"beta Karyopherins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.
| Descriptor ID |
D028961
|
| MeSH Number(s) |
D12.776.157.530.750.500.249 D12.776.543.585.750.500.249 D12.776.660.502.500
|
| Concept/Terms |
beta Karyopherins- beta Karyopherins
- Karyopherins, beta
- Kap95 protein
- p92 nuclear protein
- nuclear protein, p92
- beta Importins
- Importins, beta
- Karyopherin-beta
- Karyopherin-beta Subunit
- Karyopherin beta Subunit
- Importin-beta
- Importin beta
- Karyopherin beta
|
Below are MeSH descriptors whose meaning is more general than "beta Karyopherins".
Below are MeSH descriptors whose meaning is more specific than "beta Karyopherins".
This graph shows the total number of publications written about "beta Karyopherins" by people in this website by year, and whether "beta Karyopherins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "beta Karyopherins" by people in Profiles.
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Bi-allelic Loss-of-Function Variants in NUP188 Cause a Recognizable Syndrome Characterized by Neurologic, Ocular, and Cardiac Abnormalities. Am J Hum Genet. 2020 05 07; 106(5):623-631.
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Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture. Arthritis Rheumatol. 2016 Apr; 68(4):932-43.
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The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Hum Mol Genet. 2015 Jan 15; 24(2):582-96.