HSP90 Heat-Shock Proteins
"HSP90 Heat-Shock Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of MOLECULAR CHAPERONES whose members act in the mechanism of SIGNAL TRANSDUCTION by STEROID RECEPTORS.
| Descriptor ID |
D018841
|
| MeSH Number(s) |
D12.776.580.216.380
|
| Concept/Terms |
HSP90 Heat-Shock Proteins- HSP90 Heat-Shock Proteins
- HSP90 Heat Shock Proteins
- Heat-Shock Proteins, HSP90
- Heat-Shock Proteins 90
- Heat Shock Proteins 90
|
Below are MeSH descriptors whose meaning is more general than "HSP90 Heat-Shock Proteins".
Below are MeSH descriptors whose meaning is more specific than "HSP90 Heat-Shock Proteins".
This graph shows the total number of publications written about "HSP90 Heat-Shock Proteins" by people in this website by year, and whether "HSP90 Heat-Shock Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 1 | 3 |
| 1997 | 2 | 0 | 2 |
| 1998 | 1 | 0 | 1 |
| 1999 | 2 | 0 | 2 |
| 2000 | 2 | 1 | 3 |
| 2001 | 3 | 0 | 3 |
| 2002 | 1 | 0 | 1 |
| 2003 | 2 | 0 | 2 |
| 2004 | 2 | 0 | 2 |
| 2005 | 5 | 1 | 6 |
| 2006 | 1 | 0 | 1 |
| 2007 | 2 | 0 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 5 | 0 | 5 |
| 2010 | 4 | 0 | 4 |
| 2011 | 5 | 0 | 5 |
| 2012 | 2 | 1 | 3 |
| 2013 | 2 | 1 | 3 |
| 2014 | 1 | 1 | 2 |
| 2018 | 3 | 1 | 4 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "HSP90 Heat-Shock Proteins" by people in Profiles.
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Peng S, Woodruff J, Pathak PK, Matts RL, Deng J. Crystal structure of the middle and C-terminal domains of Hsp90a labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target. Acta Crystallogr D Struct Biol. 2022 May 01; 78(Pt 5):571-585.
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Mishra SJ, Khandelwal A, Banerjee M, Balch M, Peng S, Davis RE, Merfeld T, Munthali V, Deng J, Matts RL, Blagg BSJ. Selective Inhibition of the Hsp90a Isoform. Angew Chem Int Ed Engl. 2021 05 03; 60(19):10547-10551.
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Sengodan SK, Hemalatha SK, Nadhan R, Somanathan T, Mathew AP, Chil A, Kopczynski J, Nair RS, Kumar JM, Srinivas P. ß-hCG-induced mutant BRCA1 ignites drug resistance in susceptible breast tissue. Carcinogenesis. 2019 Nov 25; 40(11):1415-1426.
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Que NLS, Crowley VM, Duerfeldt AS, Zhao J, Kent CN, Blagg BSJ, Gewirth DT. Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding. J Med Chem. 2018 04 12; 61(7):2793-2805.
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Khandelwal A, Kent CN, Balch M, Peng S, Mishra SJ, Deng J, Day VW, Liu W, Subramanian C, Cohen M, Holzbeierlein JM, Matts R, Blagg BSJ. Structure-guided design of an Hsp90ß N-terminal isoform-selective inhibitor. Nat Commun. 2018 01 30; 9(1):425.
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Davenport J, Galam L, Matts RL. A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine. Methods Mol Biol. 2018; 1709:87-96.
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Voruganti S, Kline JT, Balch MJ, Rogers J, Matts RL, Hartson SD. Proteomic Profiling of Hsp90 Inhibitors. Methods Mol Biol. 2018; 1709:139-162.
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Floen MJ, Forred BJ, Bloom EJ, Vitiello PF. Thioredoxin-1 redox signaling regulates cell survival in response to hyperoxia. Free Radic Biol Med. 2014 Oct; 75:167-77.
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Manjarrez JR, Sun L, Prince T, Matts RL. Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex. PLoS One. 2014; 9(3):e90054.
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Sadikot T, Swink M, Eskew JD, Brown D, Zhao H, Kusuma BR, Rajewski RA, Blagg BS, Matts RL, Holzbeierlein JM, Vielhauer GA. Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol. 2013 Oct; 11(8):478-88.