Small Molecule Libraries

"Small Molecule Libraries" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.

Descriptor ID	D054852
MeSH Number(s)	D27.720.470.765
Concept/Terms	Small Molecule Libraries Small Molecule Libraries Libraries, Small Molecule Molecule Libraries, Small Molecular Libraries, Small Libraries, Small Molecular Small Molecular Libraries Chemical Libraries Libraries, Chemical

Below are MeSH descriptors whose meaning is more general than "Small Molecule Libraries".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Specialty Uses of Chemicals [D27.720]
Laboratory Chemicals [D27.720.470]
Small Molecule Libraries [D27.720.470.765]

Below are MeSH descriptors whose meaning is related to "Small Molecule Libraries".

Below are MeSH descriptors whose meaning is more specific than "Small Molecule Libraries".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Small Molecule Libraries" by people in this website by year, and whether "Small Molecule Libraries" was a major or minor topic of these publications.

Bar chart showing 11 publications over 6 distinct years, with a maximum of 3 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2011	2	0	2
2012	1	0	1
2013	1	1	2
2014	2	1	3
2018	2	0	2

Below are the most recent publications written about "Small Molecule Libraries" by people in Profiles.

Otsuka Y, Airola MV, Choi YM, Coant N, Snider J, Cariello C, Saied EM, Arenz C, Bannister T, Rahaim R, Hannun YA, Shumate J, Scampavia L, Haley JD, Spicer TP. Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening. SLAS Discov. 2021 01; 26(1):113-121.

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Yi C, Li G, Ivanov DN, Wang Z, Velasco MX, Hernández G, Kaundal S, Villarreal J, Gupta YK, Qiao M, Hubert CG, Hart MJ, Penalva LOF. Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells. RNA Biol. 2018; 15(11):1420-1432.

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Zhao H, Petrushenko ZM, Walker JK, Baudry J, Zgurskaya HI, Rybenkov VV. Small Molecule Condensin Inhibitors. ACS Infect Dis. 2018 12 14; 4(12):1737-1745.

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Anderson RH, Lensing CJ, Forred BJ, Amolins MW, Aegerter CL, Vitiello PF, Mays JR. Differentiating Antiproliferative and Chemopreventive Modes of Activity for Electron-Deficient Aryl Isothiocyanates against Human MCF-7 Cells. ChemMedChem. 2018 08 20; 13(16):1695-1710.

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Tran K, Li Y, Duan H, Arora D, Lim HY, Wang W. Identification of small molecules that protect pancreatic ß cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014 Dec 19; 9(12):2796-806.

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Rothblum K, Hu Q, Penrod Y, Rothblum LI. Selective inhibition of rDNA transcription by a small-molecule peptide that targets the interface between RNA polymerase I and Rrn3. Mol Cancer Res. 2014 Nov; 12(11):1586-96.

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Penas C, Ramachandran V, Simanski S, Lee C, Madoux F, Rahaim RJ, Chauhan R, Barnaby O, Schurer S, Hodder P, Steen J, Roush WR, Ayad NG. Casein kinase 1d-dependent Wee1 protein degradation. J Biol Chem. 2014 Jul 04; 289(27):18893-903.

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Sadikot T, Swink M, Eskew JD, Brown D, Zhao H, Kusuma BR, Rajewski RA, Blagg BS, Matts RL, Holzbeierlein JM, Vielhauer GA. Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol. 2013 Oct; 11(8):478-88.

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You J, Du L, King JB, Hall BE, Cichewicz RH. Small-molecule suppressors of Candida albicans biofilm formation synergistically enhance the antifungal activity of amphotericin B against clinical Candida isolates. ACS Chem Biol. 2013 Apr 19; 8(4):840-8.

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Kirabo A, Park SO, Wamsley HL, Gali M, Baskin R, Reinhard MK, Zhao ZJ, Bisht KS, Keseru GM, Cogle CR, Sayeski PP. The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis. Am J Pathol. 2012 Sep; 181(3):858-65.

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