Ubiquitin

"Ubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.

Descriptor ID	D025801
MeSH Number(s)	D12.776.947.500
Concept/Terms	Ubiquitin Ubiquitin ATP-Dependent Proteolysis Factor 1 ATP Dependent Proteolysis Factor 1 HMG-20 APF-1 High Mobility Protein 20 Ubiquitin, Human Ubiquitin, Human Human Ubiquitin

Below are MeSH descriptors whose meaning is more general than "Ubiquitin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Ubiquitins [D12.776.947]
Ubiquitin [D12.776.947.500]

Below are MeSH descriptors whose meaning is related to "Ubiquitin".

Below are MeSH descriptors whose meaning is more specific than "Ubiquitin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ubiquitin" by people in this website by year, and whether "Ubiquitin" was a major or minor topic of these publications.

Bar chart showing 19 publications over 11 distinct years, with a maximum of 3 publications in 2003 and 2005 and 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	2	3
2005	0	3	3
2006	0	1	1
2007	1	0	1
2008	0	2	2
2009	1	2	3
2010	0	1	1
2016	0	1	1
2017	0	1	1
2018	0	1	1
2019	0	2	2

Below are the most recent publications written about "Ubiquitin" by people in Profiles.

Fornelli L, Srzentic K, Toby TK, Doubleday PF, Huguet R, Mullen C, Melani RD, Dos Santos Seckler H, DeHart CJ, Weisbrod CR, Durbin KR, Greer JB, Early BP, Fellers RT, Zabrouskov V, Thomas PM, Compton PD, Kelleher NL. Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics. Mol Cell Proteomics. 2020 02; 19(2):405-420.

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Lee Y, Yamada H, Pradipta A, Ma JS, Okamoto M, Nagaoka H, Takashima E, Standley DM, Sasai M, Takei K, Yamamoto M. Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense. Life Sci Alliance. 2020 01; 3(1).

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Sharma D, Otto G, Warren EC, Beesley P, King JS, Williams RSB. Gamma secretase orthologs are required for lysosomal activity and autophagic degradation in Dictyostelium discoideum, independent of PSEN (presenilin) proteolytic function. Autophagy. 2019 08; 15(8):1407-1418.

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Plafker KS, Zyla K, Berry W, Plafker SM. Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence. Redox Biol. 2018 07; 17:411-422.

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Rao HB, Qiao H, Bhatt SK, Bailey LR, Tran HD, Bourne SL, Qiu W, Deshpande A, Sharma AN, Beebout CJ, Pezza RJ, Hunter N. A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination. Science. 2017 01 27; 355(6323):403-407.

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Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio IIC, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW. Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell. 2016 08 04; 19(2):205-216.

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Xulu BA, Ashby MT. Small molecular, macromolecular, and cellular chloramines react with thiocyanate to give the human defense factor hypothiocyanite. Biochemistry. 2010 Mar 09; 49(9):2068-74.

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Ju JS, Fuentealba RA, Miller SE, Jackson E, Piwnica-Worms D, Baloh RH, Weihl CC. Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol. 2009 Dec 14; 187(6):875-88.

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Beal JL, Foster SB, Ashby MT. Hypochlorous acid reacts with the N-terminal methionines of proteins to give dehydromethionine, a potential biomarker for neutrophil-induced oxidative stress. Biochemistry. 2009 Nov 24; 48(46):11142-8.

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Yu X, Kem DC. Proteasome inhibition during myocardial infarction. Cardiovasc Res. 2010 Jan 15; 85(2):312-20.

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