"Naphthoquinones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
| Descriptor ID |
D009285
|
| MeSH Number(s) |
D02.455.426.559.847.638.721 D02.806.550 D04.615.638.721
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Naphthoquinones".
Below are MeSH descriptors whose meaning is more specific than "Naphthoquinones".
This graph shows the total number of publications written about "Naphthoquinones" by people in this website by year, and whether "Naphthoquinones" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Naphthoquinones" by people in Profiles.
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Perspectives on mechanistic implications of ROS inducers for targeting viral infections. Eur J Pharmacol. 2021 Jan 05; 890:173621.
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A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species. J Med Chem. 2020 09 10; 63(17):9838-9855.
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Fabrication of juglone functionalized silver nanoparticle stabilized collagen scaffolds for pro-wound healing activities. Int J Biol Macromol. 2019 Mar 01; 124:1002-1015.
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Increased sensitivity of BRCA defective triple negative breast tumors to plumbagin through induction of DNA Double Strand Breaks (DSB). Sci Rep. 2016 05 25; 6:26631.
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Plumbagin, a naphthaquinone derivative induces apoptosis in BRCA 1/2 defective castrate resistant prostate cancer cells as well as prostate cancer stem-like cells. Pharmacol Res. 2016 Mar; 105:134-45.
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Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer. Sci Rep. 2015 May 14; 5:10194.
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Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers. Antioxid Redox Signal. 2014 Jul 10; 21(2):237-50.
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Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases. Crit Rev Eukaryot Gene Expr. 2014; 24(1):15-28.
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Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivo. Int J Cancer. 2013 Mar 01; 132(5):1201-12.
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Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold. Bioorg Med Chem. 2009 Jan 15; 17(2):634-40.