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Jessie Lai-Sim Au

TitleProf of Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
AddressCPB 303
1110 N Stonewall Ave
Oklahoma City OK 73117
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Au JL, Abbiati RA, Wientjes MG, Lu Z. Target Site Delivery and Residence of Nanomedicines: Application of Quantitative Systems Pharmacology. Pharmacol Rev. 2019 04; 71(2):157-169. PMID: 30846487.
      Citations: 6     Fields:    Translation:HumansAnimals
    2. Au JL, Lu Z, Abbiati RA, Wientjes MG. Systemic Bioequivalence Is Unlikely to Equal Target Site Bioequivalence for Nanotechnology Oncologic Products. AAPS J. 2019 02 01; 21(2):24. PMID: 30710324.
      Citations:    Fields:    Translation:Humans
    3. Fang L, Kim MJ, Li Z, Wang Y, DiLiberti CE, Au J, Hooker A, Ducharme MP, Lionberger R, Zhao L. Model-Informed Drug Development and Review for Generic Products: Summary of FDA Public Workshop. Clin Pharmacol Ther. 2018 07; 104(1):27-30. PMID: 29603191.
      Citations: 5     Fields:    Translation:Humans
    4. Jaiprasart P, Yeung BZ, Lu Z, Wientjes MG, Cui M, Hsieh CM, Woo S, Au JL. Quantitative contributions of processes by which polyanion drugs reduce intracellular bioavailability and transfection efficiency of cationic siRNA lipoplex. J Control Release. 2018 01 28; 270:101-113. PMID: 29203416.
      Citations:    Fields:    Translation:HumansCells
    5. Wang J, Yeung BZ, Cui M, Peer CJ, Lu Z, Figg WD, Guillaume Wientjes M, Woo S, Au JL. Exosome is a mechanism of intercellular drug transfer: Application of quantitative pharmacology. J Control Release. 2017 Dec 28; 268:147-158. PMID: 29054369.
      Citations: 11     Fields:    Translation:HumansCells
    6. Zhao L, Au JL, Wientjes MG. Method to Assess Interactivity of Drugs with Nonparallel Concentration Effect Relationships. Curr Cancer Drug Targets. 2017; 17(8):735-755. PMID: 28359247.
      Citations: 1     Fields:    Translation:HumansCells
    7. Ruano R, Sananes N, Wilson C, Au J, Koh CJ, Gargollo P, Shamshirsaz AA, Espinoza J, Safdar A, Moaddab A, Meyer N, Cass DL, Olutoye OO, Olutoye OA, Welty S, Roth DR, Braun MC, Belfort MA. Fetal lower urinary tract obstruction: proposal for standardized multidisciplinary prenatal management based on disease severity. Ultrasound Obstet Gynecol. 2016 Oct; 48(4):476-482. PMID: 26690832.
      Citations: 9     Fields:    Translation:Humans
    8. Au JL, Yeung BZ, Wientjes MG, Lu Z, Wientjes MG. Delivery of cancer therapeutics to extracellular and intracellular targets: Determinants, barriers, challenges and opportunities. Adv Drug Deliv Rev. 2016 Feb 01; 97:280-301. PMID: 26686425.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    9. Yeung BZ, Lu Z, Wientjes GM, Au JL. High Sensitivity RT-qPCR Assay of Nonlabeled siRNA in Small Blood Volume for Pharmacokinetic Studies: Application to Survivin siRNA. AAPS J. 2015 Nov; 17(6):1475-82. PMID: 26286676.
      Citations: 1     Fields:    Translation:Animals
    10. Wang J, Lu Z, Wang J, Cui M, Yeung BZ, Cole DJ, Wientjes MG, Au JL. Paclitaxel tumor priming promotes delivery and transfection of intravenous lipid-siRNA in pancreatic tumors. J Control Release. 2015 Oct 28; 216:103-10. PMID: 26272765.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Au JL, Lu Z, Wientjes MG. Versatility of Particulate Carriers: Development of Pharmacodynamically Optimized Drug-Loaded Microparticles for Treatment of Peritoneal Cancer. AAPS J. 2015 Sep; 17(5):1065-79. PMID: 26089090.
      Citations: 5     Fields:    Translation:HumansAnimals
    12. Cui M, Au JL, Wientjes MG, O'Donnell MA, Loughlin KR, Lu Z. Intravenous siRNA Silencing of Survivin Enhances Activity of Mitomycin C in Human Bladder RT4 Xenografts. J Urol. 2015 Jul; 194(1):230-7. PMID: 25681288.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    13. Gan Y, Lu J, Yeung BZ, Cottage CT, Wientjes MG, Au JL. Pharmacodynamics of telomerase inhibition and telomere shortening by noncytotoxic suramin. AAPS J. 2015 Jan; 17(1):268-76. PMID: 25425294.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    14. Wientjes MG, Yeung BZ, Lu Z, Wientjes MG, Au JL. Predicting diffusive transport of cationic liposomes in 3-dimensional tumor spheroids. J Control Release. 2014 Oct 28; 192:10-8. PMID: 24995948.
      Citations: 3     Fields:    Translation:HumansCells
    15. Au JL, Guo P, Gao Y, Lu Z, Wientjes MG, Tsai M, Wientjes MG. Multiscale tumor spatiokinetic model for intraperitoneal therapy. AAPS J. 2014 May; 16(3):424-39. PMID: 24570339.
      Citations: 8     Fields:    Translation:AnimalsCells
    16. Wang J, Lu Z, Yeung BZ, Wientjes MG, Cole DJ, Au JL. Tumor priming enhances siRNA delivery and transfection in intraperitoneal tumors. J Control Release. 2014 Mar 28; 178:79-85. PMID: 24462901.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    17. Lu Z, Tsai M, Wang J, Cole DJ, Wientjes MG, Au JL. Activity of drug-loaded tumor-penetrating microparticles in peritoneal pancreatic tumors. Curr Cancer Drug Targets. 2014; 14(1):70-8. PMID: 24200079.
      Citations: 2     Fields:    Translation:HumansAnimals
    18. Alvarez FJ, Kisseberth W, Hosoya K, Lara-Garcia A, Kosarek C, Murahari S, Au JL, Wientjes MG, Couto J, Couto G. Postoperative adjuvant combination therapy with doxorubicin and noncytotoxic suramin in dogs with appendicular osteosarcoma. J Am Anim Hosp Assoc. 2014 Jan-Feb; 50(1):12-8. PMID: 24216494.
      Citations: 5     Fields:    Translation:AnimalsCTClinical Trials
    19. Tsai M, Lu Z, Wientjes MG, Au JL. Paclitaxel-loaded polymeric microparticles: quantitative relationships between in vitro drug release rate and in vivo pharmacodynamics. J Control Release. 2013 Dec 28; 172(3):737-44. PMID: 24056144.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    20. Gao Y, Li M, Chen B, Shen Z, Guo P, Wientjes MG, Au JL. Predictive models of diffusive nanoparticle transport in 3-dimensional tumor cell spheroids. AAPS J. 2013 Jul; 15(3):816-31. PMID: 23605950.
      Citations: 24     Fields:    Translation:HumansCells
    21. Ramani VC, Purushothaman A, Stewart MD, Thompson CA, Vlodavsky I, Au JL, Sanderson RD. The heparanase/syndecan-1 axis in cancer: mechanisms and therapies. FEBS J. 2013 May; 280(10):2294-306. PMID: 23374281.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    22. Lustberg MB, Pant S, Ruppert AS, Shen T, Wei Y, Chen L, Brenner L, Shiels D, Jensen RR, Berger M, Mrozek E, Ramaswamy B, Grever M, Au JL, Wientjes MG, Shapiro CL. Phase I/II trial of non-cytotoxic suramin in combination with weekly paclitaxel in metastatic breast cancer treated with prior taxanes. Cancer Chemother Pharmacol. 2012 Jul; 70(1):49-56. PMID: 22729159.
      Citations: 13     Fields:    Translation:HumansCTClinical Trials
    23. Wang J, Lu Z, Gao Y, Wientjes MG, Au JL. Improving delivery and efficacy of nanomedicines in solid tumors: role of tumor priming. Nanomedicine (Lond). 2011 Nov; 6(9):1605-20. PMID: 22077464.
      Citations: 19     Fields:    Translation:HumansAnimals
    24. Li Y, Wang J, Gao Y, Zhu J, Wientjes MG, Au JL. Relationships between liposome properties, cell membrane binding, intracellular processing, and intracellular bioavailability. AAPS J. 2011 Dec; 13(4):585-97. PMID: 21904966.
      Citations: 17     Fields:    Translation:HumansCells
    25. Li Y, Wang J, Wientjes MG, Au JL. Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor. Adv Drug Deliv Rev. 2012 Jan; 64(1):29-39. PMID: 21569804.
      Citations: 42     Fields:    Translation:HumansAnimals
    26. Wong HL, Shen Z, Lu Z, Wientjes MG, Au JL. Paclitaxel tumor-priming enhances siRNA delivery and transfection in 3-dimensional tumor cultures. Mol Pharm. 2011 Jun 06; 8(3):833-40. PMID: 21417439.
      Citations: 11     Fields:    Translation:HumansCells
    27. Lu Z, Yeh TK, Wang J, Chen L, Lyness G, Xin Y, Wientjes MG, Bergdall V, Couto G, Alvarez-Berger F, Kosarek CE, Au JL. Paclitaxel gelatin nanoparticles for intravesical bladder cancer therapy. J Urol. 2011 Apr; 185(4):1478-83. PMID: 21334664.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    28. Au JL, Wientjes MG. Combination intravesical hyperthermia and chemotherapy for bladder cancer. Oncology (Williston Park). 2010 Nov 15; 24(12):1155, 1160. PMID: 21141698.
      Citations: 1     Fields:    Translation:Humans
    29. Lu Z, Wang J, Wientjes MG, Au JL. Intraperitoneal therapy for peritoneal cancer. Future Oncol. 2010 Oct; 6(10):1625-41. PMID: 21062160.
      Citations: 56     Fields:    Translation:HumansAnimals
    30. Hu L, Wientjes MG, Li J, Au JL. Bladder tissue pharmacokinetics of intravesical mitomycin C and suramin in dogs. AAPS J. 2010 Dec; 12(4):586-91. PMID: 20625863.
      Citations: 1     Fields:    Translation:Animals
    31. Wang J, Lu Z, Wientjes MG, Au JL. Delivery of siRNA therapeutics: barriers and carriers. AAPS J. 2010 Dec; 12(4):492-503. PMID: 20544328.
      Citations: 177     Fields:    Translation:HumansAnimals
    32. Li J, Wientjes MG, Au JL. Pancreatic cancer: pathobiology, treatment options, and drug delivery. AAPS J. 2010 Jun; 12(2):223-32. PMID: 20198462.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    33. Lam ET, Au JL, Otterson GA, Guillaume Wientjes M, Chen L, Shen T, Wei Y, Li X, Bekaii-Saab T, Murgo AJ, Jensen RR, Grever M, Villalona-Calero MA. Phase I trial of non-cytotoxic suramin as a modulator of docetaxel and gemcitabine therapy in previously treated patients with non-small cell lung cancer. Cancer Chemother Pharmacol. 2010 Nov; 66(6):1019-29. PMID: 20107799.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    34. Zhao L, Au JL, Wientjes MG. Comparison of methods for evaluating drug-drug interaction. Front Biosci (Elite Ed). 2010 Jan 01; 2:241-9. PMID: 20036874.
      Citations: 59     Fields:    Translation:HumansCells
    35. Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F, Reiss M, Au JL, Haffty BG, Kang Y. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell. 2009 Jan 06; 15(1):9-20. PMID: 19111877.
      Citations: 199     Fields:    Translation:HumansAnimalsCells
    36. Lerner SP, Au JL. Risk-adapted use of intravesical chemotherapy. BJU Int. 2008 Nov; 102(9 Pt B):1247-53. PMID: 19035889.
      Citations: 2     Fields:    Translation:Humans
    37. Lu Z, Tsai M, Lu D, Wang J, Wientjes MG, Au JL. Tumor-penetrating microparticles for intraperitoneal therapy of ovarian cancer. J Pharmacol Exp Ther. 2008 Dec; 327(3):673-82. PMID: 18780831.
      Citations: 40     Fields:    Translation:HumansAnimals
    38. Villalona-Calero MA, Otterson GA, Wientjes MG, Weber F, Bekaii-Saab T, Young D, Murgo AJ, Jensen R, Yeh TK, Wei Y, Zhang Y, Eng C, Grever M, Au JL. Noncytotoxic suramin as a chemosensitizer in patients with advanced non-small-cell lung cancer: a phase II study. Ann Oncol. 2008 Nov; 19(11):1903-9. PMID: 18632723.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    39. Shen Z, Shen T, Wientjes MG, O'Donnell MA, Au JL. Intravesical treatments of bladder cancer: review. Pharm Res. 2008 Jul; 25(7):1500-10. PMID: 18369709.
      Citations: 37     Fields:    Translation:HumansAnimals
    40. Walsh CT, Wei Y, Wientjes MG, Au JL. Quantitative image analysis of intra-tumoral bFGF level as a molecular marker of paclitaxel resistance. J Transl Med. 2008 Jan 18; 6:4. PMID: 18205918.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    41. Ortiz R, Au JL, Lu Z, Gan Y, Wientjes MG. Biodegradable intraprostatic doxorubicin implants. AAPS J. 2007 Jun 29; 9(2):E241-50. PMID: 17907765.
      Citations: 3     Fields:    Translation:Animals
    42. Tsai M, Lu Z, Wang J, Yeh TK, Wientjes MG, Au JL. Effects of carrier on disposition and antitumor activity of intraperitoneal Paclitaxel. Pharm Res. 2007 Sep; 24(9):1691-701. PMID: 17447121.
      Citations: 38     Fields:    Translation:AnimalsCells
    43. Lu D, Wientjes MG, Lu Z, Au JL. Tumor priming enhances delivery and efficacy of nanomedicines. J Pharmacol Exp Ther. 2007 Jul; 322(1):80-8. PMID: 17420296.
      Citations: 54     Fields:    Translation:Animals
    44. Hu L, Au JL, Wientjes MG. Computational modeling to predict effect of treatment schedule on drug delivery to prostate in humans. Clin Cancer Res. 2007 Feb 15; 13(4):1278-87. PMID: 17317840.
      Citations: 4     Fields:    Translation:HumansAnimals
    45. Wang J, Lu Z, Au JL. Protection against chemotherapy-induced alopecia. Pharm Res. 2006 Nov; 23(11):2505-14. PMID: 16972183.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    46. Kosarek CE, Hu X, Couto CG, Kisseberth WC, Green EM, Au JL, Wientjes MG. Phase I evaluation of low-dose suramin as chemosensitizer of doxorubicin in dogs with naturally occurring cancers. J Vet Intern Med. 2006 Sep-Oct; 20(5):1172-7. PMID: 17063712.
      Citations: 1     Fields:    Translation:AnimalsCTClinical Trials
    47. Gan Y, Wientjes MG, Au JL. Expression of basic fibroblast growth factor correlates with resistance to paclitaxel in human patient tumors. Pharm Res. 2006 Jun; 23(6):1324-31. PMID: 16741658.
      Citations: 26     Fields:    Translation:HumansCells
    48. Chen D, Song SH, Wientjes MG, Yeh TK, Zhao L, Villalona-Calero M, Otterson GA, Jensen R, Grever M, Murgo AJ, Au JL. Nontoxic suramin as a chemosensitizer in patients: dosing nomogram development. Pharm Res. 2006 Jun; 23(6):1265-74. PMID: 16715360.
      Citations: 3     Fields:    Translation:HumansCells
    49. Lu Z, Wientjes TS, Au JL. Nontoxic suramin treatments enhance docetaxel activity in chemotherapy-pretreated non-small cell lung xenograft tumors. Pharm Res. 2005 Jul; 22(7):1069-78. PMID: 16028007.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    50. Xin Y, Lyness G, Chen D, Song S, Wientjes MG, Au JL. Low dose suramin as a chemosensitizer of bladder cancer to mitomycin C. J Urol. 2005 Jul; 174(1):322-7. PMID: 15947683.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    51. Yeh TK, Lu Z, Wientjes MG, Au JL. Formulating paclitaxel in nanoparticles alters its disposition. Pharm Res. 2005 Jun; 22(6):867-74. PMID: 15948030.
      Citations: 17     Fields:    Translation:Animals
    52. Wientjes MG, Zheng JH, Hu L, Gan Y, Au JL. Intraprostatic chemotherapy: distribution and transport mechanisms. Clin Cancer Res. 2005 Jun 01; 11(11):4204-11. PMID: 15930358.
      Citations: 7     Fields:    Translation:Animals
    53. Zhao L, Wientjes MG, Au JL. Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses. Clin Cancer Res. 2004 Dec 01; 10(23):7994-8004. PMID: 15585635.
      Citations: 122     Fields:    Translation:AnimalsCells
    54. Lu Z, Yeh TK, Tsai M, Au JL, Wientjes MG. Paclitaxel-loaded gelatin nanoparticles for intravesical bladder cancer therapy. Clin Cancer Res. 2004 Nov 15; 10(22):7677-84. PMID: 15570001.
      Citations: 31     Fields:    Translation:AnimalsCells
    55. Ogden A, Wientjes MG, Au JL. Suramin as a chemosensitizer: oral pharmacokinetics in rats. Pharm Res. 2004 Nov; 21(11):2058-63. PMID: 15587928.
      Citations: 1     Fields:    Translation:Animals
    56. Song S, Yu B, Wei Y, Wientjes MG, Au JL. Low-dose suramin enhanced paclitaxel activity in chemotherapy-naive and paclitaxel-pretreated human breast xenograft tumors. Clin Cancer Res. 2004 Sep 15; 10(18 Pt 1):6058-65. PMID: 15447990.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    57. Jang SH, Wientjes MG, Lu D, Au JL. Drug delivery and transport to solid tumors. Pharm Res. 2003 Sep; 20(9):1337-50. PMID: 14567626.
      Citations: 117     Fields:    Translation:HumansAnimals
    58. Villalona-Calero MA, Wientjes MG, Otterson GA, Kanter S, Young D, Murgo AJ, Fischer B, DeHoff C, Chen D, Yeh TK, Song S, Grever M, Au JL. Phase I study of low-dose suramin as a chemosensitizer in patients with advanced non-small cell lung cancer. Clin Cancer Res. 2003 Aug 15; 9(9):3303-11. PMID: 12960116.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    59. Johnston JS, Johnson A, Gan Y, Wientjes MG, Au JL. Synergy between 3'-azido-3'-deoxythymidine and paclitaxel in human pharynx FaDu cells. Pharm Res. 2003 Jul; 20(7):957-61. PMID: 12880279.
      Citations: 9     Fields:    Translation:HumansCells
    60. Jang SH, Wientjes MG, Au JL. Interdependent effect of P-glycoprotein-mediated drug efflux and intracellular drug binding on intracellular paclitaxel pharmacokinetics: application of computational modeling. J Pharmacol Exp Ther. 2003 Feb; 304(2):773-80. PMID: 12538833.
      Citations: 5     Fields:    Translation:Cells
    61. Mo Y, Gan Y, Song S, Johnston J, Xiao X, Wientjes MG, Au JL. Simultaneous targeting of telomeres and telomerase as a cancer therapeutic approach. Cancer Res. 2003 Feb 01; 63(3):579-85. PMID: 12566299.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    62. Li D, Jang SH, Kim J, Wientjes MG, Au JL. Enhanced drug-induced apoptosis associated with P-glycoprotein overexpression is specific to antimicrotubule agents. Pharm Res. 2003 Jan; 20(1):45-50. PMID: 12608535.
      Citations: 3     Fields:    Translation:HumansCells
    63. Chen D, Song D, Wientjes MG, Au JL. Effect of dimethyl sulfoxide on bladder tissue penetration of intravesical paclitaxel. Clin Cancer Res. 2003 Jan; 9(1):363-9. PMID: 12538489.
      Citations: 14     Fields:    Translation:Animals
    64. Gan Y, Mo Y, Johnston J, Lu J, Wientjes MG, Au JL. Telomere maintenance in telomerase-positive human ovarian SKOV-3 cells cannot be retarded by complete inhibition of telomerase. FEBS Lett. 2002 Sep 11; 527(1-3):10-4. PMID: 12220625.
      Citations: 9     Fields:    Translation:HumansCells
    65. Au JL, Jang SH, Wientjes MG. Clinical aspects of drug delivery to tumors. J Control Release. 2002 Jan 17; 78(1-3):81-95. PMID: 11772451.
      Citations: 32     Fields:    Translation:HumansAnimalsCTClinical Trials
    66. Gan Y, Engelke KJ, Brown CA, Au JL. Telomere amount and length assay. Pharm Res. 2001 Dec; 18(12):1655-9. PMID: 11785683.
      Citations: 3     Fields:    Translation:Cells
    67. Li D, Gan Y, Wientjes MG, Badalament RA, Au JL. Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: cytochrome p450 oxidoreductase in bladder tissues and tumors. J Urol. 2001 Dec; 166(6):2500-5. PMID: 11696818.
      Citations: 2     Fields:    Translation:HumansAnimals
    68. Zhang Y, Song S, Yang F, Au JL, Wientjes MG. Nontoxic doses of suramin enhance activity of doxorubicin in prostate tumors. J Pharmacol Exp Ther. 2001 Nov; 299(2):426-33. PMID: 11602651.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    69. Jang SH, Wientjes MG, Au JL. Kinetics of P-glycoprotein-mediated efflux of paclitaxel. J Pharmacol Exp Ther. 2001 Sep; 298(3):1236-42. PMID: 11504826.
      Citations: 31     Fields:    Translation:HumansCells
    70. Song S, Wientjes MG, Walsh C, Au JL. Nontoxic doses of suramin enhance activity of paclitaxel against lung metastases. Cancer Res. 2001 Aug 15; 61(16):6145-50. PMID: 11507065.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    71. Au JL, Jang SH, Zheng J, Chen CT, Song S, Hu L, Wientjes MG. Determinants of drug delivery and transport to solid tumors. J Control Release. 2001 Jul 06; 74(1-3):31-46. PMID: 11489481.
      Citations: 46     Fields:    Translation:HumansAnimals
    72. Li D, Au JL. Mdr1 transfection causes enhanced apoptosis by paclitaxel: an effect independent of drug efflux function of P-glycoprotein. Pharm Res. 2001 Jul; 18(7):907-13. PMID: 11496948.
      Citations: 4     Fields:    Translation:HumansCells
    73. Gan Y, Mo Y, Kalns JE, Lu J, Danenberg K, Danenberg P, Wientjes MG, Au JL. Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin C activity in human bladder tumors. Clin Cancer Res. 2001 May; 7(5):1313-9. PMID: 11350900.
      Citations: 6     Fields:    Translation:Humans
    74. Jang SH, Wientjes MG, Au JL. Determinants of paclitaxel uptake, accumulation and retention in solid tumors. Invest New Drugs. 2001 May; 19(2):113-23. PMID: 11392446.
      Citations: 20     Fields:    Translation:HumansCells
    75. Au JL, Badalament RA, Wientjes MG, Young DC, Warner JA, Venema PL, Pollifrone DL, Harbrecht JD, Chin JL, Lerner SP, Miles BJ. Methods to improve efficacy of intravesical mitomycin C: results of a randomized phase III trial. J Natl Cancer Inst. 2001 Apr 18; 93(8):597-604. PMID: 11309436.
      Citations: 49     Fields:    Translation:HumansCTClinical Trials
    76. Gan Y, Lu J, Johnson A, Wientjes MG, Schuller DE, Au JL. A quantitative assay of telomerase activity. Pharm Res. 2001 Apr; 18(4):488-93. PMID: 11451036.
      Citations: 3     Fields:    Translation:HumansCells
    77. Jang SH, Wientjes MG, Au JL. Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule. J Pharmacol Exp Ther. 2001 Mar; 296(3):1035-42. PMID: 11181938.
      Citations: 40     Fields:    Translation:AnimalsCells
    78. Grecula JC, Schuller DE, Smith R, Rhoades CA, Nag S, Bauer CJ, Agrawal A, Au JL, Young D, Gahbauer RA. Long-term follow-up on an intensified treatment regimen for advanced resectable head and neck squamous cell carcinomas. Cancer Invest. 2001; 19(2):127-36. PMID: 11296617.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    79. Zheng JH, Chen CT, Au JL, Wientjes MG. Time- and concentration-dependent penetration of doxorubicin in prostate tumors. AAPS PharmSci. 2001; 3(2):E15. PMID: 11741266.
      Citations: 24     Fields:    Translation:HumansAnimals
    80. Song S, Wientjes MG, Gan Y, Au JL. Fibroblast growth factors: an epigenetic mechanism of broad spectrum resistance to anticancer drugs. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8658-63. PMID: 10890892.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    81. Kuh HJ, Jang SH, Wientjes MG, Au JL. Computational model of intracellular pharmacokinetics of paclitaxel. J Pharmacol Exp Ther. 2000 Jun; 293(3):761-70. PMID: 10869374.
      Citations: 41     Fields:    Translation:HumansCells
    82. Millenbaugh NJ, Wientjes MG, Au JL. A pharmacodynamic analysis method to determine the relative importance of drug concentration and treatment time on effect. Cancer Chemother Pharmacol. 2000; 45(4):265-72. PMID: 10755313.
      Citations: 7     Fields:    Translation:HumansCells
    83. Grecula JC, Schuller DE, Rhoades CA, Au JL, Nag S, Bauer CJ, Agrawal A, Martinez-Monge R, Johnson A, Young D, Gahbauer RA. Intensification regimen 2 for advanced head and neck squamous cell carcinomas. Arch Otolaryngol Head Neck Surg. 1999 Dec; 125(12):1313-8. PMID: 10604408.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    84. Kuh HJ, Jang SH, Wientjes MG, Weaver JR, Au JL. Determinants of paclitaxel penetration and accumulation in human solid tumor. J Pharmacol Exp Ther. 1999 Aug; 290(2):871-80. PMID: 10411604.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    85. Weaver JR, Wientjes MG, Au JL. Regional heterogeneity and pharmacodynamics in human solid tumor histoculture. Cancer Chemother Pharmacol. 1999; 44(4):335-42. PMID: 10447582.
      Citations: 2     Fields:    Translation:Humans
    86. Knemeyer I, Wientjes MG, Au JL. Cremophor reduces paclitaxel penetration into bladder wall during intravesical treatment. Cancer Chemother Pharmacol. 1999; 44(3):241-8. PMID: 10453726.
      Citations: 15     Fields:    Translation:Animals
    87. Millenbaugh NJ, Wientjes MG, Au JL. Accuracy and precision of pharmacodynamic exponent. Pharm Res. 1999 Jan; 16(1):170-3. PMID: 9950298.
      Citations:    Fields:    
    88. Johnson AL, Jurcisek JA, Trask OJ, Au JL. A method to monitor DNA transfer during transfection. AAPS PharmSci. 1999; 1(2):E6. PMID: 11741202.
      Citations: 1     Fields:    Translation:HumansCells
    89. Au JL, Kumar RR, Li D, Wientjes MG. Kinetics of hallmark biochemical changes in paclitaxel-induced apoptosis. AAPS PharmSci. 1999; 1(3):E8. PMID: 11741204.
      Citations: 11     Fields:    Translation:HumansCells
    90. Gan Y, Wientjes MG, Au JL. Relationship between paclitaxel activity and pathobiology of human solid tumors. Clin Cancer Res. 1998 Dec; 4(12):2949-55. PMID: 9865905.
      Citations: 6     Fields:    Translation:HumansCells
    91. Gan Y, Au JL, Lu J, Wientjes MG. Antiproliferative and cytotoxic effects of geldanamycin, cytochalasin E, suramin and thiacetazone in human prostate xenograft tumor histocultures. Pharm Res. 1998 Nov; 15(11):1760-6. PMID: 9834000.
      Citations: 7     Fields:    Translation:HumansAnimals
    92. Au JL. An interview with a distinguished pharmaceutical scientist: Jessie L.-S. Au. Pharm Res. 1998 Oct; 15(10):1503-6. PMID: 9794490.
      Citations:    Fields:    Translation:Humans
    93. Weaver JR, Gan Y, Au JL. Proliferation indices as molecular pharmacodynamic endpoints in evaluation of anticancer drug effect in human solid tumors. Pharm Res. 1998 Oct; 15(10):1546-51. PMID: 9794496.
      Citations:    Fields:    Translation:Humans
    94. Chen CT, Gan Y, Au JL, Wientjes MG. Androgen-dependent and -independent human prostate xenograft tumors as models for drug activity evaluation. Cancer Res. 1998 Jul 01; 58(13):2777-83. PMID: 9661891.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    95. Au JL, Li D, Gan Y, Gao X, Johnson AL, Johnston J, Millenbaugh NJ, Jang SH, Kuh HJ, Chen CT, Wientjes MG. Pharmacodynamics of immediate and delayed effects of paclitaxel: role of slow apoptosis and intracellular drug retention. Cancer Res. 1998 May 15; 58(10):2141-8. PMID: 9605758.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    96. Chen CT, Au JL, Wientjes MG. Pharmacodynamics of doxorubicin in human prostate tumors. Clin Cancer Res. 1998 Feb; 4(2):277-82. PMID: 9516911.
      Citations: 9     Fields:    Translation:HumansCells
    97. Gao X, Au JL, Badalament RA, Wientjes MG. Bladder tissue uptake of mitomycin C during intravesical therapy is linear with drug concentration in urine. Clin Cancer Res. 1998 Jan; 4(1):139-43. PMID: 9516962.
      Citations: 10     Fields:    Translation:HumansAnimals
    98. Millenbaugh NJ, Gan Y, Au JL. Cytostatic and apoptotic effects of paclitaxel in human ovarian tumors. Pharm Res. 1998 Jan; 15(1):122-7. PMID: 9487558.
      Citations: 6     Fields:    Translation:Humans
    99. Gan Y, Wientjes MG, Lu J, Au JL. Cytostatic and apoptotic effects of paclitaxel in human breast tumors. Cancer Chemother Pharmacol. 1998; 42(3):177-82. PMID: 9685052.
      Citations: 10     Fields:    Translation:HumansCells
    100. Au JL, Panchal N, Li D, Gan Y. Apoptosis: a new pharmacodynamic endpoint. Pharm Res. 1997 Dec; 14(12):1659-71. PMID: 9453051.
      Citations: 11     Fields:    Translation:HumansCells
    101. Weaver JR, Au JL. Application of automatic thresholding in image analysis scoring of cells in human solid tumors labeled for proliferation markers. Cytometry. 1997 Oct 01; 29(2):128-35. PMID: 9332819.
      Citations:    Fields:    Translation:Humans
    102. Song D, Wientjes MG, Gan Y, Au JL. Bladder tissue pharmacokinetics and antitumor effect of intravesical 5-fluorouridine. Clin Cancer Res. 1997 Jun; 3(6):901-9. PMID: 9815765.
      Citations: 5     Fields:    Translation:HumansAnimals
    103. Song D, Wientjes MG, Au JL. Isocratic high-performance liquid chromatographic determination of thiacetazone by direct injection of plasma into an internal surface reversed-phase column. J Chromatogr B Biomed Sci Appl. 1997 Mar 07; 690(1-2):289-94. PMID: 9106055.
      Citations:    Fields:    Translation:Animals
    104. Kang HJ, Wientjes MG, Au JL. Physiologically based pharmacokinetic models of 2',3'-dideoxyinosine. Pharm Res. 1997 Mar; 14(3):337-44. PMID: 9098877.
      Citations: 1     Fields:    Translation:HumansAnimals
    105. Weaver JR, Au JL. Comparative scoring by visual and image analysis of cells in human solid tumors labeled for proliferation markers. Cytometry. 1997 Feb 01; 27(2):189-99. PMID: 9012386.
      Citations: 2     Fields:    Translation:Humans
    106. Schuller DE, Grecula JC, Gahbauer RA, Bauer C, Au JL, Smith RE, Haller JR, Mountain RE, Young DC, Nag S. Intensified regimen for advanced head and neck squamous cell carcinomas. Arch Otolaryngol Head Neck Surg. 1997 Feb; 123(2):139-44. PMID: 9046279.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    107. Yen WC, Au JL. Pharmacodynamic evaluation of mitomycin C analog BMS-181174 for potential use in intravesical bladder cancer therapy. Pharm Res. 1997 Feb; 14(2):241-5. PMID: 9090717.
      Citations:    Fields:    Translation:Cells
    108. Chen CT, Au JL, Gan Y, Guillaume Wientjes M. Differential time dependency of antiproliferative and apoptotic effects of taxol in human prostate tumors. Urol Oncol. 1997 Jan-Feb; 3(1):11-7. PMID: 21227047.
      Citations: 2     Fields:    
    109. Song D, Wientjes MG, Au JL. Bladder tissue pharmacokinetics of intravesical taxol. Cancer Chemother Pharmacol. 1997; 40(4):285-92. PMID: 9225946.
      Citations: 17     Fields:    Translation:Animals
    110. Au JL, Kalns J, Gan Y, Wientjes MG. Pharmacologic effects of paclitaxel in human bladder tumors. Cancer Chemother Pharmacol. 1997; 41(1):69-74. PMID: 9443616.
      Citations: 6     Fields:    Translation:HumansCells
    111. Yen WC, Schmittgen T, Au JL. Different pH dependency of mitomycin C activity in monolayer and three-dimensional cultures. Pharm Res. 1996 Dec; 13(12):1887-91. PMID: 8987090.
      Citations: 5     Fields:    Translation:HumansCells
    112. Yen WC, Wientjes MG, Au JL. Differential effect of taxol in rat primary and metastatic prostate tumors: site-dependent pharmacodynamics. Pharm Res. 1996 Sep; 13(9):1305-12. PMID: 8893266.
      Citations: 3     Fields:    Translation:AnimalsCells
    113. Gan Y, Wientjes MG, Badalament RA, Au JL. Pharmacodynamics of doxorubicin in human bladder tumors. Clin Cancer Res. 1996 Aug; 2(8):1275-83. PMID: 9816297.
      Citations: 4     Fields:    Translation:Humans
    114. Gan Y, Wientjes MG, Schuller DE, Au JL. Pharmacodynamics of taxol in human head and neck tumors. Cancer Res. 1996 May 01; 56(9):2086-93. PMID: 8616855.
      Citations: 16     Fields:    Translation:HumansCells
    115. Yeh TK, Kang HJ, Wientjes MG, Au JL. Pharmacokinetic interaction between intravenous 2',3'-dideoxyinosine and pentamidine in rats. Pharm Res. 1996 Apr; 13(4):628-32. PMID: 8710758.
      Citations:    Fields:    Translation:Animals
    116. Song D, Au JL. Direct injection isocratic high-performance liquid chromatographic analysis of mitomycin C in plasma. J Chromatogr B Biomed Appl. 1996 Feb 09; 676(1):165-8. PMID: 8852058.
      Citations: 1     Fields:    Translation:Humans
    117. Wientjes MG, Badalament RA, Au JL. Penetration of intravesical doxorubicin in human bladders. Cancer Chemother Pharmacol. 1996; 37(6):539-46. PMID: 8612307.
      Citations: 5     Fields:    Translation:Humans
    118. Song D, Hsu LF, Au JL. Binding of taxol to plastic and glass containers and protein under in vitro conditions. J Pharm Sci. 1996 Jan; 85(1):29-31. PMID: 8926579.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    119. Gao X, Wientjes MG, Au JL. Extensive absorption of 2',3'-dideoxyinosine by intratracheal administration in rats. Pharm Res. 1995 Dec; 12(12):1901-6. PMID: 8786964.
      Citations:    Fields:    Translation:AnimalsCells
    120. Gao X, Wientjes MG, Au JL. Use of drug kinetics in dermis to predict in vivo blood concentration after topical application. Pharm Res. 1995 Dec; 12(12):2012-7. PMID: 8786981.
      Citations:    Fields:    Translation:Animals
    121. Kalns JE, Millenbaugh NJ, Wientjes MG, Au JL. Design and analysis of in vitro antitumor pharmacodynamic studies. Cancer Res. 1995 Nov 15; 55(22):5315-22. PMID: 7585594.
      Citations: 3     Fields:    Translation:Humans
    122. Wientjes MG, Pretlow TG, Badalament RA, Burgers JK, Au JL. Histocultures of human prostate tissues for pharmacologic evaluation. J Urol. 1995 Apr; 153(4):1299-302. PMID: 7532726.
      Citations: 3     Fields:    Translation:Humans
    123. Song D, Au JL. Isocratic high-performance liquid chromatographic assay of taxol in biological fluids and tissues using automated column switching. J Chromatogr B Biomed Appl. 1995 Jan 20; 663(2):337-44. PMID: 7735481.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    124. Gupta E, Wientjes MG, Au JL. Penetration kinetics of 2',3'-dideoxyinosine in dermis is described by the distributed model. Pharm Res. 1995 Jan; 12(1):108-12. PMID: 7724469.
      Citations: 7     Fields:    Translation:AnimalsCells
    125. Kang HJ, Wientjes MG, Au JL. Tissue pharmacokinetics of 2',3'-dideoxyinosine in rats. Biochem Pharmacol. 1994 Nov 29; 48(11):2109-16. PMID: 7802702.
      Citations: 2     Fields:    Translation:Animals
    126. Schmittgen TD, Weaver JM, Badalament RA, Wientjes MG, Klein EA, Young DC, Au JL. Correlation of human bladder tumor histoculture proliferation and sensitivity to mitomycin C with tumor pathobiology. J Urol. 1994 Nov; 152(5 Pt 1):1632-6. PMID: 7933219.
      Citations: 2     Fields:    Translation:Humans
    127. Gao X, Buffington CA, Au JL. Effect of interstitial cystitis on drug absorption from urinary bladder. J Pharmacol Exp Ther. 1994 Nov; 271(2):818-23. PMID: 7965801.
      Citations: 6     Fields:    Translation:AnimalsCells
    128. Chai M, Wientjes MG, Badalament RA, Burgers JK, Au JL. Pharmacokinetics of intravesical doxorubicin in superficial bladder cancer patients. J Urol. 1994 Aug; 152(2 Pt 1):374-8. PMID: 8015074.
      Citations: 7     Fields:    Translation:Humans
    129. Mukherji E, Au JL, Mathes LE. Differential antiviral activities and intracellular metabolism of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine in human cells. Antimicrob Agents Chemother. 1994 Jul; 38(7):1573-9. PMID: 7526781.
      Citations: 8     Fields:    Translation:HumansCells
    130. Mukherji E, Millenbaugh NJ, Au JL. Percutaneous absorption of 2',3'-dideoxyinosine in rats. Pharm Res. 1994 Jun; 11(6):809-15. PMID: 7937518.
      Citations: 4     Fields:    Translation:Animals
    131. Yeh TK, Dalton JT, Au JL. High-performance liquid chromatographic determination of pentamidine in plasma. J Chromatogr. 1993 Dec 22; 622(2):255-61. PMID: 8150874.
      Citations: 1     Fields:    Translation:Animals
    132. Au JL, Wientjes MG, Rosol TJ, Koolemans-Beynen A, Goebel EA, Schuller DE. Histocultures of patient head and neck tumors for pharmacodynamics studies. Pharm Res. 1993 Oct; 10(10):1493-9. PMID: 8272413.
      Citations: 3     Fields:    Translation:HumansCells
    133. Wientjes MG, Badalament RA, Wang RC, Hassan F, Au JL. Penetration of mitomycin C in human bladder. Cancer Res. 1993 Jul 15; 53(14):3314-20. PMID: 8324743.
      Citations: 15     Fields:    Translation:HumansAnimals
    134. Bramer SL, Au JL, Wientjes MG. Gastrointestinal and hepatic first-pass elimination of 2',3'-dideoxyinosine in rats. J Pharmacol Exp Ther. 1993 May; 265(2):731-8. PMID: 8496819.
      Citations: 8     Fields:    Translation:Animals
    135. Bramer SL, Wientjes MG, Au JL. Absorption of 2',3'-dideoxyinosine from lower gastrointestinal tract in rats and kinetic evidence of different absorption rates in colon and rectum. Pharm Res. 1993 May; 10(5):763-70. PMID: 8321843.
      Citations: 5     Fields:    Translation:Animals
    136. Dalton JT, Au JL. 2',3'-Dideoxyinosine is not metabolized in human placenta. Drug Metab Dispos. 1993 May-Jun; 21(3):544-6. PMID: 8100514.
      Citations: 2     Fields:    Translation:Animals
    137. Wientjes MG, Badalament RA, Au JL. Use of pharmacologic data and computer simulations to design an efficacy trial of intravesical mitomycin C therapy for superficial bladder cancer. Cancer Chemother Pharmacol. 1993; 32(4):255-62. PMID: 8324866.
      Citations: 15     Fields:    Translation:Humans
    138. Wientjes MG, Mukherji E, Au JL. Nonlinear disposition of intravenous 2',3'-dideoxyinosine in rats. Pharm Res. 1992 Aug; 9(8):1070-5. PMID: 1409380.
      Citations: 8     Fields:    Translation:Animals
    139. Wientjes MG, Au JL. Pharmacokinetics of oral 2',3'-dideoxyinosine in rats. Pharm Res. 1992 Jun; 9(6):822-5. PMID: 1409368.
      Citations: 6     Fields:    Translation:Animals
    140. Wientjes MG, Au JL. Lack of pharmacokinetic interaction between intravenous 2',3'-dideoxyinosine and 3'-azido-3'-deoxythymidine in rats. Antimicrob Agents Chemother. 1992 Mar; 36(3):665-8. PMID: 1622182.
      Citations: 5     Fields:    Translation:Animals
    141. Dalton JT, Harrington MD, Au JL. Evidence of significant absorption of antipyrine from urinary bladder of rats. J Pharmacol Exp Ther. 1992 Feb; 260(2):608-13. PMID: 1738110.
      Citations: 2     Fields:    Translation:Animals
    142. Schmittgen TD, Koolemans-Beynen A, Webb TE, Rosol TJ, Au JL. Effects of 5-fluorouracil, leucovorin, and glucarate in rat colon-tumor explants. Cancer Chemother Pharmacol. 1992; 30(1):25-30. PMID: 1586977.
      Citations:    Fields:    Translation:AnimalsCells
    143. Dalton JT, Wientjes MG, Badalament RA, Drago JR, Au JL. Pharmacokinetics of intravesical mitomycin C in superficial bladder cancer patients. Cancer Res. 1991 Oct 01; 51(19):5144-52. PMID: 1913640.
      Citations: 18     Fields:    Translation:Humans
    144. Wientjes MG, Dalton JT, Badalament RA, Drago JR, Au JL. Bladder wall penetration of intravesical mitomycin C in dogs. Cancer Res. 1991 Aug 15; 51(16):4347-54. PMID: 1907883.
      Citations: 22     Fields:    Translation:Animals
    145. Schmittgen TD, Wientjes MG, Badalament RA, Au JL. Pharmacodynamics of mitomycin C in cultured human bladder tumors. Cancer Res. 1991 Aug 01; 51(15):3849-56. PMID: 1906778.
      Citations: 19     Fields:    Translation:HumansCells
    146. Au JL, Dalton JT, Wientjes MG. Evidence of significant absorption of sodium salicylate from urinary bladder of rats. J Pharmacol Exp Ther. 1991 Jul 01; 258(1):357-64. PMID: 2072307.
      Citations: 5     Fields:    Translation:AnimalsCells
    147. Wientjes MG, Au JL. High-performance liquid chromatographic analysis of 2',3'-dideoxyinosine in biological samples. J Chromatogr. 1991 Feb 15; 563(2):400-6. PMID: 1905302.
      Citations: 6     Fields:    Translation:Animals
    148. Wientjes MG, Dalton JT, Badalament RA, Dasani BM, Drago JR, Au JL. A method to study drug concentration-depth profiles in tissues: mitomycin C in dog bladder wall. Pharm Res. 1991 Feb; 8(2):168-73. PMID: 1902562.
      Citations: 10     Fields:    Translation:Animals
    149. Schmittgen TD, Au JL, Wientjes MG, Badalament RA, Drago JR. Cultured human bladder tumors for pharmacodynamic studies. J Urol. 1991 Jan; 145(1):203-7. PMID: 1898521.
      Citations: 2     Fields:    Translation:HumansCells
    150. Dalton JT, Geuns ER, Au JL. High-performance liquid chromatographic determination of mitomycin C in rat and human plasma and urine. J Chromatogr. 1989 Oct 27; 495:330-7. PMID: 2515201.
      Citations: 2     Fields:    Translation:HumansAnimals
    151. Bramer SL, Gunnarsson LC, Au JL. Biologic activity of 5'-deoxy-5-fluorouridine by rectal administration. Pharm Res. 1989 Apr; 6(4):318-22. PMID: 2526328.
      Citations: 2     Fields:    Translation:Animals
    152. Au JL, Gunnarsson LC. Absorption of 5'-deoxy-5-fluorouridine from colon. Pharm Res. 1989 Apr; 6(4):323-7. PMID: 2526329.
      Citations: 1     Fields:    Translation:Animals
    153. Au JL, Su MH, Wientjes MG. Extraction of intracellular nucleosides and nucleotides with acetonitrile. Clin Chem. 1989 Jan; 35(1):48-51. PMID: 2535975.
      Citations: 10     Fields:    Translation:AnimalsCells
    154. Au JL, Wientjes MG, Bramer SL. Effect of uridine coadministration on 5'-deoxy-5-fluorouridine disposition in rats. Cancer Chemother Pharmacol. 1988; 22(1):5-10. PMID: 2969304.
      Citations: 2     Fields:    Translation:Animals
    155. Au JL, Su MH, Wientjes MG. Isocratic ion-pair reversed-phase high-performance liquid chromatographic analysis of ATP and ADP. J Chromatogr. 1987 Dec 25; 423:308-12. PMID: 3443664.
      Citations: 1     Fields:    Translation:HumansAnimals
    156. Wientjes MG, Au JL. Inhibition of intestinal pyrimidine nucleoside phosphorylases. Pharm Res. 1987 Oct; 4(5):425-8. PMID: 2977647.
      Citations: 2     Fields:    Translation:AnimalsCells
    157. Au JL. Disposition and availability of 5-fluorouracil prodrug 5'-deoxy-5-fluorouridine after oral administration in rats. J Pharm Sci. 1987 Sep; 76(9):699-702. PMID: 11002805.
      Citations: 3     Fields:    Translation:AnimalsCells
    158. Trave F, Canobbio L, Au JL, Rustum YM. Role of administration route in the therapeutic efficacy of doxifluridine. J Natl Cancer Inst. 1987 Mar; 78(3):527-32. PMID: 2950266.
      Citations: 3     Fields:    Translation:Animals
    159. Au JL, Rustum YM, Slocum HK. Biological activities of 5-fluorouracil and its prodrug 5'-deoxy-5-fluorouridine in rats. Cancer Drug Deliv. 1987; 4(3):137-44. PMID: 2967103.
      Citations: 2     Fields:    Translation:Animals
    160. Au JL. Effect of age on the disposition and tissue clearances of fluorinated pyrimidines in rats. Pharm Res. 1985 Nov; 2(6):279-84. PMID: 24271124.
      Citations: 3     Fields:    
    161. Sternberg A, Petrelli NJ, Au J, Rustum Y, Mittelman A, Creaven P. A combination of 5-fluorouracil and thymidine in advanced colorectal carcinoma. Cancer Chemother Pharmacol. 1984; 13(3):218-22. PMID: 6488442.
      Citations: 1     Fields:    Translation:Humans
    162. Au JL, Walker JS, Rustum Y. Pharmacokinetic studies of 5-fluorouracil and 5'-deoxy-5-fluorouridine in rats. J Pharmacol Exp Ther. 1983 Oct; 227(1):174-80. PMID: 6225866.
      Citations: 11     Fields:    Translation:AnimalsCells
    163. Au JL, Rustum YM, Minowada J, Srivastava BI. Differential selectivity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in cultured human B lymphocytes and mouse L1210 leukemia. Biochem Pharmacol. 1983 Feb 01; 32(3):541-6. PMID: 6221728.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    164. Au JL, Rustum YM, Ledesma EJ, Mittelman A, Creaven PJ. Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas. Cancer Res. 1982 Jul; 42(7):2930-7. PMID: 6211226.
      Citations: 29     Fields:    Translation:Humans
    165. Au JL, Wientjes MG, Luccioni CM, Rustum YM. Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions. J Chromatogr. 1982 Mar 12; 228:245-56. PMID: 6210703.
      Citations: 1     Fields:    Translation:Cells
    166. Au JL, Sadée W. Stereoselective metabolism of ftorafur (R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil). Cancer Chemother Pharmacol. 1981; 7(1):55-9. PMID: 6804104.
      Citations: 1     Fields:    Translation:AnimalsCells
    167. Au JL, Sadée W. Activation of Ftorafue [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil] to 5-fluorouracil and gamma-butyrolactone. Cancer Res. 1980 Aug; 40(8 Pt 1):2814-9. PMID: 6771006.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    168. Au JL, Sadée W. 5-Fluorouracil concentrations in human plasma following R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) administration. Cancer Res. 1979 Oct; 39(10):4289-90. PMID: 383283.
      Citations: 4     Fields:    Translation:Humans
    169. Wu AT, Au JL, Sadée W. Hydroxylated metabolies of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (Ftorafur) in rats and rabbits. Cancer Res. 1978 Jan; 38(1):210-4. PMID: 338145.
      Citations: 10     Fields:    Translation:AnimalsCells
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