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Natarajan Aravindan

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentRadiation Oncology Research
AddressBMSB 311
940 Stanton L Young Blvd
Oklahoma City OK 73104
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Somasundaram DB, Maher A, Aravindan S, Yu Z, Besch BM, Aravindan N. Mesenchymal stem cell-based TRAIL delivery inhibits the metastatic state of clinical therapy-resistant progressive neuroblastoma. World J Pediatr. 2023 Dec 07. PMID: 38060141.
      Citations:    Fields:    
    2. Aravindan N, Natarajan M, Somasundaram DB, Aravindan S. Chemoprevention of neuroblastoma: progress and promise beyond uncertainties. J Cancer Metastasis Treat. 2023; 9. PMID: 38249515; PMCID: PMC10798790.
    3. Somasundaram DB, Aravindan S, Gupta N, Yu Z, Baker A, Aravindan N. ALK expression, prognostic significance, and its association with MYCN expression in MYCN non-amplified neuroblastoma. World J Pediatr. 2022 04; 18(4):285-293. PMID: 35132576.
      Citations: 3     Fields:    Translation:Humans
    4. Jain D, Somasundaram DB, Aravindan S, Yu Z, Baker A, Esmaeili A, Aravindan N. Prognostic significance of NT5E/CD73 in neuroblastoma and its function in CSC stemness maintenance. Cell Biol Toxicol. 2021 Nov 13. PMID: 34773529.
      Citations: 3     Fields:    Translation:HumansCells
    5. Somasundaram DB, Aravindan S, Major R, Natarajan M, Aravindan N. MMP-9 reinforces radiation-induced delayed invasion and metastasis of neuroblastoma cells through second-signaling positive feedback with NF?B via both ERK and IKK activation. Cell Biol Toxicol. 2021 Oct 09. PMID: 34626302.
      Citations: 2     Fields:    Translation:HumansCells
    6. Rajamani K, Thirugnanasambandan SS, Natesan C, Subramaniam S, Thangavel B, Aravindan N. Squalene deters drivers of RCC disease progression beyond VHL status. Cell Biol Toxicol. 2021 08; 37(4):611-631. PMID: 33219891.
      Citations: 3     Fields:    Translation:Animals
    7. Aravindan N, Herman T, Aravindan S. Emerging therapeutic targets for neuroblastoma. Expert Opin Ther Targets. 2020 09; 24(9):899-914. PMID: 33021426.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    8. Aravindan N, Somasundaram DB, Herman TS, Aravindan S. Significance of hematopoietic surface antigen CD34 in neuroblastoma prognosis and the genetic landscape of CD34-expressing neuroblastoma CSCs. Cell Biol Toxicol. 2021 06; 37(3):461-478. PMID: 32979173.
      Citations: 8     Fields:    Translation:HumansCells
    9. Aravindan N, Subramanian K, Somasundaram DB, Herman TS, Aravindan S. MicroRNAs in neuroblastoma tumorigenesis, therapy resistance, and disease evolution. Cancer Drug Resist. 2019; 2:1086-1105. PMID: 31867575.
      Citations: 15     
    10. Aravindan N, Jain D, Somasundaram DB, Herman TS, Aravindan S. Cancer stem cells in neuroblastoma therapy resistance. Cancer Drug Resist. 2019 Dec 19; 2:948-967. PMID: 31867574.
      Citations: 19     
    11. Delma CR, Thirugnanasambandan S, Srinivasan GP, Raviprakash N, Manna SK, Natarajan M, Aravindan N. Fucoidan from marine brown algae attenuates pancreatic cancer progression by regulating p53 - NF?B crosstalk. Phytochemistry. 2019 Nov; 167:112078. PMID: 31450091.
      Citations: 13     Fields:    Translation:HumansCells
    12. Somasundaram DB, Subramanian K, Aravindan S, Yu Z, Natarajan M, Herman T, Aravindan N. De novo regulation of RD3 synthesis in residual neuroblastoma cells after intensive multi-modal clinical therapy harmonizes disease evolution. Sci Rep. 2019 08 13; 9(1):11766. PMID: 31409909.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    13. Aravindan S, Somasundaram DB, Somasundaram ST, Natarajan M, Herman TS, Aravindan N. Targeting acquired oncogenic burden in resilient pancreatic cancer: a novel benefit from marine polyphenols. Mol Cell Biochem. 2019 Oct; 460(1-2):175-193. PMID: 31367889.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    14. Somasundaram DB, Aravindan S, Yu Z, Jayaraman M, Tran NTB, Li S, Herman TS, Aravindan N. Droplet digital PCR as an alternative to FISH for MYCN amplification detection in human neuroblastoma FFPE samples. BMC Cancer. 2019 Jan 28; 19(1):106. PMID: 30691436.
      Citations: 4     Fields:    Translation:Humans
    15. Aravindan S, Somasundaram DB, Kam KL, Subramanian K, Yu Z, Herman TS, Fung KM, Aravindan N. Retinal Degeneration Protein 3 (RD3) in normal human tissues: Novel insights. Sci Rep. 2017 10 13; 7(1):13154. PMID: 29030614.
      Citations: 3     Fields:    Translation:HumansCells
    16. Griffith J, Andrade D, Mehta M, Berry W, Benbrook DM, Aravindan N, Herman TS, Ramesh R, Munshi A. Silencing BMI1 radiosensitizes human breast cancer cells by inducing DNA damage and autophagy. Oncol Rep. 2017 Apr; 37(4):2382-2390. PMID: 28260023.
      Citations: 11     Fields:    Translation:HumansCells
    17. Aravindan S, Ramraj S, Kandasamy K, Thirugnanasambandan SS, Somasundaram DB, Herman TS, Aravindan N. Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells. Oncotarget. 2017 Jan 24; 8(4):5717-5734. PMID: 27974694.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    18. Yu H, Aravindan N, Xu J, Natarajan M. Inter- and intra-cellular mechanism of NF-kB-dependent survival advantage and clonal expansion of radio-resistant cancer cells. Cell Signal. 2017 02; 31:105-111. PMID: 28069440.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    19. Aravindan N, Aravindan S, Manickam K, Natarajan M. High Energy Particle Radiation-associated Oncogenic Transformation in Normal Mice: Insight into the Connection between Activation of Oncotargets and Oncogene Addiction. Sci Rep. 2016 11 23; 6:37623. PMID: 27876887.
      Citations: 6     Fields:    Translation:AnimalsCells
    20. Natarajan M, Aravindan N, Sprague EA, Mohan S. Hemodynamic Flow-Induced Mechanotransduction Signaling Influences the Radiation Response of the Vascular Endothelium. Radiat Res. 2016 08; 186(2):175-88. PMID: 27387860.
      Citations: 7     Fields:    Translation:HumansCells
    21. Ramraj SK, Aravindan S, Somasundaram DB, Herman TS, Natarajan M, Aravindan N. Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. Oncotarget. 2016 Apr 05; 7(14):18605-19. PMID: 26921195.
      Citations: 11     Fields:    Translation:HumansAnimals
    22. Pandian V, Ramraj S, Khan FH, Azim T, Aravindan N. Erratum to: Metastatic neuroblastoma cancer stem cells exhibit flexible plasticity and adaptive stemness signaling. Stem Cell Res Ther. 2016 Feb 18; 7:32. PMID: 26892617.
      Citations: 1     Fields:    
    23. Khan FH, Pandian V, Ramraj SK, Aravindan S, Natarajan M, Azadi S, Herman TS, Aravindan N. RD3 loss dictates high-risk aggressive neuroblastoma and poor clinical outcomes. Oncotarget. 2015 Nov 03; 6(34):36522-34. PMID: 26375249.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    24. Aravindan S, Ramraj SK, Somasundaram ST, Herman TS, Aravindan N. Polyphenols from marine brown algae target radiotherapy-coordinated EMT and stemness-maintenance in residual pancreatic cancer. Stem Cell Res Ther. 2015 Sep 22; 6:182. PMID: 26395574.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    25. Khan FH, Pandian V, Ramraj S, Natarajan M, Aravindan S, Herman TS, Aravindan N. Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes. BMC Cancer. 2015 Jul 10; 15:514. PMID: 26159519.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    26. Khan FH, Pandian V, Ramraj S, Aravindan S, Herman TS, Aravindan N. Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells. BMC Genomics. 2015 Jul 07; 16:501. PMID: 26148557.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    27. Aravindan S, Ramraj SK, Somasundaram ST, Aravindan N. Novel adjuvants from seaweed impede autophagy signaling in therapy-resistant residual pancreatic cancer. J Biomed Sci. 2015 Apr 17; 22:28. PMID: 25898131.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    28. Pandian V, Ramraj S, Khan FH, Azim T, Aravindan N. Metastatic neuroblastoma cancer stem cells exhibit flexible plasticity and adaptive stemness signaling. Stem Cell Res Ther. 2015 Feb 20; 6:2. PMID: 25888913.
      Citations: 28     Fields:    Translation:HumansCells
    29. Delma CR, Somasundaram ST, Srinivasan GP, Khursheed M, Bashyam MD, Aravindan N. Fucoidan from Turbinaria conoides: a multifaceted 'deliverable' to combat pancreatic cancer progression. Int J Biol Macromol. 2015 Mar; 74:447-57. PMID: 25541359.
      Citations: 12     Fields:    Translation:HumansCells
    30. Pandian V, Aravindan N, Subramanian S, Somasundaran ST. Lipid-lowering effect of molluscan (Katelysia opima) glycosaminoglycan (GAG) in hypercholesterolemic induced rats. Biol Chem. 2014 Mar; 395(3):355-64. PMID: 24150207.
      Citations: 1     Fields:    Translation:Animals
    31. Aravindan N, Aravindan S, Pandian V, Khan FH, Ramraj SK, Natt P, Natarajan M. Acquired tumor cell radiation resistance at the treatment site is mediated through radiation-orchestrated intercellular communication. Int J Radiat Oncol Biol Phys. 2014 Mar 01; 88(3):677-85. PMID: 24411622.
      Citations: 17     Fields:    Translation:HumansCells
    32. Aravindan S, Natarajan M, Ramraj SK, Pandian V, Khan FH, Herman TS, Aravindan N. Abscopal effect of low-LET ?-radiation mediated through Rel protein signal transduction in a mouse model of nontargeted radiation response. Cancer Gene Ther. 2014 Feb; 21(2):54-9. PMID: 24357814.
      Citations: 20     Fields:    Translation:AnimalsCells
    33. Aravindan S, Natarajan M, Awasthi V, Herman TS, Aravindan N. Novel synthetic monoketone transmute radiation-triggered NF?B-dependent TNFa cross-signaling feedback maintained NF?B and favors neuroblastoma regression. PLoS One. 2013; 8(8):e72464. PMID: 23967300.
      Citations: 12     Fields:    Translation:HumansCells
    34. Aravindan S, Delma CR, Thirugnanasambandan SS, Herman TS, Aravindan N. Anti-pancreatic cancer deliverables from sea: first-hand evidence on the efficacy, molecular targets and mode of action for multifarious polyphenols from five different brown-algae. PLoS One. 2013; 8(4):e61977. PMID: 23613993.
      Citations: 13     Fields:    Translation:HumansCells
    35. Aravindan S, Natarajan M, Herman TS, Aravindan N. Radiation-induced TNFa cross signaling-dependent nuclear import of NF?B favors metastasis in neuroblastoma. Clin Exp Metastasis. 2013 Aug; 30(6):807-17. PMID: 23584794.
      Citations: 7     Fields:    Translation:HumansCells
    36. Aravindan S, Natarajan M, Herman TS, Awasthi V, Aravindan N. Molecular basis of 'hypoxic' breast cancer cell radio-sensitization: phytochemicals converge on radiation induced Rel signaling. Radiat Oncol. 2013 Mar 04; 8:46. PMID: 23452621.
      Citations: 13     Fields:    Translation:HumansCells
    37. Aravindan N, Aravindan S, Herman TS, Natarajan M. EGFR tyrosine kinase inhibitor pelitinib regulates radiation-induced p65-dependent telomerase activation in squamous cell carcinoma. Radiat Res. 2013 Mar; 179(3):304-12. PMID: 23379415.
      Citations: 4     Fields:    Translation:HumansCells
    38. Aravindan N, Thomas CR, Aravindan S, Mohan AS, Veeraraghavan J, Natarajan M. Irreversible EGFR inhibitor EKB-569 targets low-LET ?-radiation-triggered rel orchestration and potentiates cell death in squamous cell carcinoma. PLoS One. 2011; 6(12):e29705. PMID: 22242139.
      Citations: 9     Fields:    Translation:HumansCells
    39. Veeraraghavan J, Natarajan M, Lagisetty P, Awasthi V, Herman TS, Aravindan N. Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells. Pancreas. 2011 Oct; 40(7):1107-19. PMID: 21697760.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    40. Veeraraghavan J, Natarajan M, Aravindan S, Herman TS, Aravindan N. Radiation-triggered tumor necrosis factor (TNF) alpha-NFkappaB cross-signaling favors survival advantage in human neuroblastoma cells. J Biol Chem. 2011 Jun 17; 286(24):21588-600. PMID: 21527635.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    41. Aravindan N, Veeraraghavan J, Madhusoodhanan R, Herman TS, Natarajan M. Curcumin regulates low-linear energy transfer ?-radiation-induced NF?B-dependent telomerase activity in human neuroblastoma cells. Int J Radiat Oncol Biol Phys. 2011 Mar 15; 79(4):1206-15. PMID: 21236599.
      Citations: 20     Fields:    Translation:HumansCells
    42. Veeraraghavan J, Aravindan S, Natarajan M, Awasthi V, Herman TS, Aravindan N. Neem leaf extract induces radiosensitization in human neuroblastoma xenograft through modulation of apoptotic pathway. Anticancer Res. 2011 Jan; 31(1):161-70. PMID: 21273594.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    43. Veeraraghavan J, Natarajan M, Herman TS, Aravindan N. Low-dose ?-radiation-induced oxidative stress response in mouse brain and gut: regulation by NF?B-MnSOD cross-signaling. Mutat Res. 2011 Jan 10; 718(1-2):44-55. PMID: 21056117.
      Citations: 20     Fields:    Translation:AnimalsCells
    44. Veeraraghavan J, Natarajan M, Herman TS, Aravindan N. Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing's sarcoma cells. Anticancer Res. 2010 Oct; 30(10):4007-15. PMID: 21036715.
      Citations: 16     Fields:    Translation:HumansCells
    45. Madhusoodhanan R, Natarajan M, Singh JV, Jamgade A, Awasthi V, Anant S, Herman TS, Aravindan N. Effect of black raspberry extract in inhibiting NFkappa B dependent radioprotection in human breast cancer cells. Nutr Cancer. 2010; 62(1):93-104. PMID: 20043264.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    46. Madhusoodhanan R, Natarajan M, Veeraraghavan J, Herman TS, Jamgade A, Singh N, Aravindan N. NFkappaB signaling related molecular alterations in human neuroblastoma cells after fractionated irradiation. J Radiat Res. 2009 Jul; 50(4):311-24. PMID: 19436149.
      Citations: 13     Fields:    Translation:HumansCells
    47. Madhusoodhanan R, Natarajan M, Veeraraghavan J, Herman TS, Aravindan N. NFkappaB activity and transcriptional responses in human breast adenocarcinoma cells after single and fractionated irradiation. Cancer Biol Ther. 2009 May; 8(9):765-73. PMID: 19276662.
      Citations: 15     Fields:    Translation:HumansCells
    48. Aravindan N, Mohan S, Herman TS, Natarajan M. Nitric oxide-mediated inhibition of NFkappaB regulates hyperthermia-induced apoptosis. J Cell Biochem. 2009 Apr 15; 106(6):999-1009. PMID: 19204936.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    49. Aravindan N, Shanmugasundaram K, Natarajan M. Hyperthermia induced NFkappaB mediated apoptosis in normal human monocytes. Mol Cell Biochem. 2009 Jul; 327(1-2):29-37. PMID: 19219626.
      Citations: 2     Fields:    Translation:HumansCells
    50. Aravindan N, Madhusoodhanan R, Ahmad S, Johnson D, Herman TS. Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells. Cancer Biol Ther. 2008 Apr; 7(4):569-76. PMID: 18305409.
      Citations: 38     Fields:    Translation:HumansCells
    51. Aravindan N, Madhusoodhanan R, Natarajan M, Herman TS. Alteration of apoptotic signaling molecules as a function of time after radiation in human neuroblastoma cells. Mol Cell Biochem. 2008 Mar; 310(1-2):167-79. PMID: 18066712.
      Citations: 12     Fields:    Translation:HumansCells
    52. Aravindan N, Aravindan S, Shanmugasundaram K, Shaw AD. Periods of systemic partial hypoxia induces apoptosis and inflammation in rat skeletal muscle. Mol Cell Biochem. 2007 Aug; 302(1-2):51-8. PMID: 17323003.
      Citations: 8     Fields:    Translation:Animals
    53. Aravindan N, Aravindan S, Riedel BJ, Weng HR, Shaw AD. Furosemide prevents apoptosis and associated gene expression in a rat model of surgical ischemic acute renal failure. Ren Fail. 2007; 29(4):399-407. PMID: 17497460.
      Citations: 11     Fields:    Translation:Animals
    54. Nates JL, Aravindan N, Hirsch-Ginsberg C, Sizer KC, Kee S, Nguyen AT, Chen K, Shaw AD, Price KJ. Critically ill cancer patients are not consistently hypercoagulable after craniotomy. Neurocrit Care. 2007; 7(3):211-6. PMID: 17968522.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    55. Aravindan N, Cata JP, Hoffman L, Dougherty PM, Riedel BJ, Price KJ, Shaw AD. Effects of isoflurane, pentobarbital, and urethane on apoptosis and apoptotic signal transduction in rat kidney. Acta Anaesthesiol Scand. 2006 Nov; 50(10):1229-37. PMID: 16978161.
      Citations: 10     Fields:    Translation:AnimalsCells
    56. Aravindan N, Samuels J, Riedel B, Shaw A. Fenoldopam improves corticomedullary oxygen delivery and attenuates angiogenesis gene expression in acute ischemic renal injury. Kidney Blood Press Res. 2006; 29(3):165-74. PMID: 16931895.
      Citations: 8     Fields:    Translation:Animals
    57. Dang A, Mansfield P, Ilsin B, Hightower C, Aravindan N, Rice D, Riedel B. Intraoperative hyperthermic intrathoracic chemotherapy for pleural extension of pseudomyxoma peritonei. J Cardiothorac Vasc Anesth. 2007 Apr; 21(2):265-8. PMID: 17418746.
      Citations: 2     Fields:    Translation:Humans
    58. Aravindan N, Natarajan M, Shaw AD. Fenoldopam inhibits nuclear translocation of nuclear factor kappa B in a rat model of surgical ischemic acute renal failure. J Cardiothorac Vasc Anesth. 2006 Apr; 20(2):179-86. PMID: 16616657.
      Citations: 13     Fields:    Translation:AnimalsCells
    59. Aravindan N, Cata JP, Dougherty PM, Shaw AD. Effect of fenoldopam on ischemia/reperfusion-induced apoptosis. Ren Fail. 2006; 28(4):337-44. PMID: 16771250.
      Citations: 7     Fields:    Translation:AnimalsCells
    60. Aravindan N, Shaw A. Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusion. Ren Fail. 2006; 28(1):25-35. PMID: 16526316.
      Citations: 6     Fields:    Translation:Animals
    61. Weng HR, Aravindan N, Cata JP, Chen JH, Shaw AD, Dougherty PM. Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia. Neurosci Lett. 2005 Sep 23; 386(1):18-22. PMID: 15975716.
      Citations: 46     Fields:    Translation:AnimalsCells
    62. Martin CB, Shaw AD, Gal J, Aravindan N, Murphy F, Royston D, Riedel BJ. The comparison and validity of troponin I assay systems in diagnosing myocardial ischemic injury after surgical coronary revascularization. J Cardiothorac Vasc Anesth. 2005 Jun; 19(3):288-93. PMID: 16130052.
      Citations: 2     Fields:    Translation:Humans
    63. Aravindan N, Williams MT, Riedel BJ, Shaw AD. Transcriptional responses of rat skeletal muscle following hypoxia-reoxygenation and near ischaemia-reperfusion. Acta Physiol Scand. 2005 Apr; 183(4):367-77. PMID: 15799773.
      Citations: 4     Fields:    Translation:AnimalsCells
    64. Williams MT, Aravindan N, Wallace MJ, Riedel BJ, Shaw AD. Venous thromboembolism in the intensive care unit. Crit Care Clin. 2003 Apr; 19(2):185-207. PMID: 12699319.
      Citations: 8     Fields:    Translation:Humans
    65. Natarajan M, Aravindan N, Meltz ML, Herman TS. Post-translational modification of I-kappa B alpha activates NF-kappa B in human monocytes exposed to 56Fe ions. Radiat Environ Biophys. 2002 Jun; 41(2):139-44. PMID: 12201057.
      Citations: 22     Fields:    Translation:HumansCells
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