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John Kimble Frazer

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDept of Pediatrics
AddressBSEB 224
941 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-5311 ext 42375
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    K08HD053350     (FRAZER, JOHN KIMBLE)Aug 1, 2006 - Jul 31, 2012
    RNAi and DNA Methylation Control Genomic Stability and Transcriptional Silencing
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mangum DS, Meyer JA, Mason CC, Shams S, Maese LD, Gardiner JD, Downie JM, Pei D, Cheng C, Gleason A, Luo M, Pui CH, Aplenc R, Hunger SP, Loh M, Greaves M, Trede N, Raetz E, Frazer JK, Mullighan CG, Engel ME, Miles RR, Rabin KR, Schiffman JD. Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia. JAMA Oncol. 2021 Oct 01; 7(10):1521-1528. PMID: 34410295.
      Citations:    Fields:    Translation:Humans
    2. Loontiens S, Vanhauwaert S, Depestel L, Dewyn G, Van Loocke W, Moore FE, Garcia EG, Batchelor L, Borga C, Squiban B, Malone-Perez M, Volders PJ, Olexiouk V, Van Vlierberghe P, Langenau DM, Frazer JK, Durinck K, Speleman F. A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models. Leukemia. 2020 12; 34(12):3398-3403. PMID: 32591643.
      Citations: 3     Fields:    Translation:Animals
    3. Park G, Burroughs-Garcia J, Foster CA, Hasan A, Borga C, Frazer JK. Zebrafish B cell acute lymphoblastic leukemia: new findings in an old model. Oncotarget. 2020 Apr 14; 11(15):1292-1305. PMID: 32341750.
      Citations: 3     Fields:    
    4. Sinha AA, Park G, Frazer JK. Tackling Acute Lymphoblastic Leukemia-One Fish at a Time. Int J Mol Sci. 2019 Oct 25; 20(21). PMID: 31731471.
      Citations: 2     Fields:    Translation:HumansAnimals
    5. Sanghera DK, Hopkins R, Malone-Perez MW, Bejar C, Tan C, Mussa H, Whitby P, Fowler B, Rao CV, Fung KA, Lightfoot S, Frazer JK. Targeted sequencing of candidate genes of dyslipidemia in Punjabi Sikhs: Population-specific rare variants in GCKR promote ectopic fat deposition. PLoS One. 2019; 14(8):e0211661. PMID: 31369557.
      Citations: 3     Fields:    Translation:HumansAnimals
    6. Borga C, Frazer JK. Zebrafish MYC-induced leukemia models: unique in vivo systems to study B and T cell acute lymphoblastic leukemia. Int J Hematol Oncol. 2019 Feb; 8(1):IJH12. PMID: 30863529.
    7. Burroughs-Garcia J, Hasan A, Park G, Borga C, Frazer JK. Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish. J Vis Exp. 2019 02 22; (144). PMID: 30855581.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    8. Borga C, Foster CA, Iyer S, Garcia SP, Langenau DM, Frazer JK. Molecularly distinct models of zebrafish Myc-induced B cell leukemia. Leukemia. 2019 02; 33(2):559-562. PMID: 30573774.
      Citations: 10     Fields:    Translation:HumansAnimals
    9. Frazer JK, Li KJ, Galardy PJ, Perkins SL, Auperin A, Anderson JR, Pinkerton R, Buxton A, Gross TG, Michon J, Leverger G, Weinstein HJ, Harrison L, Shiramizu B, Barth MJ, Goldman SC, Patte C, Cairo MS. Excellent outcomes in children and adolescents with CNS+ Burkitt lymphoma or other mature B-NHL using only intrathecal and systemic chemoimmunotherapy: results from FAB/LMB96 and COG ANHL01P1. Br J Haematol. 2019 04; 185(2):374-377. PMID: 30117142.
      Citations: 6     Fields:    Translation:Humans
    10. Borga C, Park G, Foster C, Burroughs-Garcia J, Marchesin M, Shah R, Hasan A, Ahmed ST, Bresolin S, Batchelor L, Scordino T, Miles RR, Te Kronnie G, Regens JL, Frazer JK. Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis. Leukemia. 2019 02; 33(2):333-347. PMID: 30111845.
      Citations: 15     Fields:    Translation:HumansAnimals
    11. Squiban B, Ahmed ST, Frazer JK. Creation of a human T-ALL cell line online database. Leuk Lymphoma. 2017 11; 58(11):2728-2730. PMID: 28609209.
      Citations: 3     Fields:    Translation:HumansCells
    12. Miles RR, Shah RK, Frazer JK. Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma. Br J Haematol. 2016 05; 173(4):582-96. PMID: 26969846.
      Citations: 5     Fields:    Translation:Humans
    13. Shiramizu B, Goldman S, Smith L, Agsalda-Garcia M, Galardy P, Perkins SL, Frazer JK, Sanger W, Anderson JR, Gross TG, Weinstein H, Harrison L, Barth MJ, Mussolin L, Cairo MS. Impact of persistent minimal residual disease post-consolidation therapy in children and adolescents with advanced Burkitt leukaemia: a Children's Oncology Group Pilot Study Report. Br J Haematol. 2015 Aug; 170(3):367-71. PMID: 25858645.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    14. Goldman S, Smith L, Galardy P, Perkins SL, Frazer JK, Sanger W, Anderson JR, Gross TG, Weinstein H, Harrison L, Shiramizu B, Barth M, Cairo MS. Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: a Children's Oncology Group Report. Br J Haematol. 2014 Nov; 167(3):394-401. PMID: 25066629.
      Citations: 38     Fields:    Translation:HumansCTClinical Trials
    15. Squiban B, Frazer JK. Danio rerio: Small Fish Making a Big Splash in Leukemia. Curr Pathobiol Rep. 2014 Jun; 2(2):61-73. PMID: 26269780.
    16. West K, Miles R, Kent ML, Frazer JK. Unusual fluorescent granulomas and myonecrosis in Danio rerio infected by the microsporidian pathogen Pseudoloma neurophilia. Zebrafish. 2014 Jun; 11(3):283-90. PMID: 24707848.
      Citations: 4     Fields:    Translation:Animals
    17. Christoph S, Deryckere D, Schlegel J, Frazer JK, Batchelor LA, Trakhimets AY, Sather S, Hunter DM, Cummings CT, Liu J, Yang C, Kireev D, Simpson C, Norris-Drouin J, Hull-Ryde EA, Janzen WP, Johnson GL, Wang X, Frye SV, Earp HS, Graham DK. UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol Cancer Ther. 2013 Nov; 12(11):2367-77. PMID: 23997116.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    18. Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, Müschen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR, Schiffman JD. VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia. Leukemia. 2014 Jan; 28(1):216-20. PMID: 23881307.
      Citations: 12     Fields:    Translation:Humans
    19. Frazer JK, Batchelor LA, Bradley DF, Brown KH, Dobrinski KP, Lee C, Trede NS. Genomic amplification of an endogenous retrovirus in zebrafish T-cell malignancies. Adv Hematol. 2012; 2012:627920. PMID: 22745640.
    20. El-Mallawany NK, Frazer JK, Van Vlierberghe P, Ferrando AA, Perkins S, Lim M, Chu Y, Cairo MS. Pediatric T- and NK-cell lymphomas: new biologic insights and treatment strategies. Blood Cancer J. 2012 Apr; 2(4):e65. PMID: 22829967.
      Citations: 5     Fields:    
    21. Ridges S, Heaton WL, Joshi D, Choi H, Eiring A, Batchelor L, Choudhry P, Manos EJ, Sofla H, Sanati A, Welborn S, Agarwal A, Spangrude GJ, Miles RR, Cox JE, Frazer JK, Deininger M, Balan K, Sigman M, Müschen M, Perova T, Johnson R, Montpellier B, Guidos CJ, Jones DA, Trede NS. Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood. 2012 Jun 14; 119(24):5621-31. PMID: 22490804.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    22. Rudner LA, Brown KH, Dobrinski KP, Bradley DF, Garcia MI, Smith AC, Downie JM, Meeker ND, Look AT, Downing JR, Gutierrez A, Mullighan CG, Schiffman JD, Lee C, Trede NS, Frazer JK. Shared acquired genomic changes in zebrafish and human T-ALL. Oncogene. 2011 Oct 13; 30(41):4289-96. PMID: 21552289.
      Citations: 23     Fields:    Translation:HumansAnimals
    23. Meeker ND, Cherry AM, Bangs CD, Frazer JK. A pediatric B lineage leukemia with coincident MYC and MLL translocations. J Pediatr Hematol Oncol. 2011 Mar; 33(2):158-60. PMID: 20829716.
      Citations: 2     Fields:    Translation:Humans
    24. Frazer JK, Meeker ND, Rudner L, Bradley DF, Smith AC, Demarest B, Joshi D, Locke EE, Hutchinson SA, Tripp S, Perkins SL, Trede NS. Heritable T-cell malignancy models established in a zebrafish phenotypic screen. Leukemia. 2009 Oct; 23(10):1825-35. PMID: 19516274.
      Citations: 36     Fields:    Translation:HumansAnimals
    25. South ST, Frazer JK, Brothman AR, Chen Z. Unexpected cytogenetic finding in acute lymphoblastic leukemia: a case of del(5q) with a cryptic t(12;21). Cancer Genet Cytogenet. 2006 Jul 15; 168(2):177-8. PMID: 16843112.
      Citations: 2     Fields:    Translation:HumansCells
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