"1-Methyl-4-phenylpyridinium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
- 1 Methyl 4 phenylpyridinium
- 1 Methyl 4 phenylpyridine
- N Methyl 4 phenylpyridine
- 1-Methyl-4-phenylpyridinium Ion
- 1 Methyl 4 phenylpyridinium Ion
Below are MeSH descriptors whose meaning is more general than "1-Methyl-4-phenylpyridinium".
Below are MeSH descriptors whose meaning is more specific than "1-Methyl-4-phenylpyridinium".
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Below are the most recent publications written about "1-Methyl-4-phenylpyridinium" by people in Profiles.
A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics tools. BMC Bioinformatics. 2005 Jul 15; 6 Suppl 2:S8.
Azulenyl nitrone spin traps protect against MPTP neurotoxicity. Exp Neurol. 1998 Jul; 152(1):163-6.