Protein Tyrosine Phosphatases

"Protein Tyrosine Phosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.

Descriptor ID	D017027
MeSH Number(s)	D08.811.277.352.650.775
Concept/Terms	Protein Tyrosine Phosphatases Protein Tyrosine Phosphatases Phosphatases, Protein Tyrosine Tyrosine Phosphatases, Protein Phosphotyrosyl Protein Phosphatase Phosphatase, Phosphotyrosyl Protein Protein Phosphatase, Phosphotyrosyl Protein-Tyrosine Phosphatase Phosphatase, Protein-Tyrosine PTPase Tyrosyl Phosphoprotein Phosphatase Phosphatase, Tyrosyl Phosphoprotein Phosphoprotein Phosphatase, Tyrosyl Phosphotyrosine Phosphatase Phosphatase, Phosphotyrosine Protein-Tyrosine-Phosphatase Protein Tyrosine Phosphatase

Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
Protein Tyrosine Phosphatases [D08.811.277.352.650.775]

Below are MeSH descriptors whose meaning is related to "Protein Tyrosine Phosphatases".

Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatases".

Protein Tyrosine Phosphatases
Dual-Specificity Phosphatases
Protein Tyrosine Phosphatases, Non-Receptor
Receptor-Like Protein Tyrosine Phosphatases
SH2 Domain-Containing Protein Tyrosine Phosphatases

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Tyrosine Phosphatases" by people in this website by year, and whether "Protein Tyrosine Phosphatases" was a major or minor topic of these publications.

Bar chart showing 28 publications over 11 distinct years, with a maximum of 8 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
1997	0	1	1
1999	1	0	1
2000	0	1	1
2002	5	3	8
2003	4	0	4
2004	1	0	1
2005	1	1	2
2006	3	1	4
2010	1	1	2
2014	3	0	3

Below are the most recent publications written about "Protein Tyrosine Phosphatases" by people in Profiles.

Li J, Liu X, Chu H, Fu X, Li T, Hu L, Xing S, Li G, Gu J, Zhao ZJ. Specific dephosphorylation of Janus Kinase 2 by protein tyrosine phosphatases. Proteomics. 2015 Jan; 15(1):68-76.

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Zhao BF, Zhao ZJ. Molecular cloning and characterization of a tyrosine phosphatase from Monosiga brevicollis. Biochem Biophys Res Commun. 2014 Oct 31; 453(4):761-6.

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Wang BY, Xu XS, Cui YX, Wang H, Liu G, Zhao ZJ, Ma JF, Fu XQ. Caenorhabditis elegans eyes absent ortholog EYA-1 is required for stress resistance. Biochemistry (Mosc). 2014 Jul; 79(7):653-62.

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Havens KA, Gardner MK, Kamieniecki RJ, Dresser ME, Dawson DS. Slk19p of Saccharomyces cerevisiae regulates anaphase spindle dynamics through two independent mechanisms. Genetics. 2010 Dec; 186(4):1247-60.

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Rajala RV. Phosphoinositide 3-kinase signaling in the vertebrate retina. J Lipid Res. 2010 Jan; 51(1):4-22.

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Kaufman KM, Kelly JA, Herring BJ, Adler AJ, Glenn SB, Namjou B, Frank SG, Dawson SL, Bruner GR, James JA, Harley JB. Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus. Arthritis Rheum. 2006 Aug; 54(8):2533-40.

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Wang N, Li Z, Ding R, Frank GD, Senbonmatsu T, Landon EJ, Inagami T, Zhao ZJ. Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling. J Biol Chem. 2006 Aug 04; 281(31):21878-21883.

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Lee YH, Rho YH, Choi SJ, Ji JD, Song GG, Nath SK, Harley JB. The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis. Rheumatology (Oxford). 2007 Jan; 46(1):49-56.

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Sato M, Vaughan MB, Girard L, Peyton M, Lee W, Shames DS, Ramirez RD, Sunaga N, Gazdar AF, Shay JW, Minna JD. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res. 2006 Feb 15; 66(4):2116-28.

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Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med. 2005 Dec 05; 202(11):1587-97.

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