Phosphatidylinositol Diacylglycerol-Lyase
"Phosphatidylinositol Diacylglycerol-Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosphoester linkage in 1-phosphatidyl-1D-myo-inositol to form 1D-myo-inositol 1,2-cyclic phosphate and diacylglycerol. The enzyme was formerly classified as a phosphoric diester hydrolase (EC 3.1.4.10) and is often referred to as a TYPE C PHOSPHOLIPASES. However it is now known that a cyclic phosphate is the final product of this enzyme and that water does not enter into the reaction.
| Descriptor ID |
D043265
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| MeSH Number(s) |
D08.811.277.352.640.700.700.500 D08.811.520.650.800
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| Concept/Terms |
Phosphatidylinositol Diacylglycerol-Lyase- Phosphatidylinositol Diacylglycerol-Lyase
- Diacylglycerol-Lyase, Phosphatidylinositol
- Phosphatidylinositol Diacylglycerol Lyase
- Monophosphatidylinositol Phosphodiesterase
- Phosphodiesterase, Monophosphatidylinositol
- 1-Phosphatidylinositol Phosphodiesterase
- 1 Phosphatidylinositol Phosphodiesterase
- Phosphodiesterase, 1-Phosphatidylinositol
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Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol Diacylglycerol-Lyase".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol Diacylglycerol-Lyase".
This graph shows the total number of publications written about "Phosphatidylinositol Diacylglycerol-Lyase" by people in this website by year, and whether "Phosphatidylinositol Diacylglycerol-Lyase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2005 | 3 | 0 | 3 |
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Below are the most recent publications written about "Phosphatidylinositol Diacylglycerol-Lyase" by people in Profiles.
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Characterization of Listeria monocytogenes expressing anthrolysin O and phosphatidylinositol-specific phospholipase C from Bacillus anthracis. Infect Immun. 2005 Oct; 73(10):6639-46.
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Listeria monocytogenes phosphatidylinositol-specific phospholipase C has evolved for virulence by greatly reduced activity on GPI anchors. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12927-31.
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Phosphatidylinositol-specific phospholipase C of Bacillus anthracis down-modulates the immune response. J Immunol. 2005 Jun 15; 174(12):8011-6.
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Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors. J Biol Chem. 1999 Sep 17; 274(38):27274-80.
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Listeria monocytogenes virulence factors that stimulate endothelial cells. Infect Immun. 1998 Jan; 66(1):232-8.
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Phosrestin I undergoes the earliest light-induced phosphorylation by a calcium/calmodulin-dependent protein kinase in Drosophila photoreceptors. Neuron. 1994 May; 12(5):997-1010.
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Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes. Proc Natl Acad Sci U S A. 1992 Jun 15; 89(12):5660-4.