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Karen Lynn Abbott

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentStephenson Cancer Center
Phone405/271-8001
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    Collapse Biography 
    Collapse education and training
    Georgia College, Milledgeville, GABS1989Biology
    University of Georgia, Athens, GAPhD2004Biochemistry
    University of Georgia, Athens, GAPost Doc2009Complex Carbohydrate Research

    Collapse Research 
    Collapse research activities and funding
    R21CA229044     (ABBOTT, KAREN L.)Sep 12, 2018 - Aug 31, 2021
    NIH/NCI
    Novel Platform linking cancer-specific glycosylation with cell signaling outcomes
    Role: Principal Investigator

    U01CA226055     (ABBOTT, KAREN L.)Apr 18, 2018 - Mar 31, 2023
    NIH/NCI
    Glycomics Laboratory for the Development of Ovarian Cancer Biomarkers
    Role: Principal Investigator

    U01CA168870     (ABBOTT, KAREN L.)Sep 3, 2012 - Jun 30, 2017
    NIH/NCI
    Glycomics Laboratory for the Early Detection of Epithelial Ovarian Cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Murali P, Johnson BP, Lu Z, Climer L, Scott DA, Foulquier F, Oprea-Ilies G, Lupashin V, Drake RR, Abbott KL. Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma. Oncotarget. 2020 Jul 14; 11(28):2747-2762. PMID: 32733646.
      View in: PubMed
    2. Lu Z, Kamat K, Johnson BP, Yin CC, Scholler N, Abbott KL. Generation of a Fully Human scFv that binds Tumor-Specific Glycoforms. Sci Rep. 2019 03 25; 9(1):5101. PMID: 30911061.
      View in: PubMed
    3. Allam H, Johnson BP, Zhang M, Lu Z, Cannon MJ, Abbott KL. The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer. J Biol Chem. 2017 09 29; 292(39):16351-16359. PMID: 28842505.
      View in: PubMed
    4. Guo H, Abbott KL. Functional impact of tumor-specific N-linked glycan changes in breast and ovarian cancers. Adv Cancer Res. 2015; 126:281-303. PMID: 25727151.
      View in: PubMed
    5. Allam H, Aoki K, Benigno BB, McDonald JF, Mackintosh SG, Tiemeyer M, Abbott KL. Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions. J Proteome Res. 2015 Jan 02; 14(1):434-46. PMID: 25437919.
      View in: PubMed
    6. Dolezal S, Hester S, Kirby PS, Nairn A, Pierce M, Abbott KL. Elevated levels of glycosylphosphatidylinositol (GPI) anchored proteins in plasma from human cancers detected by C. septicum alpha toxin. Cancer Biomark. 2014 Jan 01; 14(1):55-62. PMID: 24643042.
      View in: PubMed
    7. Zhao P, Nairn AV, Hester S, Moremen KW, O'Regan RM, Oprea G, Wells L, Pierce M, Abbott KL. Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma. J Biol Chem. 2012 Jul 20; 287(30):25230-40. PMID: 22654114.
      View in: PubMed
    8. Dangaj D, Abbott KL, Mookerjee A, Zhao A, Kirby PS, Sandaltzopoulos R, Powell DJ, Lamazière A, Siegel DL, Wolf C, Scholler N. Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody. PLoS One. 2011; 6(12):e28386. PMID: 22163010.
      View in: PubMed
    9. Abbott KL, Lim JM, Wells L, Benigno BB, McDonald JF, Pierce M. Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis. Proteomics. 2010 Feb; 10(3):470-81. PMID: 19953551.
      View in: PubMed
    10. Abbott KL, Pierce JM. Lectin-based glycoproteomic techniques for the enrichment and identification of potential biomarkers. Methods Enzymol. 2010; 480:461-76. PMID: 20816222.
      View in: PubMed
    11. Abbott KL. Glycomic analysis of ovarian cancer: past, present, and future. Cancer Biomark. 2010-2011; 8(4-5):273-80. PMID: 22045358.
      View in: PubMed
    12. Yang A, Abbott KL, Desjardins A, Di Lello P, Omichinski JG, Legault P. NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase. Biochemistry. 2009 Mar 10; 48(9):1964-74. PMID: 19215094.
      View in: PubMed
    13. Abbott KL, Matthews RT, Pierce M. Receptor tyrosine phosphatase beta (RPTPbeta) activity and signaling are attenuated by glycosylation and subsequent cell surface galectin-1 binding. J Biol Chem. 2008 Nov 28; 283(48):33026-35. PMID: 18838383.
      View in: PubMed
    14. Abbott KL, Nairn AV, Hall EM, Horton MB, McDonald JF, Moremen KW, Dinulescu DM, Pierce M. Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer. Proteomics. 2008 Aug; 8(16):3210-20. PMID: 18690643.
      View in: PubMed
    15. Abbott KL, Aoki K, Lim JM, Porterfield M, Johnson R, O'Regan RM, Wells L, Tiemeyer M, Pierce M. Targeted glycoproteomic identification of biomarkers for human breast carcinoma. J Proteome Res. 2008 Apr; 7(4):1470-80. PMID: 18271524.
      View in: PubMed
    16. Abbott KL, Troupe K, Lee I, Pierce M. Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb. Exp Cell Res. 2006 Sep 10; 312(15):2837-50. PMID: 16857188.
      View in: PubMed
    17. Lee I, Guo HB, Kamar M, Abbott K, Troupe K, Lee JK, Alvarez-Manilla G, Pierce M. N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen. J Neurochem. 2006 May; 97(4):947-56. PMID: 16606368.
      View in: PubMed
    18. Abbott KL, Archambault J, Xiao H, Nguyen BD, Roeder RG, Greenblatt J, Omichinski JG, Legault P. Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1. Biochemistry. 2005 Mar 01; 44(8):2716-31. PMID: 15723517.
      View in: PubMed
    19. Abbott KL, Renfrow MB, Chalmers MJ, Nguyen BD, Marshall AG, Legault P, Omichinski JG. Enhanced binding of RNAP II CTD phosphatase FCP1 to RAP74 following CK2 phosphorylation. Biochemistry. 2005 Mar 01; 44(8):2732-45. PMID: 15723518.
      View in: PubMed
    20. Nguyen BD, Abbott KL, Potempa K, Kobor MS, Archambault J, Greenblatt J, Legault P, Omichinski JG. NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5688-93. PMID: 12732728.
      View in: PubMed
    21. Murphy TJ, Pavlath GK, Wang X, Boss V, Abbott KL, Robida AM, Nichols J, Xu K, Ellington ML, Loss JR. Retroviral vectors applied to gene regulation studies. Methods Enzymol. 2002; 345:539-51. PMID: 11665637.
      View in: PubMed
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