Methotrexate

"Methotrexate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Descriptor ID	D008727
MeSH Number(s)	D03.633.100.733.631.192.500
Concept/Terms	Methotrexate Methotrexate Amethopterin Methotrexate, (D)-Isomer Methotrexate, (D)-Isomer Methotrexate, (DL)-Isomer Methotrexate, (DL)-Isomer Mexate Mexate Methotrexate Sodium Methotrexate Sodium Sodium, Methotrexate Methotrexate, Sodium Salt Methotrexate, Disodium Salt Methotrexate Hydrate Methotrexate Hydrate Hydrate, Methotrexate Methotrexate, Dicesium Salt Methotrexate, Dicesium Salt Dicesium Salt Methotrexate

Below are MeSH descriptors whose meaning is more general than "Methotrexate".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Pteridines [D03.633.100.733]
Pterins [D03.633.100.733.631]
Aminopterin [D03.633.100.733.631.192]
Methotrexate [D03.633.100.733.631.192.500]

Below are MeSH descriptors whose meaning is related to "Methotrexate".

Below are MeSH descriptors whose meaning is more specific than "Methotrexate".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Methotrexate" by people in this website by year, and whether "Methotrexate" was a major or minor topic of these publications.

Bar chart showing 25 publications over 17 distinct years, with a maximum of 3 publications in 2005 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	1	2
1997	0	1	1
1999	0	1	1
2003	1	0	1
2005	0	3	3
2006	1	1	2
2008	0	1	1
2009	1	0	1
2011	1	1	2
2012	1	0	1
2013	0	2	2
2014	1	2	3
2015	1	0	1
2017	0	1	1
2018	1	0	1
2019	1	0	1
2020	0	1	1

Below are the most recent publications written about "Methotrexate" by people in Profiles.

Advani AS, Moseley A, O'Dwyer KM, Wood BL, Fang M, Wieduwilt MJ, Aldoss I, Park JH, Klisovic RB, Baer MR, Stock W, Bhave RR, Othus M, Harvey RC, Willman CL, Litzow MR, Stone RM, Sharon E, Erba HP. SWOG 1318: A Phase II Trial of Blinatumomab Followed by POMP Maintenance in Older Patients With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia. J Clin Oncol. 2022 May 10; 40(14):1574-1582.

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Barnhart KT, Hansen KR, Stephenson MD, Usadi R, Steiner AZ, Cedars MI, Jungheim ES, Hoeger KM, Krawetz SA, Mills B, Alston M, Coutifaris C, Senapati S, Sonalkar S, Diamond MP, Wild RA, Rosen M, Sammel MD, Santoro N, Eisenberg E, Huang H, Zhang H. Effect of an Active vs Expectant Management Strategy on Successful Resolution of Pregnancy Among Patients With a Persisting Pregnancy of Unknown Location: The ACT or NOT Randomized Clinical Trial. JAMA. 2021 08 03; 326(5):390-400.

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D'Andrea D, Matin S, Black PC, Petros FG, Zargar H, Dinney CP, Cookson MS, Kassouf W, Dall'Era MA, McGrath JS, Wright JL, Thorpe AC, Morgan TM, Holzbeierlein JM, Bivalacqua TJ, Sridhar SS, North S, Barocas DA, Lotan Y, Stephenson AJ, van Rhijn BW, Spiess PE, Daneshmand S, Shariat SF. Comparative effectiveness of neoadjuvant chemotherapy in bladder and upper urinary tract urothelial carcinoma. BJU Int. 2021 05; 127(5):528-537.

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Lee KR, Bershow A, Crowson AN. Elephantiasis nostras verrucosa secondary to scleroderma. Cutis. 2019 02; 103(2):E4-E6.

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Barnhart KT, Sammel MD, Stephenson M, Robins J, Hansen KR, Youssef WA, Santoro N, Eisenberg E, Zhang H. Optimal treatment for women with a persisting pregnancy of unknown location, a randomized controlled trial: The ACT-or-NOT trial. Contemp Clin Trials. 2018 10; 73:145-151.

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Pratap S, Pokala HR, Meyer WH, Gehrs BC, Palacios MF. Diffuse Marrow Involvement in Metastatic Osteosarcoma: An Unusual Presentation. J Oncol Pract. 2017 06; 13(6):401-403.

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Pulivarthi S, Reshi RA, McGary CT, Gurram MK. Cerebral toxoplasmosis in a patient on methotrexate and infliximab for rheumatoid arthritis. Intern Med. 2015; 54(11):1433-6.

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Zargar H, Espiritu PN, Fairey AS, Mertens LS, Dinney CP, Mir MC, Krabbe LM, Cookson MS, Jacobsen NE, Gandhi NM, Griffin J, Montgomery JS, Vasdev N, Yu EY, Youssef D, Xylinas E, Campain NJ, Kassouf W, Dall'Era MA, Seah JA, Ercole CE, Horenblas S, Sridhar SS, McGrath JS, Aning J, Shariat SF, Wright JL, Thorpe AC, Morgan TM, Holzbeierlein JM, Bivalacqua TJ, North S, Barocas DA, Lotan Y, Garcia JA, Stephenson AJ, Shah JB, van Rhijn BW, Daneshmand S, Spiess PE, Black PC. Multicenter assessment of neoadjuvant chemotherapy for muscle-invasive bladder cancer. Eur Urol. 2015 Feb; 67(2):241-9.

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Wallace CA, Ringold S, Bohnsack J, Spalding SJ, Brunner HI, Milojevic D, Schanberg LE, Higgins GC, O'Neil KM, Gottlieb BS, Hsu J, Punaro MG, Kimura Y, Hendrickson A. Extension study of participants from the trial of early aggressive therapy in juvenile idiopathic arthritis. J Rheumatol. 2014 Dec; 41(12):2459-65.

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Goldman S, Smith L, Galardy P, Perkins SL, Frazer JK, Sanger W, Anderson JR, Gross TG, Weinstein H, Harrison L, Shiramizu B, Barth M, Cairo MS. Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: a Children's Oncology Group Report. Br J Haematol. 2014 Nov; 167(3):394-401.

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