"Phenytoin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
| Descriptor ID |
D010672
|
| MeSH Number(s) |
D03.383.129.308.432.555.730
|
| Concept/Terms |
Phenytoin- Phenytoin
- 5,5-Diphenylhydantoin
- Fenitoin
- 5,5-diphenylimidazolidine-2,4-dione
- Diphenylhydantoin
Phenytoin Sodium- Phenytoin Sodium
- Sodium Diphenylhydantoinate
- Diphenylhydantoinate, Sodium
|
Below are MeSH descriptors whose meaning is more general than "Phenytoin".
Below are MeSH descriptors whose meaning is more specific than "Phenytoin".
This graph shows the total number of publications written about "Phenytoin" by people in this website by year, and whether "Phenytoin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 2 | 0 | 2 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phenytoin" by people in Profiles.
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Phenytoin versus Leviteracetam for seizure prophylaxis after brain injury - a meta analysis. BMC Neurol. 2012 May 29; 12:30.
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A confusing case of confusion. Acute porphyrias. J Okla State Med Assoc. 2008 Apr; 101(4):85-6, 89-90.
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Three-day phenytoin prophylaxis is adequate after subarachnoid hemorrhage. Neurosurgery. 2007 Jan; 60(1):99-102; discussion 102-3.
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Neuropsychiatric manifestations of phenytoin toxicity in an elderly patient. J Psychiatr Pract. 2007 Jan; 13(1):49-54.
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A case of phenytoin hypersensitivity syndrome. J Drugs Dermatol. 2002 Sep; 1(2):199-201.
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Effect of pH on the equilibrium dialysis of phenytoin suspension with and without enteral feeding formula. JPEN J Parenter Enteral Nutr. 1990 May-Jun; 14(3):275-8.
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Recovery of phenytoin suspension after in vitro administration through percutaneous endoscopic gastrostomy Pezzer catheters. Am J Hosp Pharm. 1990 Feb; 47(2):373-7.
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Gastritis with valproate therapy. Arch Neurol. 1988 Aug; 45(8):903-5.
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Pharmacological effects of enantiomers of 4-amino-N-(alpha-methylbenzyl)benzamide, a chemically novel anticonvulsant. Epilepsia. 1988 Jan-Feb; 29(1):83-90.
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Effect of diphenylhydantoin on acetyl strophanthidin. Am Heart J. 1971 Apr; 81(4):577.