Phosphogluconate Dehydrogenase
"Phosphogluconate Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to yield D-ribulose 5-phosphate, carbon dioxide, and NADPH. The reaction is a step in the pentose phosphate pathway of glucose metabolism. (From Dorland, 27th ed) EC 1.1.1.43.
| Descriptor ID |
D010734
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| MeSH Number(s) |
D08.811.682.047.150.600
|
| Concept/Terms |
Phosphogluconate Dehydrogenase- Phosphogluconate Dehydrogenase
- Dehydrogenase, Phosphogluconate
- 6-Phosphogluconate Dehydrogenase
- 6 Phosphogluconate Dehydrogenase
- Dehydrogenase, 6-Phosphogluconate
|
Below are MeSH descriptors whose meaning is more general than "Phosphogluconate Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "Phosphogluconate Dehydrogenase".
This graph shows the total number of publications written about "Phosphogluconate Dehydrogenase" by people in this website by year, and whether "Phosphogluconate Dehydrogenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 4 | 1 | 5 |
| 1999 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 3 | 0 | 3 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phosphogluconate Dehydrogenase" by people in Profiles.
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Proper orientation of the nicotinamide ring of NADP is important for the precatalytic conformational change in the 6-phosphogluconate dehydrogenase reaction. Biochemistry. 2008 Feb 19; 47(7):1862-70.
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Role of the S128, H186, and N187 triad in substrate binding and decarboxylation in the sheep liver 6-phosphogluconate dehydrogenase reaction. Biochemistry. 2006 Oct 24; 45(42):12680-6.
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The 2'-phosphate of NADP is responsible for proper orientation of the nicotinamide ring in the oxidative decarboxylation reaction catalyzed by sheep liver 6-phosphogluconate dehydrogenase. J Biol Chem. 2006 Dec 01; 281(48):36803-10.
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Importance in catalysis of the 6-phosphate-binding site of 6-phosphogluconate in sheep liver 6-phosphogluconate dehydrogenase. J Biol Chem. 2006 Sep 01; 281(35):25568-76.
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Role of methionine-13 in the catalytic mechanism of 6-phosphogluconate dehydrogenase from sheep liver. Biochemistry. 2005 Feb 22; 44(7):2432-40.
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Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalyzed reaction. Biochemistry. 1999 Aug 31; 38(35):11231-8.
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Multiple isotope effects as a probe of proton and hydride transfer in the 6-phosphogluconate dehydrogenase reaction. Biochemistry. 1998 Nov 10; 37(45):15698-702.
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Glutamate 190 is a general acid catalyst in the 6-phosphogluconate-dehydrogenase-catalyzed reaction. Biochemistry. 1998 Nov 10; 37(45):15691-7.
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Oxidative decarboxylation of 6-phosphogluconate by 6-phosphogluconate dehydrogenase proceeds by a stepwise mechanism with NADP and APADP as oxidants. Biochemistry. 1998 Sep 08; 37(36):12596-602.
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Cloning, expression, purification, and characterization of the 6-phosphogluconate dehydrogenase from sheep liver. Protein Expr Purif. 1998 Jul; 13(2):251-8.