Protein Tyrosine Phosphatases
"Protein Tyrosine Phosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.
| Descriptor ID |
D017027
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| MeSH Number(s) |
D08.811.277.352.650.775
|
| Concept/Terms |
Protein Tyrosine Phosphatases- Protein Tyrosine Phosphatases
- Phosphatases, Protein Tyrosine
- Tyrosine Phosphatases, Protein
- Phosphotyrosyl Protein Phosphatase
- Phosphatase, Phosphotyrosyl Protein
- Protein Phosphatase, Phosphotyrosyl
- Protein-Tyrosine Phosphatase
- Phosphatase, Protein-Tyrosine
- PTPase
- Tyrosyl Phosphoprotein Phosphatase
- Phosphatase, Tyrosyl Phosphoprotein
- Phosphoprotein Phosphatase, Tyrosyl
- Phosphotyrosine Phosphatase
- Phosphatase, Phosphotyrosine
- Protein-Tyrosine-Phosphatase
- Protein Tyrosine Phosphatase
|
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatases".
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatases".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatases" by people in this website by year, and whether "Protein Tyrosine Phosphatases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 5 | 3 | 8 |
| 2003 | 4 | 1 | 5 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 1 | 3 |
| 2006 | 4 | 1 | 5 |
| 2010 | 1 | 1 | 2 |
| 2014 | 3 | 0 | 3 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Tyrosine Phosphatases" by people in Profiles.
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SAR of non-hydrolysable analogs of pyridoxal 5'-phosphate against low molecular weight protein tyrosine phosphatase isoforms. Bioorg Med Chem Lett. 2020 08 15; 30(16):127342.
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Specific dephosphorylation of Janus Kinase 2 by protein tyrosine phosphatases. Proteomics. 2015 Jan; 15(1):68-76.
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Molecular cloning and characterization of a tyrosine phosphatase from Monosiga brevicollis. Biochem Biophys Res Commun. 2014 Oct 31; 453(4):761-6.
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Caenorhabditis elegans eyes absent ortholog EYA-1 is required for stress resistance. Biochemistry (Mosc). 2014 Jul; 79(7):653-62.
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Slk19p of Saccharomyces cerevisiae regulates anaphase spindle dynamics through two independent mechanisms. Genetics. 2010 Dec; 186(4):1247-60.
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Phosphoinositide 3-kinase signaling in the vertebrate retina. J Lipid Res. 2010 Jan; 51(1):4-22.
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Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus. Arthritis Rheum. 2006 Aug; 54(8):2533-40.
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Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling. J Biol Chem. 2006 Aug 04; 281(31):21878-21883.
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The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis. Rheumatology (Oxford). 2007 Jan; 46(1):49-56.
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SHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling. FEBS J. 2006 May; 273(10):2195-205.