"NF-E2-Related Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.
| Descriptor ID |
D051267
|
| MeSH Number(s) |
D12.776.260.108.737 D12.776.930.127.737
|
| Concept/Terms |
NF-E2-Related Factor 2- NF-E2-Related Factor 2
- NF E2 Related Factor 2
- Nuclear Factor E2-Related Factor 2
- Nuclear Factor E2 Related Factor 2
- Nfe2l2 Protein
- Nuclear Factor (Erythroid-Derived 2)-Like 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "NF-E2-Related Factor 2".
Below are MeSH descriptors whose meaning is more specific than "NF-E2-Related Factor 2".
This graph shows the total number of publications written about "NF-E2-Related Factor 2" by people in this website by year, and whether "NF-E2-Related Factor 2" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 1 | 2 |
| 2008 | 1 | 2 | 3 |
| 2010 | 2 | 1 | 3 |
| 2011 | 4 | 1 | 5 |
| 2012 | 2 | 2 | 4 |
| 2013 | 2 | 1 | 3 |
| 2014 | 1 | 4 | 5 |
| 2015 | 1 | 0 | 1 |
| 2016 | 4 | 1 | 5 |
| 2017 | 1 | 0 | 1 |
| 2018 | 6 | 0 | 6 |
| 2019 | 4 | 0 | 4 |
| 2020 | 1 | 1 | 2 |
| 2022 | 1 | 2 | 3 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 2 | 2 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "NF-E2-Related Factor 2" by people in Profiles.
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TCE-mediated neuroprotection against rotenone-induced dopaminergic neuronal death in PD mice: insights into the Nrf-2/PINK1/Parkin-mitophagy pathway. Metab Brain Dis. 2025 Apr 07; 40(4):172.
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Cullin 3 RING E3 ligase inactivation causes NRF2-dependent NADH reductive stress, hepatic lipodystrophy, and systemic insulin resistance. Proc Natl Acad Sci U S A. 2024 Apr 23; 121(17):e2320934121.
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Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence. Nutrients. 2024 Mar 26; 16(7).
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Microbial-induced Redox Imbalance in the Neonatal Lung Is Ameliorated by Live Biotherapeutics. Am J Respir Cell Mol Biol. 2023 03; 68(3):267-278.
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Dependence of Retinal Pigment Epithelium Integrity on the NRF2-Heme Oxygenase-1 Axis. Invest Ophthalmol Vis Sci. 2022 08 02; 63(9):30.
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Differential prognostic effect of systemic inflammation in patients with non-small cell lung cancer treated with immunotherapy or chemotherapy: A post hoc analysis of the phase 3 OAK trial. Cancer. 2022 08 15; 128(16):3067-3079.
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Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer. Cancer Res. 2022 06 15; 82(12):2254-2268.
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Shinorine ameliorates chromium induced toxicity in zebrafish hepatocytes through the facultative activation of Nrf2-Keap1-ARE pathway. Aquat Toxicol. 2020 Nov; 228:105622.
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HIV protease inhibitor ritonavir induces renal fibrosis and dysfunction: role of platelet-derived TGF-ß1 and intervention via antioxidant pathways. AIDS. 2020 06 01; 34(7):989-1000.
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Obesity-induced sympathoexcitation is associated with Nrf2 dysfunction in the rostral ventrolateral medulla. Am J Physiol Regul Integr Comp Physiol. 2020 02 01; 318(2):R435-R444.