Platelet Activating Factor
"Platelet Activating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.
|Platelet Activating Factor
- Platelet Activating Factor
- Factor, Platelet Activating
- Phosphorylcholine, Acetyl Glyceryl Ether
- Platelet Aggregating Factor
- Aggregating Factor, Platelet
- Platelet Aggregation Enhancing Factor
- Thrombocyte Aggregating Activity
- 1 Alkyl 2 acetyl sn glycerophosphocholine
- Acetyl Glyceryl Ether Phosphorylcholine
- PAF Acether
- Platelet-Activating Substance
- Platelet Activating Substance
Below are MeSH descriptors whose meaning is more general than "Platelet Activating Factor".
Below are MeSH descriptors whose meaning is more specific than "Platelet Activating Factor".
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Below are the most recent publications written about "Platelet Activating Factor" by people in Profiles.
Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. J Biol Chem. 2004 Oct 22; 279(43):44606-12.
Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation. Surgery. 2003 Jul; 134(1):86-91.
Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. J Biol Chem. 2002 Jun 21; 277(25):22685-91.
Blood transfusion and the two-insult model of post-injury multiple organ failure. Shock. 2001 Apr; 15(4):302-6.
Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling. Shock. 2000 Sep; 14(3):265-9; discussion 269-70.
Fluorescein derivatization of fibrinogen for flow cytometric analysis of fibrinogen binding to platelets. Cytometry. 1994 Dec 01; 17(4):287-93.
Synthesis of 1-acyl-2-[3H]acetyl-SN-glycero-3-phosphocholine, a structural analog of platelet activating factor, by vascular endothelial cells. Biochem Biophys Res Commun. 1991 May 15; 176(3):1557-64.