"Macrolides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.
Below are MeSH descriptors whose meaning is more general than "Macrolides".
Below are MeSH descriptors whose meaning is more specific than "Macrolides".
This graph shows the total number of publications written about "Macrolides" by people in this website by year, and whether "Macrolides" was a major or minor topic of these publications.
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Below are the most recent publications written about "Macrolides" by people in Profiles.
Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group. ACS Chem Biol. 2019 06 21; 14(6):1305-1309.
In Situ Ring Contraction and Transformation of the Rhizoxin Macrocycle through an Abiotic Pathway. J Nat Prod. 2019 04 26; 82(4):886-894.
Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes. Biochim Biophys Acta Mol Basis Dis. 2017 11; 1863(11):2924-2933.
Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions. Mol Pharm. 2016 Mar 07; 13(3):839-51.
The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors. J Proteome Res. 2013 Aug 02; 12(8):3697-706.
Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors. Bioorg Med Chem Lett. 2009 Dec 15; 19(24):6845-50.
Hydrating for resistance to radicicol. ACS Chem Biol. 2009 Apr 17; 4(4):245-7.
Initial antibiotic selection and patient outcomes: observations from the National Pneumonia Project. Clin Infect Dis. 2008 Dec 01; 47 Suppl 3:S193-201.
Reactive sulfur species: kinetics and mechanism of the hydrolysis of cysteine thiosulfinate ester. Chem Res Toxicol. 2007 Sep; 20(9):1364-72.
Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties. J Med Chem. 2007 Aug 09; 50(16):3795-803.