"Tissue Distribution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
| Descriptor ID |
D014018
|
| MeSH Number(s) |
G03.787.917 G07.690.725.949
|
| Concept/Terms |
Tissue Distribution- Tissue Distribution
- Distribution, Tissue
- Distributions, Tissue
- Tissue Distributions
|
Below are MeSH descriptors whose meaning is more general than "Tissue Distribution".
Below are MeSH descriptors whose meaning is more specific than "Tissue Distribution".
This graph shows the total number of publications written about "Tissue Distribution" by people in this website by year, and whether "Tissue Distribution" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 4 | 4 |
| 1999 | 0 | 4 | 4 |
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 10 | 10 |
| 2004 | 0 | 9 | 9 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 5 | 5 |
| 2011 | 0 | 4 | 4 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 3 | 3 |
| 2014 | 1 | 2 | 3 |
| 2016 | 0 | 3 | 3 |
| 2017 | 0 | 4 | 4 |
| 2018 | 0 | 3 | 3 |
| 2019 | 0 | 4 | 4 |
| 2020 | 0 | 4 | 4 |
| 2022 | 1 | 2 | 3 |
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Below are the most recent publications written about "Tissue Distribution" by people in Profiles.
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Gold Nanoparticles Disrupt the IGFBP2/mTOR/PTEN Axis to Inhibit Ovarian Cancer Growth. Adv Sci (Weinh). 2022 11; 9(31):e2200491.
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Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice. Int J Mol Sci. 2022 Jul 09; 23(14).
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Positron Emission Tomography (PET) with 18F-FGA for Diagnosis of Myocardial Infarction in a Coronary Artery Ligation Model. Mol Imaging. 2022; 2022:9147379.
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Analysis of topical dosing and administration effects on ocular drug delivery in a human eyeball model using computational fluid dynamics. Comput Biol Med. 2022 02; 141:105016.
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Phase IB Study of Osimertinib in Combination with Navitoclax in EGFR-mutant NSCLC Following Resistance to Initial EGFR Therapy (ETCTN 9903). Clin Cancer Res. 2021 03 15; 27(6):1604-1611.
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Oral GLP1 Gene Delivery by an Antibody-Guided Nanomaterial to Treat Type 2 Diabetes Mellitus. ACS Appl Mater Interfaces. 2020 Sep 02; 12(35):38925-38935.
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Intelligent micro-/nanorobots as drug and cell carrier devices for biomedical therapeutic advancement: Promising development opportunities and translational challenges. Biomaterials. 2020 11; 260:120163.
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Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice. AAPS J. 2020 02 21; 22(2):51.
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Extracellular Vesicles As Nanomedicine: Hopes And Hurdles In Clinical Translation. Int J Nanomedicine. 2019; 14:8847-8859.
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Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib/randomized phase II trial. Ann Oncol. 2019 10 01; 30(10):1613-1621.