NF-E2-Related Factor 2

"NF-E2-Related Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.

Descriptor ID	D051267
MeSH Number(s)	D12.776.260.108.737 D12.776.930.127.737
Concept/Terms	NF-E2-Related Factor 2 NF-E2-Related Factor 2 NF E2 Related Factor 2 Nuclear Factor E2-Related Factor 2 Nuclear Factor E2 Related Factor 2 Nfe2l2 Protein Nuclear Factor (Erythroid-Derived 2)-Like 2 Protein

Below are MeSH descriptors whose meaning is more general than "NF-E2-Related Factor 2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
NF-E2-Related Factor 2 [D12.776.260.108.737]
Transcription Factors [D12.776.930]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
NF-E2-Related Factor 2 [D12.776.930.127.737]

Below are MeSH descriptors whose meaning is related to "NF-E2-Related Factor 2".

Below are MeSH descriptors whose meaning is more specific than "NF-E2-Related Factor 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NF-E2-Related Factor 2" by people in this website by year, and whether "NF-E2-Related Factor 2" was a major or minor topic of these publications.

Bar chart showing 43 publications over 13 distinct years, with a maximum of 7 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	1	1	2
2008	1	2	3
2010	1	1	2
2011	4	2	6
2012	3	2	5
2013	1	1	2
2014	1	3	4
2015	1	0	1
2016	3	1	4
2017	2	1	3
2018	7	0	7
2019	3	0	3
2020	0	1	1

Below are the most recent publications written about "NF-E2-Related Factor 2" by people in Profiles.

Laurence J, Elhadad S, Gostynska S, Yu Z, Terry H, Varshney R, Fung KM, Choi ME, Ahamed J. HIV protease inhibitor ritonavir induces renal fibrosis and dysfunction: role of platelet-derived TGF-ß1 and intervention via antioxidant pathways. AIDS. 2020 06 01; 34(7):989-1000.

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Balasubramanian P, Asirvatham-Jeyaraj N, Monteiro R, Sivasubramanian MK, Hall D, Subramanian M. Obesity-induced sympathoexcitation is associated with Nrf2 dysfunction in the rostral ventrolateral medulla. Am J Physiol Regul Integr Comp Physiol. 2020 02 01; 318(2):R435-R444.

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Ungvari Z, Tarantini S, Nyúl-Tóth Á, Kiss T, Yabluchanskiy A, Csipo T, Balasubramanian P, Lipecz A, Benyo Z, Csiszar A. Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases. Geroscience. 2019 12; 41(6):727-738.

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Ofman G, Tipple TE. Antioxidants & bronchopulmonary dysplasia: Beating the system or beating a dead horse? Free Radic Biol Med. 2019 10; 142:138-145.

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Fulop GA, Kiss T, Tarantini S, Balasubramanian P, Yabluchanskiy A, Farkas E, Bari F, Ungvari Z, Csiszar A. Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation. Geroscience. 2018 12; 40(5-6):513-521.

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Tindell R, Wall SB, Li Q, Li R, Dunigan K, Wood R, Tipple TE. Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition. Redox Biol. 2018 10; 19:331-338.

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Dunigan K, Li Q, Li R, Locy ML, Wall S, Tipple TE. The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms. . 2018 10 01; 315(4):L545-L552.

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Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A. Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. J Gerontol A Biol Sci Med Sci. 2018 06 14; 73(7):853-863.

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Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H. Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Redox Biol. 2018 07; 17:47-58.

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Ban WH, Kang HH, Kim IK, Ha JH, Joo H, Lee JM, Lim JU, Lee SH, Rhee CK. Clinical significance of nuclear factor erythroid 2-related factor 2 in patients with chronic obstructive pulmonary disease. Korean J Intern Med. 2018 07; 33(4):745-752.

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