"Pirenzepine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
| Descriptor ID |
D010890
|
| MeSH Number(s) |
D03.633.100.079.080.070.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Pirenzepine".
Below are MeSH descriptors whose meaning is more specific than "Pirenzepine".
This graph shows the total number of publications written about "Pirenzepine" by people in this website by year, and whether "Pirenzepine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pirenzepine" by people in Profiles.
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Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats. Behav Brain Res. 2012 Feb 01; 227(1):258-64.
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Two-year multicenter, randomized, double-masked, placebo-controlled, parallel safety and efficacy study of 2% pirenzepine ophthalmic gel in children with myopia. J AAPOS. 2008 Aug; 12(4):332-9.
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Safety and efficacy of 2% pirenzepine ophthalmic gel in children with myopia: a 1-year, multicenter, double-masked, placebo-controlled parallel study. Arch Ophthalmol. 2004 Nov; 122(11):1667-74.
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Autonomic modulation during acute myocardial ischemia by low-dose pirenzepine in conscious dogs with a healed myocardial infarction: a comparison with beta-adrenergic blockade. J Cardiovasc Pharmacol. 2003 May; 41(5):671-7.
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Psychiatric symptoms in a case of intracranial tuberculosis. Psychosomatics. 2002 Jan-Feb; 43(1):82-4.
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Presynaptic muscarinic receptors modulate acetylcholine release from rat antral mucosal/submucosal nerves. Dig Dis Sci. 1994 May; 39(5):1099-106.
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Comparison of adrenergic and cholinergic receptor-mediated stimulation of gastrin release from rat antral fragments. Peptides. 1988 May-Jun; 9(3):463-8.
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Cholinergic mediation of gamma-aminobutyric acid-induced gastrin and somatostatin release from rat antrum. Gastroenterology. 1986 Nov; 91(5):1221-6.