"Receptors, Opioid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.
| Descriptor ID |
D011957
|
| MeSH Number(s) |
D12.776.543.750.695.620 D12.776.543.750.720.600.610 D12.776.543.750.750.555.610
|
| Concept/Terms |
Receptors, Opioid- Receptors, Opioid
- Opiate Receptors
- Opioid Receptor
- Receptor, Opioid
- Opioid Receptors
- Opiate Receptor
- Receptor, Opiate
- Receptors, Opiate
Enkephalin Receptor- Enkephalin Receptor
- Receptor, Enkephalin
- Receptors, Enkephalin
- Enkephalin Receptors
beta-Endorphin Receptor- beta-Endorphin Receptor
- Receptor, beta-Endorphin
- beta Endorphin Receptor
- Receptors, beta-Endorphin
- Receptors, beta Endorphin
- beta-Endorphin Receptors
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Opioid".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Opioid [D12.776.543.750.695.620]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Neuropeptide [D12.776.543.750.720.600]
- Receptors, Opioid [D12.776.543.750.720.600.610]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Neuropeptide [D12.776.543.750.750.555]
- Receptors, Opioid [D12.776.543.750.750.555.610]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Opioid".
This graph shows the total number of publications written about "Receptors, Opioid" by people in this website by year, and whether "Receptors, Opioid" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 0 | 2 |
| 1996 | 2 | 1 | 3 |
| 1997 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 2 | 1 | 3 |
| 2003 | 2 | 0 | 2 |
| 2007 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Receptors, Opioid" by people in Profiles.
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Standifer KM, Inturrisi CE, Foley KM, Pan YX. Understanding Opioid Actions, Pain and Analgesia: A Tribute to Dr. Gavril Pasternak. Cell Mol Neurobiol. 2021 Jul; 41(5):827-834.
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Awwad HO, Durand CD, Gonzalez LP, Tompkins P, Zhang Y, Lerner MR, Brackett DJ, Sherry DM, Awasthi V, Standifer KM. Post-blast treatment with Nociceptin/Orphanin FQ peptide (NOP) receptor antagonist reduces brain injury-induced hypoxia and signaling proteins in vestibulomotor-related brain regions. Behav Brain Res. 2018 03 15; 340:183-194.
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Zhang Y, Simpson-Durand CD, Standifer KM. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. Br J Pharmacol. 2015 Jan; 172(2):571-82.
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Donica CL, Awwad HO, Thakker DR, Standifer KM. Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ. Mol Pharmacol. 2013 May; 83(5):907-18.
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Stevens CW, Brasel CM, Mohan S. Cloning and bioinformatics of amphibian mu, delta, kappa, and nociceptin opioid receptors expressed in brain tissue: evidence for opioid receptor divergence in mammals. Neurosci Lett. 2007 Jun 04; 419(3):189-94.
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Mandyam CD, Thakker DR, Standifer KM. Mu-opioid-induced desensitization of opioid receptor-like 1 and mu-opioid receptors: differential intracellular signaling determines receptor sensitivity. J Pharmacol Exp Ther. 2003 Sep; 306(3):965-72.
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Thakker DR, Ozsoy HZ, Standifer KM. Assessing opioid regulation of adenylyl cyclase activity in intact cells. Methods Mol Med. 2003; 84:29-37.
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Thakker DR, Standifer KM. Induction of G protein-coupled receptor kinases 2 and 3 contributes to the cross-talk between mu and ORL1 receptors following prolonged agonist exposure. Neuropharmacology. 2002 Nov; 43(6):979-90.
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Thakker DR, Standifer KM. Orphanin FQ/nociceptin blocks chronic morphine-induced tyrosine hydroxylase upregulation. Brain Res Mol Brain Res. 2002 Sep 30; 105(1-2):38-46.
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Mandyam CD, Thakker DR, Christensen JL, Standifer KM. Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. J Pharmacol Exp Ther. 2002 Aug; 302(2):502-9.