Trinucleotide Repeat Expansion
"Trinucleotide Repeat Expansion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.
| Descriptor ID |
D019680
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| MeSH Number(s) |
G02.111.570.080.708.800.140.865 G02.111.570.080.708.800.500.850.200 G05.360.080.708.800.074.865 G05.360.080.708.800.500.850.200 G05.360.340.024.189.220.865 G05.360.340.024.850.500.850.200 G05.365.590.220.865 G05.558.220.865
|
| Concept/Terms |
Trinucleotide Repeat Expansion- Trinucleotide Repeat Expansion
- Expansion, Trinucleotide Repeat
- Expansions, Trinucleotide Repeat
- Repeat Expansion, Trinucleotide
- Repeat Expansions, Trinucleotide
- Trinucleotide Repeat Expansions
- Expanded Trinucleotide Repeat
- Expanded Trinucleotide Repeats
- Repeat, Expanded Trinucleotide
- Repeats, Expanded Trinucleotide
- Trinucleotide Repeat, Expanded
- Trinucleotide Repeats, Expanded
|
Below are MeSH descriptors whose meaning is more general than "Trinucleotide Repeat Expansion".
Below are MeSH descriptors whose meaning is more specific than "Trinucleotide Repeat Expansion".
This graph shows the total number of publications written about "Trinucleotide Repeat Expansion" by people in this website by year, and whether "Trinucleotide Repeat Expansion" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 5 | 0 | 5 |
| 2005 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2007 | 3 | 1 | 4 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Trinucleotide Repeat Expansion" by people in Profiles.
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DNA methylation in Friedreich ataxia silences expression of frataxin isoform E. Sci Rep. 2022 03 23; 12(1):5031.
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Arx expansion mutation perturbs cortical development by augmenting apoptosis without activating innate immunity in a mouse model of X-linked infantile spasms syndrome. Dis Model Mech. 2020 03 30; 13(3).
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Reversal of epigenetic promoter silencing in Friedreich ataxia by a class I histone deacetylase inhibitor. Nucleic Acids Res. 2016 06 20; 44(11):5095-104.
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Epigenetic promoter silencing in Friedreich ataxia is dependent on repeat length. Ann Neurol. 2014 Oct; 76(4):522-8.
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Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues. PLoS One. 2012; 7(10):e47085.
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Role of transcript and interplay between transcription and replication in triplet-repeat instability in mammalian cells. Nucleic Acids Res. 2011 Jan; 39(2):526-35.
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Clinical and genetic characteristics of Mexican Huntington's disease patients. Mov Disord. 2009 Oct 15; 24(13):2012-5.
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Repair of DNA double-strand breaks within the (GAA*TTC)n sequence results in frequent deletion of the triplet-repeat sequence. Nucleic Acids Res. 2008 Feb; 36(2):489-500.
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Anticipation and intergenerational repeat instability in spinocerebellar ataxia type 17. Ann Neurol. 2007 Jun; 61(6):607-10.
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Distinct distribution of autosomal dominant spinocerebellar ataxia in the Mexican population. Mov Disord. 2007 May 15; 22(7):1050-3.