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Jasimuddin Ahamed

TitleAssociate Member
InstitutionOklahoma Medical Research Foundation
DepartmentCardiovascular Biology Research Program
825 N.E. 13th Street
Oklahoma City OK 73104
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    R01HL148123     (AHAMED, JASIMUDDIN)Apr 1, 2020 - Feb 29, 2024
    The Role of TGF-beta Activation and Signaling in Aortic Stenosis Progression
    Role: Principal Investigator

    R01HL123605     (AHAMED, JASIMUDDIN)Nov 7, 2014 - Oct 31, 2020
    The Mechanism of Shear-Induced Release and Activation of TGF-beta1
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li P, Newhardt MF, Matsuzaki S, Eyster C, Pranay A, Peelor FF, Batushansky A, Kinter C, Subramani K, Subrahmanian S, Ahamed J, Yu P, Kinter M, Miller BF, Humphries KM. The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner. Geroscience. 2023 04; 45(2):983-999. PMID: 36460774; PMCID: PMC9886736.
      Citations:    Fields:    Translation:AnimalsCells
    2. Shi H, Shao B, Gao L, Venkatesan T, McDaniel JM, Zhou M, McGee S, Yu P, Ahamed J, Journeycake J, George JN, Xia L. Endothelial VWF is critical for the pathogenesis of vaso-occlusive episode in a mouse model of sickle cell disease. Proc Natl Acad Sci U S A. 2022 08 23; 119(34):e2207592119. PMID: 35969769; PMCID: PMC9407592.
      Citations: 3     Fields:    Translation:AnimalsCells
    3. Ahamed J, Laurence J. Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches. J Clin Invest. 2022 08 01; 132(15). PMID: 35912863; PMCID: PMC9337829.
      Citations: 24     Fields:    Translation:HumansCells
    4. Gostynska S, Venkatesan T, Subramani K, Cortez B, Robertson A, Subrahmanian S, Dube P, Ahamed J. Megakaryocyte/platelet-derived TGF-ß1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver. Blood Adv. 2022 06 14; 6(11):3321-3328. PMID: 35358295.
      Citations:    Fields:    Translation:AnimalsCells
    5. Elhadad S, Chadburn A, Magro C, Van Besien K, Roberson EDO, Atkinson JP, Terry H, Greenberg J, Reid W, Chapin J, Copertino D, Geramfard S, Rodriguez LB, Orfali N, Gerghis U, Shore T, Mayer S, Ahamed J, Laurence J. C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy. Bone Marrow Transplant. 2022 09; 57(9):1445-1447. PMID: 35661836.
      Citations: 2     Fields:    Translation:Humans
    6. Laurence J, Nuovo G, Racine-Brzostek SE, Seshadri M, Elhadad S, Crowson AN, Mulvey JJ, Harp J, Ahamed J, Magro C. Premortem Skin Biopsy Assessing Microthrombi, Interferon Type I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage. Am J Pathol. 2022 09; 192(9):1282-1294. PMID: 35640675.
      Citations: 4     Fields:    Translation:Humans
    7. Subrahmanian S, Varshney R, Subramani K, Murphy B, Woolington S, Ahamed J. N-Acetylcysteine Inhibits Aortic Stenosis Progression in a Murine Model by Blocking Shear-Induced Activation of Platelet Latent Transforming Growth Factor Beta 1. Antioxid Redox Signal. 2021 Dec 07. PMID: 34619980.
      Citations: 2     Fields:    
    8. Kondo Y, Larabee JL, Gao L, Shi H, Shao B, Hoover CM, McDaniel JM, Ho YC, Silasi-Mansat R, Archer-Hartmann SA, Azadi P, Srinivasan RS, Rezaie AR, Borczuk A, Laurence JC, Lupu F, Ahamed J, McEver RP, Papin JF, Yu Z, Xia L. L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus. JCI Insight. 2021 07 22; 6(14). PMID: 34291736.
      Citations: 20     Fields:    Translation:HumansCells
    9. Subrahmanian S, Borczuk A, Salvatore S, Fung KM, Merrill JT, Laurence J, Ahamed J. Tissue factor upregulation is associated with SARS-CoV-2 in the lungs of COVID-19 patients. J Thromb Haemost. 2021 09; 19(9):2268-2274. PMID: 34236752.
      Citations: 21     Fields:    Translation:HumansCells
    10. Ahamed J. Severe aortic stenosis patient risk during the COVID-19 pandemic. Open Heart. 2020 09; 7(2). PMID: 32928913.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    11. Laurence J, Elhadad S, Gostynska S, Yu Z, Terry H, Varshney R, Fung KM, Choi ME, Ahamed J. HIV protease inhibitor ritonavir induces renal fibrosis and dysfunction: role of platelet-derived TGF-ß1 and intervention via antioxidant pathways. AIDS. 2020 06 01; 34(7):989-1000. PMID: 32167970.
      Citations: 1     Fields:    Translation:AnimalsCells
    12. Kouzbari K, Hossan MR, Arrizabalaga JH, Varshney R, Simmons AD, Gostynska S, Nollert MU, Ahamed J. Oscillatory shear potentiates latent TGF-ß1 activation more than steady shear as demonstrated by a novel force generator. Sci Rep. 2019 04 15; 9(1):6065. PMID: 30988341.
      Citations: 18     Fields:    Translation:HumansCells
    13. Varshney R, Murphy B, Woolington S, Ghafoory S, Chen S, Robison T, Ahamed J. Inactivation of platelet-derived TGF-ß1 attenuates aortic stenosis progression in a robust murine model. Blood Adv. 2019 03 12; 3(5):777-788. PMID: 30846427.
      Citations: 17     Fields:    Translation:AnimalsCells
    14. Yago T, Liu Z, Ahamed J, McEver RP. Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice. Blood. 2018 09 27; 132(13):1426-1437. PMID: 30068506.
      Citations: 54     Fields:    Translation:AnimalsCells
    15. Laurence J, Elhadad S, Ahamed J. HIV-associated cardiovascular disease: importance of platelet activation and cardiac fibrosis in the setting of specific antiretroviral therapies. Open Heart. 2018; 5(2):e000823. PMID: 30018781.
      Citations: 15     Fields:    
    16. Ghafoory S, Varshney R, Robison T, Kouzbari K, Woolington S, Murphy B, Xia L, Ahamed J. Platelet TGF-ß1 deficiency decreases liver fibrosis in a mouse model of liver injury. Blood Adv. 2018 03 13; 2(5):470-480. PMID: 29490978.
      Citations: 36     Fields:    Translation:AnimalsCells
    17. Mancini D, Monteagudo J, Suárez-Fariñas M, Bander J, Varshney R, Gonzalez J, Coller BS, Ahamed J. New methodologies to accurately assess circulating active transforming growth factor-ß1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices. Transl Res. 2018 02; 192:15-29. PMID: 29175264.
      Citations: 13     Fields:    Translation:Humans
    18. Laurence J, Elhadad S, Robison T, Terry H, Varshney R, Woolington S, Ghafoory S, Choi ME, Ahamed J. HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-ß1 and can be suppressed by exogenous carbon monoxide. PLoS One. 2017; 12(10):e0187185. PMID: 29088262.
      Citations: 12     Fields:    Translation:AnimalsCells
    19. Ahamed J, Laurence J. Role of Platelet-Derived Transforming Growth Factor-ß1 and Reactive Oxygen Species in Radiation-Induced Organ Fibrosis. Antioxid Redox Signal. 2017 Nov 01; 27(13):977-988. PMID: 28562065.
      Citations: 31     Fields:    Translation:HumansCells
    20. Ahamed J, Terry H, Choi ME, Laurence J. Transforming growth factor-ß1-mediated cardiac fibrosis: potential role in HIV and HIV/antiretroviral therapy-linked cardiovascular disease. AIDS. 2016 Feb 20; 30(4):535-42. PMID: 26605511.
      Citations: 13     Fields:    Translation:HumansAnimals
    21. Zhao M, Perry JM, Marshall H, Venkatraman A, Qian P, He XC, Ahamed J, Li L. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med. 2014 Nov; 20(11):1321-6. PMID: 25326798.
      Citations: 288     Fields:    Translation:AnimalsCells
    22. Yang F, Dong A, Ahamed J, Sunkara M, Smyth SS. Granule cargo release from bone marrow-derived cells sustains cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2014 Nov 15; 307(10):H1529-38. PMID: 25239803.
      Citations:    Fields:    Translation:AnimalsCells
    23. Wang W, Vootukuri S, Meyer A, Ahamed J, Coller BS. Association between shear stress and platelet-derived transforming growth factor-ß1 release and activation in animal models of aortic valve stenosis. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1924-32. PMID: 24903096.
      Citations: 18     Fields:    Translation:AnimalsCells
    24. Palmerini T, Tomasi L, Barozzi C, Della Riva D, Mariani A, Taglieri N, Leone O, Ceccarelli C, De Servi S, Branzi A, Genereux P, Stone GW, Ahamed J. Detection of tissue factor antigen and coagulation activity in coronary artery thrombi isolated from patients with ST-segment elevation acute myocardial infarction. PLoS One. 2013; 8(12):e81501. PMID: 24349079.
      Citations: 8     Fields:    Translation:Humans
    25. Brophy TM, Coller BS, Ahamed J. Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor ß1 (TGF-ß1) activation. J Biol Chem. 2013 Apr 12; 288(15):10628-39. PMID: 23463512.
      Citations: 13     Fields:    Translation:HumansCellsCTClinical Trials
    26. Meyer A, Wang W, Qu J, Croft L, Degen JL, Coller BS, Ahamed J. Platelet TGF-ß1 contributions to plasma TGF-ß1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload. Blood. 2012 Jan 26; 119(4):1064-74. PMID: 22134166.
      Citations: 89     Fields:    Translation:AnimalsCells
    27. Ahamed JA, Madhivadhani P. Costimulatory role of CXCR4 with pre-TCR and its crosstalk with PI3K in beta-selection of thymocytes. Sci Signal. 2010 Apr 27; 3(119):jc4. PMID: 20424260.
      Citations: 4     Fields:    Translation:AnimalsCells
    28. Ahamed J, Janczak CA, Wittkowski KM, Coller BS. In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1. PLoS One. 2009 Aug 12; 4(8):e6608. PMID: 19672301.
      Citations: 31     Fields:    Translation:AnimalsCells
    29. Ahamed J, Burg N, Yoshinaga K, Janczak CA, Rifkin DB, Coller BS. In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1. Blood. 2008 Nov 01; 112(9):3650-60. PMID: 18544680.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    30. Bhattacharjee G, Ahamed J, Pawlinski R, Liu C, Mackman N, Ruf W, Edgington TS. Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circ Res. 2008 Feb 29; 102(4):457-64. PMID: 18174463.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    31. Versteeg HH, Schaffner F, Kerver M, Petersen HH, Ahamed J, Felding-Habermann B, Takada Y, Mueller BM, Ruf W. Inhibition of tissue factor signaling suppresses tumor growth. Blood. 2008 Jan 01; 111(1):190-9. PMID: 17901245.
      Citations: 143     Fields:    Translation:HumansAnimalsCells
    32. Lawson BR, Manenkova Y, Ahamed J, Chen X, Zou JP, Baccala R, Theofilopoulos AN, Yuan C. Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system. J Immunol. 2007 Apr 15; 178(8):5366-74. PMID: 17404322.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    33. Ahamed J, Niessen F, Kurokawa T, Lee YK, Bhattacharjee G, Morrissey JH, Ruf W. Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia. Blood. 2007 Jun 15; 109(12):5251-9. PMID: 17332247.
      Citations: 31     Fields:    Translation:AnimalsCells
    34. Chen VM, Ahamed J, Versteeg HH, Berndt MC, Ruf W, Hogg PJ. Evidence for activation of tissue factor by an allosteric disulfide bond. Biochemistry. 2006 Oct 03; 45(39):12020-8. PMID: 17002301.
      Citations: 84     Fields:    Translation:HumansCells
    35. Ahamed J, Versteeg HH, Kerver M, Chen VM, Mueller BM, Hogg PJ, Ruf W. Disulfide isomerization switches tissue factor from coagulation to cell signaling. Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):13932-7. PMID: 16959886.
      Citations: 139     Fields:    Translation:HumansCells
    36. Bhattacharjee G, Ahamed J, Pedersen B, El-Sheikh A, Mackman N, Ruf W, Liu C, Edgington TS. Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78. Arterioscler Thromb Vasc Biol. 2005 Aug; 25(8):1737-43. PMID: 15947236.
      Citations: 28     Fields:    Translation:AnimalsCells
    37. Belting M, Ahamed J, Ruf W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler Thromb Vasc Biol. 2005 Aug; 25(8):1545-50. PMID: 15905465.
      Citations: 65     Fields:    Translation:HumansCells
    38. Ahamed J. Choice of drugs to manage anthrax. Med Hypotheses. 2005; 64(4):883-4. PMID: 15694716.
      Citations:    Fields:    Translation:Humans
    39. Ahamed J, Belting M, Ruf W. Regulation of tissue factor-induced signaling by endogenous and recombinant tissue factor pathway inhibitor 1. Blood. 2005 Mar 15; 105(6):2384-91. PMID: 15550483.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    40. Venkatesha RT, Ahamed J, Nuesch C, Zaidi AK, Ali H. Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. J Biol Chem. 2004 Oct 22; 279(43):44606-12. PMID: 15308653.
      Citations: 19     Fields:    Translation:AnimalsCells
    41. Ahamed J, Venkatesha RT, Thangam EB, Ali H. C3a enhances nerve growth factor-induced NFAT activation and chemokine production in a human mast cell line, HMC-1. J Immunol. 2004 Jun 01; 172(11):6961-8. PMID: 15153516.
      Citations: 23     Fields:    Translation:HumansCells
    42. Belting M, Dorrell MI, Sandgren S, Aguilar E, Ahamed J, Dorfleutner A, Carmeliet P, Mueller BM, Friedlander M, Ruf W. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nat Med. 2004 May; 10(5):502-9. PMID: 15098027.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    43. Ahamed J, Ruf W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain. J Biol Chem. 2004 May 28; 279(22):23038-44. PMID: 15039423.
      Citations: 56     Fields:    Translation:HumansCells
    44. Subbarao K, Jala VR, Mathis S, Suttles J, Zacharias W, Ahamed J, Ali H, Tseng MT, Haribabu B. Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms. Arterioscler Thromb Vasc Biol. 2004 Feb; 24(2):369-75. PMID: 14656734.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    45. Ahamed J, Ali H. Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. J Biol Chem. 2002 Jun 21; 277(25):22685-91. PMID: 11934880.
      Citations: 8     Fields:    Translation:HumansCells
    46. Krug A, Ahamed J, Ali H. Regulation of inflammatory responses. Penn Dent J (Phila). 2002; 102:8-9. PMID: 15487551.
      Citations:    Fields:    Translation:HumansCells
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