"Superantigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
| Descriptor ID |
D018089
|
| MeSH Number(s) |
D23.050.820
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Superantigens".
Below are MeSH descriptors whose meaning is more specific than "Superantigens".
This graph shows the total number of publications written about "Superantigens" by people in this website by year, and whether "Superantigens" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Superantigens" by people in Profiles.
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Kurella S, Yaciuk JC, Dozmorov I, Frank MB, Centola M, Farris AD. Transcriptional modulation of TCR, Notch and Wnt signaling pathways in SEB-anergized CD4+ T cells. Genes Immun. 2005 Oct; 6(7):596-608.
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Tsitsikov EN, Laouini D, Dunn IF, Sannikova TY, Davidson L, Alt FW, Geha RS. TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. Immunity. 2001 Oct; 15(4):647-57.
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Tsytsykova AV, Goldfeld AE. Nuclear factor of activated T cells transcription factor NFATp controls superantigen-induced lethal shock. J Exp Med. 2000 Aug 21; 192(4):581-6.
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Schmitt CK, Meysick KC, O'Brien AD. Bacterial toxins: friends or foes? Emerg Infect Dis. 1999 Mar-Apr; 5(2):224-34.
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Magro CM, Crowson AN. A distinctive cutaneous reaction pattern indicative of infection by reactive arthropathy-associated microbial pathogens: the superantigen ID reaction. J Cutan Pathol. 1998 Nov; 25(10):538-44.
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Trede NS, Tsytsykova AV, Chatila T, Goldfeld AE, Geha RS. Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B. J Immunol. 1995 Jul 15; 155(2):902-8.