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Jordan Metcalf

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Pulmonary
AddressRP800 425
800 Research Parkway
Oklahoma City OK 73104
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    K08HL003106     (METCALF, JORDAN PATRICK)Sep 30, 1994 - Dec 31, 1999
    Role: Principal Investigator

    I01BX001937     (METCALF, JORDAN PATRICK)Oct 1, 2014 - Sep 30, 2019
    Antiviral Immunosuppression by Cigarette Smoke
    Role: Principal Investigator

    I01BX005023     (METCALF, JORDAN PATRICK)Oct 1, 2020 - Sep 30, 2024
    Reversing Cigarette Smoke-Induced Antiviral Immunosuppression
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wu W, Tian L, Zhang W, Booth JL, Ritchey JW, Wu S, Xu C, Brown BR, Metcalf JP. Early IFN-ß administration protects cigarette smoke exposed mice against lethal influenza virus infection without increasing lung inflammation. Sci Rep. 2022 03 08; 12(1):4080. PMID: 35260752.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. El Haj Chehade A, Metcalf J, Jacobs B. Nasal myiasis under direct bronchoscopic visualization. Respirol Case Rep. 2022 Jan; 10(1):e0892. PMID: 34987829.
    3. Bodas M, Subramaniyan B, Moore AR, Metcalf JP, Ocañas SR, Freeman WM, Georgescu C, Wren JD, Walters MS. The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation. Cells. 2021 11 18; 10(11). PMID: 34831437.
      Citations:    Fields:    Translation:HumansCells
    4. Wu W, Tian L, Zhang W, Booth JL, Ainsua-Enrich E, Kovats S, Brown BR, Metcalf JP. Long-term cigarette smoke exposure dysregulates pulmonary T cell response and IFN-? protection to influenza virus in mouse. Respir Res. 2021 Apr 20; 22(1):112. PMID: 33879121.
      Citations:    Fields:    Translation:AnimalsCells
    5. Bodas M, Moore AR, Subramaniyan B, Georgescu C, Wren JD, Freeman WM, Brown BR, Metcalf JP, Walters MS. Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2021 04; 64(4):426-440. PMID: 33444514.
      Citations: 10     Fields:    Translation:HumansCells
    6. Patel VI, Booth JL, Dozmorov M, Brown BR, Metcalf JP. Anthrax Edema and Lethal Toxins Differentially Target Human Lung and Blood Phagocytes. Toxins (Basel). 2020 07 20; 12(7). PMID: 32698436.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    7. Wu W, Metcalf JP. The Role of Type I IFNs in Influenza: Antiviral Superheroes or Immunopathogenic Villains? J Innate Immun. 2020; 12(6):437-447. PMID: 32564033.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    8. Wu W, Zhang W, Tian L, Brown BR, Walters MS, Metcalf JP. IRF7 Is Required for the Second Phase Interferon Induction during Influenza Virus Infection in Human Lung Epithelia. Viruses. 2020 03 29; 12(4). PMID: 32235406.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    9. Wu W, Wang X, Zhang W, Tian L, Booth JL, Duggan ES, More S, Liu L, Dozmorov M, Metcalf JP. RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo. Mediators Inflamm. 2018; 2018:6808934. PMID: 30532653.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    10. Booth JL, Duggan ES, Patel VI, Wu W, Burian DM, Hutchings DC, White VL, Coggeshall KM, Dozmorov MG, Metcalf JP. Gene expression profiling of primary human type I alveolar epithelial cells exposed to Bacillus anthracis spores reveals induction of neutrophil and monocyte chemokines. Microb Pathog. 2018 Aug; 121:9-21. PMID: 29704667.
      Citations:    Fields:    Translation:HumansCells
    11. Langer M, Girton AW, Popescu NI, Burgett T, Metcalf JP, Coggeshall KM. Neither Lys- and DAP-type peptidoglycans stimulate mouse or human innate immune cells via Toll-like receptor 2. PLoS One. 2018; 13(2):e0193207. PMID: 29474374.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    12. More S, Yang X, Zhu Z, Bamunuarachchi G, Guo Y, Huang C, Bailey K, Metcalf JP, Liu L. Regulation of influenza virus replication by Wnt/ß-catenin signaling. PLoS One. 2018; 13(1):e0191010. PMID: 29324866.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    13. Patel VI, Metcalf JP. Airway Macrophage and Dendritic Cell Subsets in the Resting Human Lung. Crit Rev Immunol. 2018; 38(4):303-331. PMID: 30806245.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    14. Wang X, Wu W, Zhang W, Leland Booth J, Duggan ES, Tian L, More S, Zhao YD, Sawh RN, Liu L, Zou MH, Metcalf JP. RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection. Respir Res. 2017 09 02; 18(1):166. PMID: 28865477.
      Citations: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    15. Patel VI, Booth JL, Duggan ES, Cate S, White VL, Hutchings D, Kovats S, Burian DM, Dozmorov M, Metcalf JP. Transcriptional Classification and Functional Characterization of Human Airway Macrophage and Dendritic Cell Subsets. J Immunol. 2017 02 01; 198(3):1183-1201. PMID: 28031342.
      Citations: 23     Fields:    Translation:HumansCells
    16. Wu W, Zhang W, Booth JL, Hutchings DC, Wang X, White VL, Youness H, Cross CD, Zou MH, Burian D, Metcalf JP. Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses. Respir Res. 2016 09 07; 17(1):111. PMID: 27604339.
      Citations: 18     Fields:    Translation:HumansCells
    17. Booth JL, Duggan ES, Patel VI, Langer M, Wu W, Braun A, Coggeshall KM, Metcalf JP. Bacillus anthracis spore movement does not require a carrier cell and is not affected by lethal toxin in human lung models. Microbes Infect. 2016 Oct; 18(10):615-626. PMID: 27320392.
      Citations: 4     Fields:    Translation:HumansCells
    18. Patel VI, Metcalf JP. Identification and characterization of human dendritic cell subsets in the steady state: a review of our current knowledge. J Investig Med. 2016 Apr; 64(4):833-47. PMID: 26956785.
      Citations: 7     Fields:    Translation:HumansCells
    19. Wu W, Zhang W, Duggan ES, Booth JL, Zou MH, Metcalf JP. RIG-I and TLR3 are both required for maximum interferon induction by influenza virus in human lung alveolar epithelial cells. Virology. 2015 Aug; 482:181-8. PMID: 25880109.
      Citations: 36     Fields:    Translation:HumansCells
    20. Wu W, Zhang W, More S, Booth JL, Duggan ES, Liu L, Zhao YD, Metcalf JP. Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 01; 307(11):L848-58. PMID: 25260755.
      Citations: 11     Fields:    Translation:AnimalsCells
    21. Wu W, Awab A, Metcalf JP. N-Acetylcysteine Protection in COPD: An Alternative Mechanism of Action. Chest. 2014 Jan; 145(1):193-4. PMID: 24394845.
      Citations:    Fields:    Translation:Humans
    22. Coggeshall KM, Lupu F, Ballard J, Metcalf JP, James JA, Farris D, Kurosawa S. The sepsis model: an emerging hypothesis for the lethality of inhalation anthrax. J Cell Mol Med. 2013 Jul; 17(7):914-20. PMID: 23742651.
      Citations: 21     Fields:    Translation:HumansCells
    23. Wu W, Zhang W, Booth JL, Metcalf JP. Influenza A(H1N1)pdm09 virus suppresses RIG-I initiated innate antiviral responses in the human lung. PLoS One. 2012; 7(11):e49856. PMID: 23185463.
      Citations: 16     Fields:    Translation:HumansCellsPHPublic Health
    24. Langer M, Duggan ES, Booth JL, Patel VI, Zander RA, Silasi-Mansat R, Ramani V, Veres TZ, Prenzler F, Sewald K, Williams DM, Coggeshall KM, Awasthi S, Lupu F, Burian D, Ballard JD, Braun A, Metcalf JP. Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Infect Immun. 2012 Dec; 80(12):4374-87. PMID: 23027535.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    25. Sun D, Raisley B, Langer M, Iyer JK, Vedham V, Ballard JL, James JA, Metcalf J, Coggeshall KM. Anti-peptidoglycan antibodies and Fc? receptors are the key mediators of inflammation in Gram-positive sepsis. J Immunol. 2012 Sep 01; 189(5):2423-31. PMID: 22815288.
      Citations: 21     Fields:    Translation:HumansCells
    26. Wu S, Metcalf JP, Wu W. Innate immune response to influenza virus. Curr Opin Infect Dis. 2011 Jun; 24(3):235-40. PMID: 21330918.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    27. Gregory SM, Nazir SA, Metcalf JP. Implications of the innate immune response to adenovirus and adenoviral vectors. Future Virol. 2011 Mar; 6(3):357-374. PMID: 21738557.
    28. Wu W, Patel KB, Booth JL, Zhang W, Metcalf JP. Cigarette smoke extract suppresses the RIG-I-initiated innate immune response to influenza virus in the human lung. Am J Physiol Lung Cell Mol Physiol. 2011 Jun; 300(6):L821-30. PMID: 21335520.
      Citations: 29     Fields:    Translation:HumansCells
    29. Wu S, Patel KB, Booth LJ, Metcalf JP, Lin HK, Wu W. Protective essential oil attenuates influenza virus infection: an in vitro study in MDCK cells. BMC Complement Altern Med. 2010 Nov 15; 10:69. PMID: 21078173.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    30. Iyer JK, Khurana T, Langer M, West CM, Ballard JD, Metcalf JP, Merkel TJ, Coggeshall KM. Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking. Infect Immun. 2010 Jun; 78(6):2418-28. PMID: 20308305.
      Citations: 32     Fields:    Translation:AnimalsCells
    31. Wu W, Booth JL, Duggan ES, Patel KB, Coggeshall KM, Metcalf JP. Human lung innate immune cytokine response to adenovirus type 7. J Gen Virol. 2010 May; 91(Pt 5):1155-63. PMID: 20071488.
      Citations: 20     Fields:    Translation:HumansCells
    32. Wu W, Booth JL, Duggan ES, Wu S, Patel KB, Coggeshall KM, Metcalf JP. Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model. Virology. 2010 Jan 20; 396(2):178-88. PMID: 19913271.
      Citations: 47     Fields:    Translation:HumansCells
    33. Wu W, Mehta H, Chakrabarty K, Booth JL, Duggan ES, Patel KB, Ballard JD, Coggeshall KM, Metcalf JP. Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin. J Immunol. 2009 Nov 01; 183(9):5799-806. PMID: 19812208.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    34. Dozmorov M, Wu W, Chakrabarty K, Booth JL, Hurst RE, Coggeshall KM, Metcalf JP. Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen. BMC Infect Dis. 2009 Sep 10; 9:152. PMID: 19744333.
      Citations: 14     Fields:    Translation:HumansCells
    35. Langer M, Malykhin A, Maeda K, Chakrabarty K, Williamson KS, Feasley CL, West CM, Metcalf JP, Coggeshall KM. Bacillus anthracis peptidoglycan stimulates an inflammatory response in monocytes through the p38 mitogen-activated protein kinase pathway. PLoS One. 2008; 3(11):e3706. PMID: 19002259.
      Citations: 33     Fields:    Translation:HumansCells
    36. Chakrabarty K, Wu W, Booth JL, Duggan ES, Nagle NN, Coggeshall KM, Metcalf JP. Human lung innate immune response to Bacillus anthracis spore infection. Infect Immun. 2007 Aug; 75(8):3729-38. PMID: 17517878.
      Citations: 23     Fields:    Translation:HumansCells
    37. Kem DC, Metcalf JP, Cornea A, Dunnam M, Engelbrecht A, Yu X. Is pseudo-Cushing's syndrome in a critically ill patient "pseudo"? Hypothesis and supportive case report. Endocr Pract. 2007 Mar-Apr; 13(2):153-8. PMID: 17490929.
      Citations:    Fields:    Translation:Humans
    38. Wu W, Booth JL, Coggeshall KM, Metcalf JP. Calcium-dependent viral internalization is required for adenovirus type 7 induction of IL-8 protein. Virology. 2006 Nov 10; 355(1):18-29. PMID: 16890267.
      Citations: 7     Fields:    Translation:HumansCells
    39. Chakrabarty K, Wu W, Booth JL, Duggan ES, Coggeshall KM, Metcalf JP. Bacillus anthracis spores stimulate cytokine and chemokine innate immune responses in human alveolar macrophages through multiple mitogen-activated protein kinase pathways. Infect Immun. 2006 Aug; 74(8):4430-8. PMID: 16861629.
      Citations: 21     Fields:    Translation:HumansCells
    40. Nazir SA, Metcalf JP. Innate immune response to adenovirus. J Investig Med. 2005 Sep; 53(6):292-304. PMID: 16207466.
      Citations: 13     Fields:    Translation:HumansCells
    41. Yu X, Huang S, Patterson E, Garrett MW, Kaufman KM, Metcalf JP, Zhu M, Dunn ST, Kem DC. Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2005 Nov; 289(5):H1960-7. PMID: 15994860.
      Citations: 9     Fields:    Translation:Animals
    42. Sanchez TA, Booth JL, Metcalf JP. Tumor necrosis factor-alpha activation by adenovirus E1A 13S CR3 occurs in a cell-dependent and cell-independent manner. Am J Physiol Lung Cell Mol Physiol. 2002 Sep; 283(3):L619-27. PMID: 12169582.
      Citations: 1     Fields:    Translation:HumansCells
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