1-2):31-9. PMID: 18321477; PMCID: PMC2430928.
    26. Broughan TA, Naukam R, Tan C, Van De Wiele CJ, Refai H, Teague TK. Effects of hepatic zonal oxygen levels on hepatocyte stress responses. J Surg Res. 2008 Mar; 145(1):150-60. PMID: 18164035.
      View in: PubMed
    27. Naylor MF, Chen WR, Teague TK, Perry LA, Nordquist RE. In situ photoimmunotherapy: a tumour-directed treatment for melanoma. Br J Dermatol. 2006 Dec; 155(6):1287-92. PMID: 17107404.
      View in: PubMed
    28. Marino JH, Van De Wiele CJ, Everhart JM, Masengale R, Naukam RJ, Schniederjan MJ, Vo S, Teague TK. Attenuation of cytokine responsiveness during T cell development and differentiation. J Interferon Cytokine Res. 2006 Oct; 26(10):748-59. PMID: 17032169.
      View in: PubMed
    29. Rao RS, Howard CA, Teague TK. Pulmonary endothelial permeability is increased by fluid from packed red blood cell units but not by fluid from clinically-available washed units. J Trauma. 2006 Apr; 60(4):851-8. PMID: 16612308.
      View in: PubMed
    30. Van De Wiele CJ, Marino JH, Murray BW, Vo SS, Whetsell ME, Teague TK. Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J Immunol. 2004 Apr 01; 172(7):4235-44. PMID: 15034036.
      View in: PubMed
    31. Van De Wiele CJ, Marino JH, Whetsell ME, Vo SS, Masengale RM, Teague TK. Loss of interferon-induced Stat1 phosphorylation in activated T cells. J Interferon Cytokine Res. 2004 Mar; 24(3):169-78. PMID: 15035850.
      View in: PubMed
    32. Naylor MF, Crowson N, Kuwahara R, Teague K, Garcia C, Mackinnis C, Haque R, Odom C, Jankey C, Cornelison RL. Treatment of lentigo maligna with topical imiquimod. Br J Dermatol. 2003 Nov; 149 Suppl 66:66-70. PMID: 14616356.
      View in: PubMed
    33. Woodside DG, Wooten DK, Teague TK, Miyamoto YJ, Caudell EG, Udagawa T, Andruss BF, McIntyre BW. Control of T lymphocyte morphology by the GTPase Rho. BMC Cell Biol. 2003 Feb 24; 4:2. PMID: 12600279; PMCID: PMC152646.
    34. Mitchell TC, Teague TK, Hildeman DA, Bender J, Rees WA, Kedl RM, Swanson B, Kappler JW, Marrack P. Stronger correlation of bcl-3 than bcl-2, bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival. Ann N Y Acad Sci. 2002 Dec; 975:114-31. PMID: 12538159.
      View in: PubMed
    35. Mitchell TC, Hildeman D, Kedl RM, Teague TK, Schaefer BC, White J, Zhu Y, Kappler J, Marrack P. Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nat Immunol. 2001 May; 2(5):397-402. PMID: 11323692.
      View in: PubMed
    36. Marrack P, Mitchell T, Hildeman D, Kedl R, Teague TK, Bender J, Rees W, Schaefer BC, Kappler J. Genomic-scale analysis of gene expression in resting and activated T cells. Curr Opin Immunol. 2000 Apr; 12(2):206-9. PMID: 10712937.
      View in: PubMed
    37. Teague TK, Schaefer BC, Hildeman D, Bender J, Mitchell T, Kappler JW, Marrack P. Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling. J Exp Med. 2000 Mar 20; 191(6):915-26. PMID: 10727454; PMCID: PMC2193120.
    38. McIntyre BW, Teague TK, Woodside DG, Wooten DK. Digital image analysis of lymphocyte activation. Methods Mol Biol. 2000; 134:257-63. PMID: 10730263.
      View in: PubMed
    39. Teague TK, Hildeman D, Kedl RM, Mitchell T, Rees W, Schaefer BC, Bender J, Kappler J, Marrack P. Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12691-6. PMID: 10535984; PMCID: PMC23052.
    40. Rees W, Bender J, Teague TK, Kedl RM, Crawford F, Marrack P, Kappler J. An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9781-6. PMID: 10449771; PMCID: PMC22287.
    41. Hildeman DA, Mitchell T, Teague TK, Henson P, Day BJ, Kappler J, Marrack PC. Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity. 1999 Jun; 10(6):735-44. PMID: 10403648.
      View in: PubMed
    42. Wooten DK, Teague TK, McIntyre BW. Separation of integrin-dependent adhesion from morphological changes based on differential PLC specificities. J Leukoc Biol. 1999 Jan; 65(1):127-36. PMID: 9886255.
      View in: PubMed
    43. Marrack P, Mitchell T, Bender J, Hildeman D, Kedl R, Teague K, Kappler J. T-cell survival. Immunol Rev. 1998 Oct; 165:279-85. PMID: 9850867.
      View in: PubMed
    44. Vella A, Teague TK, Ihle J, Kappler J, Marrack P. Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4. J Exp Med. 1997 Jul 21; 186(2):325-30. PMID: 9221762; PMCID: PMC2198981.
    45. Teague TK, Marrack P, Kappler JW, Vella AT. IL-6 rescues resting mouse T cells from apoptosis. J Immunol. 1997 Jun 15; 158(12):5791-6. PMID: 9190930.
      View in: PubMed
    46. Woodside DG, Teague TK, McIntyre BW. Specific inhibition of T lymphocyte coactivation by triggering integrin beta 1 reveals convergence of beta 1, beta 2, and beta 7 signaling pathways. J Immunol. 1996 Jul 15; 157(2):700-6. PMID: 8752919.
      View in: PubMed
    47. Szabo MC, Teague TK, McIntyre BW. Regulation of lymphocyte pseudopodia formation by triggering the integrin alpha 4/beta 1. J Immunol. 1995 Mar 01; 154(5):2112-24. PMID: 7868887.
      View in: PubMed
    48. Teague TK, Lazarovits AI, McIntyre BW. Integrin alpha 4 beta 7 co-stimulation of human peripheral blood T cell proliferation. Cell Adhes Commun. 1994 Dec; 2(6):539-47. PMID: 7743139.
      View in: PubMed
    49. Teague TK, McIntyre BW. MAb 18D3 triggering of integrin beta 1 will prevent but not terminate proliferation of human T cells. Cell Adhes Commun. 1994 Jun; 2(2):169-84. PMID: 7521762.
      View in: PubMed
    50. Teague TK, Munn L, Zygourakis K, McIntyre BW. Analysis of lymphocyte activation and proliferation by video microscopy and digital imaging. Cytometry. 1993 Oct; 14(7):772-82. PMID: 8243206.
      View in: PubMed
    51. Bednarczyk JL, Teague TK, Wygant JN, Davis LS, Lipsky PE, McIntyre BW. Regulation of T cell proliferation by anti-CD49d and anti-CD29 monoclonal antibodies. J Leukoc Biol. 1992 Oct; 52(4):456-62. PMID: 1383369.
      View in: PubMed
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