"Caspases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
| Descriptor ID |
D020169
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| MeSH Number(s) |
D08.811.277.656.262.500.126 D08.811.277.656.300.200.126 D12.644.360.075.405 D12.776.476.075.405
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Caspases".
Below are MeSH descriptors whose meaning is more specific than "Caspases".
This graph shows the total number of publications written about "Caspases" by people in this website by year, and whether "Caspases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 2 | 1 | 3 |
| 2002 | 1 | 3 | 4 |
| 2003 | 1 | 2 | 3 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 3 | 3 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 2 | 2 |
| 2010 | 1 | 2 | 3 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Caspases" by people in Profiles.
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CRISPR/Cas9 Knockout of Bak Mediates Bax Translocation to Mitochondria in response to TNFa/CHX-induced Apoptosis. Biomed Res Int. 2019; 2019:9071297.
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Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells. Eur J Med Chem. 2019 Apr 01; 167:226-244.
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Inhibition of BMI1, a Therapeutic Approach in Endometrial Cancer. Mol Cancer Ther. 2018 10; 17(10):2136-2143.
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HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells. Sci Rep. 2017 08 30; 7(1):9694.
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Inhibition of BMI1 induces autophagy-mediated necroptosis. Autophagy. 2016; 12(4):659-70.
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Caspase-dependent inhibition of store-operated Ca(2+) entry into apoptosis-committed Jurkat cells. Biochem Biophys Res Commun. 2010 Aug 20; 399(2):198-202.
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Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition. Brain. 2010 Aug; 133(Pt 8):2264-80.
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Effect of black raspberry extract in inhibiting NFkappa B dependent radioprotection in human breast cancer cells. Nutr Cancer. 2010; 62(1):93-104.
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Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice. Free Radic Biol Med. 2009 Jun 01; 46(11):1488-99.
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Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol. J Mol Neurosci. 2009 Sep; 39(1-2):157-68.