Bisphosphonates Zometa and Fosamax Synergize with Metformin to Prevent AOM-Induced Colon Cancer in F344 Rat Model.
Madka V, Kumar G, Pathuri G, Zhang Y, Lightfoot S, Asch AS, Mohammed A, Steele VE, Rao CV. Bisphosphonates Zometa and Fosamax Synergize with Metformin to Prevent AOM-Induced Colon Cancer in F344 Rat Model. Cancer Prev Res (Phila). 2020 02; 13(2):185-194.
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Administration, Oral
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Administration, Oral
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Alendronate
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Alendronate
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Animals
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Animals
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Anticarcinogenic Agents
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Anticarcinogenic Agents
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Apoptosis
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Apoptosis
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Azoxymethane
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Azoxymethane
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Cell Proliferation
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Cell Proliferation
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Colonic Neoplasms
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Colonic Neoplasms
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Dose-Response Relationship, Drug
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Dose-Response Relationship, Drug
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Drug Synergism
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Drug Synergism
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Drug Therapy, Combination
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Drug Therapy, Combination
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Humans
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Humans
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Male
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Male
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Metformin
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Metformin
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Neoplasms, Experimental
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Neoplasms, Experimental
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Rats
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Rats
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Rats, Inbred F344
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Rats, Inbred F344