Tissue Distribution

"Tissue Distribution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Descriptor ID	D014018
MeSH Number(s)	G03.787.917 G07.690.725.949
Concept/Terms	Tissue Distribution Tissue Distribution Distribution, Tissue Distributions, Tissue Tissue Distributions

Below are MeSH descriptors whose meaning is more general than "Tissue Distribution".

Biological Sciences [G]
Metabolism [G03]
Pharmacokinetics [G03.787]
Tissue Distribution [G03.787.917]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacokinetics [G07.690.725]
Tissue Distribution [G07.690.725.949]

Below are MeSH descriptors whose meaning is related to "Tissue Distribution".

Below are MeSH descriptors whose meaning is more specific than "Tissue Distribution".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tissue Distribution" by people in this website by year, and whether "Tissue Distribution" was a major or minor topic of these publications.

Bar chart showing 104 publications over 28 distinct years, with a maximum of 12 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1991	0	1	1
1992	0	1	1
1994	0	4	4
1995	0	3	3
1996	0	3	3
1997	0	2	2
1998	0	4	4
1999	0	6	6
2000	0	1	1
2001	0	1	1
2002	0	3	3
2003	0	12	12
2004	0	10	10
2005	0	2	2
2006	0	5	5
2007	0	6	6
2008	0	2	2
2009	0	1	1
2010	0	5	5
2011	0	4	4
2012	0	2	2
2013	0	4	4
2014	1	4	5
2016	0	4	4
2017	0	5	5
2018	0	3	3
2019	0	4	4
2020	0	1	1

Below are the most recent publications written about "Tissue Distribution" by people in Profiles.

Sharma A, Li M, Thavathiru E, Ibrahim M, Garcia-Contreras L, Benbrook DM, Woo S. Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice. AAPS J. 2020 02 21; 22(2):51.

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Weiss JM, Csoszi T, Maglakelidze M, Hoyer RJ, Beck JT, Domine Gomez M, Lowczak A, Aljumaily R, Rocha Lima CM, Boccia RV, Hanna W, Nikolinakos P, Chiu VK, Owonikoko TK, Schuster SR, Hussein MA, Richards DA, Sawrycki P, Bulat I, Hamm JT, Hart LL, Adler S, Antal JM, Lai AY, Sorrentino JA, Yang Z, Malik RK, Morris SR, Roberts PJ, Dragnev KH. Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib/randomized phase II trial. Ann Oncol. 2019 10 01; 30(10):1613-1621.

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Freedman RA, Gelman RS, Agar NYR, Santagata S, Randall EC, Gimenez-Cassina Lopez B, Connolly RM, Dunn IF, Van Poznak CH, Anders CK, Melisko ME, Silvestri K, Cotter CM, Componeschi KP, Marte JM, Moy B, Blackwell KL, Puhalla SL, Ibrahim N, Moynihan TJ, Nangia J, Tung N, Burns R, Rimawi MF, Krop IE, Wolff AC, Winer EP, Lin NU. Pre- and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022. Clin Breast Cancer. 2020 04; 20(2):145-151.e2.

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Burke BP, Miranda CS, Lee RE, Renard I, Nigam S, Clemente GS, D'Huys T, Ruest T, Domarkas J, Thompson JA, Hubin TJ, Schols D, Cawthorne CJ, Archibald SJ. 64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist. J Nucl Med. 2020 01; 61(1):123-128.

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Au JL, Lu Z, Abbiati RA, Wientjes MG. Systemic Bioequivalence Is Unlikely to Equal Target Site Bioequivalence for Nanotechnology Oncologic Products. AAPS J. 2019 02 01; 21(2):24.

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Jimeno A, Moore KN, Gordon M, Chugh R, Diamond JR, Aljumaily R, Mendelson D, Kapoun AM, Xu L, Stagg R, Smith DC. A first-in-human phase 1a study of the bispecific anti-DLL4/anti-VEGF antibody navicixizumab (OMP-305B83) in patients with previously treated solid tumors. Invest New Drugs. 2019 06; 37(3):461-472.

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Virani NA, Davis C, McKernan P, Hauser P, Hurst RE, Slaton J, Silvy RP, Resasco DE, Harrison RG. Phosphatidylserine targeted single-walled carbon nanotubes for photothermal ablation of bladder cancer. Nanotechnology. 2018 Jan 19; 29(3):035101.

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Cheki M, Papie M, Mansi L, Kitson S, Gali H. Preliminary Human Radiation Dose Estimates of PET Renal Agents, Para-18F-Fluorohippuric Acid and Ortho-124I-Iodohippuric Acid from Rat Biodistribution Data. Curr Radiopharm. 2018; 11(1):58-63.

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Houson HA, Nkepang GN, Hedrick AF, Awasthi V. Imaging of isoproterenol-induced myocardial injury with 18F labeled fluoroglucaric acid in a rat model. Nucl Med Biol. 2018 04; 59:9-15.

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Williams KM, Holter-Chakrabarty J, Lindenberg L, Duong Q, Vesely SK, Nguyen CT, Havlicek JP, Kurdziel K, Gea-Banacloche J, Lin FI, Avila DN, Selby G, Kanakry CG, Li S, Scordino T, Adler S, Bollard CM, Choyke P, Gress RE. Imaging of subclinical haemopoiesis after stem-cell transplantation in patients with haematological malignancies: a prospective pilot study. Lancet Haematol. 2018 Jan; 5(1):e44-e52.

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