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Shanjana Awasthi

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
AddressCPB 323
1110 N Stonewall Ave
Oklahoma City OK 73117
Phone405/271-6593 ext 47332
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    R01HL136325     (AWASTHI, SHANJANA)Aug 8, 2017 - Jul 31, 2022
    Surfactant protein-A regions as TLR4-immunomodulators
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chowdhury AA, Rodgers K, Godbole NM, Awasthi S. Stability and structure-activity relationship of the SPA4 peptide under ambient and stressed conditions of lung injury. RSC Adv. 2023 Jun 15; 13(27):18864-18877. PMID: 37350860; PMCID: PMC10282593.
    2. Godbole NM, Chowdhury AA, Chataut N, Awasthi S. Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury. Inflammation. 2022 Dec; 45(6):2142-2162. PMID: 35779195.
      Citations:    Fields:    Translation:HumansCells
    3. Chowdhury AA, Godbole NM, Chataut N, Kosanke S, Rodgers K, Awasthi S. Effects of SPA4 peptide on lipopolysaccharide-disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury. Physiol Rep. 2022 07; 10(13):e15353. PMID: 35838161.
      Citations: 2     Fields:    Translation:HumansAnimals
    4. Awasthi S, Kumar G, Ramani V, Awasthi V, Rodgers KK, Xie J, Beierle J, Kyere-Davies G, Singh B, Rahman N, Chowdhury AA, Chataut N. Mechanism of Anti-Inflammatory Activity of TLR4-Interacting SPA4 Peptide. Immunohorizons. 2021 08 24; 5(8):659-674. PMID: 34429343.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Awasthi S, Rahman N, Rui B, Kumar G, Awasthi V, Breshears M, Kosanke S. Lung and general health effects of Toll-like receptor-4 (TLR4)-interacting SPA4 peptide. BMC Pulm Med. 2020 Jun 23; 20(1):179. PMID: 32576172.
      Citations: 5     Fields:    Translation:Animals
    6. Awasthi V, Vilekar P, Rao G, Awasthi S. Anti-inflammatory mediators ST2 and SIGIRR are induced by diphenyldifluoroketone EF24 in lipopolysaccharide-stimulated dendritic cells. Immunobiology. 2020 03; 225(2):151886. PMID: 31812341.
      Citations:    Fields:    Translation:AnimalsCells
    7. Awasthi S, Vilekar P, Conkleton A, Rahman N. Dendritic cell-based immunization induces Coccidioides Ag2/PRA-specific immune response. Vaccine. 2019 03 14; 37(12):1685-1691. PMID: 30795939.
      Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    8. Awasthi S, Singh B, Ramani V, Xie J, Kosanke S. TLR4-interacting SPA4 peptide improves host defense and alleviates tissue injury in a mouse model of Pseudomonas aeruginosa lung infection. PLoS One. 2019; 14(1):e0210979. PMID: 30689633.
      Citations: 14     Fields:    Translation:AnimalsCells
    9. Awasthi S. Intranasal Antifungal Vaccination Using DNA-Transfected Dendritic Cells. Methods Mol Biol. 2017; 1625:75-83. PMID: 28584984.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Yadav VR, Rao G, Houson H, Hedrick A, Awasthi S, Roberts PR, Awasthi V. Nanovesicular liposome-encapsulated hemoglobin (LEH) prevents multi-organ injuries in a rat model of hemorrhagic shock. Eur J Pharm Sci. 2016 Oct 10; 93:97-106. PMID: 27503458.
      Citations: 6     Fields:    Translation:Animals
    11. Rao G, Yadav VR, Awasthi S, Roberts PR, Awasthi V. Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2016 07 01; 311(1):G180-91. PMID: 27288424.
      Citations: 3     Fields:    Translation:AnimalsCells
    12. Vilekar P, Rao G, Awasthi S, Awasthi V. Diphenyldifluoroketone EF24 Suppresses Pro-inflammatory Interleukin-1 receptor 1 and Toll-like Receptor 4 in lipopolysaccharide-stimulated dendritic cells. J Inflamm (Lond). 2015; 12:55. PMID: 26401121.
      Citations: 4     
    13. Ramani V, Awasthi S. Toll-like receptor 4-interacting SPA4 peptide suppresses the NLRP3 inflammasome in response to LPS and ATP stimuli. J Leukoc Biol. 2015 Dec; 98(6):1037-48. PMID: 26254306.
      Citations: 7     Fields:    Translation:AnimalsCells
    14. Awasthi S, Anbanandam A, Rodgers KK. Structure of a TLR4-interacting SPA4 peptide. RSC Adv. 2015; 5(35):27431-27438. PMID: 25870755.
      Citations: 6     
    15. Awasthi S. Toll-like receptor-4 modulation for cancer immunotherapy. Front Immunol. 2014; 5:328. PMID: 25120541.
      Citations: 37     Fields:    
    16. Yadav VR, Vilekar P, Awasthi S, Awasthi V. Hemorrhage-induced interleukin-1 receptor pathway in lung is suppressed by 3,5-bis(2-fluorobenzylidene)-4-piperidone in a rat model of hypovolemic shock. Artif Organs. 2014 Aug; 38(8):675-83. PMID: 24749913.
      Citations: 5     Fields:    Translation:AnimalsCells
    17. Vilekar P, King C, Lagisetty P, Awasthi V, Awasthi S. Antibacterial activity of synthetic curcumin derivatives: 3,5-bis(benzylidene)-4-piperidone (EF24) and EF24-dimer linked via diethylenetriaminepentacetic acid (EF2DTPA). Appl Biochem Biotechnol. 2014 Apr; 172(7):3363-73. PMID: 24532443.
      Citations: 6     Fields:    Translation:AnimalsCells
    18. Ramani V, Madhusoodhanan R, Kosanke S, Awasthi S. A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation. Innate Immun. 2013 Dec; 19(6):596-610. PMID: 23475791.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    19. Moriasi C, Subramaniam D, Awasthi S, Ramalingam S, Anant S. Prevention of colitis-associated cancer: natural compounds that target the IL-6 soluble receptor. Anticancer Agents Med Chem. 2012 Dec; 12(10):1221-38. PMID: 22583410.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    20. Awasthi S, Singh B, Welliver RC, Dietert RR. Lung dendritic cell developmental programming, environmental stimuli, and asthma in early periods of life. J Allergy (Cairo). 2012; 2012:176468. PMID: 23209481.
      Citations: 2     
    21. Langer M, Duggan ES, Booth JL, Patel VI, Zander RA, Silasi-Mansat R, Ramani V, Veres TZ, Prenzler F, Sewald K, Williams DM, Coggeshall KM, Awasthi S, Lupu F, Burian D, Ballard JD, Braun A, Metcalf JP. Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Infect Immun. 2012 Dec; 80(12):4374-87. PMID: 23027535.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    22. Daw K, Baghdayan AS, Awasthi S, Shankar N. Biofilm and planktonic Enterococcus faecalis elicit different responses from host phagocytes in vitro. FEMS Immunol Med Microbiol. 2012 Jul; 65(2):270-82. PMID: 22333034.
      Citations: 18     Fields:    Translation:AnimalsCells
    23. Vilekar P, Awasthi S, Natarajan A, Anant S, Awasthi V. EF24 suppresses maturation and inflammatory response in dendritic cells. Int Immunol. 2012 Jul; 24(7):455-64. PMID: 22378503.
      Citations: 18     Fields:    Translation:AnimalsCells
    24. Chandrakesan P, Ahmed I, Chinthalapally A, Singh P, Awasthi S, Anant S, Umar S. Distinct compartmentalization of NF-?B activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and/or colitis following bacterial infection. Infect Immun. 2012 Feb; 80(2):753-67. PMID: 22144489.
      Citations: 21     Fields:    Translation:AnimalsCells
    25. Awasthi S, Madhusoodhanan R, Wolf R. Surfactant protein-A and toll-like receptor-4 modulate immune functions of preterm baboon lung dendritic cell precursor cells. Cell Immunol. 2011; 268(2):87-96. PMID: 21439559.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    26. Awasthi S, Brown K, King C, Awasthi V, Bondugula R. A toll-like receptor-4-interacting surfactant protein-A-derived peptide suppresses tumor necrosis factor-a release from mouse JAWS II dendritic cells. J Pharmacol Exp Ther. 2011 Mar; 336(3):672-81. PMID: 21159752.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    27. Vilekar P, Awasthi V, Lagisetty P, King C, Shankar N, Awasthi S. In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine. BMC Immunol. 2010 Dec 10; 11:60. PMID: 21143974.
      Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    28. Awasthi S. Surfactant protein (SP)-A and SP-D as antimicrobial and immunotherapeutic agents. Recent Pat Antiinfect Drug Discov. 2010 Jun; 5(2):115-23. PMID: 20230362.
      Citations: 10     Fields:    Translation:HumansAnimals
    29. Awasthi S. Susceptibility of TLR4-defective C3H/HeJ mice to Coccidioides posadasii infection. Med Mycol. 2010 May; 48(3):470-5. PMID: 20370361.
      Citations: 10     Fields:    Translation:AnimalsCells
    30. Agashe H, Lagisetty P, Awasthi S, Awasthi V. Improved formulation of liposome-encapsulated hemoglobin with an anionic non-phospholipid. Colloids Surf B Biointerfaces. 2010 Feb 01; 75(2):573-83. PMID: 19896346.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    31. Awasthi S, Wolf R, White G. Ontogeny and phagocytic function of baboon lung dendritic cells. Immunol Cell Biol. 2009 Jul; 87(5):419-27. PMID: 19223853.
      Citations: 2     Fields:    Translation:AnimalsCells
    32. Awasthi S, Cropper J, Brown KM. Developmental expression of Toll-like receptors-2 and -4 in preterm baboon lung. Dev Comp Immunol. 2008; 32(9):1088-98. PMID: 18377992.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    33. Metkar S, Awasthi S, Denamur E, Kim KS, Gangloff SC, Teichberg S, Haziot A, Silver J, Goyert SM. Role of CD14 in responses to clinical isolates of Escherichia coli: effects of K1 capsule expression. Infect Immun. 2007 Nov; 75(11):5415-24. PMID: 17709409.
      Citations: 8     Fields:    Translation:AnimalsCells
    34. Awasthi S. Dendritic cell-based vaccine against coccidioides infection. Ann N Y Acad Sci. 2007 Sep; 1111:269-74. PMID: 17363430.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    35. Awasthi S, Cropper J. Immunophenotype and functions of fetal baboon bone-marrow derived dendritic cells. Cell Immunol. 2006 Mar; 240(1):31-40. PMID: 16842767.
      Citations: 4     Fields:    Translation:AnimalsCells
    36. Awasthi S, Awasthi V, Magee DM, Coalson JJ. Efficacy of antigen 2/proline-rich antigen cDNA-transfected dendritic cells in immunization of mice against Coccidioides posadasii. J Immunol. 2005 Sep 15; 175(6):3900-6. PMID: 16148136.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    37. Awasthi S, Magee DM. Differences in expression of cell surface co-stimulatory molecules, Toll-like receptor genes and secretion of IL-12 by bone marrow-derived dendritic cells from susceptible and resistant mouse strains in response to Coccidioides posadasii. Cell Immunol. 2004 Sep-Oct; 231(1-2):49-55. PMID: 15919369.
      Citations: 9     Fields:    Translation:AnimalsCells
    38. Awasthi S, Magee DM, Coalson JJ. Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D. Respir Res. 2004 Dec 10; 5:28. PMID: 15588319.
      Citations: 14     Fields:    Translation:Animals
    39. Awasthi S, Cox RA. Transfection of murine dendritic cell line (JAWS II) by a nonviral transfection reagent. Biotechniques. 2003 Sep; 35(3):600-2, 604. PMID: 14513565.
      Citations: 14     Fields:    Translation:AnimalsCells
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