"Spliceosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Organelles in which the splicing and excision reactions that remove introns from precursor messenger RNA molecules occur. One component of a spliceosome is five small nuclear RNA molecules (U1, U2, U4, U5, U6) that, working in conjunction with proteins, help to fold pieces of RNA into the right shapes and later splice them into the message.
| Descriptor ID |
D017381
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| MeSH Number(s) |
A11.284.430.106.279.345.850
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Spliceosomes".
Below are MeSH descriptors whose meaning is more specific than "Spliceosomes".
This graph shows the total number of publications written about "Spliceosomes" by people in this website by year, and whether "Spliceosomes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 1 | 2 |
| 2002 | 1 | 1 | 2 |
| 2004 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Spliceosomes" by people in Profiles.
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Intron distribution and emerging role of alternative splicing in fungi. FEMS Microbiol Lett. 2021 10 26; 368(19).
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Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Neuron. 2021 01 20; 109(2):241-256.e9.
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Introns and splicing elements of five diverse fungi. Eukaryot Cell. 2004 Oct; 3(5):1088-100.
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Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3551-6.
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Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE. Scand J Immunol. 2002 Oct; 56(4):399-407.
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Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens. J Immunol. 2002 Feb 15; 168(4):2054-62.
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A limited lupus anti-spliceosomal response targets a cross-reactive, proline-rich motif. J Autoimmun. 1998 Oct; 11(5):431-8.
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B-cell epitope spreading in autoimmunity. Immunol Rev. 1998 Aug; 164:185-200.
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Human lupus anti-spliceosome A protein autoantibodies bind contiguous surface structures and segregate into two sequential epitope binding patterns. J Immunol. 1996 May 15; 156(10):4018-26.
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Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B'-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity. J Exp Med. 1995 Feb 01; 181(2):453-61.