Dihydrouracil Dehydrogenase (NADP)
"Dihydrouracil Dehydrogenase (NADP)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An oxidoreductase involved in pyrimidine base degradation. It catalyzes the catabolism of THYMINE; URACIL and the chemotherapeutic drug, 5-FLUOROURACIL.
Below are MeSH descriptors whose meaning is more general than "Dihydrouracil Dehydrogenase (NADP)".
Below are MeSH descriptors whose meaning is more specific than "Dihydrouracil Dehydrogenase (NADP)".
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Below are the most recent publications written about "Dihydrouracil Dehydrogenase (NADP)" by people in Profiles.
Phase II clinical trial of capecitabine in ovarian carcinoma recurrent 6-12 months after completion of primary chemotherapy, with exploratory TS, DPD, and TP correlates: a Gynecologic Oncology Group study. Gynecol Oncol. 2005 Mar; 96(3):810-7.
Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters. Biochim Biophys Acta. 2004 Sep 01; 1701(1-2):61-74.
Secondary tritium and solvent deuterium isotope effects as a probe of the reaction catalyzed by porcine recombinant dihydropyrimidine dehydrogenase. Biochemistry. 1998 Jun 23; 37(25):9156-9.
Purification, characterization, and kinetics of porcine recombinant dihydropyrimidine dehydrogenase. Protein Expr Purif. 1997 Jul; 10(2):185-91.
Purification and characterization of dihydropyrimidine dehydrogenase from Alcaligenes eutrophus. Arch Biochem Biophys. 1996 Aug 01; 332(1):175-82.
Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies. J Biol Chem. 1993 Feb 15; 268(5):3407-13.
Kinetic mechanism of dihydropyrimidine dehydrogenase from pig liver. J Biol Chem. 1990 Aug 05; 265(22):12966-72.